Hung Chin Tsai


Affiliation: Tri-Service General Hospital
Country: Taiwan


  1. Tsai H, Chen I, Lee S, Chen Y. HIV-1 genotypic drug resistance in patients with virological failure to single-tablet antiretroviral regimens in southern Taiwan. Infect Drug Resist. 2018;11:1061-1071 pubmed publisher
    ..These findings should remind clinicians that detailed drug resistance history and close monitoring are mandatory after switching to an STR. ..
  2. Lee C, Wu P, Lu P, Tsai H. Changing Spectrum of Opportunistic Illnesses among HIV-Infected Taiwanese Patients in Response to a 10-Year National Anti-TB Programme. J Clin Med. 2019;8: pubmed publisher
    ..AOI statistics in Taiwan must be closely monitored for fluctuations. Although MTB decreased substantially after implementation of the anti-TB programmes, additional efforts to reduce MTB are required. ..
  3. Lee C, Tseng Y, Lin W, Chen Y, Tsai J, Wang W, et al. AIDS-related opportunistic illnesses and early initiation of HIV care remain critical in the contemporary HAART era: a retrospective cohort study in Taiwan. BMC Infect Dis. 2018;18:352 pubmed publisher
    ..Additional targeted interventions are required for the earlier diagnosis of patients with HIV. ..
  4. Weng Y, Tsai H, Lee S, Wu K, Sy C, Chen J, et al. Prevalence and associated factors for HIV-1 transmitted drug resistance in voluntary clients for counseling and testing in Southern Taiwan. J Microbiol Immunol Infect. 2016;49:487-93 pubmed publisher
    ..In Southern Taiwan, the HIV TDR rate was 10.6% among those receiving VCT. Our findings suggest that sexual behavior may play an important role in HIV drug-resistant strain transmission. ..
  5. Tsai H, Liu S, Wu K, Liu Y, Shi M, Chen E, et al. Dynamic changes of matrix metalloproteinase-9 in patients with Klebsiella pneumoniae meningitis. Inflammation. 2008;31:247-53 pubmed publisher
    ..The relative change in gelatin zymography is comparable to the changes of MMP-9 levels found in ELISA. MMP-9 levels in CSF may be a useful tool in follow-up in patients with K. pneumoniae meningitis. ..
  6. Tsai H, Huang Y, Chen Y, Yen C, Tsai R, Lee S, et al. 14-3-3? protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. BMC Res Notes. 2014;7:97 pubmed publisher
    ..The serum 14-3-3? concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by A. cantonensis. ..
  7. Chou C, Tsai H, Wu K, Sy C, Chen J, Chen Y, et al. Highly active antiretroviral therapy-related hepatotoxicity in human immunodeficiency virus and hepatitis C virus co-infected patients with advanced liver fibrosis in Taiwan. J Microbiol Immunol Infect. 2016;49:546-53 pubmed publisher
    ..Pre-existing advanced liver fibrosis had no influence on the frequency of TE. The use of HAART showed benefits on liver fibrosis progression in patients with underlying advanced liver fibrosis. ..
  8. Tsai H, Lee B, Yen C, Wann S, Lee S, Chen Y. Dexamethasone inhibits brain apoptosis in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. Parasit Vectors. 2015;8:200 pubmed publisher
    ..Dexamethasone administration significantly decreased Evans blue extravasations and apoptotic protein expressions. Apoptosis of mice brain homogenates can be repressed by dexamethasone treatment. ..
  9. Lee C, Tsai H, Lee S, Chen Y. Orbital apex syndrome: an unusual complication of herpes zoster ophthalmicus. BMC Infect Dis. 2015;15:33 pubmed publisher
    ..The appropriate therapy for orbital apex syndrome due to herpes zoster ophthalmicus and the potential outcomes of this condition require further investigation. ..

More Information


  1. Lee C, Tsai H, Kunin C, Lee S, Chen Y. Clinical and microbiological characteristics of purulent and non-purulent cellulitis in hospitalized Taiwanese adults in the era of community-associated methicillin-resistant Staphylococcus aureus. BMC Infect Dis. 2015;15:311 pubmed publisher
    ..Purulence was a positive predictor of MRSA as the causal agent of cellulitis. These findings provide added support for the adoption of the IDSA guidelines for empirical antimicrobial therapy of cellulitis in Taiwan. ..
  2. Tsai H, Lee B, Yen C, Wann S, Lee S, Chen Y, et al. Dexamethasone downregulated the expression of CSF 14-3-3? protein in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. Acta Trop. 2014;131:98-103 pubmed publisher
    ..In conclusion, the administration of corticosteroids in mice with eosinophilic meningitis decreased the expression of 14-3-3? protein in the CSF. ..
  3. Chang H, Tsai H, Lee S, Kunin C, Lin P, Wann S, et al. High daily doses of trimethoprim/sulfamethoxazole are an independent risk factor for adverse reactions in patients with pneumocystis pneumonia and AIDS. J Chin Med Assoc. 2016;79:314-9 pubmed publisher
    ..We found a high incidence of ADRs among patients with PJP and AIDS treated with TMP/SMX, and most involved the skin and liver. A daily dose of ≥ 16 mg/kg of TMP/SMX and age 34 years were independent risk factors for ADRs. ..
  4. Lee C, Kunin C, Chang C, Lee S, Chen Y, Tsai H. Development of a prediction model for bacteremia in hospitalized adults with cellulitis to aid in the efficient use of blood cultures: a retrospective cohort study. BMC Infect Dis. 2016;16:581 pubmed
    ..External validation of this preliminary scoring system in future trials is needed to optimize the test. ..
  5. Lee C, Chang H, Kunin C, Lee S, Chen Y, Tsai H. Efficacy and safety of switching from nevirapine immediate-release twice daily to nevirapine extended-release once daily in virologically suppressed HIV-infected patients: a retrospective cohort study in Taiwan. BMC Infect Dis. 2017;17:261 pubmed publisher
    ..Our finding of higher Ctrough levels in both groups compared with other studies conducted in Caucasian populations and the high prevalence of CYP2B6 516 GT requires further investigation in a larger Taiwanese cohort. ..
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    Tsai H, Lee S, Huang C, Yen C, Chen E, Liu Y. Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan. Am J Trop Med Hyg. 2004;71:222-6 pubmed
    ..867, P = 0.01). There was association between the presence of raw vegetable juice and CSF eosinophilia (Spearman's correlation test r = 0.816, P = 0.004)...
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    Tsai H, Huang Y, Liu Y, Wann S, Lee S, Chen E, et al. Dynamic changes of hepatocyte growth factor in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. Am J Trop Med Hyg. 2009;80:980-2 pubmed
    ..These results indicate that high concentrations of HGF in the CSF occur in eosinophilic meningitis, and may have a role in protecting against endothelial injury and reducing BBB dysfunction. ..
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    Tsai H, Liu Y, Lee S, Chen E, Yen C. Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. Am J Trop Med Hyg. 2007;76:592-5 pubmed
    ..The VEGFSERUM fluctuated during the 6-month follow-up period. These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis...