Jana D Tchekalarova



  1. Tchekalarova J, Atanasova D, Kortenska L, Lazarov N, Shishmanova Doseva M, Galchev T, et al. Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat. Brain Res Bull. 2019;147:22-35 pubmed publisher
    ..In addition, a reduction of gamma and HI bands in the frontal and parietal cortex is not associated with EEG-recorded paroxysmal events after acute injection of LCM. ..
  2. Tchekalarova J, Petkova Z, Pechlivanova D, Moyanova S, Kortenska L, Mitreva R, et al. Prophylactic treatment with melatonin after status epilepticus: effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy. Epilepsy Behav. 2013;27:174-87 pubmed publisher
    ..However, it showed a potential in reducing some of the deleterious alterations that develop during the chronic epileptic state in a diurnal phase-dependent mode. ..
  3. Tchekalarova J, Ivanova N, Pechlivanova D, Atanasova D, Lazarov N, Kortenska L, et al. Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy. Pharmacol Biochem Behav. 2014;127:27-36 pubmed publisher
  4. Moyanova S, De Fusco A, Santolini I, Celli R, Bucci D, Mastroiacovo F, et al. Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?. Int J Mol Sci. 2018;19: pubmed publisher
  5. Tchekalarova J, Loyens E, Smolders I. Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats. Epilepsy Behav. 2015;46:66-71 pubmed publisher
    ..These results suggest a lack of direct relationship between KA-induced seizure susceptibility and adaptive changes of hippocampal NAD, 5-HT, and DA levels in the effects of ZD7155 in WKY rats and SHRs. ..
  6. Tchekalarova J, Stoynova T, Ilieva K, Mitreva R, Atanasova M. Agomelatine treatment corrects symptoms of depression and anxiety by restoring the disrupted melatonin circadian rhythms of rats exposed to chronic constant light. Pharmacol Biochem Behav. 2018;171:1-9 pubmed publisher
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    Tchekalarova J, Kubová H, Mareš P. Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. Pharmacol Rep. 2013;65:847-53 pubmed
    ..Different effects of postnatal caffeine exposure persist into adulthood; the seizure ameliorating effects in a model of absences and seizure exacerbating action in a model of myoclonic seizures are dose-specific. ..
  8. Tchekalarova J, Atanasova D, Kortenska L, Atanasova M, Lazarov N. Chronic agomelatine treatment prevents comorbid depression in the post-status epilepticus model of acquired epilepsy through suppression of inflammatory signaling. Neurobiol Dis. 2018;115:127-144 pubmed publisher
    ..The present results suggest that agomelatine treatment starting after SE can provide an effective therapy of comorbid depression in chronic epileptic condition through suppression of inflammatory signaling. ..
  9. Ivanova N, Atanasova D, Pechlivanova D, Mitreva R, Lazarov N, Stoynev A, et al. Long-term intracerebroventricular infusion of angiotensin II after kainate-induced status epilepticus: Effects on epileptogenesis, brain damage, and diurnal behavioral changes. Epilepsy Behav. 2015;51:1-12 pubmed publisher
    ..However, Ang II partially prevented the neuronal damage in the hippocampus, specifically in the CA1 area. The role of AT1 and AT2 receptor activation in the effects of the octapeptide is discussed. ..

More Information


  1. Tchekalarova J, Nenchovska Z, Atanasova D, Atanasova M, Kortenska L, Stefanova M, et al. Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats. Behav Brain Res. 2016;302:11-28 pubmed publisher
  2. Tchekalarova J, Kortenska L, Marinov P, Boyanov K. Comparative power spectrum analysis of EEG activity in spontaneously hypertensive and Wistar rats in kainate model of temporal model of epilepsy. Brain Res Bull. 2016;124:62-75 pubmed publisher
  3. Tchekalarova J, Ivanova N, Atanasova D, Pechlivanova D, Lazarov N, Kortenska L, et al. Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy. Cell Mol Neurobiol. 2016;36:927-941 pubmed publisher
    ..Our results suggest that the antihypertensive therapy with an AT1 receptor blocker might be effective against seizure activity and neuronal damage in a co-morbid hypertension and epilepsy. ..
  4. Tchekalarova J, Moyanova S, Fusco A, Ngomba R. The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders. Brain Res Bull. 2015;119:80-92 pubmed publisher
  5. Tchekalarova J, Shishmanova M, Atanasova D, Stefanova M, Alova L, Lazarov N, et al. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain Res. 2015;1625:39-53 pubmed publisher
    ..However, this beneficial impact does not prevent the development of epilepsy and concomitant brain damage. ..
  6. Tchekalarova J, Atanasova D, Nenchovska Z, Atanasova M, Kortenska L, Gesheva R, et al. Agomelatine protects against neuronal damage without preventing epileptogenesis in the kainate model of temporal lobe epilepsy. Neurobiol Dis. 2017;104:1-14 pubmed publisher
    ..Our findings suggest that the beneficial impact against SE-induced neuronal loss exerted by agomelatine is not crucial for the suppression of epileptogenesis and its deleterious consequences in KA model of temporal lobe epilepsy. ..
  7. Atanasova D, Tchekalarova J, Ivanova N, Nenchovska Z, Pavlova E, Atanassova N, et al. Losartan suppresses the kainate-induced changes of angiotensin AT1 receptor expression in a model of comorbid hypertension and epilepsy. Life Sci. 2018;193:40-46 pubmed publisher
    ..Our results confirm the important role of AT1 receptor in epilepsy and suggest that the AT1receptor antagonists could be used as a therapeutic strategy for treatment of comorbid hypertension and epilepsy. ..
  8. Pechlivanova D, Petrov K, Grozdanov P, Nenchovska Z, Tchekalarova J, Stoynev A. Intracerebroventricular infusion of an Angiotensin AT2 receptor agonist Novokinin aggravates some diabetes mellitus-induced alterations in Wistar rats. Can J Physiol Pharmacol. 2017;: pubmed publisher
    ..These initial data suggest that angiotensin AT2 receptors participate in the pathogenesis of T1 DM-induced complications in the function of the nervous system...