Research Topics
| Paul N NewtonSummaryAffiliation: Mahidol University Country: Thailand Publications
| Collaborators
|
Detail Information
Publications
A collaborative epidemiological investigation into the criminal fake artesunate trade in South East AsiaPaul N Newton
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
PLoS Med 5:e32. 2008....- The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malariaSue J Lee
Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand
Malar J 7:149. 2008..Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other... - Chromoblastomycosis after a leech bite complicated by myiasis: a case reportGunther Slesak
SFE Medical Project, Luang Namtha, Lao PDR
BMC Infect Dis 11:14. 2011..Chromoblastomycosis is a chronic mycotic infection, most common in the tropics and subtropics, following traumatic fungal implantation... - Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcriptionSachel Mok
School of Biological Sciences, Nanyang Technological University, Singapore
BMC Genomics 12:391. 2011..To identify key features associated with the delayed parasite clearance phenotype, we employed DNA microarrays to profile the physiological gene expression pattern of the resistant isolates... - Fatal Chromobacterium violaceum septicaemia in northern Laos, a modified oxidase test and post-mortem forensic family G6PD analysisGunther Slesak
SFE Medical Project, Luang Namtha, Lao People s Democratic Republic
Ann Clin Microbiol Antimicrob 8:24. 2009..It is rarely described as a human pathogen, mostly from tropical and subtropical areas... 
Counterfeit anti-infective drugsPaul N Newton
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Laos
Lancet Infect Dis 6:602-13. 2006....- Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrationsPaul N Newton
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Trans R Soc Trop Med Hyg 100:184-6. 2006..Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria... - Manslaughter by fake artesunate in Asia--will Africa be next?Paul N Newton
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
PLoS Med 3:e197. 2006 - Impact of poor-quality medicines in the 'developing' worldPaul N Newton
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Trends Pharmacol Sci 31:99-101. 2010..Poor-quality drugs are a vital (but neglected) public health problem. They contribute to a 'crevasse' between the enormous effort in therapeutic research and policy decisions and implementation of good-quality medicines... - Poor quality vital anti-malarials in Africa - an urgent neglected public health priorityPaul N Newton
Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Malar J 10:352. 2011..A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa... - Sennetsu neorickettsiosis: a probable fish-borne cause of fever rediscovered in LaosPaul N Newton
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Am J Trop Med Hyg 81:190-4. 2009..sennetsu DNA by PCR, for the first time, in a fish (Anabas testudineus). These data suggest that sennetsu may be an under-recognized cause of fever and are consistent with the hypothesis that it may be contracted from eating raw fish... - Thiamin deficiency and uncomplicated falciparum malaria in LaosMayfong Mayxay
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Trop Med Int Health 12:363-9. 2007..We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos... - In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos)Mayfong Mayxay
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
Am J Trop Med Hyg 76:245-50. 2007..P. falciparum in Laos is multi-drug resistant; antimalarial immunity resulting from the use of ineffective chloroquine before 2005 probably contributes significantly to the therapeutic responses in clinical trials... - Combined molecular and clinical assessment of Plasmodium falciparum antimalarial drug resistance in the Lao People's Democratic Republic (Laos)Mayfong Mayxay
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao People Democratic Republic
Am J Trop Med Hyg 77:36-43. 2007..These findings suggest that chloroquine and sulfadoxine-pyrimethamine are no longer viable therapy in this country... - The pharmacokinetics of intravenous artesunate in adults with severe falciparum malariaPaul N Newton
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd, Bangkok 10400, Thailand
Eur J Clin Pharmacol 62:1003-9. 2006..CONCLUSION: The large inter-individual variability (10 fold) in DHA Cmax and AUC in patients with potentially lethal, severe malaria, suggests that 2.4 mg/kg should be the minimum daily dose in severe malaria... - Randomized comparison of artesunate and quinine in the treatment of severe falciparum malariaPaul N Newton
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Clin Infect Dis 37:7-16. 2003..03). Artesunate is at least as effective as quinine in the treatment of adults with severe malaria. Larger trials are required to determine whether mortality is reduced among patients treated with artesunate... - Diagnosis and management of malaria by rural community health providers in the Lao People's Democratic Republic (Laos)Mayfong Mayxay
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
Trop Med Int Health 12:540-6. 2007..This study strongly suggests that further training of Lao rural health providers in malaria diagnosis and management is needed to improve the quality of health services in areas remote from district hospitals... - Evaluation of the Panbio dengue virus nonstructural 1 antigen detection and immunoglobulin M antibody enzyme-linked immunosorbent assays for the diagnosis of acute dengue infections in LaosStuart D Blacksell
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Diagn Microbiol Infect Dis 60:43-9. 2008.... - Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast ThailandAllen C Cheng
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok, 10400, Thailand
Trans R Soc Trop Med Hyg 100:64-7. 2006..Low sensitivity and specificity of clinical rules is consistent with the protean manifestations of melioidosis and clinical difficulty in identifying patients with melioidosis... - No evidence for spread of Plasmodium falciparum artemisinin resistance to Savannakhet Province, Southern LaosMayfong Mayxay
Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos
Am J Trop Med Hyg 86:403-8. 2012..Serious adverse events did not develop during or after treatment in any patients. In conclusion, no evidence of P. falciparum in vivo resistance to artesunate was found in southern Laos... - Artemether bioavailability after oral or intramuscular administration in uncomplicated falciparum malariaKamolrat Silamut
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 47:3795-8. 2003..5 to 3.0 h) than after intramuscular administration (median, 8 h; range, 4 to 24 h) (P=0.001). Intramuscular artemether is absorbed very slowly in patients with acute malaria... - The infective causes of hepatitis and jaundice amongst hospitalised patients in Vientiane, LaosBounkong Syhavong
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Trans R Soc Trop Med Hyg 104:475-83. 2010..These patients would be expected to respond to empirical doxycycline therapy which, in the absence of virological diagnosis and treatment, may be an appropriate cost-effective intervention in Lao patients with jaundice/hepatitis... - Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDRAmpai Tanganuchitcharnchai
Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Trans R Soc Trop Med Hyg 106:563-6. 2012..However, re-evaluation of the diagnostic cut-off to an OD of 1.7 demonstrated improved diagnostic accuracy overall (sensitivity 70%; specificity 78%)... - Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malariaPaul N Newton
Mae Sot, Tak and Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd, Bangkok 10400, Thailand
Antimicrob Agents Chemother 49:1622-5. 2005..The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal... - Accuracy of rapid IgM-based immunochromatographic and immunoblot assays for diagnosis of acute scrub typhus and murine typhus infections in LaosStuart D Blacksell
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Laos
Am J Trop Med Hyg 83:365-9. 2010..6% (95% CI = 49.1-60.0%) and 94.1% (95% CI = 92.0-95.7%), respectively. Both assays had relatively good specificity but low sensitivity and thus have limited utility for admission diagnosis... - Comparison of indirect immunofluorescence assays for diagnosis of scrub typhus and murine typhus using venous blood and finger prick filter paper blood spotsRattanaphone Phetsouvanh
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People s Democratic Republic
Am J Trop Med Hyg 80:837-40. 2009..Because filter paper blood samples do not require sophisticated and expensive storage and transport, they may be an appropriate specimen collection technique for the diagnosis of rickettsial disease in the rural tropics... - Accuracy of AccessBio Immunoglobulin M and Total Antibody Rapid Immunochromatographic Assays for the Diagnosis of Acute Scrub Typhus InfectionStuart D Blacksell
Mahidol University Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
Clin Vaccine Immunol 17:263-6. 2010..7 to 97.3%), respectively. For the detection of total antibodies, the sensitivity was 97.6% (122/125 samples; 95% CI, 93.1 to 99.5%), but the specificity was much lower, at 71.4% (75/105 samples; 95% CI, 61.8 to 79.8%)... - Orientia tsutsugamushi in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endotheliumDaniel H Paris
Mahidol Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
PLoS Negl Trop Dis 6:e1466. 2012..tsutsugamushi from the initial eschar site. This newly described cellular tropism for O. tsutsugamushi may influence its interaction with local host immune responses... - A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR - implications for therapeutic failure and drug resistanceSivong Sengaloundeth
Food and Drug Department, Ministry of Health, Government of the Lao PDR, Vientiane, Lao PDR
Malar J 8:172. 2009..A countrywide stratified random survey was performed to determine the availability and quality of oral artesunate in pharmacies and outlets (shops selling medicines) in the Lao PDR (Laos)... - Causes of community-acquired bacteremia and patterns of antimicrobial resistance in Vientiane, LaosRattanaphone Phetsouvanh
Wellcome Trust- Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
Am J Trop Med Hyg 75:978-85. 2006..4/day, an important exception being B. pseudomallei. Bacteremic infants in this setting require an anti-staphylococcal antibiotic... - Prospective study to determine accuracy of rapid serological assays for diagnosis of acute dengue virus infection in LaosStuart D Blacksell
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Clin Vaccine Immunol 14:1458-64. 2007..The findings of this study suggest that currently available RDTs based on the detection of IgM antibodies for the diagnosis of acute dengue virus infections are unlikely to be useful for patient management... - A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern LaosMayfong Mayxay
Wellcome Trust, Mahosot Hospital, Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos
Am J Trop Med Hyg 83:1221-9. 2010..falciparum malaria in Laos and is associated with fewer adverse effects. The results of this study were similar to those of the larger multicentre study... - A prospective assessment of the accuracy of commercial IgM ELISAs in diagnosis of Japanese encephalitis virus infections in patients with suspected central nervous system infections in LaosCatrin E Moore
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
Am J Trop Med Hyg 87:171-8. 2012..2% (95% CI = 87-100) with Panbio Ravi criteria. Specificities were 89-100%. For admission sera from AES patients, sensitivities and specificities of the Panbio ELISA were 85.7% (95% CI = 42-100%) and 92.9% (95% CI = 83-98%), respectively... - Rickettsial infections and fever, Vientiane, LaosSimaly Phongmany
Mahosot Hospital, Vientiane, Laos
Emerg Infect Dis 12:256-62. 2006..46%, p<0.001). Rickettsioses are an underrecognized cause of undifferentiated febrile illnesses among adults in Laos. This finding has implications for the local empiric treatment of fever... - Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2Arjen M Dondorp
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
PLoS Med 2:e204. 2005..CONCLUSION: Plasma PfHRP2 concentrations may be used to estimate the total body parasite biomass in acute falciparum malaria. Severe malaria results from extensive sequestration of parasitised erythrocytes... - Clinically unapparent infantile thiamin deficiency in Vientiane, LaosSengmanivong Khounnorath
Department of Pediatrics, Mahosot Hospital, and Faculty of Postgraduate Studies, University of Health Sciences, Vientiane, Lao People s Democratic Republic
PLoS Negl Trop Dis 5:e969. 2011..Beriberi occurs in Vientiane, Lao PDR, among breastfed infants. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to other illnesses. Thiamin treatment could improve outcome... - Comparison of Ashdown's medium, Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for clinical isolation of Burkholderia pseudomalleiSharon J Peacock
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
J Clin Microbiol 43:5359-61. 2005..pseudomallei from 155 clinical specimens that proved positive for this organism. The sensitivity of each was equivalent; the selectivity of BPSA was lower than that of Ashdown's or B. cepacia medium... - Short report: disease severity and outcome of melioidosis in HIV coinfected individualsWirongrong Chierakul
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 73:1165-6. 2005..Coinfection was detected in only 8 of 524 (1.5%) adults with melioidosis in northeast Thailand. Clinical presentation and acute outcome were similar in HIV-positive and HIV-negative patients... - Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomalleiVanaporn Wuthiekanun
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
J Antimicrob Chemother 55:1029-31. 2005..Isolates assigned as 'susceptible' or 'intermediate' by disc diffusion may be viewed as 'susceptible'; those assigned as 'resistant' require further evaluation by MIC methodology... - In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of ThailandKesinee Chotivanich
Faculty of Tropical Medicine, and Department of Pathobiology, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 70:395-7. 2004..5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine... - Impaired clinical response in a patient with uncomplicated falciparum malaria who received poor-quality and underdosed intramuscular artemetherValy Keoluangkhot
Adult Infectious Disease Ward, Mahosot Hospital, Vientiane, Lao PDR
Am J Trop Med Hyg 78:552-5. 2008..Analysis of the packaging and chemical "fingerprinting" of the artemether suggested that the drug was genuine but was either substandard or had deteriorated after manufacture... - Characterization of "Yaa Chud" Medicine on the Thailand-Myanmar border: selecting for drug-resistant malaria and threatening public healthPaul N Newton
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
Am J Trop Med Hyg 79:662-9. 2008..Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance... - Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic RepublicMayfong Mayxay
Wellcome Trust-Mahosot Hospital, Oxford Tropical Medicine Research Collaboration, Vientiane, Lao PDR
Clin Infect Dis 39:1139-47. 2004..47 mu g/mL; 95% CI, 0.38-0.56 mu g/mL). CONCLUSION: Oral artesunate plus mefloquine and artemether-lumefantrine are highly effective for the treatment of uncomplicated falciparum malaria in Laos... - Accuracy of loop-mediated isothermal amplification for diagnosis of human leptospirosis in ThailandPiengchan Sonthayanon
Department of Clinical Tropical Medicine, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, 420 6 Rajvithi Road, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 84:614-20. 2011..84.6, 95% CI = 69.5-94.1). The rrs LAMP can provide an admission diagnosis in approximately half of patients with leptospirosis, but its clinical utility is reduced by a lower specificity... - Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosisDirek Limmathurotsakul
Department of Tropical Hygiene, Department of Microbiology and Immunology and Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithee Road, Bangkok, Thailand
Am J Trop Med Hyg 84:858-61. 2011..However, repeat cultures of respiratory secretions, urine, throat swabs, or pus/surface swabs provide no prognostic information. This finding highlights the need for follow-up blood cultures in patients with melioidosis... - Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern LaosMayfong Mayxay
Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
Malar J 11:184. 2012..With evidence of resistance to artemisinin derivatives in adjacent Cambodia, there has been a concern as to AL efficacy. Monitoring of AL efficacy would help the Lao Government to make decisions on appropriate malaria treatment... - Burkholderia pseudomallei detection in surface water in southern Laos using Moore's swabsKhamsing Vongphayloth
Institut de la Francophonie pour la Médecine Tropicale, BP 9519, Vientiane, Lao PDR
Am J Trop Med Hyg 86:872-7. 2012..pseudomallei. Most positive water samples were from the Sedone River, downstream of the East Saravane site. Moore's swabs are simple and inexpensive tools for detecting B. pseudomallei in surface waters... 
Simple, rapid and sensitive detection of Orientia tsutsugamushi by loop-isothermal DNA amplificationDaniel H Paris
Mahidol Oxford Tropical Medicine Programme, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithee Road, 10400 Bangkok, Thailand
Trans R Soc Trop Med Hyg 102:1239-46. 2008..This inexpensive method requires no sophisticated equipment or sample preparation, and may prove useful as a diagnostic assay in financially poor settings; however, it requires further prospective validation in the field setting...- Predictive diagnostic value of the tourniquet test for the diagnosis of dengue infection in adultsMayfong Mayxay
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
Trop Med Int Health 16:127-33. 2011..To examine the accuracy of the admission tourniquet test in the diagnosis of dengue infection among Lao adults... - Fatal bacteremia due to immotile Vibrio cholerae serogroup O21 in Vientiane, Laos - a case reportRattanaphone Phetsouvanh
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PD
Ann Clin Microbiol Antimicrob 7:10. 2008..cholerae have been described from Laos. Elsewhere, non cholera-toxin producing, non-O1, non-O139 V. cholerae have been described from blood cultures and ascitic fluid, although they are exceedingly rare isolates... - Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malariaPaul N Newton
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 46:1125-7. 2002..The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate... - The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infectionStuart D Blacksell
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom
Clin Infect Dis 42:1127-34. 2006..Immunochromatographic tests are rapid diagnostic tests (RDTs) that can be performed at the bedside, but they have not been fully validated for diagnosis of dengue infection... - Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomalleiNarisara Chantratita
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Proc Natl Acad Sci U S A 108:17165-70. 2011..The mechanism described here represents an explanation for ceftazidime treatment failure, and may be a frequent but undetected resistance event... - Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast ThailandVanaporn Wuthiekanun
Mahidol Oxford Tropical Medicine Research Unit, Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 55:5388-91. 2011..Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis... - Burkholderia pseudomallei is spatially distributed in soil in northeast ThailandDirek Limmathurotsakul
Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
PLoS Negl Trop Dis 4:e694. 2010..The aim of this study was to evaluate spatial distribution of B. pseudomallei in soil and consider the implications of this for soil sampling strategies... - Comparison of performance of serum and plasma in panbio dengue and Japanese encephalitis virus enzyme-linked immunosorbent assaysStuart D Blacksell
Lao Oxford Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Laos
Am J Trop Med Hyg 87:573-5. 2012..5% (3 of 201 for Dengue/JEV IgM and Dengue IgG) and 2.0% (4 of 201; IgM and NS1) showed discordant pairs. These results demonstrate that plasma containing EDTA is suitable for use in these ELISAs... - In vivo parasitological measures of artemisinin susceptibilityKasia Stepniewska
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
J Infect Dis 201:570-9. 2010.... - Diagnosis of scrub typhusGavin C K W Koh
Faculty of Tropical Medicine, Mahidol University, Bangkok
Am J Trop Med Hyg 82:368-70. 2010..We discuss the limitations of IFA, debate the value of other methods based on antigen detection and nucleic acid amplification, and outline recommendations for future study... - Enhanced determination of Streptococcus pneumoniae serotypes associated with invasive disease in Laos by using a real-time polymerase chain reaction serotyping assay with cerebrospinal fluidCatrin E Moore
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos
Am J Trop Med Hyg 83:451-7. 2010..Although the sample size is small, these data suggest that the PCV-7 vaccine may have relatively low efficacy in Laos. Further studies are urgently needed to guide pneumococcal vaccine policy in Laos... - Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosisWirongrong Chierakul
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Clin Infect Dis 41:1105-13. 2005..CONCLUSION: We conclude that the addition of TMP-SMX to ceftazidime therapy during initial treatment of severe melioidosis does not reduce the acute mortality rate... - Erythrocyte transketolase activity, markers of cardiac dysfunction and the diagnosis of infantile beriberiDouangdao Soukaloun
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People s Democratic Republic
PLoS Negl Trop Dis 5:e971. 2011..There are few data on biochemical markers of infantile thiamin deficiency or indices of cardiac dysfunction as potential surrogate markers... - Real-time multiplex PCR assay for detection and differentiation of rickettsiae and orientiaeDaniel H Paris
Mahidol Oxford Tropical Medicine Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Trans R Soc Trop Med Hyg 102:186-93. 2008..However, further optimisation and validation on samples taken directly from patients to assess its clinical diagnostic utility is required... - Malaria and amphetamine 'horse tablets' in ThailandPaul N Newton
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Trop Med Int Health 8:17-8. 2003..This comorbidity may cause diagnostic confusion, alter malaria pathophysiology and lead to drug interactions... - Prevalence of hepatitis E virus antibodies in pigs: implications for human infections in village-based subsistence pig farming in the Lao PDRStuart D Blacksell
Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
Trans R Soc Trop Med Hyg 101:305-7. 2007..3% (46/301) amongst village pigs. The age distribution suggested previous in-village HEV pig infections. These findings suggest a zoonotic risk associated with village-based smallholder pig farming... - Mixed-species malaria infections in humansMayfong Mayxay
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
Trends Parasitol 20:233-40. 2004 - Rapid immunofluorescence microscopy for diagnosis of melioidosisVanaporn Wuthiekanun
Faculty of Tropical Medicine, Wellcome Trust Oxford University Mahidol University Tropical Medicine Research Program, Bangkok, Thailand
Clin Diagn Lab Immunol 12:555-6. 2005..The sensitivities of both IF tests were 66%, and the specificities were 99.5 and 99.4%, respectively... - Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in CambodiaEmma K Nickerson
Mahidol Oxford Tropical Medicine Research Unit, and Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 84:313-7. 2011..The study findings have important implications for healthcare in a setting where diagnostic microbiology and access to antimicrobial drugs with efficacy against MRSA are limited... - Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipL32 genes for human leptospirosis in Thailand: a case-control studyJanjira Thaipadungpanit
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
PLoS ONE 6:e16236. 2011..Here, we compare the diagnostic sensitivity and specificity of two real-time PCR assays targeting rrs or lipL32 for the diagnosis of leptospirosis in northeast Thailand... - Defining disease heterogeneity to guide the empirical treatment of febrile illness in resource poor settingsLisa J White
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom
PLoS ONE 7:e44545. 2012..e. be spatially heterogeneous) and that national empirical treatment policies based on the aetiology measured in a single location could lead to inappropriate treatment... - Factors associated with a measles outbreak in children admitted at Mahosot Hospital, Vientiane, LaosMayfong Mayxay
Division of Post Graduate studies and Research, Faculty of Medical Sciences, National University of Laos, Vientiane, Lao PDR
BMC Public Health 7:193. 2007..We therefore conducted a study to determine risk factors associated with measles amongst children admitted at Mahosot Hospital, Vientiane... - A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infectionStuart D Blacksell
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, University of Oxford, Oxford, UK
Trans R Soc Trop Med Hyg 100:775-84. 2006..It is recommended that additional, standardized evaluations are required for other dengue ICTs... - Accuracy of Burkholderia pseudomallei identification using the API 20NE system and a latex agglutination testPremjit Amornchai
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
J Clin Microbiol 45:3774-6. 2007..mallei and 98 B. thailandensis isolates were not correctly identified. A latex agglutination test was positive for 796/800 (99.5%) B. pseudomallei isolates and negative for 120 other oxidase-positive gram-negative bacilli... - Toad poisoning in LaosSommay Keomany
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
Am J Trop Med Hyg 77:850-3. 2007..These data indicate that toad poisoning may be underestimated and that education on the seriousness of toad toxins could be a useful public health measure... - Contrasting genetic structure in Plasmodium vivax populations from Asia and South AmericaMallika Imwong
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Int J Parasitol 37:1013-22. 2007..falciparum, and have important implications for the design of association mapping studies, and interpretation of P. vivax epidemiology... - Public health impact of establishing the cause of bacterial infections in rural AsiaSharon J Peacock
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Trans R Soc Trop Med Hyg 102:5-6. 2008..These factors have major implications for empirical therapy of fever. Initiatives are urgently needed to strengthen the infrastructure of microbiology in rural Asia... - N-acetylcysteine as adjunctive treatment in severe malaria: a randomized, double-blinded placebo-controlled clinical trialPrakaykaew Charunwatthana
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Crit Care Med 37:516-22. 2009..It has been suggested that the antioxidant N-acetylcysteine (NAC) may be beneficial in treatment. We studied the efficacy and safety of parenteral NAC as an adjunct to artesunate treatment of severe falciparum malaria... - Urine antibiotic activity in patients presenting to hospitals in Laos: implications for worsening antibiotic resistanceManisone Khennavong
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Vientiane, Lao PDR
Am J Trop Med Hyg 85:295-302. 2011..0% versus 46.5%; P < 0.001). Antibiotic use based on patients histories was significantly less frequent than when estimated from urinary antibiotic activity (P < 0.0001)... - Genetic diversity and microevolution of Burkholderia pseudomallei in the environmentNarisara Chantratita
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
PLoS Negl Trop Dis 2:e182. 2008..The soil dwelling Gram-negative pathogen Burkholderia pseudomallei is the cause of melioidosis. The diversity and population structure of this organism in the environment is poorly defined... - Randomized soil survey of the distribution of Burkholderia pseudomallei in rice fields in LaosSayaphet Rattanavong
Institut de la Francophonie pour la Médecine Tropicale, BP 9519, Vientiane, Lao People s Democratic Republic
Appl Environ Microbiol 77:532-6. 2011..Further studies are needed to investigate potential climatic, soil, and biological determinants of this heterogeneity... - Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in LaosStuart D Blacksell
Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR, and Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, UK
Clin Vaccine Immunol 13:1166-9. 2006..3% and specificity of 75.5%: ELISA sensitivity of 60.9% and specificity of 65.6%) compared to the Leptospira "gold standard" microscopic agglutination test... - A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in LaosSimmaly Phongmany
Mahosot Hospital, Vientiane, Laos
Trans R Soc Trop Med Hyg 99:451-8. 2005..Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost... - Factors predicting and reducing mortality in patients with invasive Staphylococcus aureus disease in a developing countryEmma K Nickerson
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
PLoS ONE 4:e6512. 2009..The factors determining mortality in developing countries have not been identified... - A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitisPaul N Newton
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Clin Infect Dis 35:769-72. 2002.... - Retinal haemorrhage in P falciparum malariaPaul N Newton
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Lancet 360:515. 2002 - Diabetes mellitus, insulin, and melioidosis in ThailandAndrew J H Simpson
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Clin Infect Dis 36:e71-2. 2003..This provides evidence against the hypothesis that insulin deficiency contributes to the known susceptibility to melioidosis in patients with diabetes mellitus... - A simple and inexpensive container for the transport of biological specimens in limited resource situationsStuart D Blacksell
Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Trans R Soc Trop Med Hyg 100:1084-6. 2006..We have found the PVC transporter to be a useful and cost-efficient durable alternative that meets IATA Packing Instruction 650 biological transport container requirements... - Evaluation of immunoglobulin M (IgM) and IgG rapid cassette test kits for diagnosis of melioidosis in an area of endemicityVanaporn Wuthiekanun
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd, Bangkok, 10400 Thailand
J Clin Microbiol 42:3435-7. 2004..This kit represents an improvement over IHA for the diagnosis of melioidosis an area of endemicity although, as with other serological tests, it has reduced diagnostic utility in a population with high background seropositivity... - A trichinellosis outbreak in Borikhamxay Province, Lao PDRSomphou Sayasone
, Vientiane, Lao PDR
Trans R Soc Trop Med Hyg 100:1126-9. 2006..Among the 22 patients, 86% had consumed pork meat from the same source. This is the first report of an outbreak investigation in Lao PDR since 1975. It shows that the incidence of trichinellosis is much higher than currently thought... - Genetic history of hepatitis C virus in East AsiaOliver G Pybus
Department of Zoology, University of Oxford, Oxford, United Kingdom
J Virol 83:1071-82. 2009..Our analysis explains the generation and maintenance of HCV diversity in Asia and could provide a template for further investigations of HCV spread in other regions... - Recommendations for clinical practice. Management and prevention of imported Plasmodium falciparum malaria. (Revision 2007 of the 1999 Consensus conference). Short textJean-Paul Stahl
Med Mal Infect 38:54-67, 39-53. 2008 - [Retrospective analysis of 107 imported adult cases of malaria. Experience report of uncomplicated falciparum malaria treatment in adults with oral atovaquone-proguanil]Rémy Vatan
Service de médecine interne et des maladies tropicales, Hôpital Saint André, Bordeaux
Presse Med 35:571-7. 2006..We also analyzed the epidemiologic, clinical and hematologic characteristics of these patients with imported malaria... - In vitro release and stability of an artesunate rectal gel suitable for pediatric useKaren Gaudin
Laboratoire de Chimie Analytique, UFR Pharmacie, Universite Bordeaux 2, Bordeaux Cedex, France
Int J Pharm 353:1-7. 2008..The calculated in vitro release exponent (n) value suggested that artesunate is released from the gel by non-Fickian transport... - Stability of artesunate in pharmaceutical solventsKaren Gaudin
Laboratoire de Chimie Analytique UFR Pharmacie, EA 3677, Bases thérapeutiques des inflammations et infections, Universite Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
J Pharm Biomed Anal 43:1019-24. 2007..In PEG 400, significant degradation was observed after only 1 month, however DHA was the unique degradation product, which is also an efficient anti-malarial drug... - [Management and prevention of imported Plasmodium falciparum malaria (Revision 2007 of the 1999 Consensus Conference). Long text in French]Jean-Paul Stahl
Med Mal Infect 38:68-117. 2008 - [The future outlook of antimalarials]Pascal Millet
TropiVal, équipe d accueil EA 3677 Bases thérapeutiques des inflammations et des infections, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex
Rev Prat 55:875-9. 2005.... - Use of pre-packaged chloroquine for the home management of presumed malaria in Malagasy childrenArsène Ratsimbasoa
Malaria Unit Research, Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar
Malar J 5:79. 2006..The availability of treatment options by studying retailers and community-based service providers was also investigated... - Evaluation of FRET real-time PCR assay for rapid detection and differentiation of Plasmodium species in returning travellers and migrantsInnocent Safeukui
Pôle de Biologie Moléculaire, CHU de Bordeaux, Hopital Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
Malar J 7:70. 2008.... - Plasmodium berghei: dehydroepiandrosterone sulfate reverses chloroquino-resistance in experimental malaria infection; correlation with glucose 6-phosphate dehydrogenase and glutathione synthesis pathwayInnocent Safeukui
Unité 3677, Bases thérapeutiques des inflammations et infections, Université Victor Segalen Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
Biochem Pharmacol 68:1903-10. 2004..This experimental study suggests that DHEAS could be used to potentiate antimalarial action of CQ, particularly on CQ resistant strains...