Narathip Pradidphol

Summary

Affiliation: Kasetsart University
Country: Thailand

Publications

  1. doi request reprint Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Kasetsart University, Jatujak, Bangkok 10900, Thailand
    J Med Chem 53:1211-21. 2010
  2. ncbi request reprint Synthesis of novel rhinacanthins and related anticancer naphthoquinone esters
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand
    J Med Chem 47:4427-38. 2004
  3. ncbi request reprint Determination of a pyranocoumarin and three carbazole compounds in Clausena excavata by RP-HPLC
    Boonsong Kongkathip
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Kasetsart University, Bangkok 10903, Thailand
    J Chromatogr Sci 48:445-9. 2010
  4. ncbi request reprint Synthesis and anticancer evaluation of naphthoquinone esters with 2'-cyclopentyl and 2'-cyclohexyl substituents
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand
    Biosci Biotechnol Biochem 74:1205-14. 2010
  5. ncbi request reprint Potent antitumor activity of synthetic 1,2-Naphthoquinones and 1,4-Naphthoquinones
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
    Bioorg Med Chem 11:3179-91. 2003
  6. doi request reprint Biophysical and molecular docking studies of naphthoquinone derivatives on the ATPase domain of human topoisomerase II
    Nonlawat Boonyalai
    Department of Biochemistry, Faculty of Science, Kasetsart University, 50, Phahon Yothin road, Chatuchak, 10900 Bangkok, Thailand
    Biomed Pharmacother 67:122-8. 2013
  7. doi request reprint First synthesis and anticancer activity of novel naphthoquinone amides
    Narathip Pradidphol
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok, Thailand
    Eur J Med Chem 49:253-70. 2012
  8. ncbi request reprint Synthesis of novel 2-(2'-cyclopentyl)- and 2-(2'-cyclohexyl) substituted 1-naphthol derivatives with anticyclooxygenase activity
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
    Curr Med Chem 13:3663-74. 2006
  9. ncbi request reprint Bioactive deoxypreussomerins and dimeric naphthoquinones from Diospyros ehretioides fruits: deoxypreussomerins may not be plant metabolites but may be from fungal epiphytes or endophytes
    Areerat Prajoubklang
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiangmai University, Chiangmai 50200, Thailand
    Chem Biodivers 2:1358-67. 2005
  10. ncbi request reprint Antifungal azaphilones from the fungus Chaetomium cupreum CC3003
    Somdej Kanokmedhakul
    Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Prod 69:891-5. 2006

Collaborators

Detail Information

Publications25

  1. doi request reprint Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Kasetsart University, Jatujak, Bangkok 10900, Thailand
    J Med Chem 53:1211-21. 2010
    ..falciparum 3D7 cyt bc(1) and no inhibition on rat cyt bc(1). They showed IC(50) values in the nanomolar range, providing full inhibition of cyt bc(1) with one molecule inhibitor bound per cyt bc(1) monomer at the Q(o) site...
  2. ncbi request reprint Synthesis of novel rhinacanthins and related anticancer naphthoquinone esters
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand
    J Med Chem 47:4427-38. 2004
    ..Naphthoate esters exhibited greater cytotoxicity than benzoate esters. Computer modeling has been done to obtain a first look at the mode of action in connection with these observations...
  3. ncbi request reprint Determination of a pyranocoumarin and three carbazole compounds in Clausena excavata by RP-HPLC
    Boonsong Kongkathip
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Kasetsart University, Bangkok 10903, Thailand
    J Chromatogr Sci 48:445-9. 2010
    ..4 mL/min for clauszoline-J. This is the first quantitative analysis of these four anti-HIV-1 compounds from the crude extract without prior isolation and purification steps...
  4. ncbi request reprint Synthesis and anticancer evaluation of naphthoquinone esters with 2'-cyclopentyl and 2'-cyclohexyl substituents
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand
    Biosci Biotechnol Biochem 74:1205-14. 2010
    ..This work provides new information about the effect of 2'-position substituents on the cytotoxicity of naphthoquinone ester analogues...
  5. ncbi request reprint Potent antitumor activity of synthetic 1,2-Naphthoquinones and 1,4-Naphthoquinones
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
    Bioorg Med Chem 11:3179-91. 2003
    ..Moreover, compound 13 had significant cytotoxicity against HeLa cell line (IC(50) value of 9.25 microM) while it showed no toxic to vero cell...
  6. doi request reprint Biophysical and molecular docking studies of naphthoquinone derivatives on the ATPase domain of human topoisomerase II
    Nonlawat Boonyalai
    Department of Biochemistry, Faculty of Science, Kasetsart University, 50, Phahon Yothin road, Chatuchak, 10900 Bangkok, Thailand
    Biomed Pharmacother 67:122-8. 2013
    ..The further elucidation of the mechanism of action of the naphthoquinone esters and amides inhibitory activity is essential...
  7. doi request reprint First synthesis and anticancer activity of novel naphthoquinone amides
    Narathip Pradidphol
    Natural Products and Organic Synthesis Research Unit NPOS, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok, Thailand
    Eur J Med Chem 49:253-70. 2012
    ..Docking experiment revealed the same trend as the cytotoxicity and decatenation assay. Therefore, naphthamides 24 and 43 can be promising target molecules for anticancer drug development...
  8. ncbi request reprint Synthesis of novel 2-(2'-cyclopentyl)- and 2-(2'-cyclohexyl) substituted 1-naphthol derivatives with anticyclooxygenase activity
    Ngampong Kongkathip
    Natural Products and Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
    Curr Med Chem 13:3663-74. 2006
    ....
  9. ncbi request reprint Bioactive deoxypreussomerins and dimeric naphthoquinones from Diospyros ehretioides fruits: deoxypreussomerins may not be plant metabolites but may be from fungal epiphytes or endophytes
    Areerat Prajoubklang
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiangmai University, Chiangmai 50200, Thailand
    Chem Biodivers 2:1358-67. 2005
    ..7 microg/ml) and antimycobacterial (MIC 50 microg/ml) activities, but was inactive towards Candida albicans. Compound 4 also exhibited cytotoxicity against BC cells (IC50 12.3 microg/ml), but not towards KB and Vero cell lines...
  10. ncbi request reprint Antifungal azaphilones from the fungus Chaetomium cupreum CC3003
    Somdej Kanokmedhakul
    Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Prod 69:891-5. 2006
    ..Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50 values of 10.5, 16.7, 24.3, and 0.6 microg/mL, respectively...
  11. ncbi request reprint Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus
    Masahiko Isaka
    National Center for Genetic Engineering and Biotechnology, National Sciences and Technology Development Agency, Rama 6 Road, Bangkok 10400, Thailand
    J Org Chem 67:1561-6. 2002
    ..Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC(50) values of 2.2 and 6.6 microg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated...
  12. ncbi request reprint Unique diketopiperazine dimers from the insect pathogenic fungus Verticillium hemipterigenum BCC 1449
    Masahiko Isaka
    National Center for Genetic Engineering and Biotechnology BIOTEC, Thailand Science Park, 113 Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand
    Org Lett 7:2257-60. 2005
    ..The absolute stereochemistry of bisdethiodi(methylthio)-1-demethylhyalodendrin (3), previously isolated from the same fungus, was revised to the (3R,6R) configuration...
  13. ncbi request reprint New bioactive prenylflavonoids and dibenzocycloheptene derivative from roots of Dendrolobium lanceolatum
    Somdej Kanokmedhakul
    Department of Chemistry, Applied Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Prod 67:968-72. 2004
    ..2, 1.6, and 0.6 microg/mL, respectively, while 2 showed moderate cytotoxicity against the NCI-H187 cell line with an IC50 value of 8.1 microg/ mL...
  14. pmc Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance
    Palangpon Kongsaeree
    Department of Chemistry and Center for Protein Structure and Function, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Proc Natl Acad Sci U S A 102:13046-51. 2005
    ..These structural insights suggest a general approach for developing new generations of antimalarial DHFR inhibitors that, by only occupying substrate space of the active site, would retain binding affinity with the mutant enzymes...
  15. ncbi request reprint Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802
    Somdej Kanokmedhakul
    Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
    Planta Med 68:834-6. 2002
    ..These compounds were characterized by spectroscopic methods. Chaetomanone and echinulin exhibited activity towards Mycobacterium tuberculosis...
  16. ncbi request reprint Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878
    Pattama Pittayakhajonwut
    National Center for Genetic Engineering and Biotechnology BIOTEC, National Science and Technology Development Agency NSTDA, Rajdhevee, Bangkok, Thailand
    Planta Med 68:1017-9. 2002
    ..Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC 50 values of 2.0 and 1.6 microg/mL, respectively...
  17. ncbi request reprint Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides
    Palangpon Kongsaeree
    Department of Chemistry and Center for Protein Structure and Function, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Nat Prod 66:709-11. 2003
    ....
  18. ncbi request reprint A bioactive triterpenoid and vulpinic acid derivatives from the mushroom Scleroderma citrinum
    Somdej Kanokmedhakul
    Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
    Planta Med 69:568-71. 2003
    ..Compound 3 and two of its derivatives, the dibromo derivative 5 and acetate derivative 6, exhibited activity towards Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the NCI-H187 cell line...
  19. doi request reprint Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima
    Patoomratana Tuchinda
    Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Nat Prod 71:655-63. 2008
    ..The structures of 1- 7 were determined mainly on the basis of spectroscopic methods. The compounds obtained were evaluated for cytotoxic and anti-HIV-1 activities...
  20. ncbi request reprint New diketopiperazines from the entomopathogenic fungus Verticillium hemipterigenum BCC 1449
    Chongdee Nilanonta
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand
    J Antibiot (Tokyo) 56:647-51. 2003
    ..These structures were elucidated using spectroscopic methods and X-ray crystallography. Antimalarial and cytotoxic activities of these compounds were evaluated...
  21. ncbi request reprint Ketene acetal and spiroacetal constituents of the marine fungus Aigialus parvus BCC 5311
    Pornrapee Vongvilai
    Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    J Nat Prod 67:457-60. 2004
    ..The stereochemistry of aigialospirol (2), elucidated by NMR spectral analysis, suggested that this compound is possibly derived from hypothemycin (3), a metabolite previously isolated from this same fungus...
  22. ncbi request reprint Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 72:1433-5. 2006
    ..9 and 32.2 microg/mL with TI ranging from 1.5 to 11.7), while 1,3,7-trihydroxy-6-methoxy-4,5-diisoprenylxanthone (3), 4, and 8 - 10 inhibited HIV-1 reverse transcriptase with IC (50) values between 8.7 and 84.9 microg/mL...
  23. ncbi request reprint Bioactive compounds from the seed fungus Menisporopsis theobromae BCC 3975
    Maneekarn Chinworrungsee
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    J Nat Prod 69:1404-10. 2006
    ..8 microM, respectively. Substances 1, 4, 7, 8, and 9 possessed weak antimycobacterial activity (MIC 154.8-952.3 microM), while compounds 2 and 3 showed potent antimycobacterial activity with respective MIC values of 1.24 and 7.14 microM...
  24. ncbi request reprint Transformation of an irregularly bridged epidithiodiketopiperazine to trichodermamide A
    Prapairat Seephonkai
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Org Lett 8:3073-5. 2006
    ..BCC 5926. During the extensive effort to crystallize 3 for X-ray crystallographic analysis, conversion of this compound to trichodermamide A with coproduction of S(8) occurred...
  25. ncbi request reprint General strategy for stereoselective synthesis of 1-substituted exo,endo-2,6-diaryl-3,7-dioxabicyclo[3.3.0]octanes: total synthesis of (+/-)-gmelinol
    Manat Pohmakotr
    Department of Chemistry and Center of Protein Structure and Function, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 71:386-9. 2006
    ..The synthetic sequence involves alpha-methylation or alpha-hydroxylation, reduction, bislactonization, and reduction followed by furofuran formation...