Lai Shan Tam

Summary

Publications

  1. ncbi request reprint Rapid improvement in rheumatoid arthritis patients on combination of methotrexate and infliximab: clinical and magnetic resonance imaging evaluation
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hongkong, People s Republic of China
    Clin Rheumatol 26:941-6. 2007
  2. doi request reprint Infliximab is associated with improvement in arterial stiffness in patients with early rheumatoid arthritis -- a randomized trial
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 39:2267-75. 2012
  3. doi request reprint Serum soluble receptor for advanced glycation end products levels and aortic augmentation index in early rheumatoid arthritis--a prospective study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Semin Arthritis Rheum 42:333-45. 2013
  4. pmc Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Arthritis Res Ther 12:R129. 2010
  5. ncbi request reprint Are spot urine samples adequate for assessment of proteinuria in patients with lupus nephritis?
    Lai Shan Tam
    The Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Nat Clin Pract Nephrol 4:72-3. 2008
  6. ncbi request reprint Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Lupus 13:601-4. 2004
  7. ncbi request reprint Increased prevalence of squamous intraepithelial lesions in systemic lupus erythematosus: association with human papillomavirus infection
    Lai Shan Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Arthritis Rheum 50:3619-25. 2004
  8. ncbi request reprint Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study
    Lai S Tam
    Department of Medicine and Therapeutics, Department of Radiology, and the Clinical Immunology Unit, Hong Kong Cancer Institute, Hong Kong
    J Rheumatol 32:275-82. 2005
  9. pmc Acupuncture in the treatment of rheumatoid arthritis: a double-blind controlled pilot study
    Lai Shan Tam
    The Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    BMC Complement Altern Med 7:35. 2007
  10. doi request reprint Effects of rosuvastatin on subclinical atherosclerosis and arterial stiffness in rheumatoid arthritis: a randomized controlled pilot trial
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, Hong Kong, PR China
    Scand J Rheumatol 40:411-21. 2011

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Rapid improvement in rheumatoid arthritis patients on combination of methotrexate and infliximab: clinical and magnetic resonance imaging evaluation
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hongkong, People s Republic of China
    Clin Rheumatol 26:941-6. 2007
    ..Assessment of enhancing synovial volume and perfusion indices on serial MRI examination was helpful in documenting the effect of treatment over this short period...
  2. doi request reprint Infliximab is associated with improvement in arterial stiffness in patients with early rheumatoid arthritis -- a randomized trial
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 39:2267-75. 2012
    ..To determine the efficacy of methotrexate (MTX) with infliximab (IFX) compared with MTX alone in the prevention of atherosclerosis and arterial stiffness in patients with early rheumatoid arthritis (RA)...
  3. doi request reprint Serum soluble receptor for advanced glycation end products levels and aortic augmentation index in early rheumatoid arthritis--a prospective study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Semin Arthritis Rheum 42:333-45. 2013
    ....
  4. pmc Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Arthritis Res Ther 12:R129. 2010
    ..Elevated expression of IL-27 has been detected in the synovial membranes and fluid of rheumatoid arthritis (RA)...
  5. ncbi request reprint Are spot urine samples adequate for assessment of proteinuria in patients with lupus nephritis?
    Lai Shan Tam
    The Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Nat Clin Pract Nephrol 4:72-3. 2008
  6. ncbi request reprint Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Lupus 13:601-4. 2004
    ..In summary, leflunomide was more effective than placebo in treating SLE patients with mild to moderate disease activity and was safe and well-tolerated...
  7. ncbi request reprint Increased prevalence of squamous intraepithelial lesions in systemic lupus erythematosus: association with human papillomavirus infection
    Lai Shan Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Arthritis Rheum 50:3619-25. 2004
    ..The association of human papillomavirus (HPV) infection and the use of immunosuppressive agents with abnormal Pap smears in SLE was also assessed...
  8. ncbi request reprint Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study
    Lai S Tam
    Department of Medicine and Therapeutics, Department of Radiology, and the Clinical Immunology Unit, Hong Kong Cancer Institute, Hong Kong
    J Rheumatol 32:275-82. 2005
    ..We evaluated the effects of longterm antioxidant vitamins on markers of oxidative stress and antioxidant defense and endothelial function in 39 patients with SLE...
  9. pmc Acupuncture in the treatment of rheumatoid arthritis: a double-blind controlled pilot study
    Lai Shan Tam
    The Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    BMC Complement Altern Med 7:35. 2007
    ....
  10. doi request reprint Effects of rosuvastatin on subclinical atherosclerosis and arterial stiffness in rheumatoid arthritis: a randomized controlled pilot trial
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, Hong Kong, PR China
    Scand J Rheumatol 40:411-21. 2011
    ..To ascertain the effect of rosuvastatin on carotid atherosclerosis and arterial stiffness in patients with rheumatoid arthritis (RA)...
  11. doi request reprint Natural history of cervical papilloma virus infection in systemic lupus erythematosus - a prospective cohort study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 37:330-40. 2010
    ....
  12. doi request reprint Subclinical carotid atherosclerosis in patients with psoriatic arthritis
    Lai Shan Tam
    The Prince of Wales Hospital and The Chinese University of Hong Kong, Hong Kong, China
    Arthritis Rheum 59:1322-31. 2008
    ..To examine the prevalence of subclinical atherosclerosis in patients with psoriatic arthritis (PsA) compared with healthy controls, and to identify clinical and biologic markers for atherosclerotic disease in this patient population...
  13. doi request reprint Cardiovascular risk profile of patients with psoriatic arthritis compared to controls--the role of inflammation
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Rheumatology (Oxford) 47:718-23. 2008
    ..To examine the distribution of traditional and novel risk factors of cardiovascular disease (CVD) in patients with PsA compared with healthy controls...
  14. ncbi request reprint Mesangial lupus nephritis in Chinese is associated with a high rate of transformation to higher grade nephritis
    L S Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Lupus 12:665-71. 2003
    ..Our data highlight that renal biopsy should be repeated early in Chinese patients with mesangial nephritis who failed to respond to treatment in order to identify those who may require intense immunosuppressive therapy...
  15. ncbi request reprint Risk of tuberculosis in patients with rheumatoid arthritis in Hong Kong--the role of TNF blockers in an area of high tuberculosis burden
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Exp Rheumatol 28:679-85. 2010
    ....
  16. ncbi request reprint Patients with systemic lupus erythematosus show increased platelet activation and endothelial dysfunction induced by acute hyperhomocysteinemia
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
    J Rheumatol 30:1479-84. 2003
    ..Systemic lupus erythematosus (SLE) is an inflammatory disease with a high atherothrombotic tendency. We examined whether acute hyperhomocysteinemia exacerbates endothelial and platelet dysfunction in patients with SLE...
  17. ncbi request reprint The relationship between neuropsychiatric, clinical, and laboratory variables and quality of life of Chinese patients with systemic lupus erythematosus
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 35:1038-45. 2008
    ..To investigate the role of neuropsychiatric (NP), clinical, and laboratory variables in influencing the health related quality of life (HRQOL) of Chinese patients with systemic lupus erythematosus (SLE)...
  18. ncbi request reprint Risk factors and clinical features for tuberculosis among patients with systemic lupus erythematosus in Hong Kong
    Lai Shan Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Scand J Rheumatol 31:296-300. 2002
    ..To determine the risk factors associated with and to describe the clinical course of tuberculosis (TB) in patients with systemic lupus erythematosus (SLE)...
  19. doi request reprint Risk factors for squamous intraepithelial lesions in systemic lupus erythematosus: a prospective cohort study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital and The Chinese University of Hong Kong, Hong Kong, China
    Arthritis Care Res (Hoboken) 63:269-76. 2011
    ..We undertook a prospective cohort study to ascertain the risk factors for the development of squamous intraepithelial lesions (SIL) in patients with systemic lupus erythematosus (SLE)...
  20. doi request reprint Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis
    Jianxin Lu
    Departments of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Nephrology (Carlton) 17:346-51. 2012
    ..We studied the intra-renal expression of miRNA targets that were reported to be differentially expressed in peripheral blood or urine between lupus nephritis (LN) patients and normal controls...
  21. doi request reprint The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus
    Bonnie Ching Ha Kwan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Rheumatology (Oxford) 48:1491-7. 2009
    ..We studied the role of type 17 Th cells (TH17) in the pathogenesis of SLE...
  22. doi request reprint Gene expression of TWEAK/Fn14 and IP-10/CXCR3 in glomerulus and tubulointerstitium of patients with lupus nephritis
    Jianxin Lu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Nephrology (Carlton) 16:426-32. 2011
    ..The role of the tumour necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 and interferon-inducible protein (IP-10)/CXCR3 axis in the pathogenesis of lupus nephritis were studied...
  23. doi request reprint Bone microarchitecture assessment by high-resolution peripheral quantitative computed tomography in patients with systemic lupus erythematosus taking corticosteroids
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    J Rheumatol 37:1473-9. 2010
    ....
  24. ncbi request reprint The effect of immunosuppressive therapy on the messenger RNA expression of target genes in the urinary sediment of patients with active lupus nephritis
    Rebecca Wing Yan Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, China
    Nephrol Dial Transplant 21:1534-40. 2006
    ..The pattern of gene expression was compared to clinical parameters of therapeutic response...
  25. doi request reprint Is combination rituximab with cyclophosphamide better than rituximab alone in the treatment of lupus nephritis?
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Rheumatology (Oxford) 48:892-8. 2009
    ..To assess if combination rituximab and cyclophosphamide is more effective than rituximab monotherapy as an induction therapy for proliferative lupus nephritis...
  26. doi request reprint Relationship of intrarenal gene expression and the histological class of lupus nephritis -- a study on repeat renal biopsy
    Jianxin Lu
    Department of Medicine and Therapeutics and the Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong CUHK, Shatin, Hong Kong, China
    J Rheumatol 39:1942-7. 2012
    ..To study the role of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)/Fn14 and the interferon-inducible protein (IP-10)/CXCR3 axis in lupus nephritis (LN)...
  27. doi request reprint Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus
    Gang Wang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Rheumatol 31:435-40. 2012
    ....
  28. ncbi request reprint Inflammatory cytokine gene expression in the urinary sediment of patients with lupus nephritis
    Rebecca Wing Yan Chan
    Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Arthritis Rheum 48:1326-31. 2003
    ..Lupus nephritis is characterized by intrarenal inflammation and lymphocyte activation. In the present study, the expression of cytokine genes in the urinary sediment of patients with systemic lupus erythematosus (SLE) was examined...
  29. doi request reprint Socioeconomic burden of psoriatic arthritis in Hong Kong: direct and indirect costs and the influence of disease pattern
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, N T, Hong Kong
    J Rheumatol 37:1214-20. 2010
    ..To estimate the direct costs and indirect costs of patients with psoriatic arthritis (PsA) in Hong Kong...
  30. ncbi request reprint Expression of chemokine and fibrosing factor messenger RNA in the urinary sediment of patients with lupus nephritis
    Rebecca Wing Yan Chan
    Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Arthritis Rheum 50:2882-90. 2004
    ....
  31. doi request reprint The impact of flare on disease costs of patients with systemic lupus erythematosus
    Tracy Y Zhu
    Prince of Wales Hospital and The Chinese University of Hong Kong, Shatin, Hong Kong
    Arthritis Rheum 61:1159-67. 2009
    ....
  32. ncbi request reprint Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial
    Edmund K Li
    Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Arthritis Rheum 57:1143-50. 2007
    ....
  33. ncbi request reprint Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus
    Lydia Choi Wan Lit
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Rheumatol 34:89-96. 2007
    ..We investigated the immunomodulatory roles of T-bet and GATA-3 and Th1/Th2 related cytokines in the pathogenesis of systemic lupus erythematosus (SLE) and their association with disease activity...
  34. pmc Antagonist-mediated down-regulation of Toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China
    Arthritis Res Ther 14:R80. 2012
    ..This study evaluated whether abnormal host innate immune response in lupus patients may enhance HPV persistence...
  35. doi request reprint Monitoring of urinary messenger RNA levels for the prediction of flare in systemic lupus erythematosus
    Cheuk Chun Szeto
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Chim Acta 413:448-55. 2012
    ..Systemic lupus erythematosus (SLE) is characterized by disease flares and remission. We hypothesize that in clinically quiescent SLE patients, the mRNA level of target genes in the urinary sediment is an early indicator of disease flare...
  36. doi request reprint Labour and non-labour market productivity in Chinese patients with systemic lupus erythematosus
    Tracy Y Zhu
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, 9 F Clinical Sciences Building, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, N T, Hong Kong
    Rheumatology (Oxford) 51:284-92. 2012
    ..A cross-sectional study was performed to assess the self-reported loss of labour and non-labour market productivity, as well as to characterize the risk factors of loss of productivity in patients with SLE...
  37. pmc Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid
    Edmund K Li
    Department of Medicine, The Chinese University of Hong Kong, Prince Wales Hospital, 30 32 Ngan Shing Street, Sha Tin, NT, Hong Kong, PR China
    Arthritis Res Ther 12:R198. 2010
    ....
  38. doi request reprint High prevalence of asymptomatic vertebral fractures in Chinese women with systemic lupus erythematosus
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    J Rheumatol 36:1646-52. 2009
    ..To investigate the prevalence of vertebral fractures and to identify risk factors associated with vertebral fractures in Chinese women with systemic lupus erythematosus (SLE)...
  39. doi request reprint Relationship between flare and health-related quality of life in patients with systemic lupus erythematosus
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, New Territory, Hong Kong, China
    J Rheumatol 37:568-73. 2010
    ....
  40. ncbi request reprint Can the urine dipstick test reduce the need for microscopy for assessment of systemic lupus erythematosus disease activity?
    Rebecca Wing Yan Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Rheumatol 32:828-31. 2005
    ..Urine microscopic examination is an important component of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). We investigated whether the urine dipstick test can reduce the need for microscopy for the assessment of SLEDAI...
  41. ncbi request reprint Messenger RNA expression of podocyte-associated molecules in urinary sediment of patients with lupus nephritis
    Gang Wang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Rheumatol 34:2358-64. 2007
    ..To examine urinary expression of podocyte-associated molecules in patients with lupus nephritis (LN)...
  42. doi request reprint Bone density and microarchitecture: relationship between hand, peripheral, and axial skeletal sites assessed by HR-pQCT and DXA in rheumatoid arthritis
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Calcif Tissue Int 91:343-55. 2012
    ..Future longitudinal studies will be needed to investigate whether assessment by HR-pQCT can be used as a marker of disease activity and a predictor of disease progression in RA...
  43. doi request reprint Increased organ damage associated with deterioration in volumetric bone density and bone microarchitecture in patients with systemic lupus erythematosus on longterm glucocorticoid therapy
    Xiao lin Tang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Rheumatol 39:1955-63. 2012
    ..To evaluate bone quality in patients with systemic lupus erythematosus (SLE) who were undergoing longterm glucocorticoid (GC) therapy, and to focus on the correlation between bone quality and organ damage...
  44. doi request reprint Repeat renal biopsy in lupus nephritis: a change in histological pattern is common
    Jianxin Lu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, SAR, China
    Am J Nephrol 34:220-5. 2011
    ..The role of longitudinal change in sequential renal biopsies of lupus nephritis (LN) patient remains elusive...
  45. ncbi request reprint Messenger RNA expression of RANTES in the urinary sediment of patients with lupus nephritis
    Rebecca Wing Yan Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Nephrology (Carlton) 11:219-25. 2006
    ..The authors studied the mRNA expression of RANTES in the urinary sediment of lupus patients...
  46. doi request reprint Evaluation of spinal mobility measurements in predicting axial psoriatic arthritis
    Ying Ying Leung
    Department of Medicine and Geriatrics, Tai Po Hospital, 9 Chuen On Road, Tai Po, NT, Hong Kong SAR, China
    Clin Rheumatol 30:1157-62. 2011
    ..619, 0.626, and 0.618). Spinal mobility measurements and BASMI were useful in differentiating axial and peripheral PsA. Lumber side flexion and modified schober test best differentiate axial and peripheral PsA...
  47. doi request reprint Structure and strength of the distal radius in female patients with rheumatoid arthritis: a case-control study
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Bone Miner Res 28:794-806. 2013
    ..Ulnovolar periosteal apposition of the distal radius is a feature of chronic, severe RA with wrist deformity...
  48. pmc The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin
    Miao Hu
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    J Lipid Res 53:1384-9. 2012
    ....
  49. doi request reprint Societal costs of rheumatoid arthritis in Hong Kong: a prevalence-based cost-of-illness study
    Tracy Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Rheumatology (Oxford) 50:1293-301. 2011
    ..To estimate the direct and indirect costs among a cohort of Chinese patients with RA in Hong Kong...
  50. doi request reprint Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus
    Gang Wang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Rheumatol 37:2516-22. 2010
    ..Recent studies showed that micro-RNA play important roles in the pathogenesis of autoimmune diseases. We studied the levels of miR-146a and miR-155 in the serum and urinary supernatant of patients with systemic lupus erythematosus (SLE)...
  51. doi request reprint Urinary FOXP3 mRNA in patients with lupus nephritis--relation with disease activity and treatment response
    Gang Wang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Rheumatology (Oxford) 48:755-60. 2009
    ..Regulatory T lymphocytes (Tregs) probably play an important role in the pathogenesis of SLE...
  52. ncbi request reprint Leflunomide in the treatment of rheumatoid arthritis
    Edmund K Li
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, ROC
    Clin Ther 26:447-59. 2004
    ..Drugs are needed that are able to suppress inflammation and modify the underlying immune response with improved tolerability. Leflunomide is an agent that affects the inflammatory process, particularly in RA...
  53. ncbi request reprint The influence of illness and variables associated with functional limitations in Chinese patients with ankylosing spondylitis
    Lai Shan Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong and Hong Kong Society for Rehabilitation, Hong Kong
    J Rheumatol 34:1032-9. 2007
    ..To assess the effect of illness and the functional outcome of Chinese patients with ankylosing spondylitis (AS), and to identify variables associated with a poor functional outcome...
  54. pmc Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e23855. 2011
    ..Pattern recognition receptors (PRRs) such as Toll-like receptors are aberrantly expressed of peripheral blood mononuclear cells (PBMCs) in systemic lupus erythematosus (SLE) patients, for playing immunopathological roles...
  55. ncbi request reprint Comparison of 4 functional indexes in psoriatic arthritis with axial or peripheral disease subgroups using Rasch analyses
    Ying Ying Leung
    Department of Medicine and Geriatrics, Tai Po Hospital, Hong Kong, China
    J Rheumatol 35:1613-21. 2008
    ..We compared the performance of 4 functional indexes in patients with psoriatic arthritis (PsA) in axial or peripheral disease subgroups...
  56. ncbi request reprint Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Clin Rheumatol 26:1495-8. 2007
    ..Nonetheless, the atherogenic index, LDL-cholesterol/HDL-cholesterol ratio, and the LDL/apoB ratio remained unchanged. Infliximab improves insulin sensitivity and alters lipid profile in patients with active RA...
  57. pmc Intrarenal cytokine gene expression in lupus nephritis
    Rebecca Wing Yan Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Ann Rheum Dis 66:886-92. 2007
    ..Lupus nephritis is characterised by intrarenal inflammation and lymphocyte activation...
  58. doi request reprint Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients
    Miao Hu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong SAR
    Pharmacogenet Genomics 20:634-7. 2010
    ..This study identified some genetic determinants of LDL-C response to rosuvastatin in Chinese patients, which need to be replicated in other populations...
  59. doi request reprint Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis
    Da Peng Chen
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    J Ethnopharmacol 137:457-68. 2011
    ....
  60. ncbi request reprint Climatic influence on the prevalence of noncutaneous disease flare in systemic lupus erythematosus in Hong Kong
    Cheuk Chun Szeto
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China
    J Rheumatol 35:1031-7. 2008
    ..We investigated whether there is seasonal variation in the incidence of noncutaneous lupus flare in Hong Kong...
  61. ncbi request reprint Expression of cyclin B1 and cyclin dependent kinase inhibitor p21 in lymphocytes in patients with systemic lupus erythematosus
    Cheong Yip Ho
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Rheumatol 29:2537-44. 2002
    ..We measured the expression of cyclin B1 and CDK inhibitor p21 in peripheral blood lymphocytes (PBL) from patients with SLE and controls...
  62. doi request reprint Increase in ventricular-arterial stiffness in patients with psoriatic arthritis
    Qing Shang
    Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Rheumatology (Oxford) 51:2215-23. 2012
    ..The aim of this study is to determine whether there is increased ventricular and arterial stiffness in patients with PsA and any relationship with disease-related risk factors...
  63. pmc Immunopathological roles of cytokines, chemokines, signaling molecules, and pattern-recognition receptors in systemic lupus erythematosus
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Clin Dev Immunol 2012:715190. 2012
    ....
  64. doi request reprint The socioeconomic burden of systemic lupus erythematosus: state-of-the-art and prospects
    Tracy Y Zhu
    Department of Medicine and Therapeutics, 9 F Clinical Sciences Building, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Expert Rev Pharmacoecon Outcomes Res 12:53-69. 2012
    ..Several methodological considerations and unsolved issues will also be emphasized...
  65. doi request reprint Cost-of-illness studies in systemic lupus erythematosus: A systematic review
    Tracy Y Zhu
    The Chinese University of Hong Kong, Shatin, Hong Kong
    Arthritis Care Res (Hoboken) 63:751-60. 2011
    ..To summarize the state of knowledge regarding the economic burden of systemic lupus erythematosus (SLE) and to evaluate the quality of cost-of-illness (COI) studies conducted to date...
  66. doi request reprint The perspective on psoriatic arthritis in Asia
    Ying Ying Leung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Curr Rheumatol Rep 13:369-75. 2011
    ....
  67. doi request reprint Psoriatic arthritis in Asia
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Rheumatology (Oxford) 48:1473-7. 2009
    ..Carotid intima-media thickness can identify PsA patients with subclinical atherosclerosis who may benefit from early intervention...
  68. doi request reprint Systemic lupus erythematosus with neuropsychiatric manifestation incurs high disease costs: a cost-of-illness study in Hong Kong
    Tracy Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong
    Rheumatology (Oxford) 48:564-8. 2009
    ..To determine the direct and indirect costs of SLE in Hong Kong, and to ascertain the relationship between neuropsychiatric SLE (NPSLE) and disease costs...
  69. doi request reprint Tacrolimus for the treatment of systemic lupus erythematosus with pure class V nephritis
    C C Szeto
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Rheumatology (Oxford) 47:1678-81. 2008
    ..The treatment of pure membranous (class V) lupus nephropathy remains unsatisfactory. We studied the efficacy and safety of tacrolimus in the treatment of membranous nephritis secondary to SLE...
  70. doi request reprint High prevalence of subclinical left ventricular dysfunction in patients with psoriatic arthritis
    Qing Shang
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 38:1363-70. 2011
    ..The aims of our study were to determine the prevalence of subclinical left ventricular (LV) dysfunction in PsA patients and the disease-related risk factors...
  71. pmc Management of rheumatoid arthritis: consensus recommendations from the Hong Kong Society of Rheumatology
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong
    Clin Rheumatol 30:303-12. 2011
    ....
  72. doi request reprint Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation
    E K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
    Rheumatology (Oxford) 47:1358-63. 2008
    ..To examine the short-term efficacy and safety of MTX in combination with infliximab compared with infliximab and placebo in the treatment of AS using MRI to monitor its effect...
  73. ncbi request reprint Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid
    Alice Y K Chan
    Rheumatology Unit, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Rheumatol Int 25:388-90. 2005
    ..Oral danazol 200 mg twice per day was started together with low-dose prednisolone therapy. There was no further recurrence of anemia 1 month after this combined therapy...
  74. ncbi request reprint Hydroxychloroquine has no significant effect on lipids and apolipoproteins in Chinese systemic lupus erythematosus patients with mild or inactive disease
    L S Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, tamls
    Lupus 9:413-6. 2000
    ..To investigate the effects of hydroxychloroquine (HCQ) in Chinese patients with systemic lupus erythematosus who were either on a low dose of prednisone or not on prednisone...
  75. doi request reprint Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund's complete adjuvant
    Francis Fu Yuen Lam
    Department of Pharmacology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Ethnopharmacol 120:44-50. 2008
    ..In this study, we have investigated the analgesic and anti-arthritic effects of a traditional Chinese medicine (TCM) combination of Lingzhi and San Miao San (SMS) in a rat model of arthritis induced by Freund's complete adjuvant (FCA)...
  76. pmc Suppressive effect of combination treatment of leflunomide and methotrexate on chemokine expression in patients with rheumatoid arthritis
    C Y Ho
    Department of Chemical Pathology and Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Clin Exp Immunol 133:132-8. 2003
    ..7 (55.9-28.4), respectively]. Combination therapy with leflunomide and MTX exhibits anti-inflammatory activity in the suppression of chemokine expression and subsequent recruitment of inflammatory cells into the inflammatory sites in RA...
  77. ncbi request reprint Expression of T-bet, a type 1 T-helper cell transcription factor, in the urinary sediment of lupus patients predicts disease flare
    R W Y Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Rheumatology (Oxford) 46:44-8. 2007
    ..Since T-bet is the principal transcription factor for the differentiation of type-1 helper T-lymphocyte, we study the impact of urinary T-bet mRNA expression in clinically quiescent SLE patients on the risk of subsequent disease flare...
  78. ncbi request reprint Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Rheumatology (Oxford) 44:602-6. 2005
    ..Overexpression of OPN has been associated with the development of the autoimmune/lymphoproliferative syndrome...
  79. ncbi request reprint Urinary mononuclear cell and disease activity of systemic lupus erythematosus
    R W Y Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Lupus 15:262-7. 2006
    ..CD3+ and CD20+ cells are the major component of urinary mononuclear cell in SLE patients and their number correlates with lupus disease activity...
  80. doi request reprint Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
    Chun Kwok Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Immunol 127:385-93. 2008
    ..05). Ex vivo inductions of IL-17 by IL-23 or IL-18 from co-stimulated lymphocytes were significantly higher in SLE patients than controls (all p<0.05). The activated IL-23/IL-17 axis is important for the inflammatory immunity in SLE...
  81. pmc Cardiovascular risk in patients with psoriatic arthritis
    Tracy Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Int J Rheumatol 2012:714321. 2012
    ..In this paper, we discuss the current literature indicating that patients with PsA are at risk of cardiovascular diseases...
  82. doi request reprint Disease chronicity and activity predict subclinical left ventricular systolic dysfunction in patients with systemic lupus erythematosus
    G W K Yip
    Division of Cardiology, Department of Medicine and Therapeutics, SH Ho Cardiovascular and Stroke Centre, Institute of Vascular Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, PR China
    Heart 95:980-7. 2009
    ..This study investigates parameters that could predict subclinical cardiac dysfunction in systemic lupus erythematosus (SLE) in the absence of valvular, clinical coronary artery and pericardial disease...
  83. doi request reprint Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity
    C K Wong
    Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Clin Immunol 30:45-52. 2010
    ..CXCL13 can induce the trafficking of CXCR5+ T lymphocyte subset designated as follicular helper T lymphocytes (T(FH)) which are specifically involved in autoantibody production...
  84. ncbi request reprint Elevated plasma concentrations of nitric oxide, soluble thrombomodulin and soluble vascular cell adhesion molecule-1 in patients with systemic lupus erythematosus
    C Y Ho
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Rheumatology (Oxford) 42:117-22. 2003
    ....
  85. pmc Activation profile of Toll-like receptors of peripheral blood lymphocytes in patients with systemic lupus erythematosus
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Exp Immunol 159:11-22. 2010
    ..These results suggest that the innate immune response for extracellular pathogens and self-originated DNA plays immunopathological roles via TLR activation in SLE...
  86. ncbi request reprint Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Rheumatology (Oxford) 44:989-94. 2005
    ....
  87. ncbi request reprint Decreased ex vivo production of TNF-alpha and IL-8 by peripheral blood cells of patients with rheumatoid arthritis after infliximab therapy
    S W M Lun
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Int Immunopharmacol 7:1668-77. 2007
    ..Our study suggests that the reduction in synovial inflammation may be due to the decreased production of TNF-alpha and IL-8, and hence the number of neutrophils and other pro-inflammatory leukocytes infiltrating into the inflamed sites...
  88. doi request reprint Pathogenesis of ankylosing spondylitis
    Lai Shan Tam
    Department of Medicine and Therapeutics, 9 F Clinical Science Building, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Nat Rev Rheumatol 6:399-405. 2010
    ....
  89. doi request reprint ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin
    B Tomlinson
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Pharmacol Ther 87:558-62. 2010
    ..As compared with subjects with the c.421CC genotype, those with the c.421AA genotype showed a 6.9% greater reduction in LDL-C level, which would be equivalent to the effect obtained by doubling the dose of rosuvastatin...
  90. ncbi request reprint Accelerated atherosclerosis in patients with systemic lupus erythematosus: a review of the causes and possible prevention
    G N Thomas
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 8:26-32. 2002
    ....
  91. doi request reprint Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    J Clin Immunol 29:738-46. 2009
    ..Abnormal activation of intracellular signaling molecules in lymphocytes by inflammatory cytokines can instigate the inflammation in SLE...
  92. pmc Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus
    L C W Lit
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Ann Rheum Dis 65:209-15. 2006
    ..Chemokines are involved in leucocyte chemotaxis. Infiltrating leucocytes play an important role of tissue injury in systemic lupus erythematosus (SLE)...
  93. ncbi request reprint Intravenous cyclophosphamide improves cardiac dysfunction in lupus myocarditis
    Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PRC
    Scand J Rheumatol 32:306-8. 2003
    ..v.) 'pulse' cyclophosphamide. Three weeks after i.v. cyclophosphamide treatment, there was significant improvement of her heart failure symptoms with improvement in the ejection fraction from 19% to 63%...
  94. doi request reprint Increased arterial stiffness correlated with disease activity in systemic lupus erythematosus
    Q Shang
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Lupus 17:1096-102. 2008
    ..0 m/s identified SLICC > or = 1 with a sensitivity of 91% and a specificity of 67%. In conclusion, SLE was an independent risk factor of sub-clinical atherosclerosis and arterial stiffness may identify the presence of active disease...
  95. doi request reprint Costs and quality of life of patients with ankylosing spondylitis in Hong Kong
    T Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Rheumatology (Oxford) 47:1422-5. 2008
    ..To assess the annual direct, indirect and total societal costs, quality of life (QoL) of AS in a Chinese population in Hong Kong and determine the cost determinants...
  96. pmc Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Clin Exp Immunol 130:345-51. 2002
    ..05). The basal NO release was significantly higher in RSLE than that in SLE and NC (both P < 0.005). IL-18 is therefore suggested to play a crucial role in the inflammatory processes of renal disease in SLE...
  97. ncbi request reprint Decreased expression of T lymphocyte co-stimulatory molecule CD26 on invariant natural killer T cells in systemic lupus erythematosus
    P T Y Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Immunol Invest 38:350-64. 2009
    ..05). Decreased circulating number of iNKT cells and CD26 on iNKT cells can be important for the immunopathogenesis by exacerbating Th1-related inflammation in SLE...
  98. ncbi request reprint Accrual of organ damage over time in patients with systemic lupus erythematosus
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1955-9. 2003
    ....