Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genesYongjun Tan
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
Mol Cell Biol 27:1007-16. 2007
..These results identify a novel role for FoxM1 in the transcriptional response during DNA damage/checkpoint signaling and show a novel mechanism by which Chk2 protein regulates expression of DNA repair enzymes...
- Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration
Yongjun Tan
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60607 7170, USA
Gastroenterology 130:1283-300. 2006
..Here, we examined whether increased levels of HNF6 stimulate hepatocyte proliferation during mouse liver regeneration...
- Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
I Ching Wang
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, 60607 7170, USA
Mol Cell Biol 25:10875-94. 2005
..Taken together, these results demonstrate that FoxM1 regulates transcription of cell cycle genes critical for progression into S-phase and mitosis...
- Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding
Francisco M Rausa
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Mol Cell Biol 23:437-49. 2003
..This is the first reported example of a liver-enriched transcription factor (HNF-6) functioning as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2...
Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injuryVladimir V Kalinichenko
Department of Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607 7170, USA
J Biol Chem 278:37888-94. 2003
..Taken together, these results suggest that increasing FoxM1B levels is an effective means to stimulate cellular proliferation during aging and in lung diseases such as emphysema...
- Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen
Yongjun Tan
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607-7170, USA
Hepatology 35:790-8. 2002
..In conclusion, these studies show that the hepatic Glut-2 promoter is a direct target for HNF-6 transcriptional activation...
- Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage
Douglas E Hughes
University of Illinois at Chicago, College of Medicine, Department of Molecular Genetics, Chicago, IL 60607 7170, USA
Hepatology 37:1414-24. 2003
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- Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression
Xinhe Wang
Department of Molecular Genetics, University of Illinois at Chicago, College of Medicine and Dentistry, 60607, USA
J Biol Chem 277:44310-6. 2002
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- Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstruction
Ai Xuan L Holterman
Department of Surgery, Division of Pediatric Surgery, University of Illinois at Chicago, 60607 7170, USA
Hepatology 35:1392-9. 2002
..In conclusion, we propose a biologic role for diminished HNF-6 protein levels in bile duct disease...
- C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells
Yuichi Yoshida
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, IL 60607-7170, USA
Hepatology 43:276-86. 2006
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- In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction
Minhua Wang
Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA
Hepatology 40:600-8. 2004
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- Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expression
Yongjun Tan
University of Illinois at Chicago, College of Medicine, Department of Molecular Genetics, Chicago, IL 60607-7170, USA
Hepatology 35:30-9. 2002
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