AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitorsRussell W Teichert
Department of Biology, University of Utah, 254 South 1400 East, Salt Lake City, UT 84112, USA
Toxicon 44:207-14. 2004
..These results indicate that the alphaA-conotoxin family is both more structurally diverse and broadly distributed than previously believed...
Functional profiling of neurons through cellular neuropharmacologyRussell W Teichert
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 109:1388-95. 2012
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Peptide-toxin tools for probing the expression and function of fetal and adult subtypes of the nicotinic acetylcholine receptorRussell W Teichert
Department of Biology, University of Utah, Salt Lake City, Utah, USA
Ann N Y Acad Sci 1132:61-70. 2008
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- Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors
Russell W Teichert
Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
J Biol Chem 282:36905-13. 2007
..Conus parius conantokins allow for a better definition of structural and functional features of conantokins as ligands targeting NMDA receptors...
- Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor
Vernon D Twede
Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
Biochemistry 48:4063-73. 2009
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- AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists
Elsie C Jimenez
Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
Biochemistry 46:8717-24. 2007
..AlphaC-PrXA is strikingly different from the many conopeptides shown to be nicotinic antagonists; it is most similar in its general biochemical features to the snake toxins known as Waglerins...
- Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor
Russell W Teichert
Department of Biology, University of Utah, Salt Lake City, Utah, 84112, USA
Biochemistry 45:1304-12. 2006
..The rapidly reversible peptides may be most suitable for electrophysiological studies, while the relatively irreversible peptides should be most useful for binding and localization studies...
- Discovery and characterization of the short kappaA-conotoxins: a novel subfamily of excitatory conotoxins
Russell W Teichert
Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
Toxicon 49:318-28. 2007
..In contrast, the kappaA(S)-and kappaA(L)-conotoxins that diverge in several biochemical characteristics are clearly more similar in their physiological effects...
- A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors
Estuardo Lopez Vera
Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
Toxicon 49:1193-9. 2007
..Testing of alpha-PIB against other receptors indicated that the inhibitory effect is specific for skeletal muscle nAChRs. alpha-PIB shares the key biochemical and pharmacological characteristics of the alpha-conotoxin family...
- Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors
Russell W Teichert
Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
Biochemistry 44:7897-902. 2005
..Our working hypothesis is that the particular group of fish-hunting Conus species that includes Conus radiatus uses the alphaS-conotoxin family to target the muscle nAChR and paralyze prey...
- Conantokin-P, an unusual conantokin with a long disulfide loop
Konkallu Hanumae Gowd
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
Toxicon 52:203-13. 2008
..Our results suggest that different branches of the phylogenetic tree of cone snails have evolved distinct groups of conantokins, each with its own unique biochemical features...
- A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor
Russell W Teichert
Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
J Neurosci 25:732-6. 2005
..In addition to its potential as a research tool, alphaA-OIVB may have some direct biomedical applications...
- Conus venoms - a rich source of peptide-based therapeutics
Tiffany S Han
Department of Biology, University of Utah, Salt Lake City, Utah 84108, USA
Curr Pharm Des 14:2462-79. 2008
..This review summarizes recent efforts in the discovery of conopeptides, and their preclinical and clinical development...
- Characterization of two neuronal subclasses through constellation pharmacology
Russell W Teichert
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 109:12758-63. 2012
..This shift from molecular to cellular targets has important implications for basic research and drug discovery. We refer to this paradigm as "constellation pharmacology."..
- Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery
Baldomero M Olivera
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
Mol Interv 7:251-60. 2007
..The Conus peptides thus serve as a model system for reaping the pharmacological potential of biodiverse animal lineages...
- Natural products and ion channel pharmacology
Russell W Teichert
University of Utah, Department of Biology, Salt Lake City, UT 84112, USA
Future Med Chem 2:731-44. 2010
..The elucidation of molecular mechanisms mediating biotic interactions should yield a rich stream of potent and selective natural products for the drug pipeline...
- The rescue of developing avian motoneurons from programmed cell death by a selective inhibitor of the fetal muscle-specific nicotinic acetylcholine receptor
Ronald W Oppenheim
Department of Neurobiology and Anatomy and the Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Dev Neurobiol 68:972-80. 2008
..We conclude that selective inhibition of the embryonic/fetal form of the chicken muscle nAChR is sufficient to rescue MNs from PCD without any involvement of neuronal nAChRs...
- Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning
Yun Liu
Department of Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9111, USA
Development 135:1957-67. 2008
..These results demonstrate that the gamma-subunit is required for the formation of pre-patterned AChR clusters, which in turn play an essential role in determining the subsequent pattern of neuromuscular synaptogenesis...
- Prolongation of evoked and spontaneous synaptic currents at the neuromuscular junction after activity blockade is caused by the upregulation of fetal acetylcholine receptors
Xueyong Wang
Department of Neuroscience, Cell Biology, and Physiology, Wright State University, Dayton, Ohio 45435, USA
J Neurosci 26:8983-7. 2006
..This might occur if acetylcholine escapes from endplates and binds to extrajunctional fetal-type AChRs only during large, evoked EPCs. Our study is the first to demonstrate a functional role for upregulation of extrajunctional AChRs...
