Irina Y Tcherepanova

Summary

Publications

  1. pmc Multiplex RT-PCR amplification of HIV genes to create a completely autologous DC-based immunotherapy for the treatment of HIV infection
    Irina Tcherepanova
    Research and Development Department, Argos Therapeutics, Inc, Durham, North Carolina, USA
    PLoS ONE 3:e1489. 2008
  2. pmc Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion
    Irina Y Tcherepanova
    Research and Development Department, Argos Therapeutics Inc, Durham, NC, USA
    BMC Mol Biol 9:90. 2008
  3. pmc The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90
    Irina Tcherepanova
    Research and Development Department, Argos Therapeutics Inc, Durham, NC, USA
    PLoS ONE 4:e5853. 2009
  4. doi request reprint Cytokine maturation followed by CD40L mRNA electroporation results in a clinically relevant dendritic cell product capable of inducing a potent proinflammatory CTL response
    David M Calderhead
    Research Department, Argos Therapeutics Inc, Durham, NC 27704, USA
    J Immunother 31:731-41. 2008
  5. doi request reprint Potency of mature CD40L RNA electroporated dendritic cells correlates with IL-12 secretion by tracking multifunctional CD8(+)/CD28(+) cytotoxic T-cell responses in vitro
    Mark A DeBenedette
    Research Department, Argos Therapeutics, Inc, Durham, NC 27704, USA
    J Immunother 34:45-57. 2011
  6. ncbi request reprint Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent
    Mark A DeBenedette
    Research Department, Argos Therapeutics, Inc, Durham, NC 27704, USA
    J Immunol 181:5296-305. 2008
  7. doi request reprint Evaluation of RNA Amplification Methods to Improve DC Immunotherapy Antigen Presentation and Immune Response
    Jacoba G Slagter-Jäger
    Argos Therapeutics, Durham, North Carolina, USA
    Mol Ther Nucleic Acids 2:e91. 2013
  8. doi request reprint Evaluation of a microfluidics-based platform and slab electrophoresis for determination of size, integrity and quantification of in vitro transcribed RNA used as a component in therapeutic drug manufacturing
    Jacoba Grietje Slagter-Jäger
    Argos Therapeutics, Inc, 4233 Technology Drive, Durham, NC 27704, USA
    J Pharm Biomed Anal 70:657-63. 2012

Collaborators

Detail Information

Publications8

  1. pmc Multiplex RT-PCR amplification of HIV genes to create a completely autologous DC-based immunotherapy for the treatment of HIV infection
    Irina Tcherepanova
    Research and Development Department, Argos Therapeutics, Inc, Durham, North Carolina, USA
    PLoS ONE 3:e1489. 2008
    ....
  2. pmc Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion
    Irina Y Tcherepanova
    Research and Development Department, Argos Therapeutics Inc, Durham, NC, USA
    BMC Mol Biol 9:90. 2008
    ..To achieve higher levels of IL-12 secretion, a systematic approach involving modification of coding and noncoding regions was implemented to optimize protein expression in the DCs for the purpose of increasing IL-12 secretion...
  3. pmc The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90
    Irina Tcherepanova
    Research and Development Department, Argos Therapeutics Inc, Durham, NC, USA
    PLoS ONE 4:e5853. 2009
    ..Consistent with this idea are reports that defects in the C-terminus of Vpr are associated with long-term non-progression...
  4. doi request reprint Cytokine maturation followed by CD40L mRNA electroporation results in a clinically relevant dendritic cell product capable of inducing a potent proinflammatory CTL response
    David M Calderhead
    Research Department, Argos Therapeutics Inc, Durham, NC 27704, USA
    J Immunother 31:731-41. 2008
    ....
  5. doi request reprint Potency of mature CD40L RNA electroporated dendritic cells correlates with IL-12 secretion by tracking multifunctional CD8(+)/CD28(+) cytotoxic T-cell responses in vitro
    Mark A DeBenedette
    Research Department, Argos Therapeutics, Inc, Durham, NC 27704, USA
    J Immunother 34:45-57. 2011
    ..Therefore, by measuring the availability of IL-12 one can predict the potency of a DC immunotherapeutics in relation to its ability to drive distinct effector memory CTL subsets with multifunctional activities...
  6. ncbi request reprint Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent
    Mark A DeBenedette
    Research Department, Argos Therapeutics, Inc, Durham, NC 27704, USA
    J Immunol 181:5296-305. 2008
    ....
  7. doi request reprint Evaluation of RNA Amplification Methods to Improve DC Immunotherapy Antigen Presentation and Immune Response
    Jacoba G Slagter-Jäger
    Argos Therapeutics, Durham, North Carolina, USA
    Mol Ther Nucleic Acids 2:e91. 2013
    ..Molecular Therapy-Nucleic Acids (2013) 2, e91; doi:10.1038/mtna.2013.18; published online 7 May 2013...
  8. doi request reprint Evaluation of a microfluidics-based platform and slab electrophoresis for determination of size, integrity and quantification of in vitro transcribed RNA used as a component in therapeutic drug manufacturing
    Jacoba Grietje Slagter-Jäger
    Argos Therapeutics, Inc, 4233 Technology Drive, Durham, NC 27704, USA
    J Pharm Biomed Anal 70:657-63. 2012
    ..We highlight observations which need to be taken into account when developing and qualifying a method of choice for assessment of in vitro-transcribed RNA using either approach...