Rotenone, paraquat, and Parkinson's diseaseCaroline M Tanner
The Parkinson s Institute, Sunnyvale, California 94085, USA
Environ Health Perspect 119:866-72. 2011
..Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans...
Advances in environmental epidemiologyCaroline M Tanner
Clinical Research, The Parkinson s Institute, Sunnyvale, California 94085, USA
Mov Disord 25:S58-62. 2010
..The pathogenesis of PD may begin decades before motor symptoms. PD may have shared determinants with other neurodegenerative disorders involving abnormal protein aggregation...
- Solvent exposures and Parkinson disease risk in twins
Samuel M Goldman
The Parkinson s Institute, 675 Almanor Avenue, Sunnyvale, CA 94085, USA
Ann Neurol 71:776-84. 2012
..We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design...
- Head injury, α-synuclein Rep1, and Parkinson's disease
Samuel M Goldman
The Parkinson s Institute, Sunnyvale, CA 94085, USA
Ann Neurol 71:40-8. 2012
..To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk...
- Genetic modification of the association of paraquat and Parkinson's disease
Samuel M Goldman
The Parkinson s Institute, Sunnyvale, California 94085, USA
Mov Disord 27:1652-8. 2012
..GSTT1*0 is common and could potentially identify a large subpopulation at high risk of PD from oxidative stressors such as paraquat...
Head injury and Parkinson's disease risk in twinsSamuel M Goldman
The Parkinson s Institute, Sunnyvale, CA 94089, USA
Ann Neurol 60:65-72. 2006
..Twin studies circumvent some of these problems, because twins are genetically and environmentally much more similar than typical cases and control subjects...
- Occupation and risk of parkinsonism: a multicenter case-control study
Caroline M Tanner
Department of Clinical Research, The Parkinson s Institute, Sunnyvale, California 94085, USA
Arch Neurol 66:1106-13. 2009
..We examined risk of parkinsonism in occupations (agriculture, education, health care, welding, and mining) and toxicant exposures (solvents and pesticides) putatively associated with parkinsonism...
- Smell identification ability in twin pairs discordant for Parkinson's disease
Connie Marras
The Parkinson s Institute, Sunnyvale, California, USA
Mov Disord 20:687-93. 2005
..Smell identification ability may not be a sensitive indicator of future PD 7 or more years before the development of motor signs, even in a theoretically at-risk population...
- Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease
Ruksana Azhu Valappil
Clinical Research Department, The Parkinson s Institute and Clinical Center, Sunnyvale, California, USA
Mov Disord 25:2296-303. 2010
..Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD...
- Clinical features in early Parkinson disease and survival
Raymond Y Lo
The Parkinson s Institute and Clinical Center, Sunnyvale, CA 94085, USA
Arch Neurol 66:1353-8. 2009
..To examine the association between demographic and clinical features in early Parkinson disease (PD) and length of survival in a multiethnic population...
- Nicotine and Parkinson's disease: implications for therapy
Maryka Quik
The Parkinson s Institute, Sunnyvale, California, USA
Mov Disord 23:1641-52. 2008
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- Marked variation in clinical presentation and age of onset in a family with a heterozygous parkin mutation
Louis C Tan
The Parkinson s Institute, Sunnyvale, California 84089, USA
Mov Disord 18:758-63. 2003
..Clinicians should be aware that patients carrying a parkin gene mutation may present with dystonia-parkinsonism or very subtle parkinsonism with a markedly varied age of onset...
- Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies
Caroline M Tanner
Parkinson s Institute, Sunnyvale, California, USA
Adv Neurol 91:133-42. 2003
