Nicolas Tapon

Summary

Publications

  1. Bertran M, Mouilleron S, Zhou Y, Bajaj R, Uliana F, Kumar G, et al. ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Nat Commun. 2019;10:771 pubmed publisher
    ..The ASPP2 SH3 domain can discriminate between PP1 isoforms using an acidic specificity pocket in the n-Src domain, providing an exquisite mechanism where multiple motifs are used combinatorially to tune binding affinity to PP1. ..
  2. Gailite I, Aerne B, Tapon N. Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system. Proc Natl Acad Sci U S A. 2015;112:E5169-78 pubmed publisher
    ..Thus, we demonstrate a dramatically different wiring of Hpo signaling in neighboring cell populations of distinct developmental origins in the central nervous system. ..
  3. Fulford A, Tapon N, Ribeiro P. Upstairs, downstairs: spatial regulation of Hippo signalling. Curr Opin Cell Biol. 2018;51:22-32 pubmed publisher
    ..Here, we review recent advances in the field relating to the upstream regulation of Hippo signalling and the intracellular tug-of-war that tightly controls its main target, the transcriptional co-activator Yorkie/YAP. ..

Collaborators