Paiboon Sithithaworn

Summary

Affiliation: Khon Kaen
Country: Thailand

Publications

  1. pmc Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
    Prasert Saichua
    Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand
    PLoS Negl Trop Dis 7:e2228. 2013
  2. ncbi request reprint Epidemiology of Opisthorchis viverrini
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Acta Trop 88:187-94. 2003
  3. ncbi request reprint Epidemiology of Strongyloides stercoralis in north-east Thailand: application of the agar plate culture technique compared with the enzyme-linked immunosorbent assay
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Trans R Soc Trop Med Hyg 97:398-402. 2003
  4. pmc Genetic variation in Opisthorchis viverrini (Trematoda: Opisthorchiidae) from northeast Thailand and Laos PDR based on random amplified polymorphic DNA analyses
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Parasitol Res 100:613-7. 2007
  5. doi request reprint Ultrasonography assessment of hepatobiliary abnormalities in 3359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand
    Eimorn Mairiang
    Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Int 61:208-11. 2012
  6. ncbi request reprint iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel
    Somchai Pinlaor
    Department of Parasitology, Khon Kaen University, Thailand
    Int J Cancer 119:1067-72. 2006
  7. pmc Evidence of a species complex within the food-borne trematode Opisthorchis viverrini and possible co-evolution with their first intermediate hosts
    Weerachai Saijuntha
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Int J Parasitol 37:695-703. 2007
  8. ncbi request reprint Enzyme markers to identify and characterize Opisthorchis viverrini in Thailand and Lao PDR
    Weerachai Saijuntha
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Southeast Asian J Trop Med Public Health 37:43-7. 2006
  9. doi request reprint Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Cancer 127:2576-87. 2010
  10. doi request reprint Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma
    Suksanti Prakobwong
    Department of Parasitology, Khon Kaen University, Khon Kaen, Thailand
    Int J Cancer 131:E416-24. 2012

Collaborators

Detail Information

Publications59

  1. pmc Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis
    Prasert Saichua
    Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand
    PLoS Negl Trop Dis 7:e2228. 2013
    ..e., serve as a "syndromic biomarker" of the advanced pathologies from opisthorchiasis...
  2. ncbi request reprint Epidemiology of Opisthorchis viverrini
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Acta Trop 88:187-94. 2003
    ..In this review, we present the basic population features and the factors influencing transmission between the different hosts...
  3. ncbi request reprint Epidemiology of Strongyloides stercoralis in north-east Thailand: application of the agar plate culture technique compared with the enzyme-linked immunosorbent assay
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Trans R Soc Trop Med Hyg 97:398-402. 2003
    ..stercoralis is the predominant parasite in rural north-east Thailand, and that APCT and ELISA should be used as complementary diagnostic methods for community-based parasite surveys, at least among those in high-risk groups...
  4. pmc Genetic variation in Opisthorchis viverrini (Trematoda: Opisthorchiidae) from northeast Thailand and Laos PDR based on random amplified polymorphic DNA analyses
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Parasitol Res 100:613-7. 2007
    ..viverrini and fish-borne trematodes within the region. Additionally, application of these markers in such studies could have important implications in relation to the prevalence of cholangiocarcinoma in different regions of Asia...
  5. doi request reprint Ultrasonography assessment of hepatobiliary abnormalities in 3359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand
    Eimorn Mairiang
    Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Int 61:208-11. 2012
    ..This study emphasizes the current status of high O. viverrini infection rate and the existence of hepatobiliary abnormalities including suspected CCA in opisthorchiasis endemic areas of Thailand...
  6. ncbi request reprint iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel
    Somchai Pinlaor
    Department of Parasitology, Khon Kaen University, Thailand
    Int J Cancer 119:1067-72. 2006
    ..It is concluded that praziquantel can exhibit a preventive effect against OV-induced cholangiocarcinoma by inhibiting iNOS-dependent DNA damage through not only elimination of parasites but also a potential antiinflammatory effect...
  7. pmc Evidence of a species complex within the food-borne trematode Opisthorchis viverrini and possible co-evolution with their first intermediate hosts
    Weerachai Saijuntha
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Int J Parasitol 37:695-703. 2007
    ..Our findings have major implications for the implementation of effective control and surveillance programs targeted to these medically important food-borne parasites...
  8. ncbi request reprint Enzyme markers to identify and characterize Opisthorchis viverrini in Thailand and Lao PDR
    Weerachai Saijuntha
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Southeast Asian J Trop Med Public Health 37:43-7. 2006
    ....
  9. doi request reprint Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Cancer 127:2576-87. 2010
    ..The results suggest that MMP-9 expression is associated with the accumulation of peribiliary fibrosis in conjunction to the induction of iNOS and Rac1 that may potentiate DNA damage and cholangiocarcinogenesis...
  10. doi request reprint Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma
    Suksanti Prakobwong
    Department of Parasitology, Khon Kaen University, Khon Kaen, Thailand
    Int J Cancer 131:E416-24. 2012
    ..69; p = 0.020). In conclusion, plasma HYP, collagen I and MMP-7 may be useful as novel predictive markers of opisthorchiasis-related BBD, and HYP may be used as a diagnostic marker for CCA...
  11. pmc Elevated plasma IL-6 associates with increased risk of advanced fibrosis and cholangiocarcinoma in individuals infected by Opisthorchis viverrini
    Banchob Sripa
    Department of Pathology, Khon Kaen University School of Medicine, Khon Kaen, Thailand
    PLoS Negl Trop Dis 6:e1654. 2012
    ..viverrini, but to the development of the advanced and often lethal pathologies resulting from chronic O. viverrini infection...
  12. doi request reprint Oxidized alpha-1 antitrypsin as a predictive risk marker of opisthorchiasis-associated cholangiocarcinoma
    Wassana Jamnongkan
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Tumour Biol 34:695-704. 2013
    ..This marker could now be explored for screening of subjects living in endemic areas where the prevalence of opisthorchiasis still remains high...
  13. doi request reprint The systematics and population genetics of Opisthorchis viverrini sensu lato: implications in parasite epidemiology and bile duct cancer
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Int 61:32-7. 2012
    ..viverrini sensu lato in human epidemiology and genotype related morbidity as well as co-evolution of parasites with primary and secondary intermediate species of host...
  14. doi request reprint Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis
    Raynoo Thanan
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Cancer Epidemiol Biomarkers Prev 17:518-24. 2008
    ..Urinary 8-oxodG may be a useful biomarker to monitor not only infection but also carcinogenesis...
  15. pmc Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos
    Banchob Sripa
    Tropical Disease Research Laboratory, Department of Pathology, Khon Kaen University, Khon Kaen 40002, Thailand
    Acta Trop 120:S158-68. 2011
    ..Last, we comment on national control strategies in Thailand for the control of O. viverrini infection aimed at reduction in the prevalence of O. viverrini-associated liver cancer in the longer term...
  16. doi request reprint Biological variation within Opisthorchis viverrini sensu lato in Thailand and Lao PDR
    Nonglak Laoprom
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen 40002, Thailand
    J Parasitol 95:1307-13. 2009
    ..These results support the genetic/molecular data indicating a subdivision of O. viverrini populations on the basis of watershed and that propose the existence of cryptic species in Thailand and the Lao PDR...
  17. doi request reprint Specific serum IgG, but not IgA, antibody against purified Opisthorchis viverrini antigen associated with hepatobiliary disease and cholangiocarcinoma
    Porntip Pinlaor
    Centre for Research and Development in Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Int 61:212-6. 2012
    ..These results suggest that purified O. viverrini-antigen improves serodiagnosis for the evaluation of opisthorchiasis-associated HBD, and may be useful in the screening of opisthorchiasis in subjects at risk of developing CCA...
  18. doi request reprint PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group
    Watcharin Loilome
    Department of Biochemistry and Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Tumour Biol 33:2289-98. 2012
    ..Overexpression of PRKAR1A leads to secretion of ECPKA which is associated with serum autoantibody that may constitute a biomarker for human CCA genesis...
  19. doi request reprint Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis
    Prajak Sawangsoda
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Parasitol Int 61:196-202. 2012
    ..Furthermore, it may provide a better indicator of the risk of disease, particularly CCA...
  20. doi request reprint Opisthorchis viverrini-antigen induces expression of MARCKS during inflammation-associated cholangiocarcinogenesis
    Anchalee Techasen
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Int 61:140-4. 2012
    ..viverrini-infected patients was significantly higher than in healthy subjects (P = 0.02). Thus, MARCKS is significantly expressed in macrophages and plays a role in inflammation-related CCA induced by O. viverrini...
  21. pmc Proteomic identification of plasma protein tyrosine phosphatase alpha and fibronectin associated with liver fluke, Opisthorchis viverrini, infection
    Jarinya Khoontawad
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    PLoS ONE 7:e45460. 2012
    ..In conclusion, our results suggest that plasma PTPĪ± and fibronectin may be associated with opisthorchiasis and the hamster model provides the basis for development of novel diagnostic markers in the future...
  22. doi request reprint Platelet-derived growth factor may be a potential diagnostic and prognostic marker for cholangiocarcinoma
    Sirintip Boonjaraspinyo
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Tumour Biol 33:1785-802. 2012
    ..4-fold (P = 0.014). The present results suggest that PDGFA and PDGFRA may be used for CCA prognosis and/or as diagnostic candidate markers...
  23. doi request reprint Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen
    Puangrat Yongvanit
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Parasitol Res 110:1969-77. 2012
    ..These molecules may be used as the chemopreventive target for intervention of opisthorchiasis patients in an endemic area...
  24. pmc Exceptionally high prevalence of infection of Bithynia siamensis goniomphalos with Opisthorchis viverrini cercariae in different wetlands in Thailand and Lao PDR
    Nadda Kiatsopit
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Thailand
    Am J Trop Med Hyg 86:464-9. 2012
    ..Our results show that transmission of O. viverrini from humans as well as animal reservoir hosts to snail intermediate hosts is ongoing and potentially increasing in endemic areas across Thailand and Lao PDR...
  25. pmc Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6
    Banchob Sripa
    Department of Pathology, Khon Kaen University School of Medicine, Khon Kaen, Thailand
    Hepatology 50:1273-81. 2009
    ..O. viverrini-infected individuals with advanced periductal fibrosis showed other hepatobiliary abnormalities, including reduced gallbladder contractility and the presence of gallbladder sludge...
  26. doi request reprint Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Parasitol 39:825-35. 2009
    ..MMPs and TIMPs may serve as diagnostic markers for the severity of O. viverrini-induced liver injury...
  27. doi request reprint Genetic markers for studies on the systematics and population genetics of snails, Bithynia spp., the first intermediate hosts of Opisthorchis viverrini in Thailand
    Nadda Kiatsopit
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Thailand
    Acta Trop 118:136-41. 2011
    ..The genetic markers detected will form the basis for subsequent comprehensive studies on the systematics and population genetics of Bithynia snails as well as for their role in the transmission of O. viverrini and opisthorchiasis...
  28. pmc Population genetic structuring in Opisthorchis viverrini over various spatial scales in Thailand and Lao PDR
    Nonglak Laoprom
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    PLoS Negl Trop Dis 6:e1906. 2012
    ..This provides the basis for the investigation of the role of parasite genetic diversity and differentiation in transmission dynamics and control of O. viverrini...
  29. doi request reprint Microsatellite loci in the carcinogenic liver fluke, Opisthorchis viverrini and their application as population genetic markers
    Nonglak Laoprom
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Infect Genet Evol 10:146-53. 2010
    ..viverrini sensu lato in Southeast Asia...
  30. ncbi request reprint Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: an indirect effect after praziquantel treatment
    Somchai Pinlaor
    Department of Parasitology, and Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Am J Trop Med Hyg 78:564-73. 2008
    ..viverrini antigen release. Data in this study can be used as a basis to understand potential side effects of praziquantel treatment in humans...
  31. pmc Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis
    Thewarach Laha
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Int J Infect Dis 12:e49-59. 2008
    ..To isolate and characterize an asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and evaluate its expression profile, biochemical activity, and potential as an immunodiagnostic antigen...
  32. pmc Genetic markers for the identification and characterization of Opisthorchis viverrini, a medically important food borne trematode in Southeast Asia
    Weerachai Saijuntha
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Acta Trop 100:246-51. 2006
    ..viverrini, a medically important food borne trematode in Southeast Asia...
  33. doi request reprint Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis
    Kunyarat Duenngai
    Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, 40002, Thailand
    Parasitol Res 112:271-8. 2013
    ..High concordant results between diagnoses by PCR, FECT, and worm burden indicated that PCR is suitable for an early diagnosis, evaluation of drug efficacy, and also re-infection post-treatment...
  34. doi request reprint Risk factors for cholangiocarcinoma in high-risk area of Thailand: role of lifestyle, diet and methylenetetrahydrofolate reductase polymorphisms
    Nopparat Songserm
    Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Thailand
    Cancer Epidemiol 36:e89-94. 2012
    ..Change in methylenetetrahydrofolate reductase (MTHFR) activity may influence both DNA methylation and synthesis. This study investigates risk factors for CCA with a focus on lifestyle, diet and MTHFR polymorphisms...
  35. pmc The current status of opisthorchiasis and clonorchiasis in the Mekong Basin
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Int 61:10-6. 2012
    ..A more concerted effort from all community, educational, public health and government sectors is necessary to successfully combat this fatal liver disease of the poor...
  36. doi request reprint Overexpression of PDGFA and its receptor during carcinogenesis of Opisthorchis viverrini-associated cholangiocarcinoma
    Sirintip Boonjaraspinyo
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Int 61:145-50. 2012
    ..This result suggests that PDGFA is likely involved in the tumorigenesis of opisthorchiasis-associated CCA, and may be a promising candidate biomarker for diagnosis and treatment strategies of CCA...
  37. doi request reprint Genetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini from Savannakhet, Lao PDR by multilocus enzyme electrophoresis
    Nadda Kiatsopit
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 108:211-7. 2011
    ..viverrini and specific wetland systems, and raise important questions regarding the significance of the genetic differences and relationships of O. viverrini from these wetlands...
  38. doi request reprint Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Cancer 129:88-100. 2011
    ..Our results suggest that curcumin exhibits an anticarcinogenic potential via suppression of various events involved in multiple steps of carcinogenesis, which is accounted for by its ability to suppress proinflammatory pathways...
  39. doi request reprint Opisthorchis viverrini: Implications of the systematics of first intermediate hosts, Bithynia snail species in Thailand and Lao PDR
    Nadda Kiatsopit
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Infect Genet Evol 14:313-9. 2013
    ..viverrini. They are, in addition, a link in the life cycle of O. viverrini which can be used for developing and implementing programs to eliminate and control opisthorchiasis and its associated cholangiocarcinoma...
  40. pmc Liver fluke induces cholangiocarcinoma
    Banchob Sripa
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Med 4:e201. 2007
  41. ncbi request reprint Hepatobiliary changes, antibody response, and alteration of liver enzymes in hamsters re-infected with Opisthorchis viverrini
    Somchai Pinlaor
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Exp Parasitol 108:32-9. 2004
    ..This study emphasizes that there is an important relationship between the gradual decreases of inflammation with a concomitant increase in fibrosis after re-infection...
  42. pmc The bandit, a new DNA transposon from a hookworm-possible horizontal genetic transfer between host and parasite
    Thewarach Laha
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    PLoS Negl Trop Dis 1:e35. 2007
    ....
  43. ncbi request reprint Cholangiocarcinoma in experimental hamsters with long-standing Opisthorchis viverrini infection
    Nopparat Songserm
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Asian Pac J Cancer Prev 10:299-302. 2009
    ..In addition, this study confirms the previous studies both in vitro and in vivo on of effects of parasites and their metabolic products inducing cell proliferation, resulting in cholangiocarcinogenesis...
  44. doi request reprint Concomitant and protective immunity in mice exposed to repeated infections with Echinostoma malayanum
    Tuanchai Srisawangwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Exp Parasitol 127:740-4. 2011
    ..The selective effects of protective immunity on establishment, growth, and fecundity of challenged worms affected the population dynamics of E. malayanum which is a similar phenomenon to concomitant immunity in schistosomiasis...
  45. ncbi request reprint Prevalence and intensity of infection with third stage larvae of Angiostrongylus cantonensis in mollusks from Northeast Thailand
    Smarn Tesana
    Food Borne Parasite Research Group, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen Province, Thailand
    Am J Trop Med Hyg 80:983-7. 2009
    ..pesmei, and Hemiplecta distincta have the potential to transmit A. cantonensis to man. The varying density levels of larvae in infected snails may reflect observed variation in symptoms of people who traditionally eat a raw snail dish...
  46. ncbi request reprint MTHFR polymorphisms and Opisthorchis viverrini infection: a relationship with increased susceptibility to cholangiocarcinoma in Thailand
    Nopparat Songserm
    Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Thailand
    Asian Pac J Cancer Prev 12:1341-5. 2011
    ..Folate may play an important role in OV-related cholangiocarcinogenesis by upsetting the balance between DNA methylation and synthesis in the folate pathway...
  47. pmc Improvement of PCR for detection of Opisthorchis viverrini DNA in human stool samples
    Kunyarat Duenngai
    Department of Parasitology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    J Clin Microbiol 46:366-8. 2008
    ..01). PCR-positive tests identified several cases judged parasite negative by the parasitological method (28.6%), indicating the new test's advantage in the diagnosis of individuals with light infections...
  48. ncbi request reprint Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line
    Somchai Pinlaor
    Department of Parasitology, Khon Kaen University, Thailand
    Int J Parasitol 35:591-6. 2005
    ..7 cells treated with O. viverrini antigen in a dose-dependent manner. These results suggest that O. viverrini induces inflammatory response through TLR2-mediated pathway leading to NF-kappaB-mediated expression of iNOS and COX-2...
  49. doi request reprint Detection of salivary antibodies to crude antigens of Opisthorchis viverrini in opisthorchiasis and cholangiocarcinoma patients
    Ponlatham Chaiyarit
    Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, Thailand
    Clin Oral Investig 15:477-83. 2011
    ..Salivary antibodies reflect serum immune response to O. viverrini infection, and salivary IgG tends to be a good candidate for diagnosis of O. viverrini infection...
  50. ncbi request reprint Altered gene expression in Opisthorchis viverrini-associated cholangiocarcinoma in hamster model
    Watcharin Loilome
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Mol Carcinog 45:279-87. 2006
    ..These findings contribute to our understanding of the processes involved in the molecular carcinogenesis of CCA in order to provide a unique perspective on the development of new chemotherapeutics in future...
  51. doi request reprint Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis
    Nattaya Watwiengkam
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Acta Trop 128:659-65. 2013
    ..The results show that the improved Mab-ELISA method has high sensitivity and also quantifiable diagnosis of opisthorchiasis. ..
  52. doi request reprint Genetic differentiation of Artyfechinostomum malayanum and A. sufrartyfex (Trematoda: Echinostomatidae) based on internal transcribed spacer sequences
    Chairat Tantrawatpan
    Division of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathum Thani, 12121, Thailand
    Parasitol Res 112:437-41. 2013
    ..malayanum. A clade of A. malayanum was closely aligned with A. sufrartyfex and clearly distance from the cluster of other echinostomes. Our results may sufficiently suggest that the current synonymy of these species is not valid...
  53. doi request reprint A cross-sectional study on the potential transmission of the carcinogenic liver fluke Opisthorchis viverrini and other fishborne zoonotic trematodes by aquaculture fish
    Opal Pitaksakulrat
    Department of Parasitology, Khon Kaen University, Khon Kaen, Thailand
    Foodborne Pathog Dis 10:35-41. 2013
    ..This has significant impact on food quality and safety, and provides the basis for the development of an effective strategy for the prevention and control of foodborne diseases...
  54. ncbi request reprint Thiamine deficiency and parasitic infection in rural Thai children
    Tueanjit Khampitak
    Departments of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Southeast Asian J Trop Med Public Health 37:441-5. 2006
    ..The general health of the children, according to Thai standard anthropometric curves, was within the normal range. The suboptimal thiamine status and the high prevalence of parasitic infection require attention...
  55. ncbi request reprint Angiostrongylus cantonensis: experimental study on the susceptibility of apple snails, Pomacea canaliculata compared to Pila polita
    Smarn Tesana
    Food Borne Parasite Research Group, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Exp Parasitol 118:531-5. 2008
    ..i. in the mantle at 29.37%, 31.09% and 37.45%. The infection rate in P. canaliculata was too low to study distribution rates...
  56. ncbi request reprint Prevalence and co-infection of intestinal parasites among thai rural residents at high-risk of developing cholangiocarcinoma: a cross-sectional study in a prospective cohort study
    Nopparat Songserm
    Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Thailand
    Asian Pac J Cancer Prev 13:6175-9. 2012
    ..We can anticipate that the design of future control and prevention programmes will accommodate a more community-orientated and participatory approach...
  57. ncbi request reprint PCR diagnosis of Pneumocystis carinii on sputum and bronchoalveolar lavage samples in immuno-compromised patients
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 94:213-8. 2004
    ..62 and 98.41 percent, respectively. The specificity of PCR was 90% and 98.41% for BAL and sputum samples, respectively. We suggest PCR is an important tool for the epidemiological study of P. carinii in high-risk individuals...
  58. ncbi request reprint 8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini
    Somchai Pinlaor
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Biochem Biophys Res Commun 309:567-71. 2003
    ..The mechanisms of 8-oxodG and 8-nitroguanine formation via O2*- and NO production triggered by OV infection were discussed in relation to cholangiocarcinoma development...
  59. ncbi request reprint Epidemiology of food-borne trematodes and other parasite infections in a fishing community on the Nam Ngum reservoir, Lao PDR
    Paiboon Sithithaworn
    Department of Parasitology and Liver fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Southeast Asian J Trop Med Public Health 37:1083-90. 2006
    ..6%) (first and second surveys, respectively). Despite the availability of effective anthelmintic drugs, the results of our study reaf-firm that FBT are still a major health threat in this fishing area of Lao PDR, similar to a decade ago...