Norio Takizawa

Summary

Affiliation: Trim-edicine, Inc
Location: North Brunswick, USA
Grants:
Protein Therapeutics for Muscular Dystrophy, 2010-2011, NIH

Publications

  1. pmc Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency
    Jessica L Crowley
    Department of Cell Biology and Cell Dynamics Program, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 20:948-62. 2009
  2. ncbi request reprint Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery
    Norio Takizawa
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Sci 120:3792-803. 2007
  3. pmc Supervillin modulation of focal adhesions involving TRIP6/ZRP-1
    Norio Takizawa
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 174:447-58. 2006
  4. ncbi request reprint Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle
    Samudra S Gangopadhyay
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    J Cell Sci 117:5043-57. 2004
  5. ncbi request reprint F-actin and myosin II binding domains in supervillin
    Yu Chen
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:46094-106. 2003
  6. ncbi request reprint M20, the small subunit of PP1M, binds to microtubules
    Norio Takizawa
    Department of Physiology and Biomedical Imaging Group, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Physiol Cell Physiol 284:C250-62. 2003
  7. ncbi request reprint Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase
    Norio Takizawa
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Biochem Biophys Res Commun 297:773-8. 2002
  8. ncbi request reprint Dephosphorylation of the two regulatory components of myosin phosphatase, MBS and CPI17
    Norio Takizawa
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    FEBS Lett 515:127-32. 2002
  9. pmc Reconstitution of protein kinase C-induced contractile Ca2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle
    T Kitazawa
    Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA
    J Physiol 520:139-52. 1999
  10. ncbi request reprint Selective increases in isoform PP1 alpha of type-1 protein phosphatase in ascites hepatoma cells
    N Takizawa
    Section of Biochemistry, Hokkaido University
    Jpn J Cancer Res 85:274-8. 1994

Collaborators

Detail Information

Publications18

  1. pmc Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency
    Jessica L Crowley
    Department of Cell Biology and Cell Dynamics Program, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 20:948-62. 2009
    ....
  2. ncbi request reprint Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery
    Norio Takizawa
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Sci 120:3792-803. 2007
    ..Thus, the membrane protein SV apparently contributes to myosin II assembly during cell spreading by modulating myosin II regulation by L-MLCK...
  3. pmc Supervillin modulation of focal adhesions involving TRIP6/ZRP-1
    Norio Takizawa
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 174:447-58. 2006
    ..Thus, SV interactions with TRIP6 at FAs promote loss of FA structure and function. SV and TRIP6 binding partners suggest several specific mechanisms through which the SV-TRIP6 interaction may regulate FA maturation and/or disassembly...
  4. ncbi request reprint Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle
    Samudra S Gangopadhyay
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    J Cell Sci 117:5043-57. 2004
    ..These results indicate that SmAV contributes to the regulation of contractility through a CaP-mediated signaling pathway, involving PKC activation and phosphorylation of ERK1/2...
  5. ncbi request reprint F-actin and myosin II binding domains in supervillin
    Yu Chen
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:46094-106. 2003
    ..Taken together, these results suggest that supervillin may mediate actin and myosin II filament organization at cholesterol-rich membrane domains...
  6. ncbi request reprint M20, the small subunit of PP1M, binds to microtubules
    Norio Takizawa
    Department of Physiology and Biomedical Imaging Group, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Physiol Cell Physiol 284:C250-62. 2003
    ..These results suggest that M20 has a microtubule binding activity and plays a role in regulating microtubule dynamics...
  7. ncbi request reprint Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase
    Norio Takizawa
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Biochem Biophys Res Commun 297:773-8. 2002
    ..On the other hand, the phosphorylation of MBS by PAK also decreased the MLCP activity. These results raise the possibility that the PAK pathway plays a role in MLCP regulation...
  8. ncbi request reprint Dephosphorylation of the two regulatory components of myosin phosphatase, MBS and CPI17
    Norio Takizawa
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    FEBS Lett 515:127-32. 2002
    ..On the other hand, phosphorylated CPI17 is readily dephosphorylated thus likely to play a role in regulating fast phosphorylation-dephosphorylation cycle in cells...
  9. pmc Reconstitution of protein kinase C-induced contractile Ca2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle
    T Kitazawa
    Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA
    J Physiol 520:139-52. 1999
    ..7. Our results indicate that PKC requires CPI-17 phosphorylation at Thr-38 but not calponin for reconstitution of the contractile Ca2+ sensitization in the demembranated arterial smooth muscle...
  10. ncbi request reprint Selective increases in isoform PP1 alpha of type-1 protein phosphatase in ascites hepatoma cells
    N Takizawa
    Section of Biochemistry, Hokkaido University
    Jpn J Cancer Res 85:274-8. 1994
    ....
  11. pmc The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility
    Zhiyou Fang
    Department of Cell Biology, University of Massachusetts Medical School, Biotech 4, Suite 306, 377 Plantation Street, Worcester, MA 01605, USA
    Traffic 11:782-99. 2010
    ..These results suggest that supervillin, F-actin and associated proteins coordinate a rapid, basolateral membrane recycling pathway that contributes to ERK signaling and actin-based cell motility...