Keiyo Takubo



  1. Watanuki S, Kobayashi H, Sorimachi Y, Yamamoto M, Okamoto S, Takubo K. ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation. Biochem Biophys Res Commun. 2019;: pubmed publisher
    ..These findings show that ATP turnover and nutritional requirements differ between HSCs and HPCs according to the cell cycle and differentiation status. ..
  2. Morikawa T, Takubo K. Hypoxia regulates the hematopoietic stem cell niche. Pflugers Arch. 2016;468:13-22 pubmed publisher
    ..This review focuses on HIF-mediated oxygen-sensing mechanisms of adult HSCs and LSCs and their niche cells in the hypoxic bone marrow. ..
  3. Kobayashi H, Suda T, Takubo K. How hematopoietic stem/progenitors and their niche sense and respond to infectious stress. Exp Hematol. 2016;44:92-100 pubmed publisher
    ..Here we review recent advances in our understanding of HSPC responses to infection and also consider newly identified STING-mediated machinery recognizing bacteria-derived cyclic dinucleotides. ..
  4. Suzuki S, Fujita N, Hosogane N, Watanabe K, Ishii K, Toyama Y, et al. Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis Res Ther. 2015;17:316 pubmed publisher
    ..A positive feedback loop was formed between excessive ROS and TNF-alpha in AF cells. Thus, oxidative stress contributes to the progression of IVD degeneration and NAC can be a therapeutic option for IVD degeneration. ..
  5. Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, et al. p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress. Cell Stem Cell. 2016;19:192-204 pubmed publisher
    ..Our studies have therefore uncovered a p38α-mediated pathway that alters HSPC metabolism to respond to stress and promote recovery. ..
  6. request reprint
    Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, et al. Premeiotic germ cell defect in seminiferous tubules of Atm-null testis. Biochem Biophys Res Commun. 2006;351:993-8 pubmed
  7. Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell. 2010;7:391-402 pubmed publisher
    ..These data indicate that HSCs maintain cell cycle quiescence through the precise regulation of HIF-1alpha levels. ..
  8. Takubo K, Suda T. Roles of the hypoxia response system in hematopoietic and leukemic stem cells. Int J Hematol. 2012;95:478-83 pubmed publisher
  9. Takubo K, Nagamatsu G, Kobayashi C, Nakamura Ishizu A, Kobayashi H, Ikeda E, et al. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013;12:49-61 pubmed publisher
    ..Moreover, treatment of HSCs with a Pdk mimetic promoted their survival and transplantation capacity. Thus, glycolytic metabolic status governed by Pdk acts as a cell cycle checkpoint that modulates HSC quiescence and function. ..

More Information


  1. Kobayashi H, Kobayashi C, Nakamura Ishizu A, Karigane D, Haeno H, Yamamoto K, et al. Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 2015;11:71-84 pubmed publisher
    ..Our results define machinery underlying the dynamic regulation of HSPCs and their niches during bacterial infection through c-di-GMP/STING signaling. ..
  2. Karigane D, Takubo K. Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions. Int J Hematol. 2017;106:18-26 pubmed publisher