Affiliation: Chulalongkorn University
Pudhom K, Sommit D, Suwankitti N, Petsom A. Cassane furanoditerpenoids from the seed kernels of Caesalpinia bonduc from Thailand. J Nat Prod. 2007;70:1542-4 pubmed
..Compounds 1- 3 exhibited good antimalarial activity against the multidrug-resistant K1 strain of Plasmodium falciparum, while compound 4 was inactive. None of the compounds were cytotoxic against any of the tumor cell lines tested...
Pudhom K, Nuanyai T, Matsubara K. Cytotoxic and anti-angiogenic properties of minor 3,4-seco-cycloartanes from Gardenia sootepensis exudate. Chem Pharm Bull (Tokyo). 2012;60:1538-43 pubmed
..Furthermore, its angiogenic effect was found to occur mainly by suppressing endothelial cell proliferation and tubule formation, suggesting the potential of 1 as a lead compound for cancer treatment...
Anusiri P, Choodej S, Chumriang P, Adisakwattana S, Pudhom K. Inhibitory effects of flavonoids from stem bark of Derris indica on the formation of advanced glycation end products. J Ethnopharmacol. 2014;158 Pt A:437-41 pubmed publisher
..This study provided the possibility that a pyranoflavonoid (2) found in Derris indica might have therapeutic potential as an inhibitor against the formation of advanced glycation end products. ..
Chokpaiboon S, Choodej S, Boonyuen N, Teerawatananond T, Pudhom K. Highly oxygenated chromones from mangrove-derived endophytic fungus Rhytidhysteron rufulum. Phytochemistry. 2016;122:172-177 pubmed publisher
..0 to 23.3Î¼M, while rhytidchromones A and C were active against MCF-7 cells with IC50 values of 19.3 and 17.7Î¼M, respectively. ..
Choodej S, Teerawatananond T, Mitsunaga T, Pudhom K. Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum. Mar Drugs. 2016;14: pubmed publisher
..Compounds 3 and 4 selectively displayed cytotoxicity against KATO-3 cells with IC50 values of 35.0 and 25.3 ?M, respectively. ..
Pudhom K, Sommit D, Nuclear P, Ngamrojanavanich N, Petsom A. Protoxylocarpins F-H, protolimonoids from seed kernels of Xylocarpus granatum. J Nat Prod. 2009;72:2188-91 pubmed publisher
..Their structures were elucidated on the basis of extensive spectroscopic data analyses. All compounds isolated were evaluated for cytotoxic activity against five human tumor cell lines...
Pudhom K, Sommit D, Nuclear P, Ngamrojanavanich N, Petsom A. Moluccensins H-J, 30-ketophragmalin limonoids from Xylocarpus moluccensis. J Nat Prod. 2010;73:263-6 pubmed publisher
..Their structures were established by extensive spectroscopic analysis. Compound 2 displayed weak antibacterial activity against Staphylococcus hominis and Enterococcus faecalis...
Pudhom K, Nuanyai T, Matsubara K, Vilaivan T. Antiangiogenic activity of 3,4-seco-cycloartane triterpenes from Thai Gardenia spp. and their semi-synthetic analogs. Bioorg Med Chem Lett. 2012;22:512-7 pubmed publisher
..46 ?M. Its angiogenic effect was found to occur via suppression of endothelial cell proliferation and tubular formation, and was likely mediated by regulation (inhibition) of the Erk1/2 signaling pathway...
Siridechakorn I, Yue Z, Mittraphab Y, Lei X, Pudhom K. Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B. Bioorg Med Chem. 2017;25:2878-2882 pubmed publisher
..Compounds 2 and 10 displayed the most promising anti-tumor activity against both cancer cell lines. ..