Murtaza Tambuwala

Summary

Affiliation: UCD

Location: Dublin, Ireland

URL: www.murtazatambuwala.tk

PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
Kathleen A O'Hagan
Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Proc Natl Acad Sci U S A 106:2188-93. 2009
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
Murtaza M Tambuwala
The Conway Institute, University College Dublin, Ireland
Gastroenterology 139:2093-101. 2010
An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia
Susan F Fitzpatrick
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Immunol 186:1091-6. 2011

PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
Kathleen A O'Hagan
Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
Proc Natl Acad Sci U S A 106:2188-93. 2009
....
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
Murtaza M Tambuwala
The Conway Institute, University College Dublin, Ireland
Gastroenterology 139:2093-101. 2010
..Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved...
An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia
Susan F Fitzpatrick
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Immunol 186:1091-6. 2011
..These results implicate an essential role for NF-κB signaling in inflammatory gene expression in response to hypoxia both through the regulation of HIF-1 and through direct effects upon target gene expression...