Russell W Teichert

Summary

Publications

  1. ncbi request reprint AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors
    Russell W Teichert
    Department of Biology, University of Utah, 254 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 44:207-14. 2004
  2. pmc Functional profiling of neurons through cellular neuropharmacology
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 109:1388-95. 2012
  3. doi request reprint Peptide-toxin tools for probing the expression and function of fetal and adult subtypes of the nicotinic acetylcholine receptor
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah, USA
    Ann N Y Acad Sci 1132:61-70. 2008
  4. ncbi request reprint Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Biol Chem 282:36905-13. 2007
  5. doi request reprint Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor
    Vernon D Twede
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 48:4063-73. 2009
  6. ncbi request reprint AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists
    Elsie C Jimenez
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 46:8717-24. 2007
  7. ncbi request reprint Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah, 84112, USA
    Biochemistry 45:1304-12. 2006
  8. pmc Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins
    Russell W Teichert
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 49:318-28. 2007
  9. ncbi request reprint A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors
    Estuardo Lopez-Vera
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 49:1193-9. 2007
  10. ncbi request reprint Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 44:7897-902. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors
    Russell W Teichert
    Department of Biology, University of Utah, 254 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 44:207-14. 2004
    ..These results indicate that the alphaA-conotoxin family is both more structurally diverse and broadly distributed than previously believed...
  2. pmc Functional profiling of neurons through cellular neuropharmacology
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 109:1388-95. 2012
    ....
  3. doi request reprint Peptide-toxin tools for probing the expression and function of fetal and adult subtypes of the nicotinic acetylcholine receptor
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah, USA
    Ann N Y Acad Sci 1132:61-70. 2008
    ....
  4. ncbi request reprint Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Biol Chem 282:36905-13. 2007
    ..Conus parius conantokins allow for a better definition of structural and functional features of conantokins as ligands targeting NMDA receptors...
  5. doi request reprint Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor
    Vernon D Twede
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 48:4063-73. 2009
    ....
  6. ncbi request reprint AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists
    Elsie C Jimenez
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 46:8717-24. 2007
    ..AlphaC-PrXA is strikingly different from the many conopeptides shown to be nicotinic antagonists; it is most similar in its general biochemical features to the snake toxins known as Waglerins...
  7. ncbi request reprint Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah, 84112, USA
    Biochemistry 45:1304-12. 2006
    ..The rapidly reversible peptides may be most suitable for electrophysiological studies, while the relatively irreversible peptides should be most useful for binding and localization studies...
  8. pmc Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins
    Russell W Teichert
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 49:318-28. 2007
    ..In contrast, the kappaA(S)-and kappaA(L)-conotoxins that diverge in several biochemical characteristics are clearly more similar in their physiological effects...
  9. ncbi request reprint A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors
    Estuardo Lopez-Vera
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Toxicon 49:1193-9. 2007
    ..Testing of alpha-PIB against other receptors indicated that the inhibitory effect is specific for skeletal muscle nAChRs. alpha-PIB shares the key biochemical and pharmacological characteristics of the alpha-conotoxin family...
  10. ncbi request reprint Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 44:7897-902. 2005
    ..Our working hypothesis is that the particular group of fish-hunting Conus species that includes Conus radiatus uses the alphaS-conotoxin family to target the muscle nAChR and paralyze prey...
  11. pmc Conantokin-P, an unusual conantokin with a long disulfide loop
    Konkallu Hanumae Gowd
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Toxicon 52:203-13. 2008
    ..Our results suggest that different branches of the phylogenetic tree of cone snails have evolved distinct groups of conantokins, each with its own unique biochemical features...
  12. ncbi request reprint A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 25:732-6. 2005
    ..In addition to its potential as a research tool, alphaA-OIVB may have some direct biomedical applications...
  13. ncbi request reprint Conus venoms - a rich source of peptide-based therapeutics
    Tiffany S Han
    Department of Biology, University of Utah, Salt Lake City, Utah 84108, USA
    Curr Pharm Des 14:2462-79. 2008
    ..This review summarizes recent efforts in the discovery of conopeptides, and their preclinical and clinical development...
  14. pmc Characterization of two neuronal subclasses through constellation pharmacology
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 109:12758-63. 2012
    ..This shift from molecular to cellular targets has important implications for basic research and drug discovery. We refer to this paradigm as "constellation pharmacology."..
  15. ncbi request reprint Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery
    Baldomero M Olivera
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Mol Interv 7:251-60. 2007
    ..The Conus peptides thus serve as a model system for reaping the pharmacological potential of biodiverse animal lineages...
  16. doi request reprint Natural products and ion channel pharmacology
    Russell W Teichert
    University of Utah, Department of Biology, Salt Lake City, UT 84112, USA
    Future Med Chem 2:731-44. 2010
    ..The elucidation of molecular mechanisms mediating biotic interactions should yield a rich stream of potent and selective natural products for the drug pipeline...
  17. doi request reprint The rescue of developing avian motoneurons from programmed cell death by a selective inhibitor of the fetal muscle-specific nicotinic acetylcholine receptor
    Ronald W Oppenheim
    Department of Neurobiology and Anatomy and the Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Dev Neurobiol 68:972-80. 2008
    ..We conclude that selective inhibition of the embryonic/fetal form of the chicken muscle nAChR is sufficient to rescue MNs from PCD without any involvement of neuronal nAChRs...
  18. pmc Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning
    Yun Liu
    Department of Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9111, USA
    Development 135:1957-67. 2008
    ..These results demonstrate that the gamma-subunit is required for the formation of pre-patterned AChR clusters, which in turn play an essential role in determining the subsequent pattern of neuromuscular synaptogenesis...
  19. ncbi request reprint Prolongation of evoked and spontaneous synaptic currents at the neuromuscular junction after activity blockade is caused by the upregulation of fetal acetylcholine receptors
    Xueyong Wang
    Department of Neuroscience, Cell Biology, and Physiology, Wright State University, Dayton, Ohio 45435, USA
    J Neurosci 26:8983-7. 2006
    ..This might occur if acetylcholine escapes from endplates and binds to extrajunctional fetal-type AChRs only during large, evoked EPCs. Our study is the first to demonstrate a functional role for upregulation of extrajunctional AChRs...