Pornngarm Limtrakul

Summary

Affiliation: Chiang Mai University
Country: Thailand

Publications

  1. ncbi request reprint Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Cancer Chemother Pharmacol 54:525-30. 2004
  2. ncbi request reprint Inhibition of P-glycoprotein function and expression by kaempferol and quercetin
    P Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    J Chemother 17:86-95. 2005
  3. ncbi request reprint Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
    Supachai Yodkeeree
    Deparment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Eur J Pharmacol 627:8-15. 2010
  4. pmc Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin
    P Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 50200
    BMC Cancer 1:1. 2001
  5. pmc Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    BMC Cancer 4:13. 2004
  6. ncbi request reprint Curcumin as chemosensitizer
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand
    Adv Exp Med Biol 595:269-300. 2007
  7. ncbi request reprint Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells
    P Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Phytomedicine 14:381-9. 2007
  8. ncbi request reprint Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Cell Biochem 296:85-95. 2007
  9. pmc Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells
    Wanisa Punfa
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand
    Acta Pharmacol Sin 33:823-31. 2012
  10. pmc Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance
    Pornsiri Pitchakarn
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Nutr Biochem 23:76-84. 2012

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Cancer Chemother Pharmacol 54:525-30. 2004
    ....
  2. ncbi request reprint Inhibition of P-glycoprotein function and expression by kaempferol and quercetin
    P Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    J Chemother 17:86-95. 2005
    ..Among the flavonoids tested, flavonols, particularly kaempferol, exhibit the most potent MDR reversing property in KB-V1 cells...
  3. ncbi request reprint Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line
    Supachai Yodkeeree
    Deparment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Eur J Pharmacol 627:8-15. 2010
    ..These findings strongly suggest that the mechanism of DMC-mediated anti-invasive activity involves modulation of the expression of invasion-associated proteins, possibly by targeting NF-kappaB in MDA-MB-231 cells...
  4. pmc Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin
    P Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 50200
    BMC Cancer 1:1. 2001
    ..This paper reports the effects of orally administered curcumin, which was consumed as a dietary component at concentrations of 0.2 % or 1 %, in ad libitum feeding...
  5. pmc Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    BMC Cancer 4:13. 2004
    ..It is related to the overexpression of a membrane protein, P-glycoprotein (Pgp-170), thereby reducing drug cytotoxicity. A variety of studies have tried to find MDR modulators which increase drug accumulation in cancer cells...
  6. ncbi request reprint Curcumin as chemosensitizer
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand
    Adv Exp Med Biol 595:269-300. 2007
    ..The advantage is that they exhibit little or virtually no side effects and do not further increase the patient's medication burden...
  7. ncbi request reprint Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells
    P Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Phytomedicine 14:381-9. 2007
    ..This is the first report of new biological activity in this plant, which could be a potential source of a new chemosensitizer...
  8. ncbi request reprint Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Cell Biochem 296:85-95. 2007
    ..Taken together, this study clearly showed that THC inhibits the efflux function of P-gp, MXR and MRP1 and it is able to extend the MDR reversing activity of curcuminoids in vivo...
  9. pmc Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells
    Wanisa Punfa
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand
    Acta Pharmacol Sin 33:823-31. 2012
    ..To compare the anti-cancer activity and cellular uptake of curcumin (Cur) delivered by targeted and non-targeted drug delivery systems in multidrug-resistant cervical cancer cells...
  10. pmc Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance
    Pornsiri Pitchakarn
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Nutr Biochem 23:76-84. 2012
    ....
  11. ncbi request reprint Anti-invasion effect of crebanine and O-methylbulbocapnine from Stephania venosa via down-regulated matrix metalloproteinases and urokinase plasminogen activator
    Supachai Yodkeeree
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University
    Chem Pharm Bull (Tokyo) 61:1156-65. 2013
    ..These findings demonstrated that CN and OMBC mediated HT1080 cell invasion by the reduction of MMP-2, MMP-9, uPA and MT1-MMP expression, possibly by targeting of NF-κB signaling pathway in the HT1080 cells. ..
  12. pmc Biochemical mechanism of modulation of human P-glycoprotein by stemofoline
    Wisinee Chanmahasathien
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Planta Med 77:1990-5. 2011
    ..Taken together, the results exhibit that stemofoline possesses an effective MDR modulator, and may be used in combination with conventional chemotherapeutic drugs to reverse MDR in cancer cells...
  13. ncbi request reprint Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1)
    Wanida Chearwae
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand
    Cancer Chemother Pharmacol 57:376-88. 2006
    ..In summary, these results demonstrate that curcuminoids effectively inhibit MRP1-mediated transport and among curcuminoids, curcumin I, a major constituent of curcumin mixture, is the best modulator...
  14. ncbi request reprint Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines
    Songyot Anuchapreeda
    Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand
    Cancer Chemother Pharmacol 62:585-94. 2008
    ..Curcuminoids consist of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin. In this study, the effect of each curcuminoids'components on WT1 gene expression in leukemic cell lines (K562, HL60, U937, and Molt4) was investigated...
  15. ncbi request reprint Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells
    Songyot Anuchapreeda
    Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand
    Arch Pharm Res 29:866-73. 2006
    ..In summary, curcumin decreased MDR1 mRNA level in patient leukemic cells, especially in high level of MDR1 gene groups. Thus, curcumin treatment may provide a lead for clinical treatment of leukemia patients in the future...
  16. ncbi request reprint Inhibition of P-glycoprotein mediated multidrug resistance by stemofoline derivatives
    Sonthaya Umsumarng
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Chem Pharm Bull (Tokyo) 61:399-404. 2013
    ..The molecular mechanism of modulation of P-gp would be further determined...
  17. doi request reprint Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA
    Supachai Yodkeeree
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    J Nutr Biochem 20:87-95. 2009
    ..In summary, these data demonstrated that DMC and BDMC show higher antimetastasis potency than curcumin by the differentially down-regulation of ECM degradation enzymes...
  18. ncbi request reprint The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells
    Mathanaporn Boonrao
    Department of Biochemistry, Chiang Mai University, Thailand
    Arch Pharm Res 33:989-98. 2010
    ..These results suggest that Cur, DMC, and BDMC may be used as MMP-3 inhibitors to modulate MMP-3 expression...
  19. doi request reprint Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance
    Wisinee Chanmahasathien
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Phytomedicine 18:199-204. 2011
    ..This is the first report of new pharmacological activity of Stemona alkaloids, which could be a new potential MDR chemosensitizer...
  20. ncbi request reprint Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder
    W Chearwae
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Biochem Pharmacol 68:2043-52. 2004
    ..Taken together, these results indicate that curcumin I is the most effective MDR modulator among curcuminoids, and may be used in combination with conventional chemotherapeutic drugs to reverse MDR in cancer cells...
  21. ncbi request reprint Inhibitory effect of curcumin on WT1 gene expression in patient leukemic cells
    Songyot Anuchapreeda
    Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
    Arch Pharm Res 29:80-7. 2006
    ..In summary, curcumin decreased WT1 mRNA in patient leukemic cells. Thus, curcumin treatment may provide a lead for clinical treatment in leukemic patients in the future...
  22. ncbi request reprint Induction of G1 arrest and apoptosis in human cancer cells by crebanine, an alkaloid from Stephania venosa
    Pattama Wongsirisin
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand
    Chem Pharm Bull (Tokyo) 60:1283-9. 2012
    ..Our results suggest that crebanine is a promising new candidate as a chemotherapeutic agent for cancer therapy...
  23. doi request reprint Anti-P-glycoprotein conjugated nanoparticles for targeting drug delivery in cancer treatment
    Pantiwa Iangcharoen
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
    Arch Pharm Res 34:1679-89. 2011
    ..The results had confirmed the specificity and the potential of the developed targeted delivery system for overcoming multi-drug resistance induced by overexpression of P-gp on the cell membrane...
  24. ncbi request reprint Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA
    Supachai Yodkeeree
    Department of Biochemistry, Chiang Mai University, Chiang Mai, Thailand
    Acta Pharmacol Sin 29:853-60. 2008
    ..The present study investigates the effect of an ultimate metabolite of curcumin, THC, on the invasion and motility of highly-metastatic HT1080 human fibrosarcoma cells...
  25. pmc Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids
    Kanokkarn Phromnoi
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Acta Pharmacol Sin 30:1169-76. 2009
    ..In addition, we investigated the in vitro effects of flavonoids on MDA-MB-231 cell invasion...
  26. ncbi request reprint Anti-invasive activity against cancer cells of phytochemicals in red jasmine rice (Oryza sativa L.)
    Komsak Pintha
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand E mail
    Asian Pac J Cancer Prev 15:4601-7. 2014
    ..The red rice extract may have a potential to serve as a food-derived chemotherapeutic agent for cancer patients. ..
  27. doi request reprint Kuguacin J, a triterpeniod from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3
    Pornsiri Pitchakarn
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    Food Chem Toxicol 50:840-7. 2012
    ..Our results suggest that KuJ is a promising new candidate chemopreventive and chemotherapeutic agent for prostate cancer...
  28. ncbi request reprint Ellagic acid inhibits migration and invasion by prostate cancer cell lines
    Pornsiri Pitchakarn
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Asian Pac J Cancer Prev 14:2859-63. 2013
    ..Collagenase IV activity was also concentration-dependently inhibited by EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells through action on protease activity. ..
  29. ncbi request reprint Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin
    Wanida Chearwae
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Mol Cancer Ther 5:1995-2006. 2006
    ..Collectively, these data show that, among curcuminoids, curcumin I is the most potent modulator of ABCG2 and thus should be considered as a treatment to increase the efficacy of conventional chemotherapeutic drugs...
  30. ncbi request reprint Curcumin inhibits WT1 gene expression in human leukemic K562 cells
    Songyot Anuchapreeda
    Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences Chiang Mai University, Chiang Mai 50200, Thailand
    Acta Pharmacol Sin 27:360-6. 2006
    ..The purpose of this study was to investigate the modulating effects of curcumin on WT1 gene expression in the human leukemic cell line K562...
  31. ncbi request reprint Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism
    Santosh K Sandur
    Cytokine Research Section, Department of Experimental Therapeutics, Box 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 28:1765-73. 2007
    ..Overall, our results demonstrated that different analogs of curcumin present in turmeric exhibit variable anti-inflammatory and anti-proliferative activities, which do not correlate with their ability to modulate the ROS status...