Genomes and Genes
Location: Dublin, Ireland
- PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cellsKathleen A O'Hagan
Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Proc Natl Acad Sci U S A 106:2188-93. 2009....
- Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier functionMurtaza M Tambuwala
The Conway Institute, University College Dublin, Ireland
Gastroenterology 139:2093-101. 2010..Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved...
- An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxiaSusan F Fitzpatrick
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Immunol 186:1091-6. 2011..These results implicate an essential role for NF-κB signaling in inflammatory gene expression in response to hypoxia both through the regulation of HIF-1 and through direct effects upon target gene expression...