Yen Kuang Yang

Summary

Affiliation: Tri-Service General Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Associated alterations of striatal dopamine D2/D3 receptor and transporter binding in drug-naive patients with schizophrenia: a dual-isotope SPECT study
    Yen Kuang Yang
    Department of Psychiatry, Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan 704, ROC
    Am J Psychiatry 161:1496-8. 2004
  2. doi request reprint Association between DRD2, 5-HTTLPR, and ALDH2 genes and specific personality traits in alcohol- and opiate-dependent patients
    Tzu Yun Wang
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Behav Brain Res 250:285-92. 2013
  3. ncbi request reprint Association between cognitive performance and striatal dopamine binding is higher in timing and motor tasks in patients with schizophrenia
    Yen Kuang Yang
    Department of Psychiatry, College of Medicine, National Cheng Kung University and University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan
    Psychiatry Res 131:209-16. 2004
  4. doi request reprint Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese
    Ming Chuan Hu
    Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 40:144-8. 2013
  5. doi request reprint MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence
    Sheng Yu Lee
    Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
    Alcohol Clin Exp Res 34:1212-8. 2010
  6. doi request reprint Interaction between novelty seeking and the aldehyde dehydrogenase 2 gene in heroin-dependent patients
    Sheng Yu Lee
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Psychopharmacol 33:386-90. 2013
  7. doi request reprint The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence
    Tzu Yun Wang
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 43:134-9. 2013
  8. doi request reprint Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers--a SPECT study
    Po See Chen
    Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
    Neuroimage 56:1526-30. 2011
  9. doi request reprint COMT and BDNF interacted in bipolar II disorder not comorbid with anxiety disorder
    Sheng Yu Lee
    Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
    Behav Brain Res 237:243-8. 2013
  10. doi request reprint The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study
    Shih Hsien Lin
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Eur Neuropsychopharmacol 22:647-50. 2012

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Associated alterations of striatal dopamine D2/D3 receptor and transporter binding in drug-naive patients with schizophrenia: a dual-isotope SPECT study
    Yen Kuang Yang
    Department of Psychiatry, Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan 704, ROC
    Am J Psychiatry 161:1496-8. 2004
    ....
  2. doi request reprint Association between DRD2, 5-HTTLPR, and ALDH2 genes and specific personality traits in alcohol- and opiate-dependent patients
    Tzu Yun Wang
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Behav Brain Res 250:285-92. 2013
    ..Higher NS and HA traits were found in both patient groups with the interaction with DRD2, 5-HTTLPR, and ALDH2 genes. The ALDH2 gene variants had different effect in the NS and HA dimension while the DRD2 and 5-HTTLPR genes did not. ..
  3. ncbi request reprint Association between cognitive performance and striatal dopamine binding is higher in timing and motor tasks in patients with schizophrenia
    Yen Kuang Yang
    Department of Psychiatry, College of Medicine, National Cheng Kung University and University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan
    Psychiatry Res 131:209-16. 2004
    ..A decrease in striatal dopamine D(2) receptor density seems to be associated with impaired performance on optimal timing tasks and motor processing in patients with schizophrenia...
  4. doi request reprint Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese
    Ming Chuan Hu
    Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 40:144-8. 2013
    ..Therefore, we examined whether the DRD2TaqIA and MAOA-uVNTR gene polymorphisms are susceptibility factors for alcoholism comorbid with bipolar disorder (ALC+BP) in Han Chinese in Taiwan...
  5. doi request reprint MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence
    Sheng Yu Lee
    Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
    Alcohol Clin Exp Res 34:1212-8. 2010
    ..The aim of this study was to determine whether the interaction between the MAOA and the ALDH2 genes is associated with ANX/DEP ALC...
  6. doi request reprint Interaction between novelty seeking and the aldehyde dehydrogenase 2 gene in heroin-dependent patients
    Sheng Yu Lee
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Psychopharmacol 33:386-90. 2013
    ..Heroin dependence is a multifactor disorder. We investigated the association of genetic factors and heroin-dependent temperaments to determine whether a temperament-gene interaction is involved in the pathogenesis of heroin dependence...
  7. doi request reprint The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence
    Tzu Yun Wang
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 43:134-9. 2013
    ..We conclude that the protective effect of the ALDH2 polymorphism against heroin dependence may be modified by the ADH1B and DRD2 polymorphism...
  8. doi request reprint Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers--a SPECT study
    Po See Chen
    Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
    Neuroimage 56:1526-30. 2011
    ..These results together with the known role of the GNβ3 gene might provide further evidence to support the common effect of the striatal dopamine system on mood and metabolic regulation...
  9. doi request reprint COMT and BDNF interacted in bipolar II disorder not comorbid with anxiety disorder
    Sheng Yu Lee
    Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
    Behav Brain Res 237:243-8. 2013
    ..Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the involvement of dopaminergic pathway in the pathogenesis of bipolar-II...
  10. doi request reprint The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study
    Shih Hsien Lin
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Eur Neuropsychopharmacol 22:647-50. 2012
    ..A significant negative association between SERT availability and time to relapse among those who relapsed (N=7) was found...
  11. pmc Interaction between serotonin transporter and serotonin receptor 1 B genes polymorphisms may be associated with antisocial alcoholism
    Tzu Yun Wang
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Behav Brain Funct 8:18. 2012
    ..Therefore, we examined whether the 5-HTTLPR gene and 5-HT1B gene G861C polymorphism are susceptibility factors for a specific subtype of alcoholism, antisocial alcoholism in Han Chinese in Taiwan...
  12. doi request reprint Gene-temperament interactions might distinguish between bipolar I and bipolar II disorders: a cross-sectional survey of Han Chinese in Taiwan
    Yi Ann Lu
    Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Psychiatry 73:339-45. 2012
    ..In this study, we sought to clarify the relationship between bipolar I and bipolar II disorder...
  13. doi request reprint The functionality and economic costs of outpatients with schizophrenia in Taiwan
    I Hui Lee
    Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70428, Taiwan
    Psychiatry Res 158:306-15. 2008
    ..Overall, the indirect costs of treating schizophrenia were higher than the direct costs. Improving patients' functionality and decreasing caregivers' burden are essential to reducing costs...
  14. doi request reprint The role of valproate in metabolic disturbances in bipolar disorder patients
    Hui Hua Chang
    Institute of Biopharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan
    J Affect Disord 124:319-23. 2010
    ....
  15. doi request reprint Neuropsychological functions in Han Chinese patients in Taiwan with bipolar II disorder comorbid and not comorbid with alcohol abuse/alcohol dependence disorder
    Cindy Shan
    Institute of Behavioral Medicine, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 35:131-6. 2011
    ....
  16. doi request reprint Temperamentsxgenes in bipolar I and bipolar II disorder patients
    Ching I Lin
    Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R O C
    Psychiatry Res 177:364-6. 2010
    ..This study provided evidence that differences existed between BP-I and BPII in gene and temperament interactions...
  17. doi request reprint The ALDH2 and 5-HT2A genes interacted in bipolar-I but not bipolar-II disorder
    Sheng Yu Lee
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 38:247-51. 2012
    ..We examined the association of the ALDH2 and 5-HT2A-A1438G polymorphisms with bipolar I and II and possible interactions between these genes...
  18. doi request reprint Neuropsychological functions in bipolar disorders I and II with and without comorbid alcohol dependence
    Yun Hsuan Chang
    Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 37:211-6. 2012
    ..We aimed to identify the neuropsychological performance of BP patients with and without comorbid ALD in partial remission from depression or mania, and compare it with that of healthy controls (HCs)...
  19. doi request reprint A study on the sleep quality of incoming university students
    Shu Hui Cheng
    Office of Student Affairs, National Cheng Kung University, Tainan, Taiwan
    Psychiatry Res 197:270-4. 2012
    ....
  20. doi request reprint The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder
    Sheng Yu Lee
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    World J Biol Psychiatry 12:385-91. 2011
    ..CONCLUSIONS. We provide initial evidence that the COMT Val158Met and DRD3 Ser9Gly genotypes interact in bipolar I and bipolar II disorders and that bipolar I and bipolar II are genetically distinct...
  21. doi request reprint Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers-a two isotopes SPECT study
    I Hui Lee
    Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, 70428, Taiwan, Republic of China
    Psychopharmacology (Berl) 214:617-24. 2011
    ..Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability...
  22. ncbi request reprint Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholism
    Cheng Yi Hahn
    Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Arch Gen Psychiatry 63:817-23. 2006
    ....
  23. pmc Striatal dopamine transporter availability in drug-naive patients with schizophrenia: a case-control SPECT study with [(99m)Tc]-TRODAT-1 and a meta-analysis
    Kao Chin Chen
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Schizophr Bull 39:378-86. 2013
    ..Our findings suggest that striatal DAT levels are not altered in the early stages of schizophrenia before medication is introduced. We identified gender differences and aging effects that could have significance for future studies...
  24. pmc Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers
    Pei Chun Hsieh
    Department of Psychiatry, National Cheng Kung University Hospital and Dou liou Branch, Tainan, Taiwan
    J Psychiatry Neurosci 35:90-4. 2010
    ....
  25. doi request reprint Interaction of the DRD3 and BDNF gene variants in subtyped bipolar disorder
    Sheng Yu Lee
    Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 39:382-7. 2012
    ..Because BDNF regulates DRD3 expression (1), we also examined possible interactions between these genes...
  26. doi request reprint Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment
    Shiou Lan Chen
    Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Neuroimmune Pharmacol 7:1025-33. 2012
    ..We conclude that dextromethorphan might be a feasible adjuvant therapeutic for attenuating inflammation and inhibiting methadone tolerance and combined opioid use in heroin-dependent patients...
  27. doi request reprint The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder
    Sheng Yu Lee
    Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
    J Affect Disord 138:295-300. 2012
    ..Decreases in YMRS scores were greater in patients with the A1A1 (P=0.004) genotypes than with the A2A2 genotype. We conclude that the DRD2/ANKK1 TaqIA polymorphism influenced responses to DM by decreasing manic symptoms in BP patients...
  28. doi request reprint Low anxiety disorder comorbidity rate in bipolar disorders in Han Chinese in Taiwan
    Yun Hsuan Chang
    Division of Clinical Psychology, Institute of Allied Health Sciences, Department of Psychiatry, College of Medicine, National Cheng Kung University, and National Cheng Kung University Hospital, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 36:194-7. 2012
    ..The authors explored the comorbidity of anxiety disorders in different bipolar disorder subtypes in Han Chinese in Taiwan...
  29. doi request reprint The aldehyde dehydrogenase 2 gene is associated with heroin dependence
    Tzu Yun Wang
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Drug Alcohol Depend 120:220-4. 2012
    ..Therefore, we investigated the association between the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms and heroin dependence...
  30. doi request reprint Treatment response and cognitive impairment in major depression: association with C-reactive protein
    Hui Hua Chang
    Institute of Biopharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Brain Behav Immun 26:90-5. 2012
    ..Whether adjunctive anti-inflammatory medication may help to preserve cognitive function merits further investigation...
  31. doi request reprint Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study
    Pei Chun Hsieh
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Psychiatry Res 184:157-61. 2010
    ....
  32. doi request reprint Factors associated with premenstrual syndrome - a survey of new female university students
    Shu Hui Cheng
    Office of Student Affairs, National Cheng Kung University, Tainan, Taiwan
    Kaohsiung J Med Sci 29:100-5. 2013
    ..The results show that PMS is prevalent among new female university students and that lifestyle and nutritional/metabolic factors may play a role in this disorder...
  33. pmc Inflammation in patients with schizophrenia: the therapeutic benefits of risperidone plus add-on dextromethorphan
    Shiou Lan Chen
    Institute of Behavioral Medicine, Tainan, Taiwan
    J Neuroimmune Pharmacol 7:656-64. 2012
    ..Risp+ DM was more beneficial and less toxic than Risp-only treatment.Clinical Trial Registration: Protocol Record: HR-93-50; Trial Registration number: NCT01189006; URL: http://www.clinicaltrials.gov...
  34. ncbi request reprint Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers--a SPECT study
    Po See Chen
    Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, Taiwan
    Neuroimage 40:275-9. 2008
    ..These results suggest that the striatal dopamine system may be involved in body mass index regulation. Thus, molecular imaging studies measuring the striatal DAT availability should consider the BMI, rather than age, as a covariant...
  35. doi request reprint TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients
    Hsuan Chi Wang
    Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Psychopharmacology (Berl) 213:773-9. 2011
    ....
  36. doi request reprint Neuropsychological functions impairment in different subtypes of bipolar disorder with or without comorbid anxiety disorders
    Chiao Ting Chang
    Institute of Behavioral Medicine, Tainan, Taiwan
    Psychiatry Res 200:246-51. 2012
    ..However, significant effects were found only in BP-II(+AD) patients compared with BPII(-AD) patients. We hypothesized that comorbid AD worsens neuropsychological performance more in BP-II than in BP-I patients...
  37. doi request reprint Availability of dopamine and serotonin transporters in opioid-dependent users--a two-isotope SPECT study
    Tzung Lieh Yeh
    Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, 704, Taiwan
    Psychopharmacology (Berl) 220:55-64. 2012
    ..The aims of this study were to examine the differences between 32 opioid-dependent users treated with a very low dose of methadone or undergoing methadone-free abstinence and 32 controls...
  38. ncbi request reprint Correlation between striatal dopamine D2/D3 receptor binding and cardiovascular activity in healthy subjects
    Tzung Lieh Yeh
    Department of Psychiatry, National Cheng Kung University Medical Center, and Department of Neurology, Cheng Ching Hospital, Tainan, Taiwan
    Am J Hypertens 19:964-9. 2006
    ..The relationship between the striatal dopaminergic system and cardiovascular activity is not well known. The aim of this study is to investigate the relationship between striatal D2/D3 receptor binding and cardiovascular activity...
  39. doi request reprint C825T polymorphism of the GNB3 gene on valproate-related metabolic abnormalities in bipolar disorder patients
    Hui Hua Chang
    Institute of Biopharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan
    J Clin Psychopharmacol 30:512-7. 2010
    ..In the current study, we investigated the possible associations between the GNB3 variation and VPA-induced metabolic abnormalities...
  40. doi request reprint No changes in striatal dopamine transporter in antidepressant-treated patients with major depression
    Cheng Kuan Wu
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Int Clin Psychopharmacol 28:141-4. 2013
    ..58), as the Hamilton Depression Rating Scale score decreased (P=0.02). Striatal DAT availability remains intact during long-term antidepressant treatment in patients with major depressive disorder...
  41. doi request reprint Association between cholesterol plasma levels and craving among heroin users
    Shih Hsien Lin
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Addict Med 6:287-91. 2012
    ..To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving...
  42. doi request reprint Schizotypy trait and striatal dopamine receptors in healthy volunteers
    Kao Chin Chen
    Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
    Psychiatry Res 201:218-21. 2012
    ..Our findings demonstrated that the availability of striatal DA D(2/3) receptors may be associated with schizotypal features in healthy volunteers...
  43. doi request reprint Association of novelty seeking scores and striatal dopamine D₂/D₃ receptor availability of healthy volunteers: single photon emission computed tomography with ¹²³i-iodobenzamide
    Hsiang Yu Huang
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan Department of Psychiatry, Tainan Municipal Hospital, 138 Shen Li Road, Tainan, Taiwan
    J Formos Med Assoc 109:736-9. 2010
    ..25, p =0.07). A positive association was noted between the NS scores and left striatal D(2)/D(3) receptor availability (r= 0.29, p =0.04). The results suggest that a relationship might exist between NS score and dopaminergic activity...
  44. doi request reprint The risk factors of Internet addiction--a survey of university freshmen
    Hsing Fang Tsai
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Psychiatry Res 167:294-9. 2009
    ..Internet addiction is prevalent among university freshmen in Taiwan. Risk factors included male gender, habit of skipping breakfast, mental health morbidity, deficient social support; and neurotic personality characteristics...
  45. doi request reprint The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorder
    Sheng Yu Lee
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Pharmacogenet Genomics 20:500-6. 2010
    ..We examined the association of the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms with bipolar I and II disorders and possible interactions between these genes...
  46. doi request reprint Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1
    Ting Ting Chang
    Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
    Bipolar Disord 12:102-6. 2010
    ..Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients...
  47. ncbi request reprint Striatal dopamine D2/D3 receptor availability in male smokers
    Yen Kuang Yang
    Department of Psychiatry, College of Medicine, National Cheng Kung University, 138, Sheng Li Road, Tainan 704, Taiwan
    Psychiatry Res 146:87-90. 2006
    ..There was no significant difference in striatal D(2)/D(3) receptor availability between smokers and controls...
  48. ncbi request reprint Correlation between fine motor activity and striatal dopamine D2 receptor density in patients with schizophrenia and healthy controls
    Yen Kuang Yang
    Department of Psychiatry, College of Medicine, National Cheng Kung University and University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan, ROC
    Psychiatry Res 123:191-7. 2003
    ..FTT may be a more sensitive tool for detecting neuroleptic-induced motor impairment in patients with schizophrenia. The sensitivity of the FTT to age and neuroleptic effects may be explained in part by a decline in dopamine D2 density...
  49. ncbi request reprint Norms of performance of sustained attention among a community sample: Continuous Performance Test study
    Pei Chun Hsieh
    Department of Psychiatry, College of Medicine, National Cheng Kung University and Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan
    Psychiatry Clin Neurosci 59:170-6. 2005
    ..When classifying a patient as case or non-case, his/her CPT performance should be considered relative to the norms for his/her gender, age, and educational levels...
  50. doi request reprint Genotype variant associated with add-on memantine in bipolar II disorder
    Sheng Yu Lee
    Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
    Int J Neuropsychopharmacol 17:189-97. 2014
    ..004). We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II. ..
  51. doi request reprint Gender-specific association of the SLC6A4 and DRD2 gene variants in bipolar disorder
    Tzu Yun Wang
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Int J Neuropsychopharmacol 17:211-22. 2014
    ..We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder. ..
  52. doi request reprint Probing the association between dexamethasone-induced cortisol suppression and serotonin transporter availability among drug-free patients with major depressive disorder--a small-sample SPECT study with [¹²³I]ADAM
    Hsin Chun Tsai
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Douliou Branch, Yunlin, Taiwan
    Psychoneuroendocrinology 38:2805-9. 2013
    ..The association was significant when considering all participants (ρ=0.69, p=0.002). This association may have clinical implications for the treatment of MDD. ..
  53. doi request reprint Intercorrelations between the Personal and Social Performance Scale, cognitive function, and activities of daily living
    Pei Chun Hsieh
    Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, Taiwan
    J Nerv Ment Dis 199:513-5. 2011
    ..Positive correlations between the total PSP scale score and performance in the WMS-R, CPT, and ADL scores were identified. The PSP score was found to be of good reliability for cognitive function and ADL evaluation...
  54. ncbi request reprint Correlation between scores on Continuous Performance Test and plasma concentration for schizophrenic patients on risperidone
    Po See Chen
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Psychiatry Clin Neurosci 58:168-72. 2004
    ..Both RIS and 9-OH-RIS have an impact on the CPT performance of schizophrenic patients. Optimal active moiety plasma concentration for best cognitive performance needs further study...
  55. doi request reprint Serotonin transporter availability in the midbrain and perceived social support in healthy volunteers
    Hsiang Yu Huang
    Department of Psychiatry, Tainan Municipal Hospital, Tainan, Taiwan
    J Psychosom Res 75:577-81. 2013
    ..This study aimed to examine the correlation between serotonin transporter (SERT) availability and perceived social support scores in healthy volunteers...
  56. pmc Neuroprotective and neurogenesis agent for treating bipolar II disorder: Add-on memantine to mood stabilizer works
    Ru Band Lu
    Department of Psychiatry, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan Institute of Behavioral Medicine, Tainan, Taiwan Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Med Hypotheses 79:280-3. 2012
    ....
  57. doi request reprint Association between somatization subscale score and serotonin transporter availability in healthy volunteers--a single photon emission computed tomography study with [¹²³I] ADAM
    Ming Hui Chou
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Psychopharmacology (Berl) 219:1011-6. 2012
    ..This study aims to examine the correlation between somatization subscale score and serotonin transporter (SERT) availability in healthy volunteers...
  58. ncbi request reprint The psychological well-being and associated factors of caregivers of outpatients with schizophrenia in Taiwan
    Po See Chen
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Psychiatry Clin Neurosci 58:600-5. 2004
    ..Health care providers should consider the patients and their caregivers as a whole and provide psychoeducaiton to reduce the negative psychological impact of caregivers...
  59. ncbi request reprint The relationship among insight, cognitive function of patients with schizophrenia and their relatives' perception
    Kao Ching Chen
    Department of Psychiatry, National Cheng Kung University Medical Center, Tainan, Taiwan
    Psychiatry Clin Neurosci 59:657-60. 2005
    ..could influence insight of patients will still be a controversial issue. Further multidimensional survey of the relationship with insight in a larger and comprehensive design is necessary...
  60. ncbi request reprint The association between the Lie scale of the Maudsley personality inventory and striatal dopamine D2/D3 receptor availability of healthy Chinese community subjects
    Chieh Liang Huang
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan, ROC
    Eur Psychiatry 21:62-5. 2006
    ..Individual with higher Lie scale scores may have higher impulsivity due to lower dopaminergic availability...
  61. doi request reprint Frontal cerebral blood flow changes after hormone replacement therapy in depressed postmenopausal women
    Wei Jen Yao
    Department of Nuclear Medicine, National Cheng Kung University, Tainan, Taiwan
    J Cereb Blood Flow Metab 29:1885-90. 2009
    ..The changes in frontal CBF were detected only during WCST activation and were most apparent during early postmenopausal years...
  62. doi request reprint Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder
    Sheng Yu Lee
    Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
    J Psychiatr Res 47:1343-8. 2013
    ..020). We conclude that add-on memantine plus VPA treatment of BP-II depression increases the blood level of HDL-C even in the absence of change in affective symptoms...
  63. ncbi request reprint Rapid leptin elevation after initiation of olanzapine?
    Hsuan Chi Wang
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan, ROC
    Neuropsychobiology 54:182-5. 2006
    ..Moreover, higher pretreatment circulating leptin levels predicted lower weight gains after olanzapine treatments (r = -0.93; p < 0.05) after controlling for the effect of sex...
  64. doi request reprint The interaction between BDNF and DRD2 in bipolar II disorder but not in bipolar I disorder
    Chih Chun Huang
    Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Am J Med Genet B Neuropsychiatr Genet 159:501-7. 2012
    ..We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP-II disorder and that BP-I and BP-II are genetically distinct...
  65. doi request reprint No seasonal variation in human midbrain serotonin transporter availability in Taiwan
    Yu Shian Cheng
    Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Psychiatry Res 194:396-9. 2011
    ..No significant correlation between SERT availability and the duration of sunlight exposure was found...
  66. doi request reprint Neuropsychological functions in patients with bipolar I and bipolar II disorder
    Yih Lynn Hsiao
    Institute of Behavioral Medicine, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan, ROC
    Bipolar Disord 11:547-54. 2009
    ..Cognitive impairment existed in both subtypes of bipolar disorder, and was greater in BP-I patients. Rehabilitation interventions should take into account potential cognitive differences between these bipolar subtypes...
  67. doi request reprint Association between serotonin transporter availability and overall rating scores of quality of life in healthy volunteers
    Hsin Chun Tsai
    Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 33:711-4. 2009
    ..The overall rating sub scores of the WHO-QOL correlated positively with serotonin transporter availability in the males. Central serotoninergic activity may play a role in the overall rating scores of the WHO-QOL...
  68. ncbi request reprint Sexual dysfunction and physicians' perception in medicated patients with major depression in Taiwan
    Kao Ching Chen
    Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Depress Anxiety 25:E56-62. 2008
    ..Because antidepressant-associated SD is highly prevalent and seriously underestimated by physicians, greater physicians' recognition and better patients' education are imperative when prescribing antidepressants...
  69. doi request reprint Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder
    Mei Hung Chi
    Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Affect Disord 126:430-5. 2010
    ..To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD)...
  70. doi request reprint The profile and familiality of personality traits in mood disorder families
    Pei Jung Wu
    Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Affect Disord 138:367-74. 2012
    ..The current study aimed to investigate the profile of personality traits in patients with bipolar disorders and major depressive disorder (MDD). Familial aggregation of personality traits in mood disorder families was also evaluated...
  71. doi request reprint Comparison of the validity of the Chinese versions of the Hypomania Symptom Checklist-32 (HCL-32) and Mood Disorder Questionnaire (MDQ) for the detection of bipolar disorder in medicated patients with major depressive disorder
    Chia Chi Chou
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Int J Psychiatry Clin Pract 16:132-7. 2012
    ..The sensitivity and specificity of the Chinese versions of the Hypomania Symptom Checklist-32 (HCL-32) and Mood Disorder Questionnaire (MDQ) for detecting bipolar disorder in Taiwan were explored in this study...
  72. ncbi request reprint Increased plasma leptin in antipsychotic-naïve females with schizophrenia, but not in males
    Hsuan Chi Wang
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Neuropsychobiology 56:213-5. 2007
    ..In this study, we examined the leptin levels of antipsychotic-naïve schizophrenic patients...
  73. ncbi request reprint Correlation between striatal dopamine D2 receptor density and neuroticism in community volunteers
    I Hui Lee
    Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    Psychiatry Res 138:259-64. 2005
    ..The central dopaminergic system may play an important role in the neurobiological characteristics of neuroticism...
  74. ncbi request reprint Correlation between different memory systems and striatal dopamine D2/D3 receptor density: a single photon emission computed tomography study
    Po See Chen
    Department of Psychiatry, Medical College and Hospital, National Cheng Kung University, Tainan, Taiwan
    Psychol Med 35:197-204. 2005
    ..This study assessed the relationship between measures of striatal dopamine activities and indices of different memory systems in healthy individuals...
  75. doi request reprint High prevalence of metabolic disturbances in patients with bipolar disorder in Taiwan
    Hui Hua Chang
    Institute of Biopharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Affect Disord 117:124-9. 2009
    ..High prevalences of obesity and metabolic disturbances in patients with bipolar disorder (BD) have been reported in western countries. However, reports about the prevalences in Asian countries remain scant...
  76. doi request reprint Relationship between striatal dopamine transporter availability and sleep quality in healthy adults
    Nan Tsing Chiu
    Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Mol Imaging Biol 13:1267-71. 2011
    ..To further investigate the role of dopamine (DA) in the sleep-wake cycle, we explored the correlation between presynaptic dopamine transporter (DAT) availability and sleep quality in healthy volunteers...
  77. doi request reprint Empirically derived subgroups of bipolar I patients with different comorbidity patterns of anxiety and substance use disorders in Han Chinese population
    Han Chieh Tsai
    Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Taiwan
    J Affect Disord 136:81-9. 2012
    ..The present study sought to identify subgroups of BPI patients using comorbidity patterns with ANX and SUD...
  78. doi request reprint The dopamine hypothesis of social support
    Shih Hsien Lin
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Med Hypotheses 77:753-5. 2011
    ..This hypothesis may help to identify the mechanism explaining the influence of dopamine on social support and provide support for dopaminergic pharmacotherapy for deficits in social behaviors...
  79. ncbi request reprint Olanzapine in Chinese treatment-resistant patients with schizophrenia: an open-label, prospective trial
    Nan Ying Chiu
    Department of Psychiatry, Changhua Christian Hospital, Changhua, Tainan, Taiwan
    Psychiatry Clin Neurosci 57:478-84. 2003
    ..The present open study suggests that olanzapine may be effective and well-tolerated in Chinese treatment-resistant schizophrenic patients. Further double-blinded trials are needed to confirm this result...
  80. doi request reprint Comparison of antidepressant efficacy-related SNPs among Taiwanese and four populations in the HapMap database
    Mei Hung Chi
    Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Formos Med Assoc 110:478-82. 2011
    ..Further investigation is required to verify the attribution of genetic differences to ethnic-specific antidepressant responses...
  81. doi request reprint The effect of comorbid anxiety disorder on neuropsychological function in bipolar II disorder
    Hsin I Wu
    Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1841-5. 2011
    ..We examined neuropsychological functions in BP-II patients with and without comorbid ANX...
  82. ncbi request reprint Reduced frontal perfusion in depressed postmenopausal women: a SPECT study with WCST
    Wei Jen Yao
    Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    Maturitas 59:83-90. 2008
    ..To investigate frontal cerebral blood flow (CBF) in depressed postmenopausal women and its relation to cognitive function and the severity of depressive symptoms...
  83. ncbi request reprint Correlation between performance on the Continuous Performance Test and economic costs in patients with schizophrenia
    Sheng Ying Ko
    Department of Psychiatry, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    Psychiatry Clin Neurosci 57:373-7. 2003
    ..Schizophrenic patients with more severely impaired sustained attention, particularly as measured by CPT, may incur higher indirect costs...
  84. ncbi request reprint Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM
    Yen Kuang Yang
    Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan
    Psychiatry Res 154:281-4. 2007
    ..Hostility was measured with the Cook-Medley Hostility Scale. Hostile attribution, but not the other subscales of hostility, was negatively correlated with SERT availability. Central serotoninergic activities may play a role in hostility...
  85. ncbi request reprint Different dimensions of social support for the caregivers of patients with schizophrenia: main effect and stress-buffering models
    Tien Chen Lee
    Department of Psychiatry, Chi Mei Foundation Medical Center, National Cheng Kung University, Tainan, Taiwan
    Psychiatry Clin Neurosci 60:546-50. 2006
    ..The psychopathological severity of the patients has a negative impact on their caregivers' mental health. PCS has a direct effect, and RCS has a buffer effect on the mental health status of these caregivers...
  86. doi request reprint MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder
    Sheng Yu Lee
    The Institute of Behavioral Medicine, Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No 138 Sheng Li Road, Tainan, Taiwan, Republic of China
    Alcohol Clin Exp Res 33:985-90. 2009
    ..The objective of this study is to determine whether the interaction between the MAOA and the ALDH2 genes is associated with subjects with antisocial personality disorder (ASPD) having alcoholism...
  87. ncbi request reprint Psychiatric morbidity and posttraumatic symptoms among earthquake victims in primary care clinics
    Yen Kuang Yang
    Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University and University Hospital, Tainan, Taiwan
    Gen Hosp Psychiatry 25:253-61. 2003
    ..In addition, health care professionals who work with the earthquake victims need to be promptly and efficiently trained in mental health crisis intervention...
  88. ncbi request reprint Eye-hand preference in schizophrenia: sex differences and significance for hand function
    Yi Chia Liu
    Department of Psychiatry, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    Percept Mot Skills 98:1225-33. 2004
    ..8%) and controls (33.3%). Analysis of hand performance on the Purdue Pegboard Test indicated that schizophrenic patients who showed crossed eye-hand dominance scored higher than did patients without crossed eye-hand dominance...
  89. ncbi request reprint Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy
    Kao Ching Chen
    Department of Psychiatry, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    Psychiatry Clin Neurosci 57:369-71. 2003
    ..The dosage of zotepine might constitute a positive correlation with hypothermia. The combination of zotepine, valproate or benzodiazepine may cause hypothermia as a side-effect...
  90. ncbi request reprint Association between regional cerebral blood flow and eye-tracking performance and the Wisconsin Card Sorting Test in schizophrenics: a single photon emission computed tomography study
    Yen Kuang Yang
    Department of Psychiatry, College of Medicine, National Cheng Kung University and University Hospital, 138 Sheng Li Road, 70428, Tainan, Taiwan, ROC
    Psychiatry Res 123:37-48. 2003
    ..Although the frontal lobe plays a significant role in WCST performance, our findings demonstrate that WCST performance is widely involved with other regions in patients with schizophrenia...
  91. ncbi request reprint Decreased dopamine transporter availability in male smokers -- a dual isotope SPECT study
    Yen Kuang Yang
    Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 32:274-9. 2008
    ..To delineate the role of tobacco addiction in central pre- and post-synaptic dopaminergic activities, we analyzed the central D2-family receptors, the dopamine transporters (DAT), and degrees of dependence in male smokers...
  92. doi request reprint Greater availability of dopamine transporters in patients with major depression--a dual-isotope SPECT study
    Yen Kuang Yang
    Department of Psychiatry National Cheng Kung University Hospital, Tainan, Taiwan
    Psychiatry Res 162:230-5. 2008
    ..Central dopamine functions may be altered in patients with major depression, particularly in the pre-synaptic sites...
  93. ncbi request reprint Reliabilities and intercorrelations of reported and objective measures of smoking in patients with schizophrenia
    Yen Kuang Yang
    National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan
    Schizophr Res 60:9-12. 2003
    ..All measures demonstrated good test-retest reliability. Objective measures of smoking were consistently intercorrelated and should be the preferred outcome measures in studies testing strategies to reduce smoking...
  94. ncbi request reprint Starvation-induced Wernicke's encephalopathy in schizophrenia
    Hsiang Yi Tsai
    Psychiatry Clin Neurosci 58:338-9. 2004
  95. ncbi request reprint Nicotine decreases bradykinesia-rigidity in haloperidol-treated patients with schizophrenia
    Yen Kuang Yang
    National Cheng Kung University, Taiwan, China
    Neuropsychopharmacology 27:684-6. 2002
    ..Clinical assessments of bradykinesia-rigidity were lower during nicotine patch administration than during placebo patch administration...
  96. ncbi request reprint Pharmacoeconomic evaluation of schizophrenia in Taiwan: model comparison of long-acting risperidone versus olanzapine versus depot haloperidol based on estimated costs
    Yen Kuang Yang
    Department of Psychiatry, National Cheng Kung University College of Medicine, Taiwan
    Psychiatry Clin Neurosci 59:385-94. 2005
    ..The comparison model with the Kaplan-Meier decision tree may serve as an alternative to prospectively designed studies for cost-effectiveness of atypical antipsychotics...