Julian Wei Tze Tang

Summary

Publications

  1. doi request reprint Differing symptom patterns in early pandemic vs seasonal influenza infections
    Julian Wei Tze Tang
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore
    Arch Intern Med 170:861-7. 2010
  2. pmc Different types of door-opening motions as contributing factors to containment failures in hospital isolation rooms
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore
    PLoS ONE 8:e66663. 2013
  3. pmc Airflow dynamics of human jets: sneezing and breathing - potential sources of infectious aerosols
    Julian W Tang
    Alberta Provincial Laboratory for Public Health, University of Alberta Hospital, Edmonton, Canada
    PLoS ONE 8:e59970. 2013
  4. pmc Airflow dynamics of coughing in healthy human volunteers by shadowgraph imaging: an aid to aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Queenstown, Singapore
    PLoS ONE 7:e34818. 2012
  5. ncbi request reprint Tracking the emergence of pandemic Influenza A/H1N1/2009 and its interaction with seasonal influenza viruses in Singapore
    Julian W T Tang
    Department of Laboratory Medicine, Molecular Diagnosis Centre, National University Hospital, Singapore
    Ann Acad Med Singapore 39:291-4. 2010
  6. doi request reprint Observing and quantifying airflows in the infection control of aerosol- and airborne-transmitted diseases: an overview of approaches
    J W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    J Hosp Infect 77:213-22. 2011
  7. pmc Qualitative real-time schlieren and shadowgraph imaging of human exhaled airflows: an aid to aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    PLoS ONE 6:e21392. 2011
  8. pmc Seasonality of influenza A(H3N2) virus: a Hong Kong perspective (1997-2006)
    Julian W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    PLoS ONE 3:e2768. 2008
  9. doi request reprint Viral loads of herpes simplex virus in clinical samples--a 5-year retrospective analysis
    Julian W Tang
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore
    J Med Virol 82:1911-6. 2010
  10. doi request reprint Incidence of common respiratory viral infections related to climate factors in hospitalized children in Hong Kong
    J W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Epidemiol Infect 138:226-35. 2010

Collaborators

Detail Information

Publications40

  1. doi request reprint Differing symptom patterns in early pandemic vs seasonal influenza infections
    Julian Wei Tze Tang
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore
    Arch Intern Med 170:861-7. 2010
    ..Influenza incidence peaks in June through July and November through January, though influenza cases can be detected throughout the year...
  2. pmc Different types of door-opening motions as contributing factors to containment failures in hospital isolation rooms
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore
    PLoS ONE 8:e66663. 2013
    ..Further experiments involving a simulated ventilated environment are required, but from these findings alone, it appears that sliding-doors are far more effective for hospital isolation room containment. ..
  3. pmc Airflow dynamics of human jets: sneezing and breathing - potential sources of infectious aerosols
    Julian W Tang
    Alberta Provincial Laboratory for Public Health, University of Alberta Hospital, Edmonton, Canada
    PLoS ONE 8:e59970. 2013
    ..This is in contrast with some earlier estimates of sneeze velocities, and some reasons for this difference are discussed...
  4. pmc Airflow dynamics of coughing in healthy human volunteers by shadowgraph imaging: an aid to aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Queenstown, Singapore
    PLoS ONE 7:e34818. 2012
    ..The effectiveness of this intervention depends on optimum positioning of the arm over the nose and mouth during coughing, though unsightly stains on sleeves may make it unacceptable to some...
  5. ncbi request reprint Tracking the emergence of pandemic Influenza A/H1N1/2009 and its interaction with seasonal influenza viruses in Singapore
    Julian W T Tang
    Department of Laboratory Medicine, Molecular Diagnosis Centre, National University Hospital, Singapore
    Ann Acad Med Singapore 39:291-4. 2010
    ..Since the emergence of the pandemic influenza A/H1N1/2009 virus in April 2009, diagnostic testing in many countries has revealed the rapid displacement and then replacement of circulating seasonal influenza viruses by this novel virus...
  6. doi request reprint Observing and quantifying airflows in the infection control of aerosol- and airborne-transmitted diseases: an overview of approaches
    J W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    J Hosp Infect 77:213-22. 2011
    ..This article outlines each of these techniques in a non-technical manner, suitable for a clinical readership without specialist airflow or engineering knowledge...
  7. pmc Qualitative real-time schlieren and shadowgraph imaging of human exhaled airflows: an aid to aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    PLoS ONE 6:e21392. 2011
    ....
  8. pmc Seasonality of influenza A(H3N2) virus: a Hong Kong perspective (1997-2006)
    Julian W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    PLoS ONE 3:e2768. 2008
    ..The underlying basis for the seasonality of influenza A viruses is still uncertain. Phylogenetic studies investigated this phenomenon but have lacked sequences from more subtropical and tropical regions, particularly from Southeast Asia...
  9. doi request reprint Viral loads of herpes simplex virus in clinical samples--a 5-year retrospective analysis
    Julian W Tang
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore
    J Med Virol 82:1911-6. 2010
    ..These findings may therefore limit the usefulness of monitoring HSV loads in everyday clinical practice...
  10. doi request reprint Incidence of common respiratory viral infections related to climate factors in hospitalized children in Hong Kong
    J W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Epidemiol Infect 138:226-35. 2010
    ..Data from this study further reinforces the concept that the relationship between climate factors and respiratory virus incidence differ between subtropical/tropical and temperate countries...
  11. pmc The effect of environmental parameters on the survival of airborne infectious agents
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore
    J R Soc Interface 6:S737-46. 2009
    ....
  12. ncbi request reprint Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises
    J W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Hosp Infect 64:100-14. 2006
    ..On this basis, recommendations are made to improve the control of aerosol-transmitted infections in hospitals as well as in the design and construction of future isolation facilities...
  13. doi request reprint Comparison of the incidence of influenza in relation to climate factors during 2000-2007 in five countries
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    J Med Virol 82:1958-65. 2010
    ..Rainfall was not significantly correlated with the incidence of influenza A or B in any of these cities...
  14. doi request reprint A universal influenza A and B duplex real-time RT-PCR assay
    Hong Kai Lee
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    J Med Virol 84:1646-51. 2012
    ..This in-house assay offers a highly sensitive and specific option for laboratories seeking to expand their influenza testing capacity...
  15. pmc High-resolution melting approach to efficient identification and quantification of H275Y mutant influenza H1N1/2009 virus in mixed-virus-population samples
    Hong Kai Lee
    Molecular Diagnosis Center, National University of Singapore, Singapore, Republic of Singapore
    J Clin Microbiol 49:3555-9. 2011
    ....
  16. pmc Diagnostic testing for pandemic influenza in Singapore: a novel dual-gene quantitative real-time RT-PCR for the detection of influenza A/H1N1/2009
    Hong Kai Lee
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    J Mol Diagn 12:636-43. 2010
    ..It was first applied to 3512 patients with influenza-like illnesses at a tertiary hospital in Singapore, during the containment phase of the pandemic (May to July 2009)...
  17. pmc Targeting both rs12979860 and rs8099917 polymorphisms with a single-tube high-resolution melting assay for IL28b genotyping
    Kok Siong Poon
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Health System, Singapore
    J Clin Microbiol 50:3353-5. 2012
    ..A linkage study on 300 healthy Singaporeans showed variable haplotypes. When the assay was applied to plasma DNA from 50 hepatitis C virus genotype-1 (HCV-1)-infected patients, five compound heterozygous types were detected...
  18. doi request reprint An in-house HIV genotyping assay for the detection of drug resistance mutations in Southeast Asian patients infected with HIV-1
    Chun Kiat Lee
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    J Med Virol 84:394-401. 2012
    ..Therefore this assay enables further study of these C-terminal mutations in Southeast Asian populations, where there is a high prevalence of CRF01_AE and other non-subtype B HIV infections...
  19. doi request reprint Epidemiology of GB virus type C among patients infected with HIV in Singapore
    Chun Kiat Lee
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore
    J Med Virol 86:737-44. 2014
    ..J. Med. Virol. 86:737-744, 2014. © 2014 Wiley Periodicals, Inc. ..
  20. pmc Comparison of mutation patterns in full-genome A/H3N2 influenza sequences obtained directly from clinical samples and the same samples after a single MDCK passage
    Hong Kai Lee
    Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Department of Laboratory Medicine, National University Hospital, National University Health System, Singapore, Singapore
    PLoS ONE 8:e79252. 2013
    ..Potential data interpretation miscalls can therefore be avoided by careful exclusion of such D151 mutants after further sequence analysis. ..
  21. pmc Simplified large-scale Sanger genome sequencing for influenza A/H3N2 virus
    Hong Kai Lee
    Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    PLoS ONE 8:e64785. 2013
    ..However, the small genome size of the influenza virus arguably justifies the use of the more conventional Sanger sequencing technology which is still currently more readily available in most diagnostic laboratories...
  22. pmc A schlieren optical study of the human cough with and without wearing masks for aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University of Singapore, Singapore
    J R Soc Interface 6:S727-36. 2009
    ....
  23. doi request reprint Prevalence of diarrhea viruses in hospitalized children in Hong Kong in 2008
    Cheryl S Y Li
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Med Virol 81:1903-11. 2009
    ..The results support the importance of norovirus as a causative agent of diarrhea in children, which may be underestimated by the current routine diagnostic testing...
  24. doi request reprint Molecular epidemiology of hepatitis C genotype 6a from patients with chronic hepatitis C from Hong Kong
    Cheryl S Y Li
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 81:628-33. 2009
    ..Larger studies are required to confirm these findings...
  25. doi request reprint Emergence of adamantane-resistant influenza A(H3N2) viruses in Hong Kong between 1997 and 2006
    Julian W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    J Med Virol 80:895-901. 2008
    ..The underlying reasons for these findings are unclear and similar studies are required elsewhere to elucidate these and prevent this spread of drug-resistance happening again in future...
  26. doi request reprint Use of phylogenetics in the molecular epidemiology and evolutionary studies of viral infections
    Tommy Tsan Yuk Lam
    School of Biological Sciences, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Crit Rev Clin Lab Sci 47:5-49. 2010
    ..It aims to provide, with minimal mathematics and statistics, a practical overview of how phylogenetic methods can be incorporated into virological studies by clinical and laboratory specialists...
  27. ncbi request reprint Characterizing 56 complete SARS-CoV S-gene sequences from Hong Kong
    Julian W Tang
    Department of Microbiology, School of Public Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Virol 38:19-26. 2007
    ..The spike glycoprotein (S) gene of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) has been useful in analyzing the molecular epidemiology of the 2003 SARS outbreaks...
  28. ncbi request reprint Viral load, E2 gene disruption status, and lineage of human papillomavirus type 16 infection in cervical neoplasia
    Jo L K Cheung
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 194:1706-12. 2006
    ..The link between viral lineage, integration pattern, and oncogenesis deserves further study...
  29. ncbi request reprint Airflows around oxygen masks: A potential source of infection?
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, Peoples Republic of China
    Chest 130:822-6. 2006
    ..An analysis of captured digital images showed that the exhaled air at the peak of simulated exhalation reached a distance of approximately 0.40 m...
  30. ncbi request reprint The large 386-nt deletion in SARS-associated coronavirus: evidence for quasispecies?
    Julian W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Infect Dis 194:808-13. 2006
    ....
  31. ncbi request reprint Hepatitis C virus genotype distribution among intravenous drug user and the general population in Hong Kong
    Daniel X M Zhou
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    J Med Virol 78:574-81. 2006
    ..The co-circulation of a common (1b) and a rare (6a) HCV genotype in Hong Kong provides a unique opportunity for future studies to compare their transmission efficiency, clinical course, and response to treatment...
  32. ncbi request reprint Association between HLA-DRB1 polymorphism, high-risk HPV infection and cervical neoplasia in southern Chinese
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, Hong Kong, China
    J Med Virol 79:970-6. 2007
    ..The current study shows that, among southern Chinese, the outcome of HPV-infected cervical lesions is associated with HLA-DRB1 polymorphism. These associations often vary with the type of HPV infection...
  33. ncbi request reprint Viral etiology of acute exacerbations of COPD in Hong Kong
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong
    Chest 132:900-8. 2007
    ..Viral respiratory infections may precipitate acute exacerbations of COPD (AECOPD). However, little is known about viral etiology related to AECOPD in Asia. We aimed to study the viral etiology of AECOPD in Hong Kong...
  34. ncbi request reprint Factors associated with early hospital discharge of adult influenza patients
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Antivir Ther 12:501-8. 2007
    ..Understanding factors affecting length of hospital stay (LOS) in patients with severe influenza may improve their management...
  35. ncbi request reprint Profile of viral load, integration, and E2 gene disruption of HPV58 in normal cervix and cervical neoplasia
    Paul K S Chan
    Department of Microbiology, School of Public Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Infect Dis 196:868-75. 2007
    ..Routinely collected cervical samples contain a heterogeneous population of viruses, hampering the application of viral load and integration testing in clinical settings...
  36. ncbi request reprint Airflow and droplet spreading around oxygen masks: a simulation model for infection control research
    Margaret Ip
    Centre for Emerging Infectious Diseases, School of Public Health, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Am J Infect Control 35:684-9. 2007
    ..Respiratory assist devices, such as oxygen masks, may enhance the potential to spread infectious aerosols from patients with respiratory infections...
  37. doi request reprint Features of the new pandemic influenza A/H1N1/2009 virus: virology, epidemiology, clinical and public health aspects
    Julian W Tang
    Department of Laboratory Medicine, National University of Singapore, Singapore
    Curr Opin Pulm Med 16:235-41. 2010
    ..The emergence of the pandemic A/H1N1/2009 influenza virus has enabled preexisting pandemic influenza plans to be put into action. This review examines the clinical and public health impact of this new virus...
  38. pmc First reported outbreak of diarrhea due to adenovirus infection in a hematology unit for adults
    Hamid Jalal
    Clinical Microbiology and Public Health Laboratory, Addenbrooke s Hospital, Cambridge, Hills Road, Cambridge CB2 2QW, United Kingdom
    J Clin Microbiol 43:2575-80. 2005
    ..The outbreak strain was also detected in plasma of four of these patients, suggesting systemic infection. The outbreak strain was identified as type 12. Standard infection control measures were effective to control this outbreak...
  39. pmc High prevalence of the CD14-159CC genotype in patients infected with severe acute respiratory syndrome-associated coronavirus
    Fang F Yuan
    Cell Biology Laboratory, ARCBS Endeavour, 153 Clarence Street, Sydney, NSW 2000, Australia
    Clin Vaccine Immunol 14:1644-5. 2007
    ..029; odds ratio, 2.74; 95% confidence interval, 1.15 to 6.57; controls, P = 0.04; odds ratio, 2.41; 95% confidence interval, 1.05 to 5.54), and both CD14-159CC and FcgammaRIIA-RR131 are risk genotypes for severe SARS-CoV infection...
  40. ncbi request reprint Pandemic influenza forecasting: does past performance indicate future performance?
    Julian W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR
    Am J Infect Control 36:466-7. 2008