Takuji Tanaka

Summary

Publications

  1. ncbi request reprint Animal models of carcinogenesis in inflamed colorectum: potential use in chemoprevention study
    Takuji Tanaka
    Cytopatholgy Division, Tohkai Cytopathology Institute, Cancer Research and Prevention TCI CaRP, 5 1 2 Minami Uzura, Gifu City, Gifu 500 8285, Japan
    Curr Drug Targets 13:1689-97. 2012
  2. pmc Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay
    Kazuto Yoshimi
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    BMC Cancer 12:448. 2012
  3. doi request reprint Mast cells and inflammation-associated colorectal carcinogenesis
    Takuji Tanaka
    The Tohkai Cytopathology Institute Cancer Research and Prevention, 5 1 2 Minami Uzura, Gifu 500 8285, Japan
    Semin Immunopathol 35:245-54. 2013
  4. pmc Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin
    Takuji Tanaka
    The Tohkai Institute of Cytopathology Cancer Research and Prevention, 5 1 2 Minami Uzura, Gifu City, Gifu 500 8285, Japan
    J Biomed Biotechnol 2012:516981. 2012
  5. pdf Cancer chemoprevention by carotenoids
    Takuji Tanaka
    Tohkai Cytopathology Institute, Cancer Research and Prevention TCI CaRP, 5 1 2 Minami Uzura, Gifu 500 8285, Japan
    Molecules 17:3202-42. 2012
  6. doi request reprint Preventive effects of curcumin on the development of azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db obese mice
    Masaya Kubota
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Nutr Cancer 64:72-9. 2012
  7. doi request reprint Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Prev Res (Phila) 4:128-36. 2011
  8. doi request reprint Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    Yoichi Yasuda
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 101:1701-7. 2010
  9. pmc Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    BMC Cancer 11:281. 2011
  10. doi request reprint Renin-angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    Masaya Kubota
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Biochem Biophys Res Commun 410:108-13. 2011

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Animal models of carcinogenesis in inflamed colorectum: potential use in chemoprevention study
    Takuji Tanaka
    Cytopatholgy Division, Tohkai Cytopathology Institute, Cancer Research and Prevention TCI CaRP, 5 1 2 Minami Uzura, Gifu City, Gifu 500 8285, Japan
    Curr Drug Targets 13:1689-97. 2012
    ..Also, some preclinical data on chemoprevention of inflammation-associated CRC by astaxanthin and a specific inhibitor of nitric oxide synthase using these inflammation- related -CRC models is briefly introduced...
  2. pmc Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay
    Kazuto Yoshimi
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    BMC Cancer 12:448. 2012
    ..Here, we applied the KAD rat to the chemotherapeutic bioassay for CRC and showed the utility of the KAD rat...
  3. doi request reprint Mast cells and inflammation-associated colorectal carcinogenesis
    Takuji Tanaka
    The Tohkai Cytopathology Institute Cancer Research and Prevention, 5 1 2 Minami Uzura, Gifu 500 8285, Japan
    Semin Immunopathol 35:245-54. 2013
    ..Our findings also suggest that mast cells and their selected cytokines could play an important role in inflammation-mediated tumorigenesis through regulation of proinflammatory cytokines and inducible inflammatory enzymes...
  4. pmc Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin
    Takuji Tanaka
    The Tohkai Institute of Cytopathology Cancer Research and Prevention, 5 1 2 Minami Uzura, Gifu City, Gifu 500 8285, Japan
    J Biomed Biotechnol 2012:516981. 2012
    ..This paper describes the findings of our in vivo preclinical experiments to develop a strategy for cancer chemoprevention of colon, tongue, and lung neoplasms by use of CHRP and MJs...
  5. pdf Cancer chemoprevention by carotenoids
    Takuji Tanaka
    Tohkai Cytopathology Institute, Cancer Research and Prevention TCI CaRP, 5 1 2 Minami Uzura, Gifu 500 8285, Japan
    Molecules 17:3202-42. 2012
    ..In this review, cancer prevention using carotenoids are reviewed and the possible mechanisms of action are described...
  6. doi request reprint Preventive effects of curcumin on the development of azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db obese mice
    Masaya Kubota
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Nutr Cancer 64:72-9. 2012
    ..Curcumin may be useful in the chemoprevention of colorectal carcinogenesis in obese individuals...
  7. doi request reprint Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Prev Res (Phila) 4:128-36. 2011
    ..ACR may be, therefore, useful in the chemoprevention of obesity-related HCC...
  8. doi request reprint Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    Yoichi Yasuda
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 101:1701-7. 2010
    ..Therefore, some types of statins, including pitavastatin, may be a useful chemoprevention modality for colon cancer in obese individuals...
  9. pmc Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    BMC Cancer 11:281. 2011
    ..In the present study, we examined the effects of pitavastatin - a drug used for the treatment of hyperlipidemia - on the development of diethylnitrosamine (DEN)-induced liver preneoplastic lesions in C57BL/KsJ-db/db (db/db) obese mice...
  10. doi request reprint Renin-angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    Masaya Kubota
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Biochem Biophys Res Commun 410:108-13. 2011
    ..Therefore, targeting dysregulation of the RAS might be an effective strategy for chemoprevention of colorectal carcinogenesis in obese individuals...
  11. doi request reprint Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase
    Kengo Ogawa
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 103:951-8. 2012
    ....
  12. ncbi request reprint Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis
    Keiko Sakata
    Department of Pathology, Gifu University School of Medicine, Gifu, Japan
    Oncology 66:244-52. 2004
    ....
  13. doi request reprint Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice
    Junpei Iwasa
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 101:460-7. 2010
    ..In conclusion, oral BCAA supplementation improves insulin resistance and prevents the development of liver tumorigenesis in obese and diabetic mice...
  14. doi request reprint Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis
    Masahito Shimizu
    Department of Gastroenterology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Semin Immunopathol 35:191-202. 2013
    ....
  15. pmc Oral carcinogenesis and oral cancer chemoprevention: a review
    Takuji Tanaka
    Director TCI CaRP, 5 1 2 Minami Uzura, Gifu City, Gifu 500 8285, Japan
    Patholog Res Int 2011:431246. 2011
    ..New approaches, such as molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy...
  16. pmc Biomarkers for colorectal cancer
    Takuji Tanaka
    The Tohkai Cytopathology Institute Cancer Research and Prevention TCI CaRP, 5 1 2 Minami Uzura, Gifu 500 8285, Japan
    Int J Mol Sci 11:3209-25. 2010
    ..Currently, the fecal occult blood test is the most widely used method of screening for CRC. However, advances in genomics and proteomics will lead to the discovery of novel non-invasive biomarkers...
  17. ncbi request reprint Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation
    Masumi Suzui
    Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa Machi, 500 8705, Gifu, Japan
    Cancer Lett 183:31-41. 2002
    ..These two experimental systems may, therefore, be useful animal models of human colon carcinomas in patients with FAP and in patients with sporadic colon carcinomas...
  18. pmc Cancer chemopreventive ability of conjugated linolenic acids
    Takuji Tanaka
    The Tohkai Cytopathology Institute Cancer Research and Prevention TCI CaRP, 5 1 2 Minami Uzura, Gifu 500 8285, Japan
    Int J Mol Sci 12:7495-509. 2011
    ..In this review, we summarize chemopreventive efficacy of CLN against cancer development, especially colorectal cancer...
  19. pmc Understanding carcinogenesis for fighting oral cancer
    Takuji Tanaka
    TCI CaRP, 5 1 2 Minami Uzura, Gifu City, Gifu 500 8285, Japan
    J Oncol 2011:603740. 2011
    ..New approaches, such as interventions with molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy...
  20. pmc Pathobiology and chemoprevention of bladder cancer
    Takuji Tanaka
    The Tohkai Cytopathology Institute Cancer Research and Prevention TCI CaRP, 5 1 2 Minami Uzura, Gifu 500 8285, Japan
    J Oncol 2011:528353. 2011
    ..This paper summarizes the results of recent preclinical and clinical chemoprevention studies and discusses screening for bladder cancer...