A M Dondorp

Summary

Affiliation: Mahidol University
Country: Thailand

Publications

  1. pmc Evaluation of a PfHRP2 and a pLDH-based rapid diagnostic test for the diagnosis of severe malaria in 2 populations of African children
    Ilse C E Hendriksen
    Mahidol Oxford Research Unit, Bangkok, Thailand
    Clin Infect Dis 52:1100-7. 2011
  2. pmc Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial
    Sanjib Mohanty
    Depatment of Medicine and Radiology, Ispat General Hospital, Rourkela, Orissa, India
    Clin Infect Dis 53:349-55. 2011
  3. pmc Timing of enteral feeding in cerebral malaria in resource-poor settings: a randomized trial
    Richard J Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS ONE 6:e27273. 2011
  4. pmc Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria
    Debashish Das
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 56:e48-58. 2013
  5. pmc Diagnosis, clinical presentation, and in-hospital mortality of severe malaria in HIV-coinfected children and adults in Mozambique
    Ilse C E Hendriksen
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 55:1144-53. 2012
  6. pmc Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement
    Ilse C E Hendriksen
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 9:e1001297. 2012
  7. pmc Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia
    Richard J Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 209:120-9. 2014
  8. pmc Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria
    Katherine Plewes
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 13:91. 2014
  9. pmc Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand
    Paul N Newton
    Lao Oxford Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 12:229. 2013
  10. pmc Prevalence of antifolate resistance mutations in Plasmodium falciparum isolates in Afghanistan
    Ghulam R Awab
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Bangkok, Thailand
    Malar J 12:96. 2013

Collaborators

Detail Information

Publications42

  1. pmc Evaluation of a PfHRP2 and a pLDH-based rapid diagnostic test for the diagnosis of severe malaria in 2 populations of African children
    Ilse C E Hendriksen
    Mahidol Oxford Research Unit, Bangkok, Thailand
    Clin Infect Dis 52:1100-7. 2011
    ..Although these tests have been extensively evaluated in uncomplicated falciparum malaria, reliable data on their performance for diagnosing potentially lethal severe malaria is lacking...
  2. pmc Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial
    Sanjib Mohanty
    Depatment of Medicine and Radiology, Ispat General Hospital, Rourkela, Orissa, India
    Clin Infect Dis 53:349-55. 2011
    ..Coma is a frequent presentation of severe malaria in adults and an important cause of death. The role of cerebral swelling in its pathogenesis, and the possible benefit of intravenous mannitol therapy to treat this, is uncertain...
  3. pmc Timing of enteral feeding in cerebral malaria in resource-poor settings: a randomized trial
    Richard J Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS ONE 6:e27273. 2011
    ..We hypothesized that the risk of aspiration pneumonia might outweigh the potential benefits of earlier recovery and prevention of hypoglycaemia...
  4. pmc Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria
    Debashish Das
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 56:e48-58. 2013
    ..We investigated whether increasing or splitting the dose of the short-half-life drug artesunate improves parasite clearance in falciparum malaria in the 2 regions...
  5. pmc Diagnosis, clinical presentation, and in-hospital mortality of severe malaria in HIV-coinfected children and adults in Mozambique
    Ilse C E Hendriksen
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 55:1144-53. 2012
    ....
  6. pmc Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement
    Ilse C E Hendriksen
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 9:e1001297. 2012
    ..We investigated the prognostic significance of plasma PfHRP2 and used it to estimate the malaria-attributable fraction in African children diagnosed with severe malaria...
  7. pmc Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia
    Richard J Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 209:120-9. 2014
    ..Rapid parasite killing by intravenous artesunate might obscure the effects of levamisole. ..
  8. pmc Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria
    Katherine Plewes
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 13:91. 2014
    ..falciparum histidine rich protein 2 (PfHRP2), as a measure of sequestered parasite burden, with AKI in severe malaria...
  9. pmc Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand
    Paul N Newton
    Lao Oxford Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 12:229. 2013
    ..Severe malaria remains a major cause of death and morbidity amongst adults in the Asiatic tropics...
  10. pmc Prevalence of antifolate resistance mutations in Plasmodium falciparum isolates in Afghanistan
    Ghulam R Awab
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Bangkok, Thailand
    Malar J 12:96. 2013
    ..Molecular studies provide a sensitive means to investigate the current state of drug susceptibility to the SP component, and can also provide information on the likely efficacy of other potential forms of artemisinin-combination therapy...
  11. pmc Temporal trends in severe malaria in Chittagong, Bangladesh
    Richard James Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:323. 2012
    ..Chittagong Medical College Hospital (CMCH) is the major tertiary referral hospital for severe malaria in Chittagong Division...
  12. pmc Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
    Thiranut Ramutton
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:276. 2012
    ..The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene reported in both laboratory and field isolates. These issues potentially confound the interpretation of PFHRP2 measurements...
  13. pmc The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum
    Kesinee Chotivanich
    MORU, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Malar J 11:177. 2012
    ..In this study, the consequences of lipidaemia on anti-malarial drug efficacy were assessed in vitro...
  14. pmc Central venous catheter use in severe malaria: time to reconsider the World Health Organization guidelines?
    Josh Hanson
    Department of Medicine, Cairns Base Hospital, Queensland, Australia
    Malar J 10:342. 2011
    ..However there are few data from clinical trials to support this recommendation...
  15. pmc Decreasing incidence of severe malaria and community-acquired bacteraemia among hospitalized children in Muheza, north-eastern Tanzania, 2006-2010
    George Mtove
    National Institute for Medical Research Amani Centre, Tanga, Tanzania
    Malar J 10:320. 2011
    ..The annual incidence and temporal trend of severe malaria and community-acquired bacteraemia during a four-year period in Muheza, Tanzania was assessed...
  16. pmc Laboratory prediction of the requirement for renal replacement in acute falciparum malaria
    Josh Hanson
    Cairns Base Hospital, Australia
    Malar J 10:217. 2011
    ..Even when RRT is available, delaying its initiation may increase mortality. Earlier identification of patients who will need RRT may improve outcomes...
  17. pmc Coma in fatal adult human malaria is not caused by cerebral oedema
    Isabelle M Medana
    Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, Oxford, UK
    Malar J 10:267. 2011
    ....
  18. pmc Modelling malaria elimination on the internet
    Richard J Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:191. 2011
    ..There is thus an urgent need for user-friendly and accessible models purpose-designed in collaboration with policymakers to answer pertinent questions arising from the field...
  19. pmc Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies
    Wirichada Pongtavornpinyo
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 7:229. 2008
    ..Formulating an appropriate dynamic data-driven model is a powerful predictive tool for exploring the impact of these strategies quantitatively...
  20. pmc Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum
    Preeyaporn Monatrakul
    Department of Clinical Tropical Medicine, Mahidol University, 420 6 Rajvithi, Bangkok, Thailand
    Malar J 9:326. 2010
    ..This study characterized the effects of 'immune' plasma to Plasmodium falciparumon the in vitro susceptibility of P. falciparum to anti-malarial drugs...
  21. pmc FlexiChip package: an universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug resistance
    Nicolas Steenkeste
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, 5 Bd Monivong, BP 983, Phnom Penh, Cambodia
    Malar J 8:229. 2009
    ..Here a new Zip-code array is described, called FlexiChip, linked to a dedicated software program, which largely overcomes this problem...
  22. pmc Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial
    Ghulam Rahim Awab
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:105. 2010
    ..Chloroquine resistance in P. vivax is emerging in Asia. Therapeutic responses across Afghanistan have not been evaluated in detail...
  23. pmc Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009
    ..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
  24. pmc The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia
    Richard J Maude
    Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
    Malar J 8:31. 2009
    ..The use of such an approach to investigate the likely effectiveness of different containment measures with the ultimate aim of eliminating artemisinin-resistant malaria is described...
  25. pmc Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription
    Sachel Mok
    School of Biological Sciences, Nanyang Technological University, Singapore
    BMC Genomics 12:391. 2011
    ..To identify key features associated with the delayed parasite clearance phenotype, we employed DNA microarrays to profile the physiological gene expression pattern of the resistant isolates...
  26. ncbi request reprint Levamisole inhibits sequestration of infected red blood cells in patients with falciparum malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    J Infect Dis 196:460-6. 2007
    ..Binding to CD36, the major vascular receptor, is stabilized through dephosphorylation of CD36 by an alkaline phosphatase. This is inhibited by the alkaline phosphatase-inhibitor levamisole, resulting in decreased cytoadhesion...
  27. ncbi request reprint The treatment of severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 101:633-4. 2007
    ..The increasing availability of basic intensive care facilities in developing countries also has the potential to further reduce mortality...
  28. doi request reprint Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria
    A M Dondorp
    Department of Physiology, Academic Medical Centre, Amsterdam, The Netherlands
    J Infect Dis 197:79-84. 2008
    ..This study sought to describe and quantify microcirculatory changes in the mucosal surfaces of patients with severe malaria, by direct in vivo observation using orthogonal polarization spectral (OPS) imaging...
  29. ncbi request reprint Clinical significance of sequestration in adults with severe malaria
    A M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Transfus Clin Biol 15:56-7. 2008
    ..Levamisole is currently tried as adjunctive treatment in severe malaria targeting sequestration...
  30. doi request reprint Artemisinin resistance: current status and scenarios for containment
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok10400, Thailand
    Nat Rev Microbiol 8:272-80. 2010
    ..Mathematical modelling can be a useful tool to evaluate possible strategies for containment...
  31. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    ..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
  32. ncbi request reprint Abnormal blood flow and red blood cell deformability in severe malaria
    A M Dondorp
    Department of Internal Medicine, Tropical Medicine and AIDS, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Parasitol Today 16:228-32. 2000
    ..The correlation with clinical findings and possible therapeutic consequences are discussed...
  33. doi request reprint A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma
    W Hanpithakpong
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 876:61-8. 2008
    ..The method was free from matrix effects as demonstrated both graphically and quantitatively...
  34. doi request reprint Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 876:54-60. 2008
    ..These various pitfalls have undoubtedly contributed to the large inter-subject variation in plasma concentration profiles and derived pharmacokinetic parameters for these important antimalarial drugs...
  35. ncbi request reprint The resistance to physiological shear stresses of the erythrocytic rosettes formed by cells infected with Plasmodium falciparum
    K T Chotivanich
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Ann Trop Med Parasitol 94:219-26. 2000
    ..The results indicate that rosettes do resist the physiological shear forces that are encountered in the venular side of the circulation and could thus contribute to microvascular obstruction in falciparum malaria...
  36. pmc Population pharmacokinetics of intramuscular artesunate in African children with severe malaria: implications for a practical dosing regimen
    I C E Hendriksen
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Pharmacol Ther 93:443-50. 2013
    ..001), resulting in lower ARS and DHA exposure levels in smaller children. An adapted dosing regimen including a practical dosing table per weight band is proposed for young children based on the pharmacokinetic model...
  37. pmc Optimizing the culture of Plasmodium falciparum in hollow fiber bioreactors
    P Preechapornkul
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 41:761-9. 2010
    ..The system opens new possibilities for the study of in vitro drug sensitivity under conditions mimicking in vivo pharmacokinetics, and the selection of anti-malarial drug resistance and associated parasite biological and genomic changes...
  38. ncbi request reprint Fake antimalarials in Southeast Asia are a major impediment to malaria control: multinational cross-sectional survey on the prevalence of fake antimalarials
    A M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trop Med Int Health 9:1241-6. 2004
    ..To assess the prevalence of counterfeit antimalarial drugs in Southeast (SE) Asia...
  39. ncbi request reprint Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 45:149-53. 2007
    ..3 (70:30, v/v) at a flow rate of 1 mL/min. The assay was implemented for the analysis of artesunate for injection purchased from Guilin Pharmaceutical Company in China...
  40. pmc Coagulation and inflammation in scrub typhus and murine typhus--a prospective comparative study from Laos
    D H Paris
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Microbiol Infect 18:1221-8. 2012
    ..typhi and O. tsutsugamushi could differ in the early phase of infection and may contribute to disease differentiation...
  41. ncbi request reprint Oxidative stress and rheology in severe malaria
    A M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Redox Rep 8:292-4. 2003
    ..Since this seems to be caused by oxidative damage to the red blood cell membrane, the anti-oxidant N-acetylcysteine is a promising candidate for adjunctive treatment in severe malaria, which still has a mortality rate as high as 20%...
  42. ncbi request reprint The role of reduced red cell deformability in the pathogenesis of severe falciparum malaria and its restoration by blood transfusion
    A M Dondorp
    Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, Amsterdam, The Netherlands
    Trans R Soc Trop Med Hyg 96:282-6. 2002
    ..RCD can be improved by blood transfusion. Since severely reduced RCD has a strong predictive value for mortality, blood transfusion possibly improves disease outcome not only through its beneficial effect on anaemia but also on RCD...