Eugene Lin

Summary

Affiliation: Vita Genomics
Country: Taiwan

Publications

  1. ncbi A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data
    Lung Cheng Huang
    Department of Psychiatry, National Taiwan University Hospital Yun Lin Branch, Taiwan
    J Transl Med 7:81. 2009
  2. ncbi A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome
    Eugene Lin
    Vita Genomics, Inc, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 10:35-42. 2009
  3. ncbi Pharmacogenomics with antidepressants in the STAR*D study
    Eugene Lin
    Vita Genomics, Inc, 7 Fl, No 6, Sec 1, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 9:935-46. 2008
  4. ncbi Gene-gene and gene-environment interactions in interferon therapy for chronic hepatitis C
    Eugene Lin
    Vita Genomics, Inc, 7 Fl, No 6, Sec 1, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 8:1327-35. 2007
  5. ncbi Pattern-recognition techniques with haplotype analysis in pharmacogenomics
    Eugene Lin
    Vita Genomics, Inc, Floor 7, Number 6, Section 1, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 8:75-83. 2007
  6. ncbi A case study of the utility of the HapMap database for pharmacogenomic haplotype analysis in the Taiwanese population
    Eugene Lin
    Vita Genomics Inc, Taipei, Taiwan
    Mol Diagn Ther 10:367-70. 2006
  7. ncbi An artificial neural network approach to the drug efficacy of interferon treatments
    Eugene Lin
    Vita Genomics, Inc, 7 Fl, No 6, Sec 1, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 7:1017-24. 2006
  8. ncbi Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population
    Tun Jen Hsiao
    College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
    Mol Diagn Ther 14:101-6. 2010
  9. ncbi A support vector machine approach to assess drug efficacy of interferon-alpha and ribavirin combination therapy
    Eugene Lin
    Vita Genomics, Taipei, Taiwan
    Mol Diagn Ther 12:219-23. 2008
  10. ncbi Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression
    Eugene Lin
    Vita Genomics, Inc, Taipei, Taiwan
    Rejuvenation Res 12:387-93. 2009

Collaborators

Detail Information

Publications18

  1. ncbi A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data
    Lung Cheng Huang
    Department of Psychiatry, National Taiwan University Hospital Yun Lin Branch, Taiwan
    J Transl Med 7:81. 2009
    ..In this work, our goal was to compare computational tools with and without feature selection for predicting chronic fatigue syndrome (CFS) using genetic factors such as single nucleotide polymorphisms (SNPs)...
  2. ncbi A Bayesian approach to gene-gene and gene-environment interactions in chronic fatigue syndrome
    Eugene Lin
    Vita Genomics, Inc, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 10:35-42. 2009
    ..In this work, our goal is to detect gene-gene and gene-environment interactions resulting from the analysis of chronic fatigue syndrome patients' genetic and demographic factors including SNPs, age, gender and BMI...
  3. ncbi Pharmacogenomics with antidepressants in the STAR*D study
    Eugene Lin
    Vita Genomics, Inc, 7 Fl, No 6, Sec 1, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 9:935-46. 2008
    ..Future research with independent replication in large sample sizes is needed to confirm the role of the candidate genes identified in the STAR*D study in antidepressant treatment response...
  4. ncbi Gene-gene and gene-environment interactions in interferon therapy for chronic hepatitis C
    Eugene Lin
    Vita Genomics, Inc, 7 Fl, No 6, Sec 1, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 8:1327-35. 2007
    ..In this work, our goal is to detect gene-gene and gene-environment interactions resulting from an analysis of chronic hepatitis C patients' clinical factors including SNPs, viral genotype, viral load, age and gender...
  5. ncbi Pattern-recognition techniques with haplotype analysis in pharmacogenomics
    Eugene Lin
    Vita Genomics, Inc, Floor 7, Number 6, Section 1, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 8:75-83. 2007
    ..These techniques may provide tools for clinical association studies and help find genes/SNPs involved in responses to therapeutic drugs or adverse drug reactions...
  6. ncbi A case study of the utility of the HapMap database for pharmacogenomic haplotype analysis in the Taiwanese population
    Eugene Lin
    Vita Genomics Inc, Taipei, Taiwan
    Mol Diagn Ther 10:367-70. 2006
    ..The goal of this work was to evaluate the feasibility of using SNP information of the Han Chinese in Beijing (CHB) population from the HapMap database for clinical association studies in the Taiwanese (TWN) population...
  7. ncbi An artificial neural network approach to the drug efficacy of interferon treatments
    Eugene Lin
    Vita Genomics, Inc, 7 Fl, No 6, Sec 1, Jung Shing Road, Wugu Shiang, Taipei, Taiwan
    Pharmacogenomics 7:1017-24. 2006
    ....
  8. ncbi Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population
    Tun Jen Hsiao
    College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
    Mol Diagn Ther 14:101-6. 2010
    ....
  9. ncbi A support vector machine approach to assess drug efficacy of interferon-alpha and ribavirin combination therapy
    Eugene Lin
    Vita Genomics, Taipei, Taiwan
    Mol Diagn Ther 12:219-23. 2008
    ..This therapeutic approach achieves an overall sustained response rate of approximately 40%, but treatment takes 6-12 months and patients often experience significant adverse reactions...
  10. ncbi Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression
    Eugene Lin
    Vita Genomics, Inc, Taipei, Taiwan
    Rejuvenation Res 12:387-93. 2009
    ..Analyses using logistic regression models confirmed the gene-gene interactions. The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner...
  11. ncbi Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder
    Eugene Lin
    Vita Genomics, Inc, Wugu Shiang, Taipei, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 33:1167-72. 2009
    ..The aim of this study was to explore whether interaction among these genes could contribute to the pharmacogenomics of short-term antidepressant response in a Taiwanese population with major depressive disorder (MDD)...
  12. ncbi Gene-gene interactions among genetic variants from obesity candidate genes for nonobese and obese populations in type 2 diabetes
    Eugene Lin
    Bioinformatics Division, Vita Genomics, Inc, Taipei County, Taiwan
    Genet Test Mol Biomarkers 13:485-93. 2009
    ..001). The results suggest that the single nucleotide polymorphisms from the obesity candidate genes may contribute to the risk of T2D independently and/or in an interactive manner according to the presence or absence of obesity...
  13. ncbi Association and interaction analyses of genetic variants in ADIPOQ, ENPP1, GHSR, PPARgamma and TCF7L2 genes for diabetic nephropathy in a Taiwanese population with type 2 diabetes
    Lawrence Shih Hsin Wu
    1Vita Genomics, Inc, Wugu Shiang, Taipei, Taiwan
    Nephrol Dial Transplant 24:3360-6. 2009
    ....
  14. ncbi Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene
    Dun Jen Hsiao
    College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
    Pharmacogenet Genomics 19:730-3. 2009
    ..2+/-0.1 vs. 2.1+/-0.1%; P<0.001) in the combined TT+TC carriers. In contrast, sibutramine caused no significant additional effect on weight loss (P = 0.078) or on body fat percentage loss (P = 0.441) in homozygous C allele carriers...
  15. ncbi A common variant in the adiponectin gene on weight loss and body composition under sibutramine therapy in obesity
    Tun Jen Hsiao
    College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
    Clin Pharmacol 2:105-10. 2010
    ..The results suggest that the SNP rs266729 of the ADIPOQ gene may contribute to weight reduction and fat loss in response to sibutramine therapy in Taiwanese obese patients...
  16. ncbi Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population
    Tun Jen Hsiao
    College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan
    Genes Nutr 8:137-44. 2013
    ..Our study indicates that the CC genotype of the GNB3 rs5443 SNP may predict higher obesity-related metabolic traits such as triglyceride and total cholesterol in non-obese Taiwanese subjects (but not in obese subjects)...
  17. ncbi Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders
    Eugene Lin
    Vita Genomics, Inc, Wugu Shiang, Taipei, Taiwan These authors contributed equally to this work
    Pharmgenomics Pers Med 1:1-6. 2008
    ..Future research with independent replication in large sample sizes is needed to confirm the role of the BDNF Val66Met polymorphism identified in this study...
  18. ncbi Lack of synergy of erythromycin combined with penicillin or cefotaxime against Streptococcus pneumoniae in vitro
    Eugene Lin
    Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701-3655, USA
    Antimicrob Agents Chemother 47:1151-3. 2003
    ..pneumoniae...