Kok Keng Tee

Summary

Publications

  1. ncbi request reprint The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in Malaysia
    Kok Keng Tee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    AIDS Res Hum Retroviruses 21:1046-50. 2005
  2. pmc Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 84:3339-50. 2010
  3. doi request reprint Emerging and re-emerging viruses in Malaysia, 1997-2007
    Kok Keng Tee
    Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Infect Dis 13:307-18. 2009
  4. doi request reprint Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07_BC and CRF08_BC in East Asia: the relevance of genetic diversity and phylodynamics for vaccine strategies
    Yutaka Takebe
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Vaccine 28:B39-44. 2010
  5. doi request reprint Phylodynamic analysis of the dissemination of HIV-1 CRF01_AE in Vietnam
    Huanan Liao
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 391:51-6. 2009
  6. doi request reprint Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
    Yue Li
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 402:223-7. 2010
  7. pmc Temporal and spatial dynamics of human immunodeficiency virus type 1 circulating recombinant forms 08_BC and 07_BC in Asia
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 82:9206-15. 2008
  8. ncbi request reprint Short communication: low prevalence of genotypic drug resistance mutations among antiretroviral-naive HIV type 1 patients in Malaysia
    Kok Keng Tee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    AIDS Res Hum Retroviruses 22:121-4. 2006
  9. doi request reprint Estimating the date of origin of an HIV-1 circulating recombinant form
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 387:229-34. 2009
  10. pmc Isolation and characterization of a replication-competent molecular clone of an HIV-1 circulating recombinant form (CRF33_01B)
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    PLoS ONE 4:e6666. 2009

Collaborators

  • Yue Li
  • Hong Shang
  • C Y William Tong
  • Tommy Tsan Yuk Lam
  • Nguyen Tran Hien
  • Yoke Fun Chan
  • Y Takebe
  • Ling Lu
  • Kim Tien Ng
  • Wei Zhen Chow
  • Adeeba Kamarulzaman
  • Xueshan Xia
  • Lai Yee Ong
  • Yeat Mei Lee
  • Huanan Liao
  • Oliver G Pybus
  • Wenhua Zhao
  • Haider Abdulrazzaq Abed Al-Darraji
  • Sin How Lim
  • Siti Humaira Razak
  • Azureen Azmel
  • Yean Kong Yong
  • Haider Al-Darraji
  • Xiao Jie Li
  • Saiki Hase
  • Shigeru Kusagawa
  • Rie Uenishi
  • Pham Hong Thang
  • Muhammad Mahmood Mukhtar
  • Qihan Li
  • Curt H Hagedorn
  • Xiaojie Li
  • Yixiong Lin
  • Jing Yu
  • Yue Feng
  • Jianguo Wu

Detail Information

Publications21

  1. ncbi request reprint The evolving molecular epidemiology of HIV type 1 among injecting drug users (IDUs) in Malaysia
    Kok Keng Tee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    AIDS Res Hum Retroviruses 21:1046-50. 2005
    ..The results showed evidence of changing HIV-1 molecular epidemiology toward the predominance of CRF01_AE/B intersubtype recombinants among IDUs in Kuala Lumpur...
  2. pmc Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 84:3339-50. 2010
    ..We discuss the consequences of the evolutionary dynamics of EV-71 for vaccine design and compare its phylodynamic behavior with that of influenza virus...
  3. doi request reprint Emerging and re-emerging viruses in Malaysia, 1997-2007
    Kok Keng Tee
    Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Infect Dis 13:307-18. 2009
    ..Finally, the HIV/AIDS epidemic has seen the emergence of an HIV-1 recombinant form (CRF33_01B) in HIV-infected individuals from various risk groups, with evidence of ongoing and rapid expansion...
  4. doi request reprint Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07_BC and CRF08_BC in East Asia: the relevance of genetic diversity and phylodynamics for vaccine strategies
    Yutaka Takebe
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Vaccine 28:B39-44. 2010
    ....
  5. doi request reprint Phylodynamic analysis of the dissemination of HIV-1 CRF01_AE in Vietnam
    Huanan Liao
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 391:51-6. 2009
    ..In the late 1980s, the virus spread to IDUs in Southern Vietnam and subsequently in the mid-1990s to IDUs further north. Our results indicate the northward dissemination of CRF01_AE during this time...
  6. doi request reprint Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
    Yue Li
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 402:223-7. 2010
    ....
  7. pmc Temporal and spatial dynamics of human immunodeficiency virus type 1 circulating recombinant forms 08_BC and 07_BC in Asia
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 82:9206-15. 2008
    ..This is the first phylodynamic study depicting the spatiotemporal dynamics of HIV/AIDS in East Asia...
  8. ncbi request reprint Short communication: low prevalence of genotypic drug resistance mutations among antiretroviral-naive HIV type 1 patients in Malaysia
    Kok Keng Tee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    AIDS Res Hum Retroviruses 22:121-4. 2006
    ....
  9. doi request reprint Estimating the date of origin of an HIV-1 circulating recombinant form
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 387:229-34. 2009
    ..The proof-of-concept approach provides a new tool for the investigation of HIV molecular epidemiology and evolution...
  10. pmc Isolation and characterization of a replication-competent molecular clone of an HIV-1 circulating recombinant form (CRF33_01B)
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    PLoS ONE 4:e6666. 2009
    ..Availability of a CRF33_01B molecular clone will be useful in facilitating the development of vaccine candidates that match the HIV-1 strains circulating in Southeast Asia...
  11. ncbi request reprint Chronology of the HIV-1 CRF07_BC expansion in East Asia
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    AIDS 22:156-8. 2008
    ..The separate introduction of CRF07_BC into Xinjiang occurred in 1992-1995. This study illustrates the temporal dynamics of CRF07_BC spread among IDU across east Asia...
  12. ncbi request reprint Identification of a novel circulating recombinant form (CRF33_01B) disseminating widely among various risk populations in Kuala Lumpur, Malaysia
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Acquir Immune Defic Syndr 43:523-9. 2006
    ..6% (3/184) of study subjects, suggesting an ongoing recombination process in Malaysia. This new CRF seems to be bridging viral transmission between different risk populations in this country...
  13. doi request reprint Identification of a novel second-generation circulating recombinant form (CRF48_01B) in Malaysia: a descendant of the previously identified CRF33_01B
    Yue Li
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Acquir Immune Defic Syndr 54:129-36. 2010
    ..Corroborating these results, Bayesian molecular clock analyses indicated that CRF48_01B emerged in approximately 2001, approximately approximately 8 years after the emergence of CRF33_01B...
  14. ncbi request reprint Emergence of HIV-1 CRF01_AE/B unique recombinant forms in Kuala Lumpur, Malaysia
    Kok Keng Tee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    AIDS 19:119-26. 2005
    ..To investigate the molecular epidemiology of HIV-1 and to screen for the emergence of intersubtype recombinants in Kuala Lumpur, Malaysia...
  15. pmc Molecular diversity of HIV-1 among people who inject drugs in Kuala Lumpur, Malaysia: massive expansion of circulating recombinant form (CRF) 33_01B and emergence of multiple unique recombinant clusters
    Wei Zhen Chow
    Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 8:e62560. 2013
    ..The emergence of numerous previously unknown recombinant clades highlights the escalating genetic complexity of HIV-1 in the Southeast Asian region...
  16. ncbi request reprint Prevalence and pattern of drug resistance mutations among antiretroviral-treated HIV-1 patients with suboptimal virological response in Malaysia
    Kok Keng Tee
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Med Microbiol Immunol 195:107-12. 2006
    ..The prevalence of major drug resistance mutations among ARV-treated patients with detectable VL is high in Kuala Lumpur. Genotypic drug resistance testing is therefore important for monitoring patients experiencing ARV regimen failure...
  17. pmc Evolutionary history of HIV-1 subtype B and CRF01_AE transmission clusters among men who have sex with men (MSM) in Kuala Lumpur, Malaysia
    Kim Tien Ng
    Centre of Excellence for Research in AIDS CERiA, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 8:e67286. 2013
    ....
  18. pmc Genome sequences of a novel HIV-1 CRF53_01B identified in Malaysia
    Wei Zhen Chow
    Centre of Excellence for Research in AIDS, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Virol 86:11398-9. 2012
    ..The genome sequences may contribute to HIV-1 molecular surveillance and future vaccine development in the region...
  19. pmc Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia
    Kim Tien Ng
    Centre of Excellence for Research in AIDS, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Virol 86:11405-6. 2012
    ....
  20. doi request reprint Complete genome sequencing and phylogenetic analysis of HCV isolates from China reveals a new subtype, designated 6u
    Xueshan Xia
    Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunan, China
    J Med Virol 80:1740-6. 2008
    ..Because its designation does not meet the criteria described in the updated HCV nomenclature proposal, this "6u" isolate should be reclassified...
  21. pmc The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co-infected with HIV-1 in Yunnan, China
    Xueshan Xia
    Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China
    J Med Virol 80:1142-52. 2008
    ..Routes of drug trafficking and the resulting high prevalence of HIV-1 infection may have contributed to this pattern of HCV genotype distribution...