Nikolaos Tezapsidis

Summary

Publications

  1. pmc Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
    Steven J Greco
    Neurotez, Inc, Research and Development, 991 Highway 22, Suite 200A, Bridgewater, NJ 08807, USA
    Biochem Biophys Res Commun 380:98-104. 2009
  2. pmc Leptin: a novel therapeutic strategy for Alzheimer's disease
    Nikolaos Tezapsidis
    Neurotez, Inc, Bridgewater, New Jersey 08807, USA
    J Alzheimers Dis 16:731-40. 2009
  3. ncbi request reprint Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential
    Jane M Johnston
    Neurotez, Inc, 991 Highway 22, Suite 200A, Bridgewater, New Jersey 08807, USA
    Curr Alzheimer Res 11:165-74. 2014
  4. pmc Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells
    Steven J Greco
    Research and Development, Neurotez, Inc, Bridgewater, NJ 08807, USA
    Neurosci Lett 455:191-4. 2009
  5. pmc Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease
    Steven J Greco
    Neurotez, Inc, Bridgewater, NJ 08807, USA
    J Alzheimers Dis 19:1155-67. 2010
  6. pmc Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons
    Steven J Greco
    Neurotez Inc, Bridgewater, NJ 08807, USA
    Biochem Biophys Res Commun 414:170-4. 2011
  7. ncbi request reprint Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest
    Steven J Greco
    Neurotez, Inc 991 Highway 22, Suite 200A Bridgewater, New Jersey 08807, USA
    Curr Alzheimer Res 9:1168-73. 2012
  8. pmc Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells
    Steven J Greco
    Neurotez Inc, Bridgewater, NJ, USA
    Biochem Biophys Res Commun 376:536-41. 2008

Research Grants

  1. Leptin as a treatment for Alzheimer's Disease
    Nikolaos Tezapsidis; Fiscal Year: 2007

Collaborators

Detail Information

Publications8

  1. pmc Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
    Steven J Greco
    Neurotez, Inc, Research and Development, 991 Highway 22, Suite 200A, Bridgewater, NJ 08807, USA
    Biochem Biophys Res Commun 380:98-104. 2009
    ..The data implicate that AMPK is a key regulator of both AD-related pathways...
  2. pmc Leptin: a novel therapeutic strategy for Alzheimer's disease
    Nikolaos Tezapsidis
    Neurotez, Inc, Bridgewater, New Jersey 08807, USA
    J Alzheimers Dis 16:731-40. 2009
    ..Furthermore, a leptin deficiency may aggravate insulin-controlled pathways, known to be aberrant in AD. These observations suggest that a leptin replacement therapy may be beneficial for these patients...
  3. ncbi request reprint Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential
    Jane M Johnston
    Neurotez, Inc, 991 Highway 22, Suite 200A, Bridgewater, New Jersey 08807, USA
    Curr Alzheimer Res 11:165-74. 2014
    ..Thus, these data indicate that trials of leptin in low leptin MCI/early-stage AD patients should be conducted to test the hypothesis. ..
  4. pmc Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells
    Steven J Greco
    Research and Development, Neurotez, Inc, Bridgewater, NJ 08807, USA
    Neurosci Lett 455:191-4. 2009
    ..These studies provide further insight into Leptin's mechanism of action in suppressing AD-related pathways...
  5. pmc Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease
    Steven J Greco
    Neurotez, Inc, Bridgewater, NJ 08807, USA
    J Alzheimers Dis 19:1155-67. 2010
    ..These findings solidly demonstrate the potential for leptin as a disease modifying therapeutic in transgenic animals of AD, driving optimism for its safety and efficacy in humans...
  6. pmc Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons
    Steven J Greco
    Neurotez Inc, Bridgewater, NJ 08807, USA
    Biochem Biophys Res Commun 414:170-4. 2011
    ..This may also be a legitimate strategy for therapy...
  7. ncbi request reprint Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest
    Steven J Greco
    Neurotez, Inc 991 Highway 22, Suite 200A Bridgewater, New Jersey 08807, USA
    Curr Alzheimer Res 9:1168-73. 2012
    ..To this end, we have developed a quick and simple method to isotype the human TOMM40 variable length polymorphism using a PCR- and restriction digest-based approach, enabling rapid genotyping of TOMM40 variants...
  8. pmc Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells
    Steven J Greco
    Neurotez Inc, Bridgewater, NJ, USA
    Biochem Biophys Res Commun 376:536-41. 2008
    ..Thus, leptin, which ameliorates both amyloid beta and tau-related pathological pathways, holds promise as a novel therapeutic for Alzheimer's disease...

Research Grants2

  1. Leptin as a treatment for Alzheimer's Disease
    Nikolaos Tezapsidis; Fiscal Year: 2007
    ..Seminal preclinical research conducted by Neurotez's founder, Nikolaos Tezapsidis and his team, was published in December 2004, showing that leptin augmentation therapy substantially ..