Morikawa T, Takubo K. Hypoxia regulates the hematopoietic stem cell niche. Pflugers Arch. 2015;: pubmed
..This review focuses on HIF-mediated oxygen-sensing mechanisms of adult HSCs and LSCs and their niche cells in the hypoxic bone marrow. ..
Kobayashi H, Suda T, Takubo K. How hematopoietic stem/progenitors and their niche sense and respond toÂ infectious stress. Exp Hematol. 2016;44:92-100 pubmed publisher
..Here we review recent advances in our understanding of HSPC responses to infection and also consider newly identified STING-mediated machinery recognizing bacteria-derived cyclic dinucleotides. ..
Suzuki S, Fujita N, Hosogane N, Watanabe K, Ishii K, Toyama Y, et al
. Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis Res Ther. 2015;17:316 pubmed publisher
..A positive feedback loop was formed between excessive ROS and TNF-alpha in AF cells. Thus, oxidative stress contributes to the progression of IVD degeneration and NAC can be a therapeutic option for IVD degeneration. ..
Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, et al
. p38Î± Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress. Cell Stem Cell. 2016;19:192-204 pubmed publisher
..Our studies have therefore uncovered a p38Î±-mediated pathway that alters HSPC metabolism to respond to stress and promote recovery. ..
Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, et al
. Premeiotic germ cell defect in seminiferous tubules of Atm-null testis. Biochem Biophys Res Commun. 2006;351:993-8 pubmed
Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, et al
. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell. 2010;7:391-402 pubmed publisher
..These data indicate that HSCs maintain cell cycle quiescence through the precise regulation of HIF-1alpha levels. ..
Takubo K, Suda T. Roles of the hypoxia response system in hematopoietic and leukemic stem cells. Int J Hematol. 2012;95:478-83 pubmed publisher
Takubo K, Nagamatsu G, Kobayashi C, Nakamura Ishizu A, Kobayashi H, Ikeda E, et al
. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013;12:49-61 pubmed publisher
..Moreover, treatment of HSCs with a Pdk mimetic promoted their survival and transplantation capacity. Thus, glycolytic metabolic status governed by Pdk acts as a cell cycle checkpoint that modulates HSC quiescence and function. ..
Kobayashi H, Kobayashi C, Nakamura Ishizu A, Karigane D, Haeno H, Yamamoto K, et al
. Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 2015;11:71-84 pubmed publisher
..Our results define machinery underlying the dynamic regulation of HSPCs and their niches during bacterial infection through c-di-GMP/STING signaling. ..