Toshiaki Tanaka

Summary

Publications

  1. ncbi Growth hormone treatment in Japan: past, present, and future
    Toshiaki Tanaka
    Tanaka Grdwth Clinic, Famille Yoga 1F, 2 36 7 Yoga, Setagaya Ku, Tokyo 158 0097, Japan
    Pediatr Endocrinol Rev 10:89-97. 2012
  2. ncbi XI International Congress of AUXOLOGY, September 9-12, 2007, Tokyo, Japan
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    Pediatr Endocrinol Rev 5:804-9. 2008
  3. ncbi The 41st Annual Meeting of the Japanese Society for Pediatric Endocrinology (JSPE), Yokohama, Japan, 7-9 November 2007
    Toshiaki Tanaka
    Tanaka Growth Clinic, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Endocrinol Rev 5:912-4. 2008
  4. ncbi Gene expression of mesenchyme forkhead 1 (FOXC2) significantly correlates with the degree of lymph node metastasis in colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    Int Surg 96:207-16. 2011
  5. ncbi Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: a study matched for T classification and tumor location
    Yoshihiro Kazama
    Department of Surgical Oncology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Surg Oncol 97:278-83. 2008
  6. doi Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Diagn Mol Pathol 18:219-25. 2009
  7. doi New reference growth charts for Japanese girls with Turner syndrome
    Tsuyoshi Isojima
    Clinical Research Center, National Center for Child Health and Development, Ohkura, Setagaya Ku, Tokyo, 157 8535, Japan
    Pediatr Int 51:709-14. 2009
  8. doi Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Clin Colorectal Cancer 10:134-41. 2011
  9. doi Long-term efficacy and safety of two doses of growth hormone in short Japanese children born small for gestational age
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    Horm Res Paediatr 76:411-8. 2011
  10. ncbi Identification and functional characterization of two novel NPR2 mutations in Japanese patients with short stature
    Naoko Amano
    Department of Pediatrics N A, S N, T H, Keio University School of Medicine, Tokyo 160 8582, Japan Department of Pediatrics T M, Asahikawa Kosei General Hospital, Asahikawa 078 8211, Japan Department of Basic Sciences Y I, The Japanese Red Cross Hokkaido College of Nursing, Kitami 090 0011, Japan Tanaka Growth Clinic T T, Tokyo 158 0097, Japan Department of Medical Subspecialties S Y, National Center for Child Health and Development, Tokyo 157 0074, Japan Department of Pediatrics T O, Hamamatsu University School of Medicine, Hamamatsu 431 3125, Japan and Japan Growth Genome Consortium T M, Y I, T T, S Y, T O, T H
    J Clin Endocrinol Metab 99:E713-8. 2014

Collaborators

Detail Information

Publications41

  1. ncbi Growth hormone treatment in Japan: past, present, and future
    Toshiaki Tanaka
    Tanaka Grdwth Clinic, Famille Yoga 1F, 2 36 7 Yoga, Setagaya Ku, Tokyo 158 0097, Japan
    Pediatr Endocrinol Rev 10:89-97. 2012
    ..With early diagnosis, early high-dose treatment, and low-dose estrogen replacement therapy, both adult height and quality of life (QOL) of the patients with Turner syndrome have been improved...
  2. ncbi XI International Congress of AUXOLOGY, September 9-12, 2007, Tokyo, Japan
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    Pediatr Endocrinol Rev 5:804-9. 2008
  3. ncbi The 41st Annual Meeting of the Japanese Society for Pediatric Endocrinology (JSPE), Yokohama, Japan, 7-9 November 2007
    Toshiaki Tanaka
    Tanaka Growth Clinic, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Endocrinol Rev 5:912-4. 2008
  4. ncbi Gene expression of mesenchyme forkhead 1 (FOXC2) significantly correlates with the degree of lymph node metastasis in colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    Int Surg 96:207-16. 2011
    ..FOXC2 appears to be involved in determining the aggressiveness of lymph node metastasis in colorectal cancer...
  5. ncbi Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: a study matched for T classification and tumor location
    Yoshihiro Kazama
    Department of Surgical Oncology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Surg Oncol 97:278-83. 2008
    ..Extensive genetic and epigenetic analysis of poorly differentiated colorectal adenocarcinomas (Por) has been difficult, as the number of cases is too small...
  6. doi Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Diagn Mol Pathol 18:219-25. 2009
    ..This novel molecular predictor is helpful in identifying patients who would benefit from surgical resection...
  7. doi New reference growth charts for Japanese girls with Turner syndrome
    Tsuyoshi Isojima
    Clinical Research Center, National Center for Child Health and Development, Ohkura, Setagaya Ku, Tokyo, 157 8535, Japan
    Pediatr Int 51:709-14. 2009
    ..These charts were published in 1992 and may no longer be valid for the evaluation of stature and growth in girls with TS in clinical settings. Thus, we need to establish new clinical growth charts...
  8. doi Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Clin Colorectal Cancer 10:134-41. 2011
    ..This study aimed to build a predictive model for the development of UC-Ca based on gene expression levels measured by reverse-transcription polymerase chain reaction (RT-PCR) analysis in nonneoplastic rectal mucosa...
  9. doi Long-term efficacy and safety of two doses of growth hormone in short Japanese children born small for gestational age
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    Horm Res Paediatr 76:411-8. 2011
    ..To investigate the long-term efficacy and safety of two doses (33 and 67 μg/kg/day) of growth hormone (GH) in short Japanese children born small for gestational age (SGA)...
  10. ncbi Identification and functional characterization of two novel NPR2 mutations in Japanese patients with short stature
    Naoko Amano
    Department of Pediatrics N A, S N, T H, Keio University School of Medicine, Tokyo 160 8582, Japan Department of Pediatrics T M, Asahikawa Kosei General Hospital, Asahikawa 078 8211, Japan Department of Basic Sciences Y I, The Japanese Red Cross Hokkaido College of Nursing, Kitami 090 0011, Japan Tanaka Growth Clinic T T, Tokyo 158 0097, Japan Department of Medical Subspecialties S Y, National Center for Child Health and Development, Tokyo 157 0074, Japan Department of Pediatrics T O, Hamamatsu University School of Medicine, Hamamatsu 431 3125, Japan and Japan Growth Genome Consortium T M, Y I, T T, S Y, T O, T H
    J Clin Endocrinol Metab 99:E713-8. 2014
    ..Biallelic NPR2 mutations cause acromesomelic dysplasia, type Maroteaux, which is bone dysplasia characterized by severe short stature and short limbs. A monoallelic NPR2 mutation has been suggested to mildly impair long bone growth...
  11. ncbi Determination of biotin (vitamin H) by the high-performance affinity chromatography with a trypsin-treated avidin-bound column
    Kou Hayakawa
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 869:93-100. 2008
    ..This affinity-chromatographic method for biotin determination was shown to be a robust and reliable and is well suited for biochemical and nutritional research...
  12. ncbi A nationwide attempt to standardize growth hormone assays
    Toshiaki Tanaka
    The GH and Its Related Factors Study Committee, The Foundation for Growth Science, Tokyo, Japan
    Horm Res 64:6-11. 2005
    ..As a result the diagnostic cut-off peak GH has changed from 10 to 6 ng/ml...
  13. ncbi Efficacy and safety of growth hormone treatment in children born small for gestational age in Japan
    Toshiaki Tanaka
    Tanaka Growth Clinic, Tokyo, Japan
    J Pediatr Endocrinol Metab 21:423-31. 2008
    ..Oral glucose tolerance tests indicated a mostly normal pattern of plasma glucose before and after 12-month GH treatment. The growth-promoting effect was significantly higher with GH treatment at 0.067 mg/kg/day...
  14. ncbi Trends in age and anthropometric data at start of growth hormone treatment for girls with Turner syndrome in Japan
    Tsuyoshi Isojima
    Clinical Research Center, National Center for Child Health and Development, Setagaya Ku, Tokyo, Japan
    Endocr J 55:1065-70. 2008
    ..25). We concluded that age and shortness at initiation of GH treatment had been improving over time. However, these favorable trends have not fully met the conditions recommended by international clinical guidelines for TS...
  15. ncbi Loss of Smad4 protein expression and 18qLOH as molecular markers indicating lymph node metastasis in colorectal cancer--a study matched for tumor depth and pathology
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    J Surg Oncol 97:69-73. 2008
    ..In this report, we studied the significance of chromosome 18q deletion and loss of Smad4 protein expression in association with lymph node metastasis...
  16. ncbi Growth hormone treatment in short Japanese children born small for gestational age
    Reiko Horikawa
    Division of Endocrinology and Metabolism, National Center for Child Health and Development, Tokyo, Japan
    Horm Res 62:128-36. 2004
    ..Careful observation is also necessary to assess the metabolic effects of high-dose GH, especially on carbohydrate metabolism...
  17. doi Inconsistent determination of overweight by two anthropometric indices in girls with Turner syndrome
    Tsuyoshi Isojima
    Clinical Research Center, National Center for Child Health and Development, Ohkura, Setagaya Ku, Tokyo, Japan
    Acta Paediatr 98:513-8. 2009
    ....
  18. ncbi Nonclassic steroid 21-hydroxylase deficiency due to a homozygous V281L mutation in CYP21A2 detected by the neonatal mass-screening program in Japan
    Takashi Shinagawa
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Endocr J 54:1021-5. 2007
    ....
  19. ncbi The Third International Congress of the GRS and the IGF Society, November 11-15, 2006, Kobe, Japan
    Toshiaki Tanaka
    Department of Clinical Laboratory Medicine, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Endocrinol Rev 4:362-5. 2007
  20. doi Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Dis Colon Rectum 52:1941-8. 2009
    ..Our objective here was to identify a set of discriminating genes that can be used for characterization and prediction of lymph node metastasis...
  21. ncbi Hearing loss in Turner syndrome
    Noriko Morimoto
    Department of Otolaryngology, National Center for Child Health and Development, Tokyo, Japan
    J Pediatr 149:697-701. 2006
    ..To address the characteristics of hearing loss in patients with Turner syndrome (TS), we evaluated hearing levels of patients with TS and analyzed causative factors...
  22. doi Analysis of weight at birth and at diagnosis of childhood-onset type 2 diabetes mellitus in Japan
    Shigetaka Sugihara
    Department of Pediatrics, Tokyo Women s Medical University Medical Center East, Tokyo, Japan
    Pediatr Diabetes 9:285-90. 2008
    ..We examined the associations of weight at birth, weight at diagnosis of T2DM, and clinical characteristics of childhood-onset T2DM...
  23. doi Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin
    Tomoyasu Hirose
    The Kitasato Institute, Kitasato Institute for Life Science and Graduate School of Infection Control Sciences, Kitasato University, Minato ku, Tokyo, Japan
    J Antibiot (Tokyo) 62:495-500. 2009
    ....
  24. ncbi Molecular genetic analysis of MODY candidate genes in Japanese patients with non-obese juvenile onset diabetes mellitus
    Masayo Kagami-Takasugi
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    J Pediatr Endocrinol Metab 19:143-8. 2006
    ..5%. The significance of the new promoter variant in the development of DM is unclear; however, a promoter mutation in the HNF-1alpha gene could be diabetogenic...
  25. ncbi Results of long-term follow-up after treatment of central precocious puberty with leuprorelin acetate: evaluation of effectiveness of treatment and recovery of gonadal function. The TAP-144-SR Japanese Study Group on Central Precocious Puberty
    Toshiaki Tanaka
    Department of Endocrinology and Metabolism, National Center for Child Health and Development, 2 10 1, Okura, Setagaya, Tokyo, 157 8535, Japan
    J Clin Endocrinol Metab 90:1371-6. 2005
    ..Serum testosterone levels reached normal adult level in all boys. In conclusion, long-term leuprorelin treatment for children with CPP improved AH and had no adverse effects on recovery of reproductive function...
  26. ncbi Novel compound heterozygous AIRE mutations in a Japanese patient with APECED
    Utako Sato
    Division of Endocrinology and Metabolism, Department of Medicine, National Center for Child Health and Development, Tokyo, Japan
    J Pediatr Endocrinol Metab 17:917-21. 2004
    ..The other was a G-->A transition at IVS11+1. Her mother was heterozygous for 1471 delCinsTT and was normal homozygous for IVS11+1. We found novel compound heterozygous mutations in the AIRE gene of a Japanese female with APECED...
  27. ncbi The 40th Annual Meeting of the Japanese Society for Pediatric Endocrinology (JSPE), Hamamatsu, Japan, 27-29 September 2006
    Toshiaki Tanaka
    Department of Clinical Laboratory Medicine, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Endocrinol Rev 4:237-8. 2007
  28. ncbi Nuclear Notch3 Expression is Associated with Tumor Recurrence in Patients with Stage II and III Colorectal Cancer
    Tsuyoshi Ozawa
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 21:2650-8. 2014
    ..In the present study, we investigated Notch1 and Notch3 expression in Stage II and III CRC to assess their association with clinicopathological characteristics...
  29. doi Salivary cortisol monitoring: determination of reference values in healthy children and application in asthmatic children
    Toshikazu Nagakura
    Yoga Allergy Clinic, Tokyo, Japan
    Allergy Asthma Proc 33:362-9. 2012
    ..Longer-term studies that incorporate testing of the hypothalamic-pituitary-adrenal axis are warranted to confirm our findings...
  30. ncbi Replacement of alanine with asparagic acid at position 203 in human steroidogenic acute regulatory protein impairs the ability to enhance steroidogenesis in vitro
    Noriyuki Katsumata
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Endocr J 53:427-31. 2006
    ..Together, these results indicate that the alanine at position 203 in human StAR is functionally important and that the D203 StAR is extremely unlikely to be a polymorphism...
  31. ncbi Novel missense mutation in the P-box of androgen receptor in a patient with androgen insensitivity syndrome
    Noriyuki Katsumata
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Endocr J 55:225-8. 2008
    ....
  32. ncbi Determination of specific activities and kinetic constants of biotinidase and lipoamidase in LEW rat and Lactobacillus casei (Shirota)
    Kou Hayakawa
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 844:240-50. 2006
    ..Therefore, this HPLC determination method for the enzyme kinetic parameters in tissues is expected to be an indispensable tool for the investigation of the various diseases in humans...
  33. doi Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation
    Tomofumi Fujino
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    J Biochem 152:577-86. 2012
    ....
  34. ncbi Statural growth in 31 Japanese patients with SHOX haploinsufficiency: support for a disadvantageous effect of gonadal estrogens
    Maki Fukami
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Endocr J 51:197-200. 2004
    ..8, P = 0.0060). The results imply that gonadal estrogens have a deleterious effect on pubertal growth in SHOX haploinsufficiency, and that the growth disadvantage is recognizable by longitudinal rather than cross-sectional growth studies...
  35. ncbi Genitourinary phenotype in XX patients with distal 9p monosomy
    Yoko Fujimoto
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Mol Genet Metab 82:173-9. 2004
    ..In addition, it is possible that a gene(s) for anoperineal and renal development also maps distal to D9S168 and that for external genital development maps distal to D9S285 at the position approximately 16 Mb from the 9p telomere...
  36. doi Total synthesis and determination of the absolute configuration of guadinomines B and C2
    Tomoyasu Hirose
    Kitasato Institute for Life Science, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, 108 8641, Japan
    Chemistry 14:8220-38. 2008
    ..The novel feature of our method is an intramolecular S(N)2 cyclization that uses PPh(3) and I(2) to construct the unique 5-membered cyclic guanidine substructure...
  37. ncbi Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children
    Toshiaki Tanaka
    Department of Endocrinology and Metabolism, National Children s Medical Research Center, Tokyo, Japan
    Growth Horm IGF Res 12:323-41. 2002
  38. ncbi Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones
    Junichiro Tanaka
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Surg Oncol 96:611-8. 2007
    ..To the best of our knowledge, this is the first to report that left-sided CRCs show significantly less frequent methylation at several loci and CpG island methylator phenotype (CIMP) than right-sided ones...
  39. doi Novel functional hepatocyte cell line derived from spontaneous dwarf rat: model of growth hormone function in vitro
    Mayumi Ishikawa
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    Hum Cell 23:164-72. 2010
    ..In summary, we established a novel hepatocyte cell line (SDRL-1), that appears to display normal function, which we propose can serve as a good in vitro model for studying GH-target organ interactions...