Wanchai De-Eknamkul

Summary

Affiliation: Chulalongkorn University
Country: Thailand

Publications

  1. ncbi Purification and characterization of deacetylipecoside synthase from Alangium lamarckii Thw
    W De-Eknamkul
    Department of Pharmacognosy, Faculty of Pharmaceutical Scieces, Chulalongkorn University, Bangkok, Thailand
    Phytochemistry 55:177-81. 2000
  2. doi QSAR study of natural estrogen-like isoflavonoids and diphenolics from Thai medicinal plants
    Wanchai De-Eknamkul
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Mol Graph Model 29:784-94. 2011
  3. ncbi Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units
    Wanchai De-Eknamkul
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 62:389-98. 2003
  4. doi Flavonoid and stilbenoid production in callus cultures of Artocarpus lakoocha
    Suthira Maneechai
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 81:42-9. 2012
  5. doi A screening assay for neuraminidase inhibitors using neuraminidases N1 and N3 from a baculovirus expression system
    Jarinrat Kongkamnerd
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Enzyme Inhib Med Chem 27:5-11. 2012
  6. ncbi TLC-densitometric analysis of artemisinin for the rapid screening of high-producing plantlets of Artemisia annua L
    Thongchai Koobkokkruad
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Phytochem Anal 18:229-34. 2007
  7. ncbi Membrane-bound geranylgeranyl diphosphate phosphatases: purification and characterization from Croton stellatopilosus leaves
    Natsajee Nualkaew
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pyathai Road, Pathumwan, Bangkok 10330, Thailand
    Phytochemistry 67:1613-20. 2006
  8. ncbi Improvement of artemisinin production by chitosan in hairy root cultures of Artemisia annua L
    Waraporn Putalun
    Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand
    Biotechnol Lett 29:1143-6. 2007
  9. ncbi Transcription profiles analysis of genes encoding 1-deoxy-D-xylulose 5-phosphate synthase and 2C-methyl-D-erythritol 4-phosphate synthase in plaunotol biosynthesis from Croton stellatopilosus
    Juraithip Wungsintaweekul
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    Biol Pharm Bull 31:852-6. 2008
  10. pmc Acute and chronic oral toxicity of a partially purified plaunotol extract from Croton stellatopilosus Ohba
    Chatchai Chaotham
    Pharmaceutical Technology International Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Bangkok 10330, Thailand
    Biomed Res Int 2013:303162. 2013

Collaborators

Detail Information

Publications26

  1. ncbi Purification and characterization of deacetylipecoside synthase from Alangium lamarckii Thw
    W De-Eknamkul
    Department of Pharmacognosy, Faculty of Pharmaceutical Scieces, Chulalongkorn University, Bangkok, Thailand
    Phytochemistry 55:177-81. 2000
    ..DIS presumably provides (R)-deacetylipecoside for the formation of tetrahydroisoquinoline monoterpene glucosides that also possess an (R)-configuration at the same chiral center...
  2. doi QSAR study of natural estrogen-like isoflavonoids and diphenolics from Thai medicinal plants
    Wanchai De-Eknamkul
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Mol Graph Model 29:784-94. 2011
    ....
  3. ncbi Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units
    Wanchai De-Eknamkul
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 62:389-98. 2003
    ..Since the biosynthesis of phytosterol has so far been reported to be mainly from the classical mevalonate pathway, this study provides a new evidence on the biosynthesis of phytosterols via the novel deoxyxylulose pathway...
  4. doi Flavonoid and stilbenoid production in callus cultures of Artocarpus lakoocha
    Suthira Maneechai
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 81:42-9. 2012
    ..In assays for DPPH free radical scavenging activity and tyrosinase inhibitory potential, the stilbenoids appeared to possess moderate effects, whereas the flavonoids showed only weak activity...
  5. doi A screening assay for neuraminidase inhibitors using neuraminidases N1 and N3 from a baculovirus expression system
    Jarinrat Kongkamnerd
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Enzyme Inhib Med Chem 27:5-11. 2012
    ..The obtained results suggest that recombinant baculovirus expressing neuraminidase located on the virus membrane capsule can be used to set up affordable and reliable neuraminidase inhibitors screening assays...
  6. ncbi TLC-densitometric analysis of artemisinin for the rapid screening of high-producing plantlets of Artemisia annua L
    Thongchai Koobkokkruad
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Phytochem Anal 18:229-34. 2007
    ..02 to 0.67% w/w dry weight. These results demonstrate that densitometric TLC can be a cheap and simple technique for the accurate screening of high-artemisinin-producing plants...
  7. ncbi Membrane-bound geranylgeranyl diphosphate phosphatases: purification and characterization from Croton stellatopilosus leaves
    Natsajee Nualkaew
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pyathai Road, Pathumwan, Bangkok 10330, Thailand
    Phytochemistry 67:1613-20. 2006
    ..stellatopilosus is consistent with its putative involvement in the biosynthetic pathway of plaunotol although whether PI or PII is the actual enzyme involved in the pathway remains to be clarified...
  8. ncbi Improvement of artemisinin production by chitosan in hairy root cultures of Artemisia annua L
    Waraporn Putalun
    Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand
    Biotechnol Lett 29:1143-6. 2007
    ..The increase was dose-dependent. Similar treatment of hairy roots with methyl jasmonate (0.2 mM) or yeast extract (2 mg ml(-1)) increased artemisinin production to 1.5 and 0.9 microg mg(-1) dry wt, respectively...
  9. ncbi Transcription profiles analysis of genes encoding 1-deoxy-D-xylulose 5-phosphate synthase and 2C-methyl-D-erythritol 4-phosphate synthase in plaunotol biosynthesis from Croton stellatopilosus
    Juraithip Wungsintaweekul
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    Biol Pharm Bull 31:852-6. 2008
    ..Neither the CSDXS nor the CSMEPS were expressed in roots, where plaunotol was not detected. From this study, it can be concluded that plaunotol is biosynthesized in the chloroplastic tissue and regulated by the CSDXS and the CSMEPS...
  10. pmc Acute and chronic oral toxicity of a partially purified plaunotol extract from Croton stellatopilosus Ohba
    Chatchai Chaotham
    Pharmaceutical Technology International Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Bangkok 10330, Thailand
    Biomed Res Int 2013:303162. 2013
    ..These results suggest that PPE is potentially safe for further development as a therapeutic agent in humans...
  11. doi Molecular cloning and catalytic activity of a membrane-bound prenyl diphosphate phosphatase from Croton stellatopilosus Ohba
    Natsajee Nualkaew
    Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    Phytochemistry 91:140-7. 2013
    ..stellatopilosus...
  12. ncbi Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines
    Orawan Monthakantirat
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 68:361-4. 2005
    ..Along with 4, 5, 7, and 9, 3 was shown to stimulate not only MCF-7 but also T-47D human breast cancer cell proliferation...
  13. doi Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus
    Jarinrat Kongkamnerd
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand
    Bioorg Med Chem 20:2152-7. 2012
    ..The alkylation of the free 5-amino group in oseltamivir carboxylate introducing an isopropyl group seemed to increase the inhibitory effect for both N1 and N3 neuraminidases, displaying a more pronounced effect against N1...
  14. doi Recent progress and challenges in the discovery of new neuraminidase inhibitors
    Supakarn Chamni
    Chulalongkorn University, Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Bangkok 10330, Thailand
    Expert Opin Ther Pat 23:409-23. 2013
    ..Sudden changes in NAI susceptibility have stressed the urgent need in searching for novel inhibitors...
  15. doi Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase IIα activity
    Wanlaya Naowaratwattana
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Med Food 13:1045-56. 2010
    ....
  16. ncbi Establishment of Croton stellatopilosus suspension culture for geranylgeraniol production and diterpenoid biosynthesis
    Juraithip Wungsintaweekul
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    Z Naturforsch C 62:389-96. 2007
    ..The optimum medium for GGOH production was MS medium supplemented with 2.0 mg/l 2,4-D and 2 mg/l BA that could produce GGOH with a yield of 1.14 mg/g FW...
  17. ncbi Artemisinin production by shoot regeneration of Artemisia annua L. using thidiazuron
    Wanwimon Lualon
    Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand
    Z Naturforsch C 63:96-100. 2008
    ..73 -/+ 0.23) microg/mg DW]. This system exhibited a potential for a rapid propagation of shoots from the stem explant and makes it possible to develop a clonal propagation of A. annua...
  18. doi Effects of low-dose gamma irradiation on artemisinin content and amorpha-4,11-diene synthase activity in Artemisia annua L
    Thongchai Koobkokkruad
    Biomedicinal Chemistry Program, Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand
    Int J Radiat Biol 84:878-84. 2008
    ..The obtained variants were then evaluated for the correlation between their artemisinin content and enzyme activity of amorpha-4,11-diene synthase (ADS), the first enzyme of the artemisinin pathway...
  19. doi Protective effect of plaunotol against doxorubicin-induced renal cell death
    Chatchai Chaotham
    Pharmaceutical Technology International Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand
    J Nat Med 67:311-9. 2013
    ..Results indicated that plaunotol had no significantly protective effect in human lung carcinoma cells, whereas it sensitized melanoma cells to drug-induced cell death...
  20. ncbi Avicequinone C isolated from Avicennia marina exhibits 5α-reductase-type 1 inhibitory activity using an androgenic alopecia relevant cell-based assay system
    Ruchy Jain
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    Molecules 19:6809-21. 2014
    ..94 ± 0.33 µg/mL or 38.8 ± 1.29 µM. This paper is the first to report anti-androgenic activity through 5α-R1 inhibition of AM and avicequinone C. ..
  21. ncbi Potential targets in the discovery of new hair growth promoters for androgenic alopecia
    Ruchy Jain
    Chulalongkorn University, Faculty of Pharmaceutical Sciences, Pharmaceutical Technology, Bangkok, 10330, Thailand
    Expert Opin Ther Targets 18:787-806. 2014
    ..It is unlikely that single targeted agents will be sufficient for treating AGA, and therefore, it would be a challenge to obtain compounds with multiple activities. ..
  22. doi Benzophenone synthase from Garcinia mangostana L. pericarps
    Natsajee Nualkaew
    Khon Kaen University, Khon Kaen 40002, Thailand
    Phytochemistry 77:60-9. 2012
    ..Thus, providing GmBPS with various substrates in vivo might redirect the xanthone biosynthetic pathway...
  23. doi Protection of HT22 neuronal cells against glutamate toxicity mediated by the antioxidant activity of Pueraria candollei var. mirifica extracts
    Apirada Sucontphunt
    Pharmaceutical Technology International Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Med 65:1-8. 2011
    ....
  24. doi The quenching effect of flavonoids on 4-methylumbelliferone, a potential pitfall in fluorimetric neuraminidase inhibition assays
    Jarinrat Kongkamnerd
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Biomol Screen 16:755-64. 2011
    ..Altogether, the collected data imply that all of the tested flavonoids could produce false-positive results in the neuraminidase inhibition assay using 4-MUNANA as a substrate...
  25. ncbi Estrogenic constituents of the heartwood of Dalbergia parviflora
    Kaoru Umehara
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Phytochemistry 69:546-52. 2008
    ..Furthermore, these compounds were tested in the estrogen-responsive transient luciferase reporter assay...
  26. ncbi Aromatic and pyrone polyketides synthesized by a stilbene synthase from Rheum tataricum
    Supachai Samappito
    Leibniz Institut für Pflanzenbiochemie, Weinberg 3, D 06120 Halle Saale, Germany
    Phytochemistry 62:313-23. 2003
    ..Few stilbene synthases have been found in plants, and the identification of RtSTS provides additional sequence and catalytic information with which to study the evolution of plant polyketide synthases...