Ranking Gene Ontology terms for predicting non-classical secretory proteins in eukaryotes and prokaryotesWen lin Huang
Department of Management Information System, Asia Pacific Institute of Creativity, No 110 XueFu Rd, Tou Fen, Miaoli, Taiwan, ROC
J Theor Biol 312:105-13. 2012
..Additionally, the method Sec-GO is easily implemented and its web tool of prediction is available at iclab.life.nctu.edu.tw/secgo...
ProLoc-GO: utilizing informative Gene Ontology terms for sequence-based prediction of protein subcellular localizationWen lin Huang
Institute of Bioinformatics, National Chiao Tung University, Hsinchu, Taiwan
BMC Bioinformatics 9:80. 2008
..An accurate prediction method for predicting subcellular localization of novel proteins without known accession numbers, using only the input sequence, is worth developing...
FRKAS: Knowledge Acquisition Using a Fuzzy Rule Base Approach to Insight of DNA-Binding Domains/ProteinsHui Ling Huang
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan
Protein Pept Lett 20:299-308. 2013
..The proposed knowledge acquisition method by establishing a fuzzy rule-based classifier can also be applicable to predict and analyze other protein functions from sequences...
Predicting protein subnuclear localization using GO-amino-acid composition featuresWen lin Huang
Department of Management Information System, Chin Min Institute of Technology, Miaoli, Taiwan
Biosystems 98:73-9. 2009
..4%. Experimental results show that the set of informative GO terms are effective features for protein subnuclear localization. The prediction server based on PGAC has been implemented at http://iclab.life.nctu.edu.tw/prolocgac...
Predicting and analyzing DNA-binding domains using a systematic approach to identifying a set of informative physicochemical and biochemical propertiesHui Lin Huang
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan
BMC Bioinformatics 12:S47. 2011
..However, there exists a troublesome problem for designers that some different physicochemical properties have similar vectors of representing 20 amino acids and some closely related physicochemical properties have dissimilar vectors...
Prediction and analysis of protein solubility using a novel scoring card method with dipeptide compositionHui Ling Huang
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan
BMC Bioinformatics 13:S3. 2012
..It is desirable to develop a simple and easily interpretable method for predicting protein solubility, compared to existing complex SVM-based methods...
Accurate prediction of enzyme subfamily class using an adaptive fuzzy k-nearest neighbor methodWen lin Huang
Institute of Information Engineering and Computer Science, Feng Chia University, Taichung, Taiwan
Biosystems 90:405-13. 2007
..The accuracy of AFK-NN on the new large-scale dataset of oxidoreductases family is 83.3%, and the mean accuracy of the six families is 92.1%...
ProLoc: prediction of protein subnuclear localization using SVM with automatic selection from physicochemical composition featuresWen lin Huang
Institute of Information Engineering and Computer Science, Feng Chia University, Taichung, Taiwan
Biosystems 90:573-81. 2007
..4% for the SVM-based system using k-peptide composition features applied on SNL6, and 64.32% for an optimized evidence-theoretic k-nearest neighbor classifier utilizing pseudo amino acid composition applied on SNL9, respectively...