I Min Liu

Summary

Affiliation: Tajen University
Country: Taiwan

Publications

  1. pmc A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis, Ameliorates Insulin Resistance Induced by A High-Fructose Diet in Rats
    I Min Liu
    Department of Pharmacy, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan
    Evid Based Complement Alternat Med 2011:248231. 2011
  2. pmc Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, China
    Evid Based Complement Alternat Med 2011:150752. 2011
  3. pmc Beneficial effect of traditional chinese medicinal formula danggui-shaoyao-san on advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats
    I Min Liu
    Department of Pharmacy and The Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien 90701, Taiwan
    Evid Based Complement Alternat Med 2012:140103. 2012
  4. pmc Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-α in High-Fat-Diet-Induced Obese Rats
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Pingtung City, Pingtung County 90065, Taiwan
    Evid Based Complement Alternat Med 2012:827278. 2012
  5. pmc Wound repair and anti-inflammatory potential of Lonicera japonica in excision wound-induced rats
    Wei Cheng Chen
    Department of Bioengineering, Tatung University, Taipei City, Taiwan
    BMC Complement Altern Med 12:226. 2012
  6. ncbi request reprint Angelica acutiloba root alleviates advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats
    I Min Liu
    Dept of Pharmacy and Graduate Inst of Pharmaceutical Technology, Tajen Univ, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC
    J Food Sci 76:H165-74. 2011
  7. ncbi request reprint Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus
    I Min Liu
    Department of Pharmacy, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC
    Planta Med 73:1054-60. 2007
  8. ncbi request reprint The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription
    I Min Liu
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, 20 Weishin Road, Yanpu Shiang, Yen Pou, Ping Tung Shien, Taiwan, ROC
    J Ethnopharmacol 124:211-8. 2009
  9. doi request reprint Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity
    I M Liu
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC
    Phytother Res 24:233-9. 2010
  10. doi request reprint Regulation of obesity and lipid disorders by extracts from Angelica acutiloba root in high-fat diet-induced obese rats
    I Min Liu
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yenpu Township, Pingtung Country, Taiwan, R O C
    Phytother Res 26:223-30. 2012

Collaborators

  • Juei Tang Cheng
  • Thing Fong Tzeng
  • Shorong Shii Liou
  • Yang Chang Wu
  • Weng Cheng Chang
  • Pei Feng Chen
  • Yat Ching Tong
  • Shung Te Kao
  • Tatsuo Yamamoto
  • Mao tsun Lin
  • Chia Ju Chang
  • Feng Lin Hsu
  • Shih Pei Chang
  • Kar Lok Wong
  • Chin Chuan Tsai
  • Ho Shan Niu
  • Tsang Pai Liu
  • Wang Chuan Chen
  • Paul Chan
  • Jen Hao Hsu
  • Yuan Shiun Chang
  • Chang Chih Chen
  • Dar Ming Lai
  • Shuo Bin Jou
  • Yu Hsuan Chen
  • Wei Cheng Chen
  • Tung Yuan Lai
  • Wei Chan Huang
  • Hui Chen Su
  • Chin Hui Su
  • Ting Ting Yang
  • Liang Ming Lee
  • Ko Yu Liu
  • Chih Fen Su
  • Ping Ying Lee
  • Chang Jer Huang
  • Wen Ching Ko
  • Wen Kung Lee
  • Yong Kwang Tu
  • Cheng Kuei Chang
  • Hung Yu Yang
  • Satoshi Hayakawa
  • Yu Wan Cheng
  • Huang Kuang Chang
  • Chiang Shan Niu
  • Lap Ming Tang
  • Hsi Hsien Hsu
  • Chao Tien Hsu
  • Shiow Ling Lee
  • Hsien Hui Chung
  • Hung Tsung Wu
  • Che Ling Lin
  • Wen Chen Yu
  • Kai Chun Cheng
  • Dai Huang Kou
  • Wency Chen
  • Chyou Shen Lee
  • Ju Chi Liu
  • Ching Chiu Huang
  • Lee Wen Huang
  • Tz Hurng Cheng
  • Daih Huang Kuo
  • Tzu Lin Yang
  • Tzyylin Yang
  • Po Chin Yu

Detail Information

Publications76

  1. pmc A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis, Ameliorates Insulin Resistance Induced by A High-Fructose Diet in Rats
    I Min Liu
    Department of Pharmacy, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan
    Evid Based Complement Alternat Med 2011:248231. 2011
    ..DBT is therefore proposed as potentially useful adjuvant therapy for patients with insulin resistance and/or the patients who wish to increase insulin sensitivity...
  2. pmc Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, China
    Evid Based Complement Alternat Med 2011:150752. 2011
    ....
  3. pmc Beneficial effect of traditional chinese medicinal formula danggui-shaoyao-san on advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats
    I Min Liu
    Department of Pharmacy and The Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien 90701, Taiwan
    Evid Based Complement Alternat Med 2012:140103. 2012
    ....
  4. pmc Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-α in High-Fat-Diet-Induced Obese Rats
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Pingtung City, Pingtung County 90065, Taiwan
    Evid Based Complement Alternat Med 2012:827278. 2012
    ....
  5. pmc Wound repair and anti-inflammatory potential of Lonicera japonica in excision wound-induced rats
    Wei Cheng Chen
    Department of Bioengineering, Tatung University, Taipei City, Taiwan
    BMC Complement Altern Med 12:226. 2012
    ..The ethanol extract of the flowering aerial parts of L. japonica (LJEE) was investigated for its healing efficiency in a rat excision wound model...
  6. ncbi request reprint Angelica acutiloba root alleviates advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats
    I Min Liu
    Dept of Pharmacy and Graduate Inst of Pharmaceutical Technology, Tajen Univ, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC
    J Food Sci 76:H165-74. 2011
    ..The results show that A. acutiloba root has an anti-diabetic property that involves antihyperglycemia accompanied by amelioration of glycation-mediated renal damage...
  7. ncbi request reprint Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus
    I Min Liu
    Department of Pharmacy, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC
    Planta Med 73:1054-60. 2007
    ..Myricetin might be used as a model substance for the development of antidiabetic compounds...
  8. ncbi request reprint The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription
    I Min Liu
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, 20 Weishin Road, Yanpu Shiang, Yen Pou, Ping Tung Shien, Taiwan, ROC
    J Ethnopharmacol 124:211-8. 2009
    ..Wu-Ling-San (Hoelen Five Herb Formula) is a Chinese prescription used to promote water metabolism...
  9. doi request reprint Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity
    I M Liu
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC
    Phytother Res 24:233-9. 2010
    ..A. moschatus is therefore proposed as potentially useful adjuvant therapy for patients with insulin resistance and/or the subjects wishing to increase insulin sensitivity...
  10. doi request reprint Regulation of obesity and lipid disorders by extracts from Angelica acutiloba root in high-fat diet-induced obese rats
    I Min Liu
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yenpu Township, Pingtung Country, Taiwan, R O C
    Phytother Res 26:223-30. 2012
    ....
  11. ncbi request reprint Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats
    I Min Liu
    Department of Pharmacy, Tajen University, Yen Pou, Ping Tung Shien, Taiwan, ROC
    Life Sci 81:1479-88. 2007
    ..These findings indicate that myricetin improves insulin sensitivity through the enhancement of insulin action on IRS-1-associated PI 3-kinase and GLUT 4 activity in soleus muscles of animals exhibiting insulin resistance...
  12. ncbi request reprint Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats
    I Min Liu
    Department of Pharmacy, Tajen Institute of Technology, Yen Pou, Ping Tung Shien, Taiwan, R O C
    Planta Med 71:617-21. 2005
    ..These results suggest that myricetin has an ability to enhance glucose utilization to lower plasma glucose in diabetic rats lacking insulin...
  13. ncbi request reprint Release of acetylcholine by Die-Huang-Wan to enhance insulin secretion for lowering plasma glucose in Wistar rats
    Shorong Shii Liou
    Department of Pharmacy, Tajen Institute of Technology, Yen Pou, Ping Tung Shien, Taiwan
    Auton Neurosci 100:21-6. 2002
    ..The results suggest that Die-Huang-Wan may enhance the release of acetylcholine from nerve terminals to stimulate the muscarinic M3 receptors for augmenting insulin release to produce plasma glucose lowering action...
  14. ncbi request reprint Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats
    Paul Chan
    Divison of Cardiovascular Medicine, Graduate Institute of Medical Science, Taipei Medical University, Taipei City, Taiwan, ROC
    J Hypertens 21:761-9. 2003
    ....
  15. ncbi request reprint The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin-induced diabetic rats
    Shorong Shii Liou
    Department of Pharmacy, Tajen University, Yen Pou, Ping Tung Shien, Taiwan, ROC
    J Ethnopharmacol 106:256-62. 2006
    ....
  16. doi request reprint Cassia tora (Leguminosae) seed extract alleviates high-fat diet-induced nonalcoholic fatty liver
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Pingtung County, Taiwan, ROC
    Food Chem Toxicol 51:194-201. 2013
    ..Targeting AMPK activation with CSEE may represent a promising approach for the prevention and treatment of obesity-related non-alcoholic fatty liver disease...
  17. ncbi request reprint Increase of insulin sensitivity in diabetic rats received die-huang-wan, a herbal mixture used in Chinese traditional medicine
    Yang Chang Wu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan, China
    Acta Pharmacol Sin 23:1181-7. 2002
    ..Effects on insulin sensitivity of die-huang-wan, the herbal mixture widely used to treat diabetic disorder in Chinese traditional medicine, were investigated in vivo...
  18. ncbi request reprint Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats
    Wen Kung Lee
    Graduate School of Chinese Traditional Medicine, China Medical University, Taichung City, Taiwan, ROC
    Clin Exp Pharmacol Physiol 33:27-32. 2006
    ..ginseng root. Thus, ginsenoside Rh2 may be applied as an adjuvant for the management of diabetes...
  19. ncbi request reprint Dioscorea as the principal herb of Die-Huang-Wan, a widely used herbal mixture in China, for improvement of insulin resistance in fructose-rich chow-fed rats
    Jen Hao Hsu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan, ROC
    J Ethnopharmacol 112:577-84. 2007
    ..These results suggest that dioscorea is the major herb for the improvement of insulin sensitivity produced by Die-Huang-Wan. This can be applied to use as an adjuvant for subjects who need to increase insulin sensitivity...
  20. ncbi request reprint Increase of acetylcholine release by Panax ginseng root enhances insulin secretion in Wistar rats
    Chih Fen Su
    Department of Nursing Sciences, National Tainan Institute of Nursing, Tainan City 70201, Taiwan, ROC
    Neurosci Lett 412:101-4. 2007
    ....
  21. doi request reprint Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats
    Liang Ming Lee
    Department of Urology, College of Medicine and Wan Fang Hospital, Taipei Medical University, Taipei City, Taiwan, ROC
    Neurosci Lett 441:201-4. 2008
    ..The results suggest that cardiac M2-mAChR gene expression is raised in type-1 like diabetic rats but not in type-2 like diabetic rats, this difference mainly due to hyperglycemia, for the production of hypotension in diabetic disorders...
  22. doi request reprint Emodin protects against high-fat diet-induced obesity via regulation of AMP-activated protein kinase pathways in white adipose tissue
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Pingtung County, Taiwan
    Planta Med 78:943-50. 2012
    ..Our findings suggest that emodin could attenuate lipid accumulation in white adipose tissue through AMP-activated protein kinase activation...
  23. ncbi request reprint Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice
    Hsi Hsien Hsu
    Department of Surgery, Mackay Memorial Hospital, Taipei City, Taiwan, R O C
    Planta Med 68:999-1003. 2002
    ..The obtained data suggest that an activation of alpha 1A -AR by puerarin in C 2 C 12 cells may increase the glucose uptake via the PLC-PKC pathway...
  24. doi request reprint 6-gingerol inhibits rosiglitazone-induced adipogenesis in 3T3-L1 adipocytes
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Pingtung County, Taiwan, Republic of China
    Phytother Res 28:187-92. 2014
    ..Our data suggests that 6-gingerol may be beneficial in obesity, by reducing adipogenesis partly through the down-regulating PPARγ activity...
  25. ncbi request reprint Comparison of the antinociceptive action of crude Fuzei, the root of Aconitum, and its processed products
    Shorong Shii Liou
    Department of Pharmacy, Tajen Institute of Technology, Yen Pou, Ping Tung Shien, Taiwan, ROC
    J Ethnopharmacol 99:379-83. 2005
    ..These results demonstrate that Fuzei processed by salt baking possesses analgesic effects within a large therapeutic range, probably via a mechanism involving central opioid receptors that mediate the antinociception...
  26. ncbi request reprint Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats
    I Min Liu
    Department of Pharmacy, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC
    J Ethnopharmacol 104:199-206. 2006
    ..Opioid mu-receptor activation is held responsible for the enhancement of muscle GLUT 4 gene expression and the attenuation of hepatic PEPCK gene expression observed in these myricetin-treated diabetic animals...
  27. ncbi request reprint Stimulatory effect of paeoniflorin on adenosine release to increase the glucose uptake into white adipocytes of Wistar rat
    Lap Ming Tang
    Department of Emergency Medicine, Mackay Memorial Hospital, Taipei City, Taiwan, ROC
    Planta Med 69:332-6. 2003
    ..These findings suggest that paeoniflorin could induce the release of adenosine from isolated rat white adipocytes and the released adenosine may activate the adenosine A 1 receptor to enhance glucose uptake...
  28. ncbi request reprint Activation of muscarinic M1 receptors by acetylcholine to increase glucose uptake into cultured C2C12 cells
    Tsang Pai Liu
    Department of General Surgery, Mackay Memorial Hospital, Taipei City, Taiwan, ROC
    Auton Neurosci 96:113-8. 2002
    ..Therefore, the obtained data suggest that increase of the glucose uptake evoked by ACh is mainly due to the activation of muscarinic M1 receptors in cultured myoblast C2C12 cells...
  29. ncbi request reprint Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats
    Dar Ming Lai
    Neurosurgical Division, Department of Surgery, National Taiwan University Hospital, Taipei City, Taiwan, R O C
    Planta Med 72:9-13. 2006
    ....
  30. ncbi request reprint Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis
    Jen Hao Hsu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan, ROC
    Neurosci Lett 404:112-6. 2006
    ..Thus, oleanolic acid is one of the active principles responsible for the increase of plasma insulin produced by cornus fruit in rats...
  31. ncbi request reprint Activation of alpha1A-adrenoceptors by genistein at concentrations lower than that to inhibit tyrosine kinase in cultured C2C12 cells
    Shuo Bin Jou
    Department of Neurology, School of Medicine and Hospital, China Medical University, Taichung City, Taiwan, R O C
    Planta Med 70:610-4. 2004
    ..The obtained data indicate an activation of alpha (1A)-AR by genistein to increase the glucose uptake into C2C12 cells and this supports the application of genistein as a TK inhibitor...
  32. doi request reprint 6-gingerol prevents adipogenesis and the accumulation of cytoplasmic lipid droplets in 3T3-L1 cells
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Pingtung County, Taiwan, ROC
    Phytomedicine 20:481-7. 2013
    ..6-Gingerol also inhibited differentiation in 3T3-L1 cells by attenuating the Akt/GSK3β pathway. Our findings provide important insights into the mechanisms underlying the anti-adipogenic activity of 6-gingerol...
  33. ncbi request reprint Increase of anti-oxidation by exercise in the liver of obese Zucker rats
    Shih Pei Chang
    Department of Physical Education and Department of Medical Technology, Chung Tai Institute of Health Sciences and Technology, Taiwan, ROC
    Clin Exp Pharmacol Physiol 31:506-11. 2004
    ..5. The results of the present study suggest that regular moderate exercise could improve the anti-oxidant defence function of Mn-SOD, GPx and GSH in obese Zucker rats...
  34. ncbi request reprint Corni fructus as the major herb of Die-Huang-Wan for lowering plasma glucose in Wistar rats
    Shorong Shii Liou
    Department of Pharmacy, Tajen Institute of Technology, Yen Pou, Ping Tung Shien, Taiwan 90701
    J Pharm Pharmacol 56:1443-7. 2004
    ..These results suggest that cornus is the major contributor to the plasma glucose-lowering action in Die-Huang-Wan in normal rats...
  35. ncbi request reprint Increase of adiponectin receptor gene expression by physical exercise in soleus muscle of obese Zucker rats
    Shih Pei Chang
    Department of Physical Education and Department of Medical Technology, Central Taiwan University of Science and Technology, 4060, Taichung City, Taiwan, ROC
    Eur J Appl Physiol 97:189-95. 2006
    ..Thus, an endurance exercise training is probably helpful clinically for obese individuals with insulin resistance...
  36. ncbi request reprint Effect of opioid mu-receptors activation on insulin signals damaged by tumor necrosis factor alpha in myoblast C2C12 cells
    Wen Ching Ko
    Department of Surgery, Mackay Memorial Hospital and Mackay College of Nursing and Technology, Taipei City, Taiwan, ROC
    Neurosci Lett 397:274-8. 2006
    ..In conclusion, activation of opioid mu-receptors may reverse the insulin signals damaged by inflammatory cytokine...
  37. ncbi request reprint Activation of mu-opioid receptors improves insulin sensitivity in obese Zucker rats
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Taiwan, ROC
    Life Sci 80:1508-16. 2007
    ..Our results suggest that activation of peripheral mu-opioid receptors can ameliorate insulin resistance in animals, and provide a new target for therapy of insulin resistance...
  38. ncbi request reprint Release of acetylcholine by Hon-Chi to raise insulin secretion in Wistar rats
    Chang Chih Chen
    Department of Emergency Medicine, Mackay Memorial Hospital and College of Oral Medicine, Taipei Medical University, Taipei City, Taiwan, ROC
    Neurosci Lett 404:117-21. 2006
    ..Thus, Hon-Chi seems suitable to employ as the health food for increase of insulin secretion in the prevention of type-2 diabetes...
  39. doi request reprint Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats
    Ko Yu Liu
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung City, Taiwan, ROC
    Neurosci Lett 434:195-9. 2008
    ....
  40. doi request reprint Beneficial impact of Zingiber zerumbet on insulin sensitivity in fructose-fed rats
    Chia Ju Chang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, ROC
    Planta Med 78:317-25. 2012
    ..This study suggests that EEZZ may be an ethnomedicine for improving insulin sensitivity...
  41. doi request reprint Mediation of protein kinase C zeta in mu-opioid receptor activation for increase of glucose uptake into cultured myoblast C2C12 cells
    Ting Ting Yang
    Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung City 40401, Taiwan, ROC
    Neurosci Lett 465:177-80. 2009
    ..Activation of PKC-zeta by MOR stimulation is highly relevant to the search for therapeutic targets for glucose transport in insulin-sensitive tissues...
  42. doi request reprint Reduction of lipid accumulation in white adipose tissues by Cassia tora (Leguminosae) seed extract is associated with AMPK activation
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Pingtung County, Taiwan, ROC
    Food Chem 136:1086-94. 2013
    ..CSEE could attenuate lipid accumulation in WAT via AMPK signaling pathway activation...
  43. doi request reprint Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats
    Chin Hui Su
    Department of Otorhinolaryngology, Mackay Memorial Hospital, Taipei City 10401, Taiwan, ROC
    Neurosci Lett 457:125-8. 2009
    ....
  44. doi request reprint Role of sympathetic tone in the loss of syringin-induced plasma glucose lowering action in conscious Wistar rats
    Ho Shan Niu
    Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan, ROC
    Neurosci Lett 445:113-6. 2008
    ....
  45. ncbi request reprint Lipid-lowering effects of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, in high-fat diet-induced hyperlipidemic hamsters
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Pingtung County, Taiwan, ROC
    Food Chem Toxicol 69:132-9. 2014
    ..Zerumbone is effective to improve dyslipidemia by modulating the genes expression involving in the lipolytic and lipogenic pathways of lipids metabolism. ..
  46. ncbi request reprint Vasodilatation induced by sinomenine lowers blood pressure in spontaneously hypertensive rats
    Ping Ying Lee
    Division of Cardiology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medicine, Nursing and Management College, Taipei, Taiwan
    Clin Exp Pharmacol Physiol 34:979-84. 2007
    ..Glibenclamide (1-100 micromol/L) abolished the effects of sinomenine. 5. In conclusion, sinomenine causes vascular relaxation by opening ATP-sensitive K(+) channels, thus decreasing [Ca(2+)](i)...
  47. ncbi request reprint Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells
    Kar Lok Wong
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan, R O C
    Planta Med 70:108-12. 2004
    ..Alteration in the Kv channel also plays a critical role in the inhibitory action of isosteviol...
  48. pmc Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Pingtung City, Pingtung County 90064, Taiwan
    Evid Based Complement Alternat Med 2012:781812. 2012
    ..Our findings suggest emodin could attenuate lipid accumulation by decreasing lipogenesis and increasing mitochondrial fatty acid β-oxidation mediated by activation of the AMPK signaling pathway...
  49. pmc Myricetin Increases Hepatic Peroxisome Proliferator-Activated Receptor α Protein Expression and Decreases Plasma Lipids and Adiposity in Rats
    Chia Ju Chang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan
    Evid Based Complement Alternat Med 2012:787152. 2012
    ....
  50. pmc Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats
    I Min Liu
    Department of Pharmacy, Tajen University, Yen Pou, Ping Tung Shien, Taiwan
    Int J Exp Pathol 89:292-300. 2008
    ..Hyperglycaemia induced an increase in cardiac M(2)-mAChR gene expression, suggesting a role in the pathogenesis of hypotension in diabetic disorders...
  51. pmc The Ethanol Extract of Zingiber zerumbet Attenuates Streptozotocin-Induced Diabetic Nephropathy in Rats
    Thing Fong Tzeng
    Department of Internal Medicine, Pao Chien Hospital, Pingtung City, Pingtung County 90064, Taiwan
    Evid Based Complement Alternat Med 2013:340645. 2013
    ..This study suggested that the renoprotective effects of EEZZR may be similar, with the action of metformin, to the prevention of AMPK dephosphorylation and upregulate the expressions of renal nephrin and podocin...
  52. doi request reprint The ethanol extract of Lonicera japonica (Japanese honeysuckle) attenuates diabetic nephropathy by inhibiting p-38 MAPK activity in streptozotocin-induced diabetic rats
    Thing Fong Tzeng
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Township, Pingtung County, Taiwan ROC
    Planta Med 80:121-9. 2014
    ..The results suggest that it has the property to inhibit the activity of p-38 MAPK-mediated inflammatory response to halt the progression of diabetic nephropathy. ..
  53. doi request reprint The ethanol extract of Zingiber zerumbet Smith attenuates non-alcoholic fatty liver disease in hamsters fed on high-fat diet
    Chia Ju Chang
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Shiang, Ping Tung Shien, Taiwan, ROC
    Food Chem Toxicol 65:33-42. 2014
    ..In conclusion, these findings suggest that EEZZR has the promising potential to ameliorate NAFLD. ..
  54. doi request reprint Kaempferol regulates the lipid-profile in high-fat diet-fed rats through an increase in hepatic PPARα levels
    Chia Ju Chang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan
    Planta Med 77:1876-82. 2011
    ....
  55. ncbi request reprint Improvement of insulin resistance by miracle fruit (Synsepalum dulcificum) in fructose-rich chow-fed rats
    Chang Chih Chen
    Department of Emergency Medicine, Mackay Memorial Hospital and College of Oral Medicine, Taipei Medical University, Taipei City, Taiwan 10401, ROC
    Phytother Res 20:987-92. 2006
    ..In conclusion, the results suggest that miracle fruit may be used as an adjuvant for treating diabetic patients with insulin resistance because this fruit has the ability to improve insulin sensitivity...
  56. ncbi request reprint Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats
    Juei Tang Cheng
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan 70101, ROC
    Diabetes 55:819-25. 2006
    ....
  57. ncbi request reprint Merit of physical exercise to reverse the higher gene expression of hepatic phosphoenolpyruvate carboxykinase in obese Zucker rats
    Shih Pei Chang
    Department of Physical Education and Department of Medical Technology, Centre Taiwan University of Science and Technology, Taichung City 40601, Taiwan
    Life Sci 79:240-6. 2006
    ..Thus, endurance exercise training could aid in the prevention and/or treatment of individuals with insulin resistance...
  58. ncbi request reprint Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats
    Tsang Pai Liu
    Department of General Surgery, Mackay Memorial Hospital, Taipei City, Taiwan, Republic of China
    Clin Exp Pharmacol Physiol 32:649-54. 2005
    ..senticosus root has the ability to improve insulin sensitivity and delay the development of insulin resistance in rats and, thus, may be used as an adjuvant therapy for patients with insulin resistance...
  59. ncbi request reprint Increase of beta-endorphin biosynthesis in the adrenal gland of streptozotocin-induced diabetic rats
    Chao Tien Hsu
    Division of Neuroscience and Neuropathology, Graduate School of Medicine, China Medical College, Taichung City, 40401 Taiwan
    Neurosci Lett 318:57-60. 2002
    ..These results suggest that hyperglycemia is responsible for the increase of POMC gene expression to enhance beta-endorphin biosynthesis in the adrenal gland of STZ-diabetic rats...
  60. ncbi request reprint Rapid induction of insulin resistance in opioid mu-receptor knock-out mice
    Juei Tang Cheng
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan 70101
    Neurosci Lett 339:139-42. 2003
    ..Our results indicated that opioid mu-receptor is related to the delay of insulin resistance induced by fructose-fed method or insulin repeated injection...
  61. doi request reprint Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats
    Ho Shan Niu
    Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan
    Planta Med 74:109-13. 2008
    ..The ability of syringin to enhance glucose utilization and lower plasma glucose level in rats suffering from insulin deficiency suggest that this chemical may be useful in the treatment of human diabetes...
  62. ncbi request reprint Alteration of alpha(1A)-adrenoceptor gene expression in the prostate of streptozotocin-induced diabetic rats
    Yat Ching Tong
    Departments of Urology and Pharmacology, National Cheng Kung University College of Medicine, Tainan, Taiwan
    Pharmacology 68:115-20. 2003
    ..In conclusion, the gene expression of alpha(1A)-AR is increased in the prostate of diabetic rats. Hyperglycemia plays a major role in this alteration...
  63. ncbi request reprint Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats
    Feng Lin Hsu
    Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, Taipei City, Taiwan 110 31
    J Nat Prod 66:788-92. 2003
    ..These results suggest that puerarin can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin...
  64. ncbi request reprint Increase of peroxisome proliferator-activated receptor delta gene expression in the lungs of streptozotocin-induced diabetic rats
    Chang Jer Huang
    Department of Surgery, Mackay Memorial Hospital, and Mackay Medicine, Nursing and Management College, Taipei City, Taiwan 10401, ROC
    Pulm Pharmacol Ther 20:69-74. 2007
    ..The obtained results suggest that increase of plasma glucose is responsible for the higher gene expression of PPARdelta in the lung of STZ-diabetic rats...
  65. ncbi request reprint Mediation of beta-endorphin by the isoflavone puerarin to lower plasma glucose in streptozotocin-induced diabetic rats
    Wang Chuan Chen
    Department of Obstetrics and Gynaecology, School of Medicine, Nihon University, Tokyo City, Japan
    Planta Med 70:113-6. 2004
    ..In conclusion, our results suggest that puerarin may activate alpha (1)-adrenoceptors on the adrenal gland to enhance the secretion of beta-endorphin to result in a decrease of plasma glucose in STZ-diabetic rats...
  66. ncbi request reprint Activation of imidazoline receptor by agmatine to lower plasma glucose in streptozotocin-induced diabetic rats
    Shuo Bin Jou
    Department of Neurology, School of Medicine and Hospital, China Medical University, Taichung City, Taiwan
    Neurosci Lett 358:111-4. 2004
    ..In conclusion, we suggest that an activation of I(2)-imidazoline receptors in the brain may lower plasma glucose without insulin in animal...
  67. ncbi request reprint The plasma glucose lowering action of tetrandrine in streptozotocin-induced diabetic rats
    Wang Chuan Chen
    Department of Obstetrics and Gynaecology, School of Medicine, Nihon University, Tokyo City, Japan
    J Pharm Pharmacol 56:643-8. 2004
    ..These results suggest that tetrandrine has the ability to enhance glucose utilization in peripheral tissue, resulting in the lowering of plasma glucose in diabetic rats lacking insulin...
  68. ncbi request reprint Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats
    I Min Liu
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan 70101, Republic of China
    J Pharmacol Exp Ther 307:1196-204. 2003
    ....
  69. ncbi request reprint Role of striatal glutamate in heatstroke-induced damage in streptozotocin-induced diabetic rats
    Chiang Shan Niu
    Department of Physiology, National Yang Ming University, Taipei 11221, Taiwan
    Neurosci Lett 348:77-80. 2003
    ..Therefore, heatstroke was more easily induced via the elevated striatal glutamate in STZ-diabetic rats by high temperature exposure. Insulin treatment seems helpful in the prevention of heatstroke in STZ-diabetic rats...
  70. ncbi request reprint Role of cGMP signals in tetramethylpyrazine induced relaxation of the isolated rat aortic strip
    Chin Chuan Tsai
    School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung City, Taiwan 40402, ROC
    Life Sci 77:1416-24. 2005
    ..These results suggest that relaxation of rat aortic strip by TMP is induced in the cGMP-dependent manner...
  71. ncbi request reprint Increase of adenosine A1 receptor gene expression in cerebral ischemia of Wistar rats
    Dar Ming Lai
    Neurosurgical Division, Department of Surgery, National Taiwan University Hospital, Taipei 10001, Taiwan
    Neurosci Lett 387:59-61. 2005
    ..These data suggest that the gene expression of adenosine A1 receptor was increased by ischemia probably due to the compensative response of brain. The raised adenosine A1 receptor may play a protective role in these damaged tissues...
  72. ncbi request reprint Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro
    Chin Chuan Tsai
    Department of Traditional Medicine, School of Post Baccalaureate Chinese Medicine, China Medical College, Taichung City 40401, Taiwan
    Life Sci 71:1321-30. 2002
    ..The obtained results indicated that vasodilatation induced by TMP is related to the opening of SK(Ca) and K(ATP) channels...
  73. ncbi request reprint Tetramethylpyrazine as potassium channel opener to lower calcium influx into cultured aortic smooth muscle cells
    Chin Chuan Tsai
    Department of Traditional Medicine, School of Post Baccalaureate Chinese Medicine, China Medical College, Taichung City, Taiwan
    Planta Med 69:557-8. 2003
    ..The obtained results indicate that the decrease of Ca 2+ influx into A7r5 cells by TMP is mainly mediated by the opening of potassium channels...
  74. ncbi request reprint Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro
    Huang Kuang Chang
    Department of Urology, Mackay Memorial Hospital, Mackay Junior College of Nursing, Taipei City, Taiwan
    J Pharm Pharmacol 55:833-7. 2003
    ..In conclusion, our data indicated that methoxylation and/or hydroxylation of cinnamic acid might raise the affinity for alpha(1A)-adrenoceptors...
  75. ncbi request reprint Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat
    Kar Lok Wong
    Graduate Institute of Medical Science, Taipei Medical University, Taipei 106, Taiwan
    Life Sci 74:2379-87. 2004
    ..The obtained results indicated that vasodilatation induced by isosteviol is related to the opening of SK(Ca) and K(ATP) channels...