Kittisak Likhitwitayawuid

Summary

Affiliation: Chulalongkorn University
Country: Thailand

Publications

  1. ncbi request reprint Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Bioorg Med Chem Lett 16:5650-3. 2006
  2. ncbi request reprint Antiherpetic flavones from the heartwood of Artocarpus gomezianus
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Chem Biodivers 3:1138-43. 2006
  3. ncbi request reprint A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus
    K Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 64:1457-9. 2001
  4. ncbi request reprint Flavones with free radical scavenging activity from Goniothalamus tenuifolius
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Arch Pharm Res 29:199-202. 2006
  5. ncbi request reprint Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Nat Prod Res 19:177-82. 2005
  6. pmc Microemulsion-based oxyresveratrol for topical treatment of herpes simplex virus (HSV) infection: physicochemical properties and efficacy in cutaneous HSV-1 infection in mice
    Pattaraporn Sasivimolphan
    Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok, 10330, Thailand
    AAPS PharmSciTech 13:1266-75. 2012
  7. doi request reprint Topical cream-based oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice
    Vimolmas Lipipun
    Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand
    Antiviral Res 91:154-60. 2011
  8. doi request reprint Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice
    Taksina Chuanasa
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Antiviral Res 80:62-70. 2008
  9. ncbi request reprint Flavonoids with anti-HSV activity from the root bark of Artocarpus lakoocha
    Boonchoo Sritularak
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Nat Prod Commun 8:1079-80. 2013
  10. doi request reprint Flavonoid and stilbenoid production in callus cultures of Artocarpus lakoocha
    Suthira Maneechai
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 81:42-9. 2012

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Bioorg Med Chem Lett 16:5650-3. 2006
    ..Thus, facile preparations of a potent tyrosinase inhibitor (7) and a strong cytotoxic agent (6) from the natural product 1 were achieved through simple chemical reactions...
  2. ncbi request reprint Antiherpetic flavones from the heartwood of Artocarpus gomezianus
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Chem Biodivers 3:1138-43. 2006
    ..Compounds 2, 3, 6 and 7 showed moderate activities against both types of HSV, while 1, 4 and 5 were basically inactive...
  3. ncbi request reprint A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus
    K Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 64:1457-9. 2001
    ..Both 1 and 2 showed moderate tyrosinase inhibitory activity with IC(50) values of 68 and 39 microM, respectively...
  4. ncbi request reprint Flavones with free radical scavenging activity from Goniothalamus tenuifolius
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Arch Pharm Res 29:199-202. 2006
    ..The data obtained in this study suggested that the ortho 3',4'-diphenolic structure was essential for the activity of these flavonol derivatives...
  5. ncbi request reprint Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Nat Prod Res 19:177-82. 2005
    ..The heartwood of A. lakoocha, which contains a large amount of oxyresveratrol, could be considered as a source of starting material for the development of new natural product-based anti-HSV and anti-HIV agents...
  6. pmc Microemulsion-based oxyresveratrol for topical treatment of herpes simplex virus (HSV) infection: physicochemical properties and efficacy in cutaneous HSV-1 infection in mice
    Pattaraporn Sasivimolphan
    Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok, 10330, Thailand
    AAPS PharmSciTech 13:1266-75. 2012
    ..05). These results demonstrated that topical oxyresveratrol microemulsion at 20-30% w/w was suitable for cutaneous HSV-1 mouse infection...
  7. doi request reprint Topical cream-based oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice
    Vimolmas Lipipun
    Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand
    Antiviral Res 91:154-60. 2011
    ..05). These results demonstrated that topical administration of oxyresveratrol in novel cream vehicle reduced the concentration of oxyresveratrol to 10% and was suitable for cutaneous HSV infection...
  8. doi request reprint Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice
    Taksina Chuanasa
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Antiviral Res 80:62-70. 2008
    ..05). Topical application of 30% oxyresveratrol ointment five times daily significantly delayed the development of skin lesions and protected mice from death (P<0.0001)...
  9. ncbi request reprint Flavonoids with anti-HSV activity from the root bark of Artocarpus lakoocha
    Boonchoo Sritularak
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Nat Prod Commun 8:1079-80. 2013
    ..Compounds 1 and 4 showed moderate and weak activity against both types of HSV, respectively, whereas 2 and 3 were devoid of activity...
  10. doi request reprint Flavonoid and stilbenoid production in callus cultures of Artocarpus lakoocha
    Suthira Maneechai
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 81:42-9. 2012
    ..In assays for DPPH free radical scavenging activity and tyrosinase inhibitory potential, the stilbenoids appeared to possess moderate effects, whereas the flavonoids showed only weak activity...
  11. doi request reprint Neolignans from leaves of Miliusa mollis
    Kanokporn Sawasdee
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Fitoterapia 85:49-56. 2013
    ..Miliumollinone possessed weak inhibitory effects against herpes simplex virus types 1 and 2. None of the isolates displayed inhibitory activity against avian influenza H5N1 neuraminidase...
  12. doi request reprint Bioactive compounds from Carissa spinarum
    Ruchira Wangteeraprasert
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Phytother Res 26:1496-9. 2012
    ..Moderate anti-DPPH free radical activity was observed for all the lignans. None of the isolates showed antibacterial activity...
  13. ncbi request reprint Flavonoids from the roots of Millettia erythrocalyx
    Boonchoo Sritularak
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 61:943-7. 2002
    ..Their structures were elucidated on the basis of analyses of their spectroscopic data...
  14. ncbi request reprint Novel biflavonoids from the stem bark of Ochna integerrima
    Rawiwun Kaewamatawong
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 65:1027-9. 2002
    ..The structures of 1 and 2 were determined by spectral data interpretation...
  15. ncbi request reprint New phenolic compounds from Dendrobium capillipes and Dendrobium secundum
    Thanawuth Phechrmeekha
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Asian Nat Prod Res 14:748-54. 2012
    ..Some of the isolated bibenzyls showed cytotoxicity against KB, NCI-H187, and MCF-7 cancer cells, whereas all of the glycosidic flavonoids were devoid of activity...
  16. doi request reprint New 2-arylbenzofurans from the root bark of Artocarpus lakoocha
    Boonchoo Sritularak
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Molecules 15:6548-58. 2010
    ..Their structures were elucidated through analysis of their spectroscopic data, and their antiherpetic potential was evaluated by the plaque reduction assay...
  17. doi request reprint New neolignans and a phenylpropanoid glycoside from twigs of Miliusa mollis
    Kanokporn Sawasdee
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Molecules 15:639-48. 2010
    ..Their structures were elucidated through analysis of their spectroscopic data...
  18. ncbi request reprint Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri
    Kittisak Likhitwitayawuid
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences Chulalongkorn University, Bangkok, Thailand
    Planta Med 68:841-3. 2002
    ..Potent but non-selective activity was found for the stilbenoids 7-9 (IC(50) 1.29 - 4.92 microM) whereas weak or no activity was observed for the flavonoids 1-6...
  19. ncbi request reprint New flavones from Millettia erythrocalyx
    Boonchoo Sritularak
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330 Thailand
    J Nat Prod 65:589-91. 2002
    ..The structures of the new isolates were elucidated on the basis of spectroscopic data interpretation...
  20. doi request reprint Quantitative analysis of oxyresveratrol content in Artocarpus lakoocha and 'Puag-Haad'
    Suthira Maneechai
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Med Princ Pract 18:223-7. 2009
    ..To develop a thin-layer chromatography (TLC) densitometric method for the determination of oxyresveratrol content in Artocarpuslakoocha heartwood and in the traditional drug 'Puag-Haad'...
  21. ncbi request reprint Oxyresveratrol protects against DNA damage induced by photosensitized riboflavin
    Manussanunt Chatsumpun
    Department of Phamacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Nat Prod Commun 6:41-4. 2011
    ..The results suggest potential applications for oxyresveratrol as an anti-aging agent and a riboflavin stabilizer...
  22. ncbi request reprint Flavonoids from the pods of Millettia erythrocalyx
    Boonchoo Sritularak
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Phytochemistry 67:812-7. 2006
    ..Their structures were elucidated through analysis of their spectroscopic data...
  23. ncbi request reprint A new bibenzyl from Dendrobium secundum
    Boonchoo Sritularak
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Z Naturforsch C 66:205-8. 2011
    ..All of these isolates showed appreciable DPPH free radical scavenging potential, except for brittonin A, which was devoid of activity...
  24. doi request reprint Inhibitory activity of oxyresveratrol on wild-type and drug-resistant varicella-zoster virus replication in vitro
    Pattaraporn Sasivimolphan
    Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand
    Antiviral Res 84:95-7. 2009
    ..Thus oxyresveratrol showed a broad spectrum of anti-VZV activity with a mechanism of action different from that of acyclovir...
  25. ncbi request reprint A new pimarane from Mitrephora tomentosa
    Butsarakham Supudompol
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Nat Prod Res 18:387-90. 2004
    ..A new diterpenoid named (-)-8beta-hydroxypimar-15-en-18-oic acid was isolated, along with (-)-kaur-16-en-19-oic acid, 13,14-dihydrooropheic acid and beta-sitosterol, from the bark of Mitrephora tomentosa...
  26. ncbi request reprint Phloroglucinol derivatives from Mallotus pallidus
    Butsarakham Supudompol
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 65:2589-94. 2004
    ..Their structures were determined by means of spectroscopic methods of analysis...
  27. ncbi request reprint Anti-metastatic activities of bibenzyls from Dendrobium pulchellum
    Pithi Chanvorachote
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Nat Prod Commun 8:115-8. 2013
    ..The preliminary data obtained disclose the inhibitory effect on cancer cell metastasis of the isolated compounds, and provide an important new approach for cancer drug development...
  28. doi request reprint A new phenanthrenequinone from Dendrobium draconis
    Boonchoo Sritularak
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Asian Nat Prod Res 13:251-5. 2011
    ..In the DPPH-free radical assay, these stilbene derivatives showed appreciable antioxidant activity...
  29. ncbi request reprint Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha
    Apirak Puntumchai
    Department of Chemistry, Faculty of Science, Mahidol University, Thailand
    J Nat Prod 67:485-6. 2004
    ..1 microg/mL) but inactive (at 20 microg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC(50) values of 3.1 and 6.1 microg/mL, respectively...