Wen sheng Wu

Summary

Affiliation: Tzu Chi University
Country: Taiwan

Publications

  1. ncbi request reprint Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells
    W S Wu
    Department of Medical Technology, Tzu Chi University, No 701, Chung Yang Rd, Sec 3, Hualien, Taiwan 970
    Biochem Biophys Res Commun 285:183-7. 2001
  2. ncbi request reprint ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a
    Wu Wen-Sheng
    Department of Medical Technology, Tzu Chi University, Hualien, Taiwan
    Oncogene 22:955-63. 2003
  3. ncbi request reprint Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2
    Wu Wen-Sheng
    Department of Medical Technology, Tzu Chi University, Taiwan
    J Biomed Sci 12:289-96. 2005
  4. ncbi request reprint Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2
    Wu Wen-Sheng
    Department of Medical Technology, Tzu Chi University, No 701, Chung Yang Rd, Sec 3, Hualien 970, Taiwan, ROC
    Cancer Lett 239:27-35. 2006
  5. ncbi request reprint Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2
    Wen sheng Wu
    Department of Medical Technology, Tzu Chi University, No 701, Chung Yang Road, Section 3, Hualien 970, Taiwan
    Mol Cancer Res 4:747-58. 2006
  6. ncbi request reprint The signaling mechanism of ROS in tumor progression
    Wen sheng Wu
    Department of Medical Technology, Tzu Chi University, No 701, Chung Yang Rd, Sec 3, Hualien 970, Taiwan
    Cancer Metastasis Rev 25:695-705. 2006
  7. doi request reprint Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species
    Wen sheng Wu
    Department of Medical Technology, Tzu Chi University, Hualien, Taiwan
    Cancer Metastasis Rev 27:303-14. 2008
  8. doi request reprint PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2
    Chi Tan Hu
    Research Centre for Hepatology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    Cell Signal 25:1457-67. 2013
  9. doi request reprint The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2
    Chi Tan Hu
    Research Centre for Hepatology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    J Biomed Sci 15:343-55. 2008
  10. doi request reprint The role of endosomal signaling triggered by metastatic growth factors in tumor progression
    Chi Tan Hu
    Research Centre for Hepatology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    Cell Signal 25:1539-45. 2013

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells
    W S Wu
    Department of Medical Technology, Tzu Chi University, No 701, Chung Yang Rd, Sec 3, Hualien, Taiwan 970
    Biochem Biophys Res Commun 285:183-7. 2001
    ..The results suggest that both saikosaponin a and TPA-induced HepG2 growth inhibition are associated with p-15(INK4a) and p-16(INK4b) gene expression and might be mediated by PKC signaling pathway...
  2. ncbi request reprint ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a
    Wu Wen-Sheng
    Department of Medical Technology, Tzu Chi University, Hualien, Taiwan
    Oncogene 22:955-63. 2003
    ..These results suggested that activation of ERK together with its downstream transcriptional machinery mediated p15(INK4b) and p16(INK4a) expression that led to HepG2 growth inhibition...
  3. ncbi request reprint Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2
    Wu Wen-Sheng
    Department of Medical Technology, Tzu Chi University, Taiwan
    J Biomed Sci 12:289-96. 2005
    ..Taken together, we concluded that PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition...
  4. ncbi request reprint Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2
    Wu Wen-Sheng
    Department of Medical Technology, Tzu Chi University, No 701, Chung Yang Rd, Sec 3, Hualien 970, Taiwan, ROC
    Cancer Lett 239:27-35. 2006
    ..Taken together, we conclude that PKCalpha may activate MEK, independently of Raf and Ras, to trigger sustained ERK (MAPK) signaling and cell cycle arrest of HepG2 induced by TPA...
  5. ncbi request reprint Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2
    Wen sheng Wu
    Department of Medical Technology, Tzu Chi University, No 701, Chung Yang Road, Section 3, Hualien 970, Taiwan
    Mol Cancer Res 4:747-58. 2006
    ..In conclusion, ROS play a central role in mediating TPA-triggered sustained PKC and ERK signaling for regulation of gene expression of integrins and E-cahedrin that are responsible for EMT and migration of HepG2...
  6. ncbi request reprint The signaling mechanism of ROS in tumor progression
    Wen sheng Wu
    Department of Medical Technology, Tzu Chi University, No 701, Chung Yang Rd, Sec 3, Hualien 970, Taiwan
    Cancer Metastasis Rev 25:695-705. 2006
    ....
  7. doi request reprint Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species
    Wen sheng Wu
    Department of Medical Technology, Tzu Chi University, Hualien, Taiwan
    Cancer Metastasis Rev 27:303-14. 2008
    ..In the future, ROS will be validated as the promising therapeutic targets for prevention of tumor metastasis...
  8. doi request reprint PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2
    Chi Tan Hu
    Research Centre for Hepatology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    Cell Signal 25:1457-67. 2013
    ..In conclusion, PKC is critical for mediating HGF-induced fluctuant ERK-paxillin signaling during cell migration, probably via triggering endosomal degradation of c-Met...
  9. doi request reprint The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2
    Chi Tan Hu
    Research Centre for Hepatology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    J Biomed Sci 15:343-55. 2008
    ..Our results demonstrated that Snail play diverse trans-regulatory roles in HepG2. Notably, we suggested that Snail may upregulate p15(INK4b) gene expression by directly activating its promoter...
  10. doi request reprint The role of endosomal signaling triggered by metastatic growth factors in tumor progression
    Chi Tan Hu
    Research Centre for Hepatology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    Cell Signal 25:1539-45. 2013
    ..Moreover, many critical regulators within the RTK signal pathway such as Grb2, p38, PKC and Src were also modulators of endocytosis. In the future, these may constitute a new category of targets for prevention of tumor metastasis...
  11. doi request reprint Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b
    Chi Tan Hu
    Research Centre for Hepatology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    FEBS J 277:1202-18. 2010
    ..In conclusion, Snail associates with EGR-1 and SP-1 to mediate TPA-induced transcriptional upregulation of p15(INK4b) in HepG2...
  12. doi request reprint Ethambutol induces PKC-dependent cytotoxic and antiproliferative effects on human retinal pigment cells
    Rong Kung Tsai
    Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Exp Eye Res 87:594-603. 2008
    ..In conclusion, EMB may exert toxic effects in RPE including suppression of cell growth, formation of cytoplasmic vacuoles and reduction of phagocytic functions via PKC signal pathway...
  13. pmc PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells
    Rong Kung Tsai
    Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Mol Vis 17:1564-76. 2011
    ..In the present study, we sought to identify the PKC isozyme(s) involved...
  14. pmc Enhanced PKCδ and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF
    Yu Jung Chen
    Department of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien, Taiwan
    PLoS ONE 7:e44937. 2012
    ..In conclusion, migration of RPE cells can be synergistically induced by HGF coupled with HB-EGF or EGF, which were mediated by enhanced PKCδ activation and ERK phosphorylation...
  15. ncbi request reprint Porcine heterotopic composite tissue allograft transplantation using a large animal model for preclinical studies
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC
    Chang Gung Med J 29:268-74. 2006
    ..Evidence has shown that small-animal model (rodents) immunotherapy protocols cannot be directly applied to humans. This study investigated whether a miniature porcine model is reproducible for preclinical studies...