Veerapol Kukongviriyapan


Affiliation: Khon Kaen
Country: Thailand


  1. Wandee J, Prawan A, Senggunprai L, Kongpetch S, Kukongviriyapan V. Metformin sensitizes cholangiocarcinoma cell to cisplatin-induced cytotoxicity through oxidative stress mediated mitochondrial pathway. Life Sci. 2019;217:155-163 pubmed publisher
    ..The chemosensitizing effect of Met in combination with Cis is causally associated with increased oxidative stress-mediated mitochondrial cell death pathway. Met may improve the efficacy of Cis in the treatment of cancer. ..
  2. Maneesai P, Bunbupha S, Potue P, Berkban T, Kukongviriyapan U, Kukongviriyapan V, et al. Hesperidin Prevents Nitric Oxide Deficiency-Induced Cardiovascular Remodeling in Rats via Suppressing TGF-β1 and MMPs Protein Expression. Nutrients. 2018;10: pubmed publisher
    ..These data suggested that hesperidin had cardioprotective effects in l-NAME hypertensive rats. The possible mechanism may involve antioxidant and anti-inflammatory effects. ..
  3. Wandee J, Prawan A, Senggunprai L, Kongpetch S, Tusskorn O, Kukongviriyapan V. Metformin enhances cisplatin induced inhibition of cholangiocarcinoma cells via AMPK-mTOR pathway. Life Sci. 2018;207:172-183 pubmed publisher
    ..The cytotoxic effect of the drug combination was mimicked by AICAR, an AMPK agonist. Met may be a novel agent to increase the efficacy of Cis to treat CCA. ..
  4. Senaphan K, Kukongviriyapan U, Sangartit W, Pakdeechote P, Pannangpetch P, Prachaney P, et al. Ferulic Acid Alleviates Changes in a Rat Model of Metabolic Syndrome Induced by High-Carbohydrate, High-Fat Diet. Nutrients. 2015;7:6446-64 pubmed publisher
    ..Our results suggest that supplementation of FA may have health benefits by minimizing the cardiovascular complications of MS and alleviating its symptoms. ..
  5. Tusskorn O, Khunluck T, Prawan A, Senggunprai L, Kukongviriyapan U, Kukongviriyapan V. Suppression of glutathione S-transferases potentiates the cytotoxic effect of phenethyl isothiocyanate in cholangiocarcinoma cells. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:657-667 pubmed publisher
    ..The present study shows that the antitumor effect of PEITC was potentiated by the suppression of GST activity. The inhibition of GST could be a crucial strategy to potentiate chemotherapeutic effect of PEITC on CCA. ..
  6. Kukongviriyapan U, Kukongviriyapan V, Pannangpetch P, Donpunha W, Sripui J, Sae Eaw A, et al. Mamao Pomace Extract Alleviates Hypertension and Oxidative Stress in Nitric Oxide Deficient Rats. Nutrients. 2015;7:6179-94 pubmed publisher
    ..The present results provide evidence for the antihypertensive effect of MP and suggest that MP might be useful as a dietary supplement against hypertension. ..
  7. Boonla O, Kukongviriyapan U, Pakdeechote P, Kukongviriyapan V, Pannangpetch P, Thawornchinsombut S. Peptides-Derived from Thai Rice Bran Improves Endothelial Function in 2K-1C Renovascular Hypertensive Rats. Nutrients. 2015;7:5783-99 pubmed publisher
    ..Our results suggest that RBP possesses antihypertensive properties which are mainly due to the inhibition of ACE, and its vasodilatory and antioxidant activity. ..
  8. Berkban T, Boonprom P, Bunbupha S, Welbat J, Kukongviriyapan U, Kukongviriyapan V, et al. Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats. Nutrients. 2015;7:5265-80 pubmed publisher
    ..Our results indicate that ellagic acid attenuates hypertension by reducing NADPH oxidase subunit p47phox expression, which prevents oxidative stress and restores NO bioavailability. ..
  9. Boonloh K, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan U, Thawornchinsombut S, Pannangpetch P. Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet. Nutrients. 2015;7:6313-29 pubmed publisher
    ..In conclusion, the present findings support the consumption of RBP as a functional food to improve insulin resistance and to prevent the development of metabolic syndrome. ..

More Information


  1. Sompakdee V, Prawan A, Senggunprai L, Kukongviriyapan U, Samathiwat P, Wandee J, et al. Suppression of Nrf2 confers chemosensitizing effect through enhanced oxidant-mediated mitochondrial dysfunction. Biomed Pharmacother. 2018;101:627-634 pubmed publisher
    ..Luteolin inhibited Nrf2 and markedly enhanced cytotoxicity in combination with Cis. Inhibition of Nrf2 is a feasible strategy in enhancing antitumor activity of chemotherapeutic agents and improving efficacy of chemotherapy in CCA. ..
  2. Boonloh K, Kukongviriyapan U, Pannangpetch P, Kongyingyoes B, Senggunprai L, Prawan A, et al. Rice bran protein hydrolysates prevented interleukin-6- and high glucose-induced insulin resistance in HepG2 cells. Food Funct. 2015;6:566-73 pubmed publisher
    ..Our results suggested that RBP suppresses inflammatory cytokine signaling and activates AMPK, and thereby these effects may underlie the insulin sensitizing effect. ..
  3. Maneesai P, Prasarttong P, Bunbupha S, Kukongviriyapan U, Kukongviriyapan V, Tangsucharit P, et al. Synergistic Antihypertensive Effect of Carthamus tinctorius L. Extract and Captopril in L-NAME-Induced Hypertensive Rats via Restoration of eNOS and AT₁R Expression. Nutrients. 2016;8:122 pubmed publisher
    ..These data indicate that there are synergistic antihypertensive effects of CT extract and captopril. These effects are likely mediated by their anti-oxidative properties and their inhibition of RAS. ..
  4. Samatiwat P, Prawan A, Senggunprai L, Kukongviriyapan U, Kukongviriyapan V. Nrf2 inhibition sensitizes cholangiocarcinoma cells to cytotoxic and antiproliferative activities of chemotherapeutic agents. Tumour Biol. 2016;37:11495-507 pubmed publisher
    ..Inhibition of Nrf2 could be a novel strategy in enhancing antitumor activity of chemotherapeutic agent in control of resistant cancer. ..
  5. Boonloh K, Lee E, Kim H, Kwon M, Kim Y, Pannangpetch P, et al. Rice bran protein hydrolysates attenuate diabetic nephropathy in diabetic animal model. Eur J Nutr. 2018;57:761-772 pubmed publisher
  6. Tusskorn O, Senggunprai L, Prawan A, Kukongviriyapan U, Kukongviriyapan V. Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells. BMC Cancer. 2013;13:571 pubmed publisher
    ..The multiple effects of PEITC may be useful for the development of novel chemotherapy for CCA. ..
  7. request reprint
    Kukongviriyapan V, Somparn N, Senggunprai L, Prawan A, Kukongviriyapan U, Jetsrisuparb A. Endothelial dysfunction and oxidant status in pediatric patients with hemoglobin E-beta thalassemia. Pediatr Cardiol. 2008;29:130-5 pubmed
    ..Endothelial function is impaired in young thalassemia patients, and impaired endothelial function is associated with oxidant stress. ..
  8. Kukongviriyapan V, Prawan A, Tassaneyakul W, Aiemsa Ard J, Warasiha B. Arylamine N-acetyltransferase-2 genotypes in the Thai population. Br J Clin Pharmacol. 2003;55:278-81 pubmed
    ..2% slow acetylators. The pattern of NAT2 alleles of Thais is similar to those of many Asian populations, although the frequency of NAT2*4 is significantly lower and NAT2*7 is higher than that of Oriental populations. ..
  9. Pakdeechote P, Bunbupha S, Kukongviriyapan U, Prachaney P, Khrisanapant W, Kukongviriyapan V. Asiatic acid alleviates hemodynamic and metabolic alterations via restoring eNOS/iNOS expression, oxidative stress, and inflammation in diet-induced metabolic syndrome rats. Nutrients. 2014;6:355-70 pubmed publisher
    ..05). In conclusion, asiatic acid improved metabolic, hemodynamic abnormalities in MS rats that could be associated with its antioxidant, anti-inflammatory effects and recovering regulation of eNOS/iNOS expression...