C H Chen

Summary

Affiliation: Tzu Chi University
Country: Taiwan

Publications

  1. ncbi request reprint High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien, Taiwan
    Mol Psychiatry 4:33-8. 1999
  2. ncbi request reprint Systematic mutation analysis of the catechol O-methyltransferase gene as a candidate gene for schizophrenia
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Am J Psychiatry 156:1273-5. 1999
  3. ncbi request reprint Debrisoquine 4-hydroxylase (CYP2D6) genetic polymorphisms and susceptibility to schizophrenia in Chinese patients from Taiwan
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Psychiatr Genet 11:153-5. 2001
  4. ncbi request reprint Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Mol Psychiatry 4:566-71. 1999
  5. ncbi request reprint Systematic search for mutations in the human tissue inhibitor of metalloproteinases-3 (TIMP-3) gene on chromosome 22 and association study with schizophrenia
    C C Hung
    Department of Psychiatry, Tzu Chi General Hospital and Institute of Human Genetics, Tzu Chi University, Hualien City, Taiwan
    Am J Med Genet 105:275-8. 2001
  6. ncbi request reprint Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients
    Y H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Am J Med Genet 105:753-7. 2001
  7. doi request reprint Prevalence of metabolic syndrome among patients with schizophrenia or schizoaffective disorder in Taiwan
    M C Huang
    Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan
    Acta Psychiatr Scand 120:274-80. 2009
  8. doi request reprint Identification and molecular characterization of two novel chromosomal deletions associated with autism
    W H Chien
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Clin Genet 78:449-56. 2010
  9. doi request reprint Cytogenetic and molecular characterization of a three-generation family with chromosome 5p terminal deletion
    J S Fang
    Graduate Institute of Human Genetics, Tzu Chi University, Hualien, Taiwan
    Clin Genet 73:585-90. 2008
  10. ncbi request reprint Characteristics of postictal psychosis in a psychiatric center
    H C Liu
    Department of Psychiatry, Taipei City Psychiatric Center, Taiwan
    Psychiatry Clin Neurosci 55:635-9. 2001

Collaborators

Detail Information

Publications47

  1. ncbi request reprint High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien, Taiwan
    Mol Psychiatry 4:33-8. 1999
    ..Our finding needs further independent verification from other research groups and the clinical relevance of this preliminary observation deserves further study...
  2. ncbi request reprint Systematic mutation analysis of the catechol O-methyltransferase gene as a candidate gene for schizophrenia
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Am J Psychiatry 156:1273-5. 1999
    ..Recent linkage studies of schizophrenia and molecular studies of velocardiofacial syndrome suggest that the COMT gene might be a candidate gene for schizophrenia...
  3. ncbi request reprint Debrisoquine 4-hydroxylase (CYP2D6) genetic polymorphisms and susceptibility to schizophrenia in Chinese patients from Taiwan
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Psychiatr Genet 11:153-5. 2001
    ..Our data suggest that the CYP2D6 gene may not be a susceptibility gene for schizophrenia in Chinese schizophrenic patients...
  4. ncbi request reprint Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers
    C H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Mol Psychiatry 4:566-71. 1999
    ..In summary, our data support the finding that BDV infection might be a contributory factor to the pathogenesis of schizophrenia in the Chinese population...
  5. ncbi request reprint Systematic search for mutations in the human tissue inhibitor of metalloproteinases-3 (TIMP-3) gene on chromosome 22 and association study with schizophrenia
    C C Hung
    Department of Psychiatry, Tzu Chi General Hospital and Institute of Human Genetics, Tzu Chi University, Hualien City, Taiwan
    Am J Med Genet 105:275-8. 2001
    ..This finding supports that 22q12 is a schizophrenia susceptible region, and it is likely that there might be other genetic mutations in the neighborhood of the TIMP-3 gene locus that may contribute to the susceptibility of schizophrenia...
  6. ncbi request reprint Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients
    Y H Chen
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, Taiwan
    Am J Med Genet 105:753-7. 2001
    ..The result suggests that the c.-469delG and possibly other variants of the NR4A2 gene may be of relevance to the complex factors involved in the pathogenesis of schizophrenia...
  7. doi request reprint Prevalence of metabolic syndrome among patients with schizophrenia or schizoaffective disorder in Taiwan
    M C Huang
    Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan
    Acta Psychiatr Scand 120:274-80. 2009
    ..Because of ethnic differences in metabolic syndrome (MS) criteria, this study aimed to investigate the MS prevalence among patients with schizophrenia or schizoaffective disorder in Taiwan...
  8. doi request reprint Identification and molecular characterization of two novel chromosomal deletions associated with autism
    W H Chien
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Clin Genet 78:449-56. 2010
    ....
  9. doi request reprint Cytogenetic and molecular characterization of a three-generation family with chromosome 5p terminal deletion
    J S Fang
    Graduate Institute of Human Genetics, Tzu Chi University, Hualien, Taiwan
    Clin Genet 73:585-90. 2008
    ..Our study suggests that other factors besides the size and location of 5p deletions may modify the mental presentations of patients with 5p deletions...
  10. ncbi request reprint Characteristics of postictal psychosis in a psychiatric center
    H C Liu
    Department of Psychiatry, Taipei City Psychiatric Center, Taiwan
    Psychiatry Clin Neurosci 55:635-9. 2001
    ..9 +/- 10.7 years) prior to the development of postictal psychosis than has been previously reported. The possible mechanisms in the pathophysiology of psychosis in epileptics were discussed...
  11. doi request reprint A novel microdeletion at chromosome 2q31.1-31.2 in a three-generation family presenting duplication of great toes with clinodactyly
    L P Tsai
    Department of Pediatrics, Tzu Chi General Hospital, Xindian, Taipei, Taiwan
    Clin Genet 75:449-56. 2009
    ....
  12. ncbi request reprint Lack of evidence to support the association of the human prion gene with schizophrenia
    M T Tsai
    Department of Psychiatry, Tzu Chi General Hospital, Hualien City, 970 Taiwan
    Mol Psychiatry 6:74-8. 2001
    ..Besides, no other mutations in the prion gene were identified in these 62 patients. Hence, our results suggest that the prion gene may not play a major role in conferring susceptibility to schizophrenia...
  13. ncbi request reprint The Chinese version of the Davidson Trauma Scale: a practice test for validation
    C H Chen
    Department of Psychiatry, Tsao-Tun Psychiatric Center, Nantao, Taiwan
    Psychiatry Clin Neurosci 55:493-9. 2001
    ..The psychometric strength of DTS-C is reliable for its future use, particularly for screening for subjects with possible diagnosis of PTSD...
  14. ncbi request reprint Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population
    W H Lin
    Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road, Section 2, Taipei, 11529 Taiwan
    Diabetologia 49:1214-21. 2006
    ..1, a region previously shown to harbour type 2 diabetes susceptibility genes. We investigated whether the SLC2A10 gene could be a type 2 diabetes susceptibility gene in the Taiwanese population...
  15. ncbi request reprint Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia
    C H Chen
    Division of Psychiatry, Cheng Hsin Rehabilitation and Medical Center, Taipei, Taiwan
    Am J Med Genet 74:40-3. 1997
    ..Our study does not support the contention that the Ser9Gly polymorphism of the DRD3 gene plays a major role in schizophrenia...
  16. ncbi request reprint The homozygote AA genotype of the alpha1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women
    J J Lin
    Department of Neurology, Chushang Show Chwan Hospital, 75 Sec 2 Chi Shang Road, Chushang Jenn, Nantou 557, Taiwan
    Parkinsonism Relat Disord 10:469-73. 2004
    ..796, 95% CI=0.749-0.847, p<0.0001). This study shows that ACT-AA may confer a modest protection against developing early-onset PD in women...
  17. pmc Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    Hwai I Yang
    Genomics Research Center, Academia Sinica and Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 100:1134-43. 2008
    ..We examined the HCC risk associated with HBV genotypes and common variants in the precore and basal core promoter (BCP) regions...
  18. ncbi request reprint Genetic polymorphisms of the promoter region of dopamine D2 receptor and dopamine transporter genes and alcoholism among four aboriginal groups and Han Chinese in Taiwan
    W J Chen
    Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Psychiatr Genet 11:187-95. 2001
    ..The results suggest that both the DRD2 promoter region and the DAT gene do not play a significant role in conferring vulnerability to alcoholism...
  19. ncbi request reprint Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problems
    H G Hwu
    Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan
    Am J Med Genet 96:797-800. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:797-800, 2000...
  20. ncbi request reprint A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females
    J J Lin
    Department of Neurology, Chushang Show Chwan Hospital, Nantou, 557, Taiwan, ROC
    Parkinsonism Relat Disord 12:9-13. 2006
    ..576, P = 0.030). In conclusion, results of this study indicate the pCD14 polymorphism to be a genetic risk factor for PD in females...
  21. ncbi request reprint Interacting factors of students' perceptions on an effective curriculum
    A P Fan
    Taipei, Taiwan
    Med Educ 38:1196-7. 2004
  22. ncbi request reprint Functional mutation in the promoter region of thrombomodulin gene in relation to carotid atherosclerosis
    Y H Li
    Department of Internal Medicine, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, 70428, Tainan, Taiwan, ROC
    Atherosclerosis 154:713-9. 2001
    ..Our findings suggest that G-33A mutation reduces the thrombomodulin promoter activity and is associated with carotid atherosclerosis in younger subjects...
  23. pmc IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice
    J F Klement
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110, USA
    Mol Cell Biol 16:2341-9. 1996
    ..An increased percentage of monocytes/macrophages was detected in spleen cells taken from 5-, 7-, and 9-day-old pups. Death is accompanied by severe widespread dermatitis and increased levels of TNF-alpha mRNA in the skin...
  24. ncbi request reprint Endoscopic detection of colonic tuberculosis in an asymptomatic patient
    C C Yang
    Division of Gastroenterology, Department of Internal Medicine, Show Chwan Memorial Hospital, Taiwan, Republic of China
    Endoscopy 39:E40. 2007
  25. ncbi request reprint An integrated healthcare enterprise information portal and healthcare information system framework
    S L Hsieh
    Inf Syst Office, Nat Taiwan Univ Hosp, Taipei, Taiwan
    Conf Proc IEEE Eng Med Biol Soc 1:4731-4. 2006
    ..The preliminary performance of multi-media, time-based data exchanges over the wireless HEIP side is collected to evaluate the efficiency of the architecture...
  26. ncbi request reprint [Correlations of father's attitudes regarding breast feeding, father-infant attachment and marital adjustment]
    S C Yang
    Department of Nursing, Chungtai Institute of Health Sciences and Technology
    Hu Li Yan Jiu 9:279-88. 2001
    ..This study reveals the importance of evaluating fathers' attitudes regarding breast-feeding and marital adjustment in terms of enhancing family-centered nursing and breast-feeding compliance...
  27. ncbi request reprint [Maternal concerns and social support during postpartum period]
    H R Cheng
    Department of Nursing, Chung Hwa College of Medical Technology
    Hu Li Yan Jiu 9:322-32. 2001
    ..It is suggested that postpartum health education should provide more information and technical practice focusing on maternal role. Obstetric nurses and community health nurses should enhance postnatal follow-up...
  28. doi request reprint Diagnosis and development of screening items for migraine in neurological practice in Taiwan
    Shuu Jiun Wang
    Neurological Institute, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, 201 Section 2 Shih Pai Road, Taipei, Taiwan
    J Formos Med Assoc 107:485-94. 2008
    ....
  29. ncbi request reprint Hydroxymethylbilane synthase: complete genomic sequence and amplifiable polymorphisms in the human gene
    H W Yoo
    Division of Medical and Molecular Genetics, Mount Sinai School of Medicine, New York, New York 10029
    Genomics 15:21-9. 1993
    ..abstract truncated at 250 words)..
  30. pmc Variation in dinucleotide (GT) repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro
    P S Gao
    J Med Genet 41:535-9. 2004
  31. ncbi request reprint A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia-stimulated TNF alpha production
    H L Eng
    Department of Pathology, Chang Gung University and Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan, Republic of China
    Genes Immun 5:426-30. 2004
    ..In conclusion, the single base pair polymorphism of CD14 promoter gene is associated with CD14 expression and Chlamydia-stimulated TNFalpha production, and may thus play some role in the chlamydia-induced inflammatory response...
  32. ncbi request reprint Serum PCDD/F concentration distribution in residents living in the vicinity of an incinerator and its association with predicted ambient dioxin exposure
    H L Chen
    The Institute of Basic Medical Sciences, Taiwan, ROC
    Chemosphere 54:1421-9. 2004
    ..Results also suggest that ambient exposure might not be the most important contributor to serum concentrations when compared to other exposure sources, such as dietary intake...
  33. ncbi request reprint Community-based epidemiological study on hypertension in Pu-Li, Taiwan
    P Chou
    Institute of Public Health, National Yang-Ming Medical College, Taipei, Republic of China, Taiwan
    Am J Hypertens 5:608-15. 1992
    ..6, 95% CI 1.6 to 7.8), physical activity (frequent v infrequent, OR 0.4, 95% CI 0.2 to 0.7), and alcohol intake (yes v no, OR 2.3, 95% CI 1.1 to 4.6).(ABSTRACT TRUNCATED AT 250 WORDS)..
  34. pmc Sequences in the NS5A protein of hepatitis C virus and the serum alanine aminotransferase response to interferon therapy in Japanese patients
    K Nagayama
    Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan, 113-8519
    Gut 48:830-5. 2001
    ..0; 95% confidence interval 5.0-286) in multivariate analyses. CONCLUSIONS: A HCV genomic region that correlates with the ALT response to IFN therapy appears to be present in virologically IFN ineffective patients...
  35. ncbi request reprint Deletion mapping of chromosome 16q24 in hepatocellular carcinoma in Taiwan and mutational analysis of the 17-beta-HSD gene localized to the region
    Y W Lin
    Department of Internal Medicine, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cancer 93:74-9. 2001
    ..Furthermore, the presence of the other 2 frequent LOH regions suggest that the putative tumor suppressor genes at these locations might be involved in the development of HCC...
  36. pmc Detection and typing of vancomycin-resistance genes of enterococci from clinical and nosocomial surveillance specimens by multiplex PCR
    J J Lu
    Department of Pathology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
    Epidemiol Infect 126:357-63. 2001
    ..9% and 100%, respectively. The results suggest that genotypic characterization of vancomycin-resistance is necessary for all clinical VRE isolates and that the multiplex PCR assay can be an alternative method for this purpose...
  37. ncbi request reprint Breastfeeding knowledge and attitudes of health professionals and students
    C H Chen
    Division of Neonatology, Department of Pediatrics, Taichung Veterans General Hospital, 160, Chung-Kang Road, Sec. 3, Taichung 407, Taiwan
    Acta Paediatr Taiwan 42:207-11. 2001
    ..The mechanism of lactation, management of breast problems and infant problems, contraindications for breastfeeding, the properties of human milk and the benefits of breastfeeding for the infant should all be included...
  38. ncbi request reprint Women's perceptions of helpful and unhelpful nursing behaviors during labor: a study in Taiwan
    C H Chen
    College of Nursing, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Rd, Kaohsiung, Taiwan, ROC
    Birth 28:180-5. 2001
    ..The findings may help obstetric team members better understand patients' needs, and enable them to provide better support during labor and to prevent unhelpful nursing behaviors...
  39. ncbi request reprint Functional correlates of central arterial geometric phenotypes
    A Scuteri
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Hypertension 38:1471-5. 2001
    ..The interplay among these factors, particularly circumferential wall and FSS, likely determines the CGP; conversely, the resultant CGP may modulate the FSS and wall stress for a given pressure and flow...
  40. ncbi request reprint A study comparing precision of the maximum multipoint heterogeneity LOD statistic to three model-free multipoint linkage methods
    S J Finch
    Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, New York, USA
    Genet Epidemiol 21:315-25. 2001
    ..The marker loci with maximum value of the Kong and Cox extensions of the NPL statistic also were closer to the trait locus than the marker locus with maximum value of the NPL statistic...
  41. ncbi request reprint Two-trait-locus linkage analyses of asthma susceptibility
    S K Nath
    Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th St, Oklahoma City, OK 73104, USA
    Genet Epidemiol 21:S278-83. 2001
    ..The regions where hold or nonparametric linkage scores were greater than 2.0 were selected for further investigation using two-trait-locus linkage analysis models...
  42. ncbi request reprint Transmission/disequilibrium test analysis of total serum IgE levels in the Hutterite and Collaborative Study on the Genetics of Asthma data sets
    C M Jedrey
    Dept. of Epidemiology and Biostatistics, Case Western Reserve University, MetroHealth Medical Center, R-258, 2500 MetroHealth Dr, Cleveland, OH 44109, USA
    Genet Epidemiol 21:S298-302. 2001
    ..Statistically significant results common to both data sets were found on chromosomes 1 and 3. A noteworthy result, significant at p < 10(-4), was detected on chromosome 18 in the Hutterites...
  43. ncbi request reprint Aspirin differentially regulates endotoxin-induced IL-12 and TNF-alpha production in human dendritic cells
    L J Ho
    Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Scand J Rheumatol 30:346-52. 2001
    ..CONCLUSION: The various effects of aspirin on LPS-stimulated DC may influence the understanding of the diverse immunomodulatory mechanisms of this anti-inflammatory drug...
  44. ncbi request reprint Prevalence and clinical implications of hepatitis B virus genotypes in southern Taiwan
    C M Lee
    Liver Unit, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Scand J Gastroenterol 38:95-101. 2003
    ..Hepatitis B virus (HBV) infection is a major health problem. HBV genotypes may be associated with progression of liver disease. The distribution and clinical implications of HBV genotypes in southern Taiwan are evaluated...
  45. ncbi request reprint Free radical-scavenging activity of Taiwanese native plants
    W C Hou
    Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei, Taiwan
    Phytomedicine 10:170-5. 2003
    ..buerferianum var. formosanum, C. japonica var. morii, C. stenophylla var. stenophylloides, and M. zuihoensis with great potency in these assay systems and may be candidates for the development of natural antioxidants...
  46. ncbi request reprint Epidemiology of otitis media in Chinese children
    C H Chen
    Department of Otorhinolaryngology, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan judith
    Clin Otolaryngol Allied Sci 28:442-5. 2003
    ..4% for 4-year-olds, 11.8% for 5-year-olds, and 6.1% for 6-year-olds. Considering the genetic factors and the previous history of otitis media, there was a significant difference between the normal group and the sick group...
  47. ncbi request reprint B-group vitamins, MTHFR C677T polymorphism and carotid intima-media thickness in clinically healthy subjects
    C S Liu
    Department of Neurology, Chung Shan Medical University Hospital, Taichung, Taiwan
    Eur J Clin Nutr 61:996-1003. 2007
    ..Plasma B-group vitamins and age may affect the carotid intima-media thickness (IMT) in subjects with different 677TT genotype of the methylenetetrahydrofolate reductase (MTHFR) gene...