Steven D Targum

Summary

Publications

  1. ncbi request reprint Evaluating rater competency for CNS clinical trials
    Steven D Targum
    UBC PharmaStar, Wayne, PA, USA
    J Clin Psychopharmacol 26:308-10. 2006
  2. doi request reprint A comparative analysis between site-based and centralized ratings and patient self-ratings in a clinical trial of Major Depressive Disorder
    Steven D Targum
    Clintara LLC, 505 Tremont Street 907, Boston, MA 02116, United States BrainCells Inc, San Diego, CA, United States Electronic address
    J Psychiatr Res 47:944-54. 2013
  3. pmc A cross-cultural comparison study of depression assessments conducted in Japan
    Steven D Targum
    Clintara LLC, 505 Tremont Street, 907, Boston, MA 02116, USA
    Ann Gen Psychiatry 12:9. 2013
  4. pmc A structured interview guide for global impressions: increasing reliability and scoring accuracy for CNS trials
    Steven D Targum
    Clintara LLC, 505 Tremont Street, Boston, MA, 02116, USA
    Ann Gen Psychiatry 12:2. 2013
  5. doi request reprint A global measure to assess switching antipsychotic medications in the treatment of schizophrenia
    Steven D Targum
    Clintara LLC, Boston, Massachusetts, USA
    Hum Psychopharmacol 27:455-63. 2012
  6. doi request reprint Development of a clinical global impression scale for fatigue
    Steven D Targum
    Clintara LLC, 505 Tremont Street 907, Boston, MA 02116, USA
    J Psychiatr Res 46:370-4. 2012
  7. doi request reprint Redefining affective disorders: relevance for drug development
    Steven D Targum
    Department of Psychiatry, Clinical Trials Network and Institute, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    CNS Neurosci Ther 14:2-9. 2008
  8. doi request reprint Targeted scoring criteria reduce variance in global impressions
    Steven D Targum
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Hum Psychopharmacol 23:629-33. 2008
  9. doi request reprint An exploratory study of combination buspirone and melatonin SR in major depressive disorder (MDD): a possible role for neurogenesis in drug discovery
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    J Psychiatr Res 46:1553-63. 2012
  10. doi request reprint RESEARCH: Validation of the Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ)
    Gregory M Chandler
    Massachusetts General Hospital Clinical Trials Network and Institute, Boston, USA
    CNS Neurosci Ther 16:322-5. 2010

Detail Information

Publications13

  1. ncbi request reprint Evaluating rater competency for CNS clinical trials
    Steven D Targum
    UBC PharmaStar, Wayne, PA, USA
    J Clin Psychopharmacol 26:308-10. 2006
    ..The findings show that rater training improves rater competency at all levels of clinical experience. Furthermore, more stringent criteria for rater eligibility and comprehensive rater training programs can improve ratings competency...
  2. doi request reprint A comparative analysis between site-based and centralized ratings and patient self-ratings in a clinical trial of Major Depressive Disorder
    Steven D Targum
    Clintara LLC, 505 Tremont Street 907, Boston, MA 02116, United States BrainCells Inc, San Diego, CA, United States Electronic address
    J Psychiatr Res 47:944-54. 2013
    ..The use of "dual" scoring criteria may help to confirm symptom severity scores and improve ratings precision, particularly prior to enrolling subjects into CNS trials...
  3. pmc A cross-cultural comparison study of depression assessments conducted in Japan
    Steven D Targum
    Clintara LLC, 505 Tremont Street, 907, Boston, MA 02116, USA
    Ann Gen Psychiatry 12:9. 2013
    ..We examined the cross-cultural applicability of the Montgomery-Asberg Depression Rating Scale (MADRS) in Japan...
  4. pmc A structured interview guide for global impressions: increasing reliability and scoring accuracy for CNS trials
    Steven D Targum
    Clintara LLC, 505 Tremont Street, Boston, MA, 02116, USA
    Ann Gen Psychiatry 12:2. 2013
    ..abstract:..
  5. doi request reprint A global measure to assess switching antipsychotic medications in the treatment of schizophrenia
    Steven D Targum
    Clintara LLC, Boston, Massachusetts, USA
    Hum Psychopharmacol 27:455-63. 2012
    ..The conventional Clinical Global Impression (CGI) of severity scale is a well-understood measure to track switching effects but does not differentiate between the severity of clinical symptoms and the impact of side effects....
  6. doi request reprint Development of a clinical global impression scale for fatigue
    Steven D Targum
    Clintara LLC, 505 Tremont Street 907, Boston, MA 02116, USA
    J Psychiatr Res 46:370-4. 2012
    ..868 (CGI-I) and Cronbach's alpha = 0.998 (CGI-S) and 0.941 (CGI-I). As shown here, the modified CGI and PGI instruments for fatigue are reliable measures of fatigue and both measures are validated with the MGH-CPFQ instrument...
  7. doi request reprint Redefining affective disorders: relevance for drug development
    Steven D Targum
    Department of Psychiatry, Clinical Trials Network and Institute, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    CNS Neurosci Ther 14:2-9. 2008
    ..In this article, we propose operational criteria to delineate a more symptom-specific and ecologically valid approach to the identification of the valid patient for clinical trials...
  8. doi request reprint Targeted scoring criteria reduce variance in global impressions
    Steven D Targum
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Hum Psychopharmacol 23:629-33. 2008
    ....
  9. doi request reprint An exploratory study of combination buspirone and melatonin SR in major depressive disorder (MDD): a possible role for neurogenesis in drug discovery
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    J Psychiatr Res 46:1553-63. 2012
    ..These preliminary findings have clinical implications and suggest that a platform of pre-clinical neurogenesis matched with confirmatory behavioral assays may be useful as a drug discovery strategy...
  10. doi request reprint RESEARCH: Validation of the Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ)
    Gregory M Chandler
    Massachusetts General Hospital Clinical Trials Network and Institute, Boston, USA
    CNS Neurosci Ther 16:322-5. 2010
    ..Although the MGH ATRQ tended to underreport the number of unsuccessful treatment trials relative to the clinical interviews, its accuracy in cases it detected was confirmed by raters...
  11. doi request reprint Rater scoring variability in the serial assessment of anxiety symptoms
    Steven D Targum
    J Clin Psychopharmacol 28:118-9. 2008
  12. ncbi request reprint Culture and assessment of manic symptoms
    Paul Mackin
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Br J Psychiatry 189:379-80. 2006
    ..001) and between India and UK (P<0.001) rater groups. Overall, differences between India and US rater groups were less marked (P=0.28). These differences suggest that cultural biases influence the interpretation of manic symptoms...
  13. ncbi request reprint Psychosis in elderly patients: classification and pharmacotherapy
    Jacobo Mintzer
    Medical University of South Carolina, Institute of Psychiatry, Charleston 29406, USA
    J Geriatr Psychiatry Neurol 16:199-206. 2003
    ..The authors review common diagnostics associated with psychosis in the elderly and clinical guidelines to selecting antipsychotic pharmacotherapy...