Daniel H Libraty

Summary

Affiliation: Center for Infectious Disease and Vaccine Research
Country: Thailand

Publications

  1. ncbi Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 185:1213-21. 2002
  2. ncbi Clinical and immunological risk factors for severe disease in Japanese encephalitis
    Daniel H Libraty
    Center for Infectious Diseases and Vaccine Research, University of Massachusetts School of Medicine, Worcester, MA, USA
    Trans R Soc Trop Med Hyg 96:173-8. 2002
  3. ncbi Assessment of body fluid compartment volumes by multifrequency bioelectrical impedance spectroscopy in children with dengue
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    Trans R Soc Trop Med Hyg 96:295-9. 2002
  4. pmc Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005
    Anon Srikiatkhachorn
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Clin Infect Dis 50:1135-43. 2010
  5. ncbi Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication
    Kamolwish Laoprasopwattana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 195:1108-16. 2007
  6. pmc Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators
    James A Potts
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Negl Trop Dis 4:e769. 2010
  7. ncbi Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection
    Kamolwish Laoprasopwattana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, 01655, USA
    J Infect Dis 192:510-9. 2005
  8. ncbi High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655, USA
    J Infect Dis 186:1165-8. 2002
  9. pmc Classification of dengue illness based on readily available laboratory data
    James A Potts
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Trop Med Hyg 83:781-8. 2010
  10. pmc Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status
    Anon Srikiatkhachorn
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e51335. 2012

Collaborators

Detail Information

Publications31

  1. ncbi Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 185:1213-21. 2002
    ..Quantitative differences in virus burden and host immune responses, and the timing of type 1 cytokine responses, have differing influences on the severity of disease manifestations during secondary dengue-3 virus infections...
  2. ncbi Clinical and immunological risk factors for severe disease in Japanese encephalitis
    Daniel H Libraty
    Center for Infectious Diseases and Vaccine Research, University of Massachusetts School of Medicine, Worcester, MA, USA
    Trans R Soc Trop Med Hyg 96:173-8. 2002
    ..An anamnestic, anti-flavivirus, immune response induced by a prior dengue virus infection can be an important means of providing this protection...
  3. ncbi Assessment of body fluid compartment volumes by multifrequency bioelectrical impedance spectroscopy in children with dengue
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    Trans R Soc Trop Med Hyg 96:295-9. 2002
    ..During the course of dengue illness, multifrequency BIS did not improve on serial haematocrit and bodyweight determinations for monitoring plasma volume contraction and ECW expansion, respectively...
  4. pmc Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005
    Anon Srikiatkhachorn
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Clin Infect Dis 50:1135-43. 2010
    ..The ability of these guidelines to categorize severe dengue illness has recently been questioned...
  5. ncbi Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication
    Kamolwish Laoprasopwattana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 195:1108-16. 2007
    ..In the present study, we examined the ability of plasma obtained before secondary DV infection to induce ADCC of DV-infected cells...
  6. pmc Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators
    James A Potts
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Negl Trop Dis 4:e769. 2010
    ..Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries...
  7. ncbi Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection
    Kamolwish Laoprasopwattana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, 01655, USA
    J Infect Dis 192:510-9. 2005
    ..Preexisting nonneutralizing antibodies to DV that enhance the infection of Fc gamma receptor-bearing cells have been implicated in DV pathogenesis...
  8. ncbi High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655, USA
    J Infect Dis 186:1165-8. 2002
    ..An elevated free sNS1 level (> or =600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF...
  9. pmc Classification of dengue illness based on readily available laboratory data
    James A Potts
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Trop Med Hyg 83:781-8. 2010
    ..These models could be used to calculate a probability and classify patients based on readily available clinical laboratory data, and they will need to be validated in other dengue-endemic regions...
  10. pmc Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status
    Anon Srikiatkhachorn
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e51335. 2012
    ..The in vivo targets of DENV and the relation between the viral burden in these cells and disease severity are not known...
  11. pmc Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model
    Daniel H Libraty
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 9:e88944. 2014
    ..Our data support a plausible hypothesis as to why well-nourished infants are at risk for developing DHF with their first DENV infection. ..
  12. pmc A comparative study of leptospirosis and dengue in Thai children
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Negl Trop Dis 1:e111. 2007
    ..An enhanced ability to distinguish leptospirosis from dengue in children would guide clinicians and public health personnel in the appropriate use of limited healthcare resources...
  13. pmc Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever
    Anon Srikiatkhachorn
    Center for Infectious Diseases and Vaccine Research, Rm S5 326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 81:1592-600. 2007
    ..Dengue virus-induced changes in surface and soluble VEGFR2 expression may be an important mechanism of plasma leakage in DHF...
  14. ncbi Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren
    Marlou M Mangada
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Infect Dis 185:1697-703. 2002
    ..This study, thought to be the first to investigate T cell responses to DV in preinfection PBMC, suggests that the pattern of preexisting T cell responses influences the risk for severe disease...
  15. pmc A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States
    PLoS Med 6:e1000171. 2009
    ..The widely accepted explanation for the pathogenesis of DHF in these settings, particularly during infancy, is antibody-dependent enhancement (ADE) of DENV infection...
  16. pmc The role of MyD88 signaling in heterosubtypic influenza A virus infections
    Rachel F Madera
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Virus Res 171:216-21. 2013
    ..Our results have important implications for the generation of effective universal influenza vaccines...
  17. pmc Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants
    Jennifer P Wang
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation, Worcester, MA 01605, USA
    BMC Immunol 13:35. 2012
    ..Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs)...
  18. pmc The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses
    Rachel F Madera
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e29412. 2011
    ..A better understanding of the critical signaling pathways by which RNA-like IRMs stimulate CD4+ Th1 responses is relevant to the rational design of improved vaccine adjuvants...
  19. pmc Circulating levels of soluble MICB in infants with symptomatic primary dengue virus infections
    Daniel H Libraty
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 9:e98509. 2014
    ..The elevation of sMICB during acute primary DENV infections in infants likely represents an immune evasion strategy and contributes to the severity of the acute illness. ..
  20. pmc Toll-like receptor induced pro-interleukin-1β and interleukin-6 in monocytes are lower in healthy infants compared to adults
    Daniel H Libraty
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e78018. 2013
    ..Lower TLR-induced production of pro-IL-1β and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility...
  21. pmc Dengue virus infection differentially regulates endothelial barrier function over time through type I interferon effects
    Ping Liu
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 200:191-201. 2009
    ..We hypothesized that direct viral effects on endothelial responsiveness to inflammatory and angiogenesis mediators can explain the DHF vascular leakage syndrome...
  22. pmc Intracellular cytokine production by dengue virus-specific T cells correlates with subclinical secondary infection
    Steven Hatch
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    J Infect Dis 203:1282-91. 2011
    ....
  23. ncbi Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study
    Anon Srikiatkhachorn
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Infect Dis J 26:283-90; discussion 291-2. 2007
    ..We employed serial ultrasound examination to delineate the locations and the timing of plasma leakage and to evaluate the usefulness of ultrasound in detecting plasma leakage in DHF...
  24. pmc Dengue virus type 2 modulates endothelial barrier function through CD73
    Chinmay Patkar
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Trop Med Hyg 88:89-94. 2013
    ..Our findings suggest that during DENV2 infection, endothelial barrier homeostasis is maintained by a balance between pro-inflammatory and pro-angiogenic cytokines, and type I interferon-dependent CD73 expression and activity...
  25. ncbi Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:7114-21. 2006
    ..A greater understanding of viral RNA-TLR7 activity relationships will promote rational approaches to interventional and vaccine strategies for important human viral pathogens...
  26. pmc Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Virology 368:317-21. 2007
    ..This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4(+) T-cell immune responses...
  27. ncbi Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand
    Timothy P Endy
    Division of Virology, United States Army Medical Research Institute of Infectious Diseases, United States Army Medical Research and Materiel Command, Ft Detrick, Maryland, USA
    J Infect Dis 189:990-1000. 2004
    ..Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood...
  28. pmc Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein
    Julie A Pavlin
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, USA
    J Infect Dis 198:836-42. 2008
    ..Human metapneumovirus (hMPV) is a newly discovered paramyxovirus that causes acute respiratory illness. Despite apparent near-universal exposure during early childhood, immunity is transient...
  29. ncbi Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study
    Katie B Anderson
    Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Lancet 369:1452-9. 2007
    ..Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand...
  30. ncbi Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand
    Timothy P Endy
    Department of Virology, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Epidemiol 156:52-9. 2002
    ..The authors' findings emphasize the complexity of dengue serotype-specific virus transmission and severe dengue disease and have important implications for dengue control and vaccine development...
  31. ncbi A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity
    Sathit Pichyangkul
    Department of Immunology, Armed Forces Research Institute of Medical Sciences, Queen Sirikit National Institute of Child Health, Bangkok, Thailand
    J Immunol 171:5571-8. 2003
    ..A blunted blood PDC response to dengue virus infection was associated with higher viremia levels, and was part of an altered innate immune response and pathogenetic cascade leading to severe disease...