Somchai Pinlaor

Summary

Affiliation: Khon Kaen University, Thailand
Location: Khon Kaen, Thailand
Summary:
Lectuer and reseacher in infection and cancer, especially in liver fluke, Opisthorchis viverrini and cholangiocarcinoma. The research topics include host-parasite interaction contribution to disease and cancer, infection-inflammation mediate the disease and cancer, infection-inflammation induces oxidative and nitrative stress, gene/protein expression during inflammation related the disease and cancer, biomarker discovery from infection-inflammation, proteomics analysis for host-parasite interaction, drug and herb chemoprevention/treatment of infection-inflammation mediates the disease and cancer, etc.,
Grants:
Thailand Research fund (TRF), The Office of the Higher Education Commission, The Royal Golden Jubilee PhD Programme, National Research Council of Thailand, The Higher Education Research Promotion and National Research University Project of Thailand, Research Team Strengthening Grant, National Center for Genetic engineering and Biotechnology, National Science and Technology Development Agency, Thailand, Khon Kaen University Research foundation, Invitation Research from Faculty of Medicine, Khon Kaen University, Thailand, Graduate school of Khon Kaen University, Thailand.

Publications

  1. doi request reprint Tissue invasive macrophage density is correlated with prognosis in cholangiocarcinoma
    Chutima Subimerb
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Mol Med Report 3:597-605. 2010
  2. doi request reprint Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Parasitol 39:825-35. 2009
  3. doi request reprint Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma
    Thidarut Boonmars
    Department of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 105:1273-81. 2009
  4. doi request reprint Effect of praziquantel treatment on the expression of matrix metalloproteinases in relation to tissue resorption during fibrosis in hamsters with acute and chronic Opisthorchis viverrini infection
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Acta Trop 111:181-91. 2009
  5. doi request reprint Turmeric reduces inflammatory cells in hamster opisthorchiasis
    Sirintip Boonjaraspinyo
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 105:1459-63. 2009
  6. ncbi request reprint Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Mol Nutr Food Res 53:1316-28. 2009
  7. doi request reprint Lipid peroxidation and etheno DNA adducts in white blood cells of liver fluke-infected patients: protection by plasma alpha-tocopherol and praziquantel
    Somkid Dechakhamphu
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Cancer Epidemiol Biomarkers Prev 19:310-8. 2010
  8. doi request reprint Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Cancer 127:2576-87. 2010
  9. ncbi request reprint Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Eur J Pharmacol 638:134-41. 2010
  10. ncbi request reprint Proteomic identification of peroxiredoxin 6 for host defence against Opisthorchis viverrini infection
    J Khoontawad
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasite Immunol 32:314-23. 2010

Collaborators

Detail Information

Publications53

  1. doi request reprint Tissue invasive macrophage density is correlated with prognosis in cholangiocarcinoma
    Chutima Subimerb
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Mol Med Report 3:597-605. 2010
    ..They may therefore serve as a prognostic marker for poor clinical outcome, and represent novel targets for the therapeutic intervention of CCA...
  2. doi request reprint Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Parasitol 39:825-35. 2009
    ..MMPs and TIMPs may serve as diagnostic markers for the severity of O. viverrini-induced liver injury...
  3. doi request reprint Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma
    Thidarut Boonmars
    Department of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 105:1273-81. 2009
    ....
  4. doi request reprint Effect of praziquantel treatment on the expression of matrix metalloproteinases in relation to tissue resorption during fibrosis in hamsters with acute and chronic Opisthorchis viverrini infection
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Acta Trop 111:181-91. 2009
    ..These results suggest that in animals with chronic O. viverrini infection, praziquantel treatment induces the expression of TGF-beta, and TIMPs and resultant inhibition of MMP activity, leading to slow resorption of hepatic fibrosis...
  5. doi request reprint Turmeric reduces inflammatory cells in hamster opisthorchiasis
    Sirintip Boonjaraspinyo
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 105:1459-63. 2009
    ..The present study found that turmeric clearly reduces the inflammatory cells in hamster opisthorchiasis at an early stage. This finding may be connected with a reduction in the risk factors of cholangiocarcinoma development...
  6. ncbi request reprint Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Mol Nutr Food Res 53:1316-28. 2009
    ..Therefore, curcumin may be used as a chemopreventive agent to reduce the severity of OV-associated diseases and the risk of cholangiocarcinoma (CCA)...
  7. doi request reprint Lipid peroxidation and etheno DNA adducts in white blood cells of liver fluke-infected patients: protection by plasma alpha-tocopherol and praziquantel
    Somkid Dechakhamphu
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Cancer Epidemiol Biomarkers Prev 19:310-8. 2010
    ..Etheno adducts in WBC and urine should be explored as a risk marker for opisthorchiasis-related cholangiocarcinoma, and to assess the efficacy of preventive and therapeutic interventions...
  8. doi request reprint Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Cancer 127:2576-87. 2010
    ..The results suggest that MMP-9 expression is associated with the accumulation of peribiliary fibrosis in conjunction to the induction of iNOS and Rac1 that may potentiate DNA damage and cholangiocarcinogenesis...
  9. ncbi request reprint Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Eur J Pharmacol 638:134-41. 2010
    ..In conclusion, curcumin may serve as a promising nutraceutical agent exerting antifibrotic effect in O. viverrini-infected patients and contribute to cholangiocarcinoma prevention...
  10. ncbi request reprint Proteomic identification of peroxiredoxin 6 for host defence against Opisthorchis viverrini infection
    J Khoontawad
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasite Immunol 32:314-23. 2010
    ..These results suggest that Prdx6 is important for host defence against O. viverrini infection. This study provides basic information for Prdx6 as a potential biomarker and therapeutic target for opisthorchiasis...
  11. doi request reprint Accumulation of miscoding etheno-DNA adducts and highly expressed DNA repair during liver fluke-induced cholangiocarcinogenesis in hamsters
    Somkid Dechakhamphu
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Mutat Res 691:9-16. 2010
    ..Our results implicate accumulation of inflammation-related, promutagenic DNA damage in target tissue and possibly imbalanced repair in the onset of cholangiocarcinogenesis...
  12. doi request reprint Candidate genes involving in tumorigenesis of cholangiocarcinoma induced by Opisthorchis viverrini infection
    Zhiliang Wu
    Department of Parasitology, Gifu University Graduate School of Medicine, Yanagido1 1, Gifu 501 1194, Japan
    Parasitol Res 109:657-73. 2011
    ....
  13. pmc Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Carcinogenesis 32:1372-80. 2011
    ..Overall, our results indicate that curcumin mediates its antiproliferative and apoptotic effects through activation of multiple cell signaling pathways, and thus, its activity against CCA should be further investigated...
  14. doi request reprint Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters
    Lakhanawan Charoensuk
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Int J Parasitol 41:615-26. 2011
    ..viverrini infection via induction of Nrf2 and suppression of NF-κB-mediated pathways. Nrf2 may also be a novel therapeutic target for not only parasitic diseases but other types of inflammation-mediated diseases...
  15. doi request reprint Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis
    Suksanti Prakobwong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Cancer 129:88-100. 2011
    ..Our results suggest that curcumin exhibits an anticarcinogenic potential via suppression of various events involved in multiple steps of carcinogenesis, which is accounted for by its ability to suppress proinflammatory pathways...
  16. pmc Circulating CD14(+) CD16(+) monocyte levels predict tissue invasive character of cholangiocarcinoma
    C Subimerb
    Department of Biochemistry, and Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Clin Exp Immunol 161:471-9. 2010
    ..If confirmed in subsequent studies, the level of CD14(+) CD16(+) monocytes may serve as a marker for disease activity in CCA patients and serve as a target for pathogenic macrophage specific drug development...
  17. doi request reprint Involvement of c-Ski oncoprotein in carcinogenesis of cholangiocacinoma induced by Opisthorchis viverrini and N-nitrosodimethylamine
    Thidarut Boonmars
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Pathol Oncol Res 17:219-27. 2011
    ..These results suggest that c-Ski is likely involved in the carcinogenesis of CCA induced by O. viverrini infection through regulating TGF-β signaling pathway...
  18. doi request reprint Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters
    Umawadee Laothong
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    J Pineal Res 49:271-82. 2010
    ..Thus, melatonin may be an effective chemopreventive agent against O. viverrini-induced cholangiocarcinoma by reducing oxidative and nitrosative DNA damage via induction of Nrf2 and inhibition of NF-κB-mediated pathways...
  19. pmc Evidence of a species complex within the food-borne trematode Opisthorchis viverrini and possible co-evolution with their first intermediate hosts
    Weerachai Saijuntha
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Int J Parasitol 37:695-703. 2007
    ..Our findings have major implications for the implementation of effective control and surveillance programs targeted to these medically important food-borne parasites...
  20. pmc Genetic markers for the identification and characterization of Opisthorchis viverrini, a medically important food borne trematode in Southeast Asia
    Weerachai Saijuntha
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Acta Trop 100:246-51. 2006
    ..viverrini, a medically important food borne trematode in Southeast Asia...
  21. ncbi request reprint Cholangiocarcinoma in experimental hamsters with long-standing Opisthorchis viverrini infection
    Nopparat Songserm
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Asian Pac J Cancer Prev 10:299-302. 2009
    ..In addition, this study confirms the previous studies both in vitro and in vivo on of effects of parasites and their metabolic products inducing cell proliferation, resulting in cholangiocarcinogenesis...
  22. ncbi request reprint Altered gene expression in Opisthorchis viverrini-associated cholangiocarcinoma in hamster model
    Watcharin Loilome
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Mol Carcinog 45:279-87. 2006
    ..These findings contribute to our understanding of the processes involved in the molecular carcinogenesis of CCA in order to provide a unique perspective on the development of new chemotherapeutics in future...
  23. ncbi request reprint Hepatobiliary changes, antibody response, and alteration of liver enzymes in hamsters re-infected with Opisthorchis viverrini
    Somchai Pinlaor
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Exp Parasitol 108:32-9. 2004
    ..This study emphasizes that there is an important relationship between the gradual decreases of inflammation with a concomitant increase in fibrosis after re-infection...
  24. doi request reprint Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis
    Raynoo Thanan
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Cancer Epidemiol Biomarkers Prev 17:518-24. 2008
    ..Urinary 8-oxodG may be a useful biomarker to monitor not only infection but also carcinogenesis...
  25. ncbi request reprint iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel
    Somchai Pinlaor
    Department of Parasitology, Khon Kaen University, Thailand
    Int J Cancer 119:1067-72. 2006
    ..It is concluded that praziquantel can exhibit a preventive effect against OV-induced cholangiocarcinoma by inhibiting iNOS-dependent DNA damage through not only elimination of parasites but also a potential antiinflammatory effect...
  26. ncbi request reprint Angiostrongylus cantonensis: experimental study on the susceptibility of apple snails, Pomacea canaliculata compared to Pila polita
    Smarn Tesana
    Food Borne Parasite Research Group, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Exp Parasitol 118:531-5. 2008
    ..i. in the mantle at 29.37%, 31.09% and 37.45%. The infection rate in P. canaliculata was too low to study distribution rates...
  27. ncbi request reprint Epidemiology of Opisthorchis viverrini
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Acta Trop 88:187-94. 2003
    ..In this review, we present the basic population features and the factors influencing transmission between the different hosts...
  28. pmc Liver fluke induces cholangiocarcinoma
    Banchob Sripa
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Med 4:e201. 2007
  29. ncbi request reprint Epidemiology of Strongyloides stercoralis in north-east Thailand: application of the agar plate culture technique compared with the enzyme-linked immunosorbent assay
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Trans R Soc Trop Med Hyg 97:398-402. 2003
    ..stercoralis is the predominant parasite in rural north-east Thailand, and that APCT and ELISA should be used as complementary diagnostic methods for community-based parasite surveys, at least among those in high-risk groups...
  30. pmc Genetic variation in Opisthorchis viverrini (Trematoda: Opisthorchiidae) from northeast Thailand and Laos PDR based on random amplified polymorphic DNA analyses
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Parasitol Res 100:613-7. 2007
    ..viverrini and fish-borne trematodes within the region. Additionally, application of these markers in such studies could have important implications in relation to the prevalence of cholangiocarcinoma in different regions of Asia...
  31. doi request reprint Microsatellite loci in the carcinogenic liver fluke, Opisthorchis viverrini and their application as population genetic markers
    Nonglak Laoprom
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Infect Genet Evol 10:146-53. 2010
    ..viverrini sensu lato in Southeast Asia...
  32. doi request reprint Biological variation within Opisthorchis viverrini sensu lato in Thailand and Lao PDR
    Nonglak Laoprom
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen 40002, Thailand
    J Parasitol 95:1307-13. 2009
    ..These results support the genetic/molecular data indicating a subdivision of O. viverrini populations on the basis of watershed and that propose the existence of cryptic species in Thailand and the Lao PDR...
  33. pmc The bandit, a new DNA transposon from a hookworm-possible horizontal genetic transfer between host and parasite
    Thewarach Laha
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    PLoS Negl Trop Dis 1:e35. 2007
    ....
  34. pmc Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis
    Thewarach Laha
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Int J Infect Dis 12:e49-59. 2008
    ..To isolate and characterize an asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and evaluate its expression profile, biochemical activity, and potential as an immunodiagnostic antigen...
  35. ncbi request reprint Enzyme markers to identify and characterize Opisthorchis viverrini in Thailand and Lao PDR
    Weerachai Saijuntha
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Southeast Asian J Trop Med Public Health 37:43-7. 2006
    ....
  36. ncbi request reprint Prevalence and intensity of infection with third stage larvae of Angiostrongylus cantonensis in mollusks from Northeast Thailand
    Smarn Tesana
    Food Borne Parasite Research Group, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen Province, Thailand
    Am J Trop Med Hyg 80:983-7. 2009
    ..pesmei, and Hemiplecta distincta have the potential to transmit A. cantonensis to man. The varying density levels of larvae in infected snails may reflect observed variation in symptoms of people who traditionally eat a raw snail dish...
  37. pmc Improvement of PCR for detection of Opisthorchis viverrini DNA in human stool samples
    Kunyarat Duenngai
    Department of Parasitology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    J Clin Microbiol 46:366-8. 2008
    ..01). PCR-positive tests identified several cases judged parasite negative by the parasitological method (28.6%), indicating the new test's advantage in the diagnosis of individuals with light infections...
  38. ncbi request reprint Thiamine deficiency and parasitic infection in rural Thai children
    Tueanjit Khampitak
    Departments of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Southeast Asian J Trop Med Public Health 37:441-5. 2006
    ..The general health of the children, according to Thai standard anthropometric curves, was within the normal range. The suboptimal thiamine status and the high prevalence of parasitic infection require attention...
  39. pmc Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6
    Banchob Sripa
    Department of Pathology, Khon Kaen University School of Medicine, Khon Kaen, Thailand
    Hepatology 50:1273-81. 2009
    ..O. viverrini-infected individuals with advanced periductal fibrosis showed other hepatobiliary abnormalities, including reduced gallbladder contractility and the presence of gallbladder sludge...
  40. ncbi request reprint 8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini
    Somchai Pinlaor
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Biochem Biophys Res Commun 309:567-71. 2003
    ..The mechanisms of 8-oxodG and 8-nitroguanine formation via O2*- and NO production triggered by OV infection were discussed in relation to cholangiocarcinoma development...
  41. ncbi request reprint Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line
    Somchai Pinlaor
    Department of Parasitology, Khon Kaen University, Thailand
    Int J Parasitol 35:591-6. 2005
    ..7 cells treated with O. viverrini antigen in a dose-dependent manner. These results suggest that O. viverrini induces inflammatory response through TLR2-mediated pathway leading to NF-kappaB-mediated expression of iNOS and COX-2...
  42. pmc Proteomic identification of plasma protein tyrosine phosphatase alpha and fibronectin associated with liver fluke, Opisthorchis viverrini, infection
    Jarinya Khoontawad
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    PLoS ONE 7:e45460. 2012
    ..In conclusion, our results suggest that plasma PTPα and fibronectin may be associated with opisthorchiasis and the hamster model provides the basis for development of novel diagnostic markers in the future...
  43. doi request reprint Distribution and abundance of Opisthorchis viverrini metacercariae in cyprinid fish in Northeastern Thailand
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Korean J Parasitol 51:703-10. 2013
    ..5 cysts), Nakhon Phanom (4.3), Mukdahan (4.1), Khon Kaen, (3.5) and Si Sa Ket (3.4). In conclusion, OV MC are prevalent in natural cyprinid fish, with the infection rate varying according to fish species and habitats. ..
  44. ncbi request reprint PCR diagnosis of Pneumocystis carinii on sputum and bronchoalveolar lavage samples in immuno-compromised patients
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 94:213-8. 2004
    ..62 and 98.41 percent, respectively. The specificity of PCR was 90% and 98.41% for BAL and sputum samples, respectively. We suggest PCR is an important tool for the epidemiological study of P. carinii in high-risk individuals...
  45. ncbi request reprint Detection of opportunistic and non-opportunistic intestinal parasites and liver flukes in HIV-positive and HIV-negative subjects
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Southeast Asian J Trop Med Public Health 36:841-5. 2005
    ..These results suggest that infection with these parasites increases during HIV infection. The epidemiological distribution of Cryptosporidium and S. stercoralis may have implications for AIDS-related diseases...
  46. ncbi request reprint Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: an indirect effect after praziquantel treatment
    Somchai Pinlaor
    Department of Parasitology, and Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Am J Trop Med Hyg 78:564-73. 2008
    ..viverrini antigen release. Data in this study can be used as a basis to understand potential side effects of praziquantel treatment in humans...
  47. ncbi request reprint Epidemiology of food-borne trematodes and other parasite infections in a fishing community on the Nam Ngum reservoir, Lao PDR
    Paiboon Sithithaworn
    Department of Parasitology and Liver fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Southeast Asian J Trop Med Public Health 37:1083-90. 2006
    ..6%) (first and second surveys, respectively). Despite the availability of effective anthelmintic drugs, the results of our study reaf-firm that FBT are still a major health threat in this fishing area of Lao PDR, similar to a decade ago...
  48. ncbi request reprint Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis
    Somchai Pinlaor
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Nitric Oxide 11:175-83. 2004
    ..In conclusion, nitrative and oxidative DNA damage via iNOS expression in hamsters infected with OV may participate in CHCA carcinogenesis...
  49. ncbi request reprint The influence of pregnancy on intestinal parasite infection in Thai women
    Ursula Herter
    Department of Tropical Medicine, Hygiene Institute, University of Heidelberg, 69120 Heidelberg, Germany
    Acta Trop 101:200-6. 2007
    ..Our study therefore supports the hypothesis that pregnancy does not influence the course of human infection with helminths...
  50. ncbi request reprint Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase
    Somchai Pinlaor
    Department of Environmental and Molecular Medicine and Department of Anatomy, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Carcinogenesis 25:1535-42. 2004
    ....
  51. ncbi request reprint Clonorchis sinensis and Opisthorchis viverrini: development of a mitochondrial-based multiplex PCR for their identification and discrimination
    Thanh Hoa Le
    Institute of Biotechnology, Viet Nam
    Exp Parasitol 112:109-14. 2006
    ....
  52. doi request reprint Development and evaluation of a polymerase chain reaction (PCR) assay for the detection of Opisthorchis viverrini in fish
    Ammini Parvathi
    Department of Fishery Microbiology, Karnataka Veterinary, Animal and Fisheries Sciences University, College of Fisheries, Mangalore 575 002, India
    Acta Trop 107:13-6. 2008
    ..viverrini DNA while in artificially spiked fish meat, 3 metacercariae could be detected. The results suggest that the PCR method described here is specific to O. viverrini with potential application in fish quarantining...
  53. pmc Specific and common antigens of Clonorchis sinensis and Opisthorchis viverrini(Opisthorchidae, Trematoda)
    Min Ho Choi
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, Korea
    Korean J Parasitol 41:155-63. 2003
    ..The frequency and intensity of the immunoblot reactions were positively correlated with the intensity of the liver fluke infection...