Rapid improvement in rheumatoid arthritis patients on combination of methotrexate and infliximab: clinical and magnetic resonance imaging evaluationLai Shan Tam
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hongkong, People s Republic of China
Clin Rheumatol 26:941-6. 2007
..Assessment of enhancing synovial volume and perfusion indices on serial MRI examination was helpful in documenting the effect of treatment over this short period...
Infliximab is associated with improvement in arterial stiffness in patients with early rheumatoid arthritis -- a randomized trialLai Shan Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
J Rheumatol 39:2267-75. 2012
..To determine the efficacy of methotrexate (MTX) with infliximab (IFX) compared with MTX alone in the prevention of atherosclerosis and arterial stiffness in patients with early rheumatoid arthritis (RA)...
- Serum soluble receptor for advanced glycation end products levels and aortic augmentation index in early rheumatoid arthritis--a prospective study
Lai Shan Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
Semin Arthritis Rheum 42:333-45. 2013
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Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritisChun K Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
Arthritis Res Ther 12:R129. 2010
..Elevated expression of IL-27 has been detected in the synovial membranes and fluid of rheumatoid arthritis (RA)...
- Risk of tuberculosis in patients with rheumatoid arthritis in Hong Kong--the role of TNF blockers in an area of high tuberculosis burden
L S Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Clin Exp Rheumatol 28:679-85. 2010
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- Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus
L S Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Lupus 13:601-4. 2004
..In summary, leflunomide was more effective than placebo in treating SLE patients with mild to moderate disease activity and was safe and well-tolerated...
- The relationship between neuropsychiatric, clinical, and laboratory variables and quality of life of Chinese patients with systemic lupus erythematosus
Lai Shan Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
J Rheumatol 35:1038-45. 2008
..To investigate the role of neuropsychiatric (NP), clinical, and laboratory variables in influencing the health related quality of life (HRQOL) of Chinese patients with systemic lupus erythematosus (SLE)...
- Risk factors for squamous intraepithelial lesions in systemic lupus erythematosus: a prospective cohort study
Lai Shan Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital and The Chinese University of Hong Kong, Hong Kong, China
Arthritis Care Res (Hoboken) 63:269-76. 2011
..We undertook a prospective cohort study to ascertain the risk factors for the development of squamous intraepithelial lesions (SIL) in patients with systemic lupus erythematosus (SLE)...
- Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study
Lai S Tam
Department of Medicine and Therapeutics, Department of Radiology, and the Clinical Immunology Unit, Hong Kong Cancer Institute, Hong Kong
J Rheumatol 32:275-82. 2005
..We evaluated the effects of longterm antioxidant vitamins on markers of oxidative stress and antioxidant defense and endothelial function in 39 patients with SLE...
- Are spot urine samples adequate for assessment of proteinuria in patients with lupus nephritis?
Lai Shan Tam
The Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Nat Clin Pract Nephrol 4:72-3. 2008
- Increased prevalence of squamous intraepithelial lesions in systemic lupus erythematosus: association with human papillomavirus infection
Lai Shan Tam
Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Arthritis Rheum 50:3619-25. 2004
..The association of human papillomavirus (HPV) infection and the use of immunosuppressive agents with abnormal Pap smears in SLE was also assessed...
- Mesangial lupus nephritis in Chinese is associated with a high rate of transformation to higher grade nephritis
L S Tam
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Lupus 12:665-71. 2003
..Our data highlight that renal biopsy should be repeated early in Chinese patients with mesangial nephritis who failed to respond to treatment in order to identify those who may require intense immunosuppressive therapy...
- Subclinical carotid atherosclerosis in patients with psoriatic arthritis
Lai Shan Tam
The Prince of Wales Hospital and The Chinese University of Hong Kong, Hong Kong, China
Arthritis Rheum 59:1322-31. 2008
..To examine the prevalence of subclinical atherosclerosis in patients with psoriatic arthritis (PsA) compared with healthy controls, and to identify clinical and biologic markers for atherosclerotic disease in this patient population...
- Patients with systemic lupus erythematosus show increased platelet activation and endothelial dysfunction induced by acute hyperhomocysteinemia
Lai Shan Tam
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
J Rheumatol 30:1479-84. 2003
..Systemic lupus erythematosus (SLE) is an inflammatory disease with a high atherothrombotic tendency. We examined whether acute hyperhomocysteinemia exacerbates endothelial and platelet dysfunction in patients with SLE...
- Cardiovascular risk profile of patients with psoriatic arthritis compared to controls--the role of inflammation
L S Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Rheumatology (Oxford) 47:718-23. 2008
..To examine the distribution of traditional and novel risk factors of cardiovascular disease (CVD) in patients with PsA compared with healthy controls...
- Natural history of cervical papilloma virus infection in systemic lupus erythematosus - a prospective cohort study
Lai Shan Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
J Rheumatol 37:330-40. 2010
....
- Risk factors and clinical features for tuberculosis among patients with systemic lupus erythematosus in Hong Kong
Lai Shan Tam
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Scand J Rheumatol 31:296-300. 2002
..To determine the risk factors associated with and to describe the clinical course of tuberculosis (TB) in patients with systemic lupus erythematosus (SLE)...
- Acupuncture in the treatment of rheumatoid arthritis: a double-blind controlled pilot study
Lai Shan Tam
The Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
BMC Complement Altern Med 7:35. 2007
....
- Effects of rosuvastatin on subclinical atherosclerosis and arterial stiffness in rheumatoid arthritis: a randomized controlled pilot trial
L S Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, Hong Kong, PR China
Scand J Rheumatol 40:411-21. 2011
..To ascertain the effect of rosuvastatin on carotid atherosclerosis and arterial stiffness in patients with rheumatoid arthritis (RA)...
- Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis
Jianxin Lu
Departments of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Nephrology (Carlton) 17:346-51. 2012
..We studied the intra-renal expression of miRNA targets that were reported to be differentially expressed in peripheral blood or urine between lupus nephritis (LN) patients and normal controls...
- Gene expression of TWEAK/Fn14 and IP-10/CXCR3 in glomerulus and tubulointerstitium of patients with lupus nephritis
Jianxin Lu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Nephrology (Carlton) 16:426-32. 2011
..The role of the tumour necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 and interferon-inducible protein (IP-10)/CXCR3 axis in the pathogenesis of lupus nephritis were studied...
- Bone microarchitecture assessment by high-resolution peripheral quantitative computed tomography in patients with systemic lupus erythematosus taking corticosteroids
Edmund K Li
Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
J Rheumatol 37:1473-9. 2010
....
- Relationship of intrarenal gene expression and the histological class of lupus nephritis -- a study on repeat renal biopsy
Jianxin Lu
Department of Medicine and Therapeutics and the Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong CUHK, Shatin, Hong Kong, China
J Rheumatol 39:1942-7. 2012
..To study the role of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)/Fn14 and the interferon-inducible protein (IP-10)/CXCR3 axis in lupus nephritis (LN)...
- Is combination rituximab with cyclophosphamide better than rituximab alone in the treatment of lupus nephritis?
Edmund K Li
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Rheumatology (Oxford) 48:892-8. 2009
..To assess if combination rituximab and cyclophosphamide is more effective than rituximab monotherapy as an induction therapy for proliferative lupus nephritis...
- Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus
Gang Wang
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Clin Rheumatol 31:435-40. 2012
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- Can the urine dipstick test reduce the need for microscopy for assessment of systemic lupus erythematosus disease activity?
Rebecca Wing Yan Chan
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
J Rheumatol 32:828-31. 2005
..Urine microscopic examination is an important component of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). We investigated whether the urine dipstick test can reduce the need for microscopy for the assessment of SLEDAI...
- The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus
Bonnie Ching Ha Kwan
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Rheumatology (Oxford) 48:1491-7. 2009
..We studied the role of type 17 Th cells (TH17) in the pathogenesis of SLE...
- Socioeconomic burden of psoriatic arthritis in Hong Kong: direct and indirect costs and the influence of disease pattern
Tracy Y Zhu
Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, N T, Hong Kong
J Rheumatol 37:1214-20. 2010
..To estimate the direct costs and indirect costs of patients with psoriatic arthritis (PsA) in Hong Kong...
- Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial
Edmund K Li
Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
Arthritis Rheum 57:1143-50. 2007
....
- Messenger RNA expression of podocyte-associated molecules in urinary sediment of patients with lupus nephritis
Gang Wang
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
J Rheumatol 34:2358-64. 2007
..To examine urinary expression of podocyte-associated molecules in patients with lupus nephritis (LN)...
- The impact of flare on disease costs of patients with systemic lupus erythematosus
Tracy Y Zhu
Prince of Wales Hospital and The Chinese University of Hong Kong, Shatin, Hong Kong
Arthritis Rheum 61:1159-67. 2009
....
- Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus
Lydia Choi Wan Lit
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
J Rheumatol 34:89-96. 2007
..We investigated the immunomodulatory roles of T-bet and GATA-3 and Th1/Th2 related cytokines in the pathogenesis of systemic lupus erythematosus (SLE) and their association with disease activity...
- Monitoring of urinary messenger RNA levels for the prediction of flare in systemic lupus erythematosus
Cheuk Chun Szeto
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Clin Chim Acta 413:448-55. 2012
..Systemic lupus erythematosus (SLE) is characterized by disease flares and remission. We hypothesize that in clinically quiescent SLE patients, the mRNA level of target genes in the urinary sediment is an early indicator of disease flare...
- Labour and non-labour market productivity in Chinese patients with systemic lupus erythematosus
Tracy Y Zhu
Department of Medicine and Therapeutics, Chinese University of Hong Kong, 9 F Clinical Sciences Building, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, N T, Hong Kong
Rheumatology (Oxford) 51:284-92. 2012
..A cross-sectional study was performed to assess the self-reported loss of labour and non-labour market productivity, as well as to characterize the risk factors of loss of productivity in patients with SLE...
- Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid
Edmund K Li
Department of Medicine, The Chinese University of Hong Kong, Prince Wales Hospital, 30 32 Ngan Shing Street, Sha Tin, NT, Hong Kong, PR China
Arthritis Res Ther 12:R198. 2010
....
- High prevalence of asymptomatic vertebral fractures in Chinese women with systemic lupus erythematosus
Edmund K Li
Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
J Rheumatol 36:1646-52. 2009
..To investigate the prevalence of vertebral fractures and to identify risk factors associated with vertebral fractures in Chinese women with systemic lupus erythematosus (SLE)...
- Relationship between flare and health-related quality of life in patients with systemic lupus erythematosus
Tracy Y Zhu
Department of Medicine and Therapeutics, The Prince of Wales Hospital, New Territory, Hong Kong, China
J Rheumatol 37:568-73. 2010
....
- Increased organ damage associated with deterioration in volumetric bone density and bone microarchitecture in patients with systemic lupus erythematosus on longterm glucocorticoid therapy
Xiao lin Tang
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
J Rheumatol 39:1955-63. 2012
..To evaluate bone quality in patients with systemic lupus erythematosus (SLE) who were undergoing longterm glucocorticoid (GC) therapy, and to focus on the correlation between bone quality and organ damage...
- Repeat renal biopsy in lupus nephritis: a change in histological pattern is common
Jianxin Lu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, SAR, China
Am J Nephrol 34:220-5. 2011
..The role of longitudinal change in sequential renal biopsies of lupus nephritis (LN) patient remains elusive...
- Evaluation of spinal mobility measurements in predicting axial psoriatic arthritis
Ying Ying Leung
Department of Medicine and Geriatrics, Tai Po Hospital, 9 Chuen On Road, Tai Po, NT, Hong Kong SAR, China
Clin Rheumatol 30:1157-62. 2011
..619, 0.626, and 0.618). Spinal mobility measurements and BASMI were useful in differentiating axial and peripheral PsA. Lumber side flexion and modified schober test best differentiate axial and peripheral PsA...
- Structure and strength of the distal radius in female patients with rheumatoid arthritis: a case-control study
Tracy Y Zhu
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
J Bone Miner Res 28:794-806. 2013
..Ulnovolar periosteal apposition of the distal radius is a feature of chronic, severe RA with wrist deformity...
- The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin
Miao Hu
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
J Lipid Res 53:1384-9. 2012
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- Antagonist-mediated down-regulation of toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus
Shui Lian Yu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China
Arthritis Res Ther 14:R80. 2012
..This study evaluated whether abnormal host innate immune response in lupus patients may enhance HPV persistence...
- Societal costs of rheumatoid arthritis in Hong Kong: a prevalence-based cost-of-illness study
Tracy Y Zhu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
Rheumatology (Oxford) 50:1293-301. 2011
..To estimate the direct and indirect costs among a cohort of Chinese patients with RA in Hong Kong...
- Leflunomide in the treatment of rheumatoid arthritis
Edmund K Li
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, ROC
Clin Ther 26:447-59. 2004
..Drugs are needed that are able to suppress inflammation and modify the underlying immune response with improved tolerability. Leflunomide is an agent that affects the inflammatory process, particularly in RA...
- The influence of illness and variables associated with functional limitations in Chinese patients with ankylosing spondylitis
Lai Shan Tam
Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong and Hong Kong Society for Rehabilitation, Hong Kong
J Rheumatol 34:1032-9. 2007
..To assess the effect of illness and the functional outcome of Chinese patients with ankylosing spondylitis (AS), and to identify variables associated with a poor functional outcome...
- Urinary FOXP3 mRNA in patients with lupus nephritis--relation with disease activity and treatment response
Gang Wang
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Rheumatology (Oxford) 48:755-60. 2009
..Regulatory T lymphocytes (Tregs) probably play an important role in the pathogenesis of SLE...
- Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus
Gang Wang
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
J Rheumatol 37:2516-22. 2010
..Recent studies showed that micro-RNA play important roles in the pathogenesis of autoimmune diseases. We studied the levels of miR-146a and miR-155 in the serum and urinary supernatant of patients with systemic lupus erythematosus (SLE)...
- Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production
Shui Lian Yu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
PLoS ONE 6:e23855. 2011
..Pattern recognition receptors (PRRs) such as Toll-like receptors are aberrantly expressed of peripheral blood mononuclear cells (PBMCs) in systemic lupus erythematosus (SLE) patients, for playing immunopathological roles...
- Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis
Lai Shan Tam
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Clin Rheumatol 26:1495-8. 2007
..Nonetheless, the atherogenic index, LDL-cholesterol/HDL-cholesterol ratio, and the LDL/apoB ratio remained unchanged. Infliximab improves insulin sensitivity and alters lipid profile in patients with active RA...
- Comparison of 4 functional indexes in psoriatic arthritis with axial or peripheral disease subgroups using Rasch analyses
Ying Ying Leung
Department of Medicine and Geriatrics, Tai Po Hospital, Hong Kong, China
J Rheumatol 35:1613-21. 2008
..We compared the performance of 4 functional indexes in patients with psoriatic arthritis (PsA) in axial or peripheral disease subgroups...
- Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients
Miao Hu
Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong SAR
Pharmacogenet Genomics 20:634-7. 2010
..This study identified some genetic determinants of LDL-C response to rosuvastatin in Chinese patients, which need to be replicated in other populations...
- Bone density and microarchitecture: relationship between hand, peripheral, and axial skeletal sites assessed by HR-pQCT and DXA in rheumatoid arthritis
Tracy Y Zhu
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Calcif Tissue Int 91:343-55. 2012
..Future longitudinal studies will be needed to investigate whether assessment by HR-pQCT can be used as a marker of disease activity and a predictor of disease progression in RA...
- Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis
Da Peng Chen
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
J Ethnopharmacol 137:457-68. 2011
....
- Climatic influence on the prevalence of noncutaneous disease flare in systemic lupus erythematosus in Hong Kong
Cheuk Chun Szeto
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China
J Rheumatol 35:1031-7. 2008
..We investigated whether there is seasonal variation in the incidence of noncutaneous lupus flare in Hong Kong...
- Increase in ventricular-arterial stiffness in patients with psoriatic arthritis
Qing Shang
Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Rheumatology (Oxford) 51:2215-23. 2012
..The aim of this study is to determine whether there is increased ventricular and arterial stiffness in patients with PsA and any relationship with disease-related risk factors...
- Immunopathological roles of cytokines, chemokines, signaling molecules, and pattern-recognition receptors in systemic lupus erythematosus
Shui Lian Yu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, Hong Kong
Clin Dev Immunol 2012:715190. 2012
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- The socioeconomic burden of systemic lupus erythematosus: state-of-the-art and prospects
Tracy Y Zhu
Department of Medicine and Therapeutics, 9 F Clinical Sciences Building, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
Expert Rev Pharmacoecon Outcomes Res 12:53-69. 2012
..Several methodological considerations and unsolved issues will also be emphasized...
- The perspective on psoriatic arthritis in Asia
Ying Ying Leung
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Curr Rheumatol Rep 13:369-75. 2011
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- Systemic lupus erythematosus with neuropsychiatric manifestation incurs high disease costs: a cost-of-illness study in Hong Kong
Tracy Y Zhu
Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong
Rheumatology (Oxford) 48:564-8. 2009
..To determine the direct and indirect costs of SLE in Hong Kong, and to ascertain the relationship between neuropsychiatric SLE (NPSLE) and disease costs...
- Cost-of-illness studies in systemic lupus erythematosus: A systematic review
Tracy Y Zhu
The Chinese University of Hong Kong, Shatin, Hong Kong
Arthritis Care Res (Hoboken) 63:751-60. 2011
..To summarize the state of knowledge regarding the economic burden of systemic lupus erythematosus (SLE) and to evaluate the quality of cost-of-illness (COI) studies conducted to date...
- Psoriatic arthritis in Asia
Lai Shan Tam
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Rheumatology (Oxford) 48:1473-7. 2009
..Carotid intima-media thickness can identify PsA patients with subclinical atherosclerosis who may benefit from early intervention...
- Tacrolimus for the treatment of systemic lupus erythematosus with pure class V nephritis
C C Szeto
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Rheumatology (Oxford) 47:1678-81. 2008
..The treatment of pure membranous (class V) lupus nephropathy remains unsatisfactory. We studied the efficacy and safety of tacrolimus in the treatment of membranous nephritis secondary to SLE...
- High prevalence of subclinical left ventricular dysfunction in patients with psoriatic arthritis
Qing Shang
Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
J Rheumatol 38:1363-70. 2011
..The aims of our study were to determine the prevalence of subclinical left ventricular (LV) dysfunction in PsA patients and the disease-related risk factors...
- Intrarenal cytokine gene expression in lupus nephritis
Rebecca Wing Yan Chan
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Ann Rheum Dis 66:886-92. 2007
..Lupus nephritis is characterised by intrarenal inflammation and lymphocyte activation...
- Management of rheumatoid arthritis: consensus recommendations from the Hong Kong Society of Rheumatology
Chi Chiu Mok
Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong
Clin Rheumatol 30:303-12. 2011
....
- Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation
E K Li
Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
Rheumatology (Oxford) 47:1358-63. 2008
..To examine the short-term efficacy and safety of MTX in combination with infliximab compared with infliximab and placebo in the treatment of AS using MRI to monitor its effect...
- Hydroxychloroquine has no significant effect on lipids and apolipoproteins in Chinese systemic lupus erythematosus patients with mild or inactive disease
L S Tam
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, tamls
Lupus 9:413-6. 2000
..To investigate the effects of hydroxychloroquine (HCQ) in Chinese patients with systemic lupus erythematosus who were either on a low dose of prednisone or not on prednisone...
- Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid
Alice Y K Chan
Rheumatology Unit, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
Rheumatol Int 25:388-90. 2005
..Oral danazol 200 mg twice per day was started together with low-dose prednisolone therapy. There was no further recurrence of anemia 1 month after this combined therapy...
- Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund's complete adjuvant
Francis Fu Yuen Lam
Department of Pharmacology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
J Ethnopharmacol 120:44-50. 2008
..In this study, we have investigated the analgesic and anti-arthritic effects of a traditional Chinese medicine (TCM) combination of Lingzhi and San Miao San (SMS) in a rat model of arthritis induced by Freund's complete adjuvant (FCA)...
- Suppressive effect of combination treatment of leflunomide and methotrexate on chemokine expression in patients with rheumatoid arthritis
C Y Ho
Department of Chemical Pathology and Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
Clin Exp Immunol 133:132-8. 2003
..7 (55.9-28.4), respectively]. Combination therapy with leflunomide and MTX exhibits anti-inflammatory activity in the suppression of chemokine expression and subsequent recruitment of inflammatory cells into the inflammatory sites in RA...
- Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus
C K Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Rheumatology (Oxford) 44:602-6. 2005
..404, P = 0.037). CONCLUSION: The above results suggest that the production of OPN is associated with the inflammatory process and SLE development, and may serve as a potential disease marker of SLE...
- Expression of T-bet, a type 1 T-helper cell transcription factor, in the urinary sediment of lupus patients predicts disease flare
R W Y Chan
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Rheumatology (Oxford) 46:44-8. 2007
..Since T-bet is the principal transcription factor for the differentiation of type-1 helper T-lymphocyte, we study the impact of urinary T-bet mRNA expression in clinically quiescent SLE patients on the risk of subsequent disease flare...
- Urinary mononuclear cell and disease activity of systemic lupus erythematosus
R W Y Chan
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Lupus 15:262-7. 2006
..CD3+ and CD20+ cells are the major component of urinary mononuclear cell in SLE patients and their number correlates with lupus disease activity...
- Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
Chun Kwok Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Clin Immunol 127:385-93. 2008
..05). Ex vivo inductions of IL-17 by IL-23 or IL-18 from co-stimulated lymphocytes were significantly higher in SLE patients than controls (all p<0.05). The activated IL-23/IL-17 axis is important for the inflammatory immunity in SLE...
- Cardiovascular risk in patients with psoriatic arthritis
Tracy Y Zhu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
Int J Rheumatol 2012:714321. 2012
..In this paper, we discuss the current literature indicating that patients with PsA are at risk of cardiovascular diseases...
- Decreased ex vivo production of TNF-alpha and IL-8 by peripheral blood cells of patients with rheumatoid arthritis after infliximab therapy
S W M Lun
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Int Immunopharmacol 7:1668-77. 2007
..Our study suggests that the reduction in synovial inflammation may be due to the decreased production of TNF-alpha and IL-8, and hence the number of neutrophils and other pro-inflammatory leukocytes infiltrating into the inflamed sites...
- Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus
C K Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Rheumatology (Oxford) 44:989-94. 2005
..Plasma sCTLA concentration could potentially serve as a surrogate marker of SLE disease activity...
- Elevated plasma concentrations of nitric oxide, soluble thrombomodulin and soluble vascular cell adhesion molecule-1 in patients with systemic lupus erythematosus
C Y Ho
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
Rheumatology (Oxford) 42:117-22. 2003
..05). CONCLUSION: Elevated plasma NO, sTM, and sVCAM-1 concentrations have significant intercorrelations and are strongly associated with renal involvement in SLE...
- Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity
C K Wong
Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
J Clin Immunol 30:45-52. 2010
..CXCL13 can induce the trafficking of CXCR5+ T lymphocyte subset designated as follicular helper T lymphocytes (T(FH)) which are specifically involved in autoantibody production...
- Activation profile of Toll-like receptors of peripheral blood lymphocytes in patients with systemic lupus erythematosus
C K Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Clin Exp Immunol 159:11-22. 2010
..These results suggest that the innate immune response for extracellular pathogens and self-originated DNA plays immunopathological roles via TLR activation in SLE...
- Disease chronicity and activity predict subclinical left ventricular systolic dysfunction in patients with systemic lupus erythematosus
G W K Yip
Division of Cardiology, Department of Medicine and Therapeutics, SH Ho Cardiovascular and Stroke Centre, Institute of Vascular Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, PR China
Heart 95:980-7. 2009
..This study investigates parameters that could predict subclinical cardiac dysfunction in systemic lupus erythematosus (SLE) in the absence of valvular, clinical coronary artery and pericardial disease...
- Pathogenesis of ankylosing spondylitis
Lai Shan Tam
Department of Medicine and Therapeutics, 9 F Clinical Science Building, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Nat Rev Rheumatol 6:399-405. 2010
....
- Accelerated atherosclerosis in patients with systemic lupus erythematosus: a review of the causes and possible prevention
G N Thomas
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Med J 8:26-32. 2002
....
- Intravenous cyclophosphamide improves cardiac dysfunction in lupus myocarditis
Y K Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PRC
Scand J Rheumatol 32:306-8. 2003
..v.) 'pulse' cyclophosphamide. Three weeks after i.v. cyclophosphamide treatment, there was significant improvement of her heart failure symptoms with improvement in the ejection fraction from 19% to 63%...
- Increased arterial stiffness correlated with disease activity in systemic lupus erythematosus
Q Shang
Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
Lupus 17:1096-102. 2008
..0 m/s identified SLICC > or = 1 with a sensitivity of 91% and a specificity of 67%. In conclusion, SLE was an independent risk factor of sub-clinical atherosclerosis and arterial stiffness may identify the presence of active disease...
- ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin
B Tomlinson
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Clin Pharmacol Ther 87:558-62. 2010
..As compared with subjects with the c.421CC genotype, those with the c.421AA genotype showed a 6.9% greater reduction in LDL-C level, which would be equivalent to the effect obtained by doubling the dose of rosuvastatin...
- Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus
L C W Lit
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Ann Rheum Dis 65:209-15. 2006
....
- Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus
Chun K Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
J Clin Immunol 29:738-46. 2009
..Abnormal activation of intracellular signaling molecules in lymphocytes by inflammatory cytokines can instigate the inflammation in SLE...
- Costs and quality of life of patients with ankylosing spondylitis in Hong Kong
T Y Zhu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
Rheumatology (Oxford) 47:1422-5. 2008
..To assess the annual direct, indirect and total societal costs, quality of life (QoL) of AS in a Chinese population in Hong Kong and determine the cost determinants...
- Decreased expression of T lymphocyte co-stimulatory molecule CD26 on invariant natural killer T cells in systemic lupus erythematosus
P T Y Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Immunol Invest 38:350-64. 2009
..05). Decreased circulating number of iNKT cells and CD26 on iNKT cells can be important for the immunopathogenesis by exacerbating Th1-related inflammation in SLE...
- Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus
C K Wong
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
Clin Exp Immunol 130:345-51. 2002
..05). The basal NO release was significantly higher in RSLE than that in SLE and NC (both P < 0.005). IL-18 is therefore suggested to play a crucial role in the inflammatory processes of renal disease in SLE...
- Accrual of organ damage over time in patients with systemic lupus erythematosus
Dafna D Gladman
University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5-034, Toronto, Ontario, Canada M5T 2S8
J Rheumatol 30:1955-9. 2003
..CONCLUSION: While the overall accrual of damage is gradual, the specific systems demonstrate varying patterns of damage accrual...
- The effect of immunosuppressive therapy on the messenger RNA expression of target genes in the urinary sediment of patients with active lupus nephritis
Rebecca Wing-Yan Chan
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, China
Nephrol Dial Transplant 21:1534-40. 2006
..Measurement of urinary mRNA expression of target genes may be a potential non-invasive tool for the monitoring of lupus disease activity...
- Expression of chemokine and fibrosing factor messenger RNA in the urinary sediment of patients with lupus nephritis
Rebecca Wing-Yan Chan
Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Arthritis Rheum 50:2882-90. 2004
..CONCLUSION: The measurement of urinary mRNA expression may be a noninvasive method for the assessment of lupus disease activity and the severity of renal involvement in patients with lupus nephritis...
- Expression of cyclin B1 and cyclin dependent kinase inhibitor p21 in lymphocytes in patients with systemic lupus erythematosus
Cheong-Yip Ho
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
J Rheumatol 29:2537-44. 2002
..CONCLUSION: Downregulated p21 in PHA stimulated PBL from patients with SLE may be closely related to aberration of cell division in SLE lymphocytes...
- Inflammatory cytokine gene expression in the urinary sediment of patients with lupus nephritis
Rebecca Wing-Yan Chan
Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Arthritis Rheum 48:1326-31. 2003
..Measurement of cytokine gene expression in urinary sediment may be a useful noninvasive tool for assessing the severity of renal involvement in SLE...
- Messenger RNA expression of RANTES in the urinary sediment of patients with lupus nephritis
Rebecca Wing-Yan Chan
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
Nephrology (Carlton) 11:219-25. 2006
..Measurement of urinary mRNA expression may be a novel non-invasive method for the assessment of lupus disease activity and the severity of renal involvement...
