Emerging and re-emerging viruses in Malaysia, 1997-2007Kok Keng Tee
Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Int J Infect Dis 13:307-18. 2009
..Finally, the HIV/AIDS epidemic has seen the emergence of an HIV-1 recombinant form (CRF33_01B) in HIV-infected individuals from various risk groups, with evidence of ongoing and rapid expansion...
The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in MalaysiaKok Keng Tee
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
AIDS Res Hum Retroviruses 21:1046-50. 2005
..The results showed evidence of changing HIV-1 molecular epidemiology toward the predominance of CRF01_AE/B intersubtype recombinants among IDUs in Kuala Lumpur...
Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 geneKok Keng Tee
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
J Virol 84:3339-50. 2010
..We discuss the consequences of the evolutionary dynamics of EV-71 for vaccine design and compare its phylodynamic behavior with that of influenza virus...
- Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07_BC and CRF08_BC in East Asia: the relevance of genetic diversity and phylodynamics for vaccine strategies
Yutaka Takebe
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Vaccine 28:B39-44. 2010
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- Phylodynamic analysis of the dissemination of HIV-1 CRF01_AE in Vietnam
Huanan Liao
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Virology 391:51-6. 2009
..In the late 1980s, the virus spread to IDUs in Southern Vietnam and subsequently in the mid-1990s to IDUs further north. Our results indicate the northward dissemination of CRF01_AE during this time...
- Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
Yue Li
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Virology 402:223-7. 2010
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- Temporal and spatial dynamics of human immunodeficiency virus type 1 circulating recombinant forms 08_BC and 07_BC in Asia
Kok Keng Tee
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
J Virol 82:9206-15. 2008
..This is the first phylodynamic study depicting the spatiotemporal dynamics of HIV/AIDS in East Asia...
- Short communication: low prevalence of genotypic drug resistance mutations among antiretroviral-naive HIV type 1 patients in Malaysia
Kok Keng Tee
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
AIDS Res Hum Retroviruses 22:121-4. 2006
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- Estimating the date of origin of an HIV-1 circulating recombinant form
Kok Keng Tee
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Virology 387:229-34. 2009
..The proof-of-concept approach provides a new tool for the investigation of HIV molecular epidemiology and evolution...
- Isolation and characterization of a replication-competent molecular clone of an HIV-1 circulating recombinant form (CRF33_01B)
Kok Keng Tee
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
PLoS ONE 4:e6666. 2009
..Availability of a CRF33_01B molecular clone will be useful in facilitating the development of vaccine candidates that match the HIV-1 strains circulating in Southeast Asia...
- Chronology of the HIV-1 CRF07_BC expansion in East Asia
Kok Keng Tee
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
AIDS 22:156-8. 2008
..The separate introduction of CRF07_BC into Xinjiang occurred in 1992-1995. This study illustrates the temporal dynamics of CRF07_BC spread among IDU across east Asia...
- Identification of a novel circulating recombinant form (CRF33_01B) disseminating widely among various risk populations in Kuala Lumpur, Malaysia
Kok Keng Tee
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
J Acquir Immune Defic Syndr 43:523-9. 2006
..6% (3/184) of study subjects, suggesting an ongoing recombination process in Malaysia. This new CRF seems to be bridging viral transmission between different risk populations in this country...
- Identification of a novel second-generation circulating recombinant form (CRF48_01B) in Malaysia: a descendant of the previously identified CRF33_01B
Yue Li
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
J Acquir Immune Defic Syndr 54:129-36. 2010
..Corroborating these results, Bayesian molecular clock analyses indicated that CRF48_01B emerged in approximately 2001, approximately approximately 8 years after the emergence of CRF33_01B...
- Emergence of HIV-1 CRF01_AE/B unique recombinant forms in Kuala Lumpur, Malaysia
Kok Keng Tee
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
AIDS 19:119-26. 2005
..The emergence of highly identical CRF01_AE/B intersubtype recombinants suggests the possibility of the appearance of a new circulating recombinant form in Kuala Lumpur...
- Prevalence and pattern of drug resistance mutations among antiretroviral-treated HIV-1 patients with suboptimal virological response in Malaysia
Kok Keng Tee
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Med Microbiol Immunol 195:107-12. 2006
..The prevalence of major drug resistance mutations among ARV-treated patients with detectable VL is high in Kuala Lumpur. Genotypic drug resistance testing is therefore important for monitoring patients experiencing ARV regimen failure...
- Genome sequences of a novel HIV-1 CRF53_01B identified in Malaysia
Wei Zhen Chow
Centre of Excellence for Research in AIDS, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
J Virol 86:11398-9. 2012
..The genome sequences may contribute to HIV-1 molecular surveillance and future vaccine development in the region...
- Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia
Kim Tien Ng
Centre of Excellence for Research in AIDS, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
J Virol 86:11405-6. 2012
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- Complete genome sequencing and phylogenetic analysis of HCV isolates from China reveals a new subtype, designated 6u
Xueshan Xia
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunan, China
J Med Virol 80:1740-6. 2008
..Because its designation does not meet the criteria described in the updated HCV nomenclature proposal, this "6u" isolate should be reclassified...
- The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co-infected with HIV-1 in Yunnan, China
Xueshan Xia
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China
J Med Virol 80:1142-52. 2008
..Routes of drug trafficking and the resulting high prevalence of HIV-1 infection may have contributed to this pattern of HCV genotype distribution...
