Chiou Chung Yuan

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Whole-body PET with (fluorine-18)-2-deoxyglucose for detecting recurrent ovarian carcinoma. Initial report
    C C Yuan
    Department of Obstetrics and Gynecology, Veterans General Hospital Taipei, School of Medicine, National Yang Ming University, Taiwan
    J Reprod Med 44:775-8. 1999
  2. ncbi request reprint Detecting cytokeratin 19 mRNA in the peripheral blood cells of cervical cancer patients and its clinical-pathological correlation
    Chiou Chung Yuan
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, 112, Taiwan
    Gynecol Oncol 85:148-53. 2002
  3. ncbi request reprint New strategies and advances in the management of cervical carcinoma
    Chiou Chung Yuan
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, R O C
    Gan To Kagaku Ryoho 29:143-9. 2002
  4. ncbi request reprint Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and Institute of Clinical Medicine, Taiwan
    Gynecol Oncol 86:45-52. 2002
  5. ncbi request reprint High cyclooxygenase-2 expression in cervical adenocarcinomas
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital Institute of Clinical Medicine, and National Yang Ming University, Taipei, Taiwan
    Gynecol Oncol 88:379-85. 2003
  6. ncbi request reprint Pregnancy following treatment of symptomatic myomas with laparoscopic bipolar coagulation of uterine vessels
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Hum Reprod 18:1077-81. 2003
  7. doi request reprint Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
    Virchows Arch 455:431-40. 2009
  8. ncbi request reprint Rapid enlargement of uterine myomas after laparoscopic bipolar coagulation of uterine vessels
    Yuan Kuei Yen
    Department of Obstetrics and Gynecology, Veterans General Hospital Taipei, National Yang Ming University, Taipei, Taiwan
    J Am Assoc Gynecol Laparosc 9:93-7. 2002
  9. ncbi request reprint Altered mRNA expressions of sialyltransferases in ovarian cancers
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Gynecol Oncol 99:631-9. 2005
  10. ncbi request reprint Laparoscopic bipolar coagulation of uterine vessels to manage delayed postpartum hemorrhage
    Yu Ching Chou
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Road, Taipei 112, Taiwan
    J Am Assoc Gynecol Laparosc 9:541-4. 2002

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Whole-body PET with (fluorine-18)-2-deoxyglucose for detecting recurrent ovarian carcinoma. Initial report
    C C Yuan
    Department of Obstetrics and Gynecology, Veterans General Hospital Taipei, School of Medicine, National Yang Ming University, Taiwan
    J Reprod Med 44:775-8. 1999
    ..To investigate positron emission tomography (PET) with (fluorine-18)-2-deoxyglucose (FDG) for detecting recurrent ovarian carcinoma...
  2. ncbi request reprint Detecting cytokeratin 19 mRNA in the peripheral blood cells of cervical cancer patients and its clinical-pathological correlation
    Chiou Chung Yuan
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, 112, Taiwan
    Gynecol Oncol 85:148-53. 2002
    ....
  3. ncbi request reprint New strategies and advances in the management of cervical carcinoma
    Chiou Chung Yuan
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, R O C
    Gan To Kagaku Ryoho 29:143-9. 2002
    ..Carcinoma of the cervix is still common female cancer in Taiwan. A large portion of patients die of the disease in spite of various kinds of therapies and even the combination of multi-modality treatment...
  4. ncbi request reprint Expression of sialyltransferase family members in cervix squamous cell carcinoma correlates with lymph node metastasis
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and Institute of Clinical Medicine, Taiwan
    Gynecol Oncol 86:45-52. 2002
    ..This study further investigates their changes in mRNA expression of the four STs in FIGO stage IB1 squamous cell carcinoma to assess the extent of sialylation associated with lymph node metastases...
  5. ncbi request reprint High cyclooxygenase-2 expression in cervical adenocarcinomas
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital Institute of Clinical Medicine, and National Yang Ming University, Taipei, Taiwan
    Gynecol Oncol 88:379-85. 2003
    ..The purpose of this study was to examine the relationships between cyclooxygenase-2 (COX-2) expression and prognostic factors in cervical carcinomas...
  6. ncbi request reprint Pregnancy following treatment of symptomatic myomas with laparoscopic bipolar coagulation of uterine vessels
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Hum Reprod 18:1077-81. 2003
    ..Laparoscopic bipolar coagulation of uterine vessels (LBCUV) has been employed for women with symptomatic uterine myomas, but its effect on subsequent pregnancy has not been characterized...
  7. doi request reprint Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
    Virchows Arch 455:431-40. 2009
    ..023) than the Aurora B low expression group using univariate analysis (log-rank statistic). Aurora B is an effective predictor of aggressive epithelial ovarian carcinoma in terms of differentiation, metastasis, and prognosis...
  8. ncbi request reprint Rapid enlargement of uterine myomas after laparoscopic bipolar coagulation of uterine vessels
    Yuan Kuei Yen
    Department of Obstetrics and Gynecology, Veterans General Hospital Taipei, National Yang Ming University, Taipei, Taiwan
    J Am Assoc Gynecol Laparosc 9:93-7. 2002
    ..The combination of degenerative and iatrogenic changes resulted in a histologic appearance resembling diffuse hyalinization and hydropic degeneration of the leiomyomas...
  9. ncbi request reprint Altered mRNA expressions of sialyltransferases in ovarian cancers
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Gynecol Oncol 99:631-9. 2005
    ....
  10. ncbi request reprint Laparoscopic bipolar coagulation of uterine vessels to manage delayed postpartum hemorrhage
    Yu Ching Chou
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, 201, Section 2, Shih Pai Road, Taipei 112, Taiwan
    J Am Assoc Gynecol Laparosc 9:541-4. 2002
    ..We successfully performed a relatively new method--laparoscopic bipolar coagulation of uterine vessels--to stop bleeding and preserve the uterus...
  11. ncbi request reprint Postconization cervical perforation during laparoscopic surgery
    Pi Lin Sung
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, and National Yang Ming University School of Medicine, Taipei, Taiwan
    Taiwan J Obstet Gynecol 46:71-2. 2007
    ..Complications during laparoscopic surgery involving the bladder, bowel, and major vessels have been reported extensively. However, uterine manipulator-associated injuries are seldom reported...
  12. ncbi request reprint Early pregnancy uninterrupted by laparoscopic bipolar coagulation of uterine vessels
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Veterans General Hospital Taipei, 201, Section 2, Shin Pai Road, Taipei 11217, Taiwan
    J Am Assoc Gynecol Laparosc 9:79-83. 2002
    ..The intrauterine pregnancy was terminated at the woman's request. Pregnancy may be possible after LBCUV, although none has been reported...
  13. doi request reprint Symptomatic myoma treated with laparoscopic uterine vessel occlusion and subsequent immediate myomectomy: which is the optimal surgical approach?
    Peng Hui Wang
    Department of Obstetrics and Gynecology, National Yang Ming University School of Medicine and Taipei Veterans General Hospital, Taipei, Taiwan
    Fertil Steril 92:762-9. 2009
    ..To determine the optimal surgical approach when patients are treated with laparoscopic uterine vessel occlusion (LUVO) combined with myomectomy in the management of women with symptomatic uterine fibroids...
  14. ncbi request reprint Overexpression of dihydrodiol dehydrogenase is associated with cisplatin-based chemotherapy resistance in ovarian cancer patients
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    Gynecol Oncol 97:110-7. 2005
    ..We examined the relationships between DDH expression and chemotherapy resistance in ovarian cancer patients...
  15. ncbi request reprint Comparison of two procedures for laparoscopic-assisted vaginal hysterectomy of large myomatous uteri
    Yuan Kuei Yen
    Department of Obstetrics and Gynecology, Veterans General Hospital Taipei, National Yang Ming University, Taipei, Taiwan
    J Am Assoc Gynecol Laparosc 9:63-9. 2002
    ..To evaluate whether laparoscopic bipolar coagulation of uterine vessels (LBCUV) and supracervical amputation improve laparoscopic-assisted vaginal hysterectomy (LAVH)...
  16. ncbi request reprint Effect of peer review and trial of labor on lowering cesarean section rates
    Wei Hsing Liang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:281-6. 2004
    ..In an attempt to lower cesarean section rates, a cesarean surveillance system and a selective trial of labor were introduced in a tertiary hospital in Taiwan...
  17. doi request reprint Suppression of migratory/invasive ability and induction of apoptosis in adenomyosis-derived mesenchymal stem cells by cyclooxygenase-2 inhibitors
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Institute of Clinical Medicin, National Yang Ming University, Taipei, Taiwan
    Fertil Steril 94:1972-9, 1979.e1-4. 2010
    ..To investigate if stem or progenitor cells are found in adenomyosis and to characterize the role of cyclooxygenase-2 (COX-2) in adenomyosis-derived mesenchymal stem cell (AMSC)-related pathogenesis of adenomyosis...
  18. doi request reprint Comparison of ultraminilaparotomy for myomectomy through midline vertical incision or modified Pfannenstiel incision--a prospective short-term follow-up
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Fertil Steril 91:1945-50. 2009
    ..To evaluate the short-term therapeutic outcome of myomectomy using ultraminilaparotomy (UMLT) through a midline vertical incision (MVI) or a modified Pfannenstiel incision (MPI) in the treatment of myomas...
  19. ncbi request reprint Alpha 2,6-sialyltransferase I expression in the placenta of patients with preeclampsia
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, R O C
    J Chin Med Assoc 70:152-8. 2007
    ..Inadequate trophoblast invasion to the spiral artery in the 2nd trimester of pregnancy was believed to be correlated with pregnancy complications, including preeclampsia...
  20. ncbi request reprint Wound endometriosis: risk factor evaluation and treatment
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 66:113-9. 2003
    ..Wound endometriosis is still a rare phenomenon. In this study, we tried to identify its risk factors and presented our experience in managing such disease...
  21. ncbi request reprint Establishment of an efficient method to quantify embryo attachment to endometrial epithelial cell monolayers
    Hsin Yang Li
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, and Department of Obstetrics and Gynecology, Veterans General Hospital, Taipei, Taiwan, Republic of China
    In Vitro Cell Dev Biol Anim 38:505-11. 2002
    ..Using 96-well plates for coculture, centrifugation, and examination to minimize transfer procedures, our assay system is readily applicable to investigate implantation mechanisms...
  22. ncbi request reprint Acute urinary retention after use of assisted reproductive technology. A report of 2 cases
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan
    J Reprod Med 48:560-2. 2003
    ..Various conditions can cause it, including surgery, childbirth, pelvic masses, procidentia, vulva hematoma, incarceration of a gravid uterus, urologic disease, neurogenic disease and psychiatric disorders...
  23. ncbi request reprint Effects of period-free hormone replacement therapy in postmenopausal women in Taiwan
    Tzay Shing Yang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan, ROC
    Zhonghua Yi Xue Za Zhi (Taipei) 65:23-8. 2002
    ..To compare the effects of continuous combined hormone replacement therapy (Kliogest) and placebo on climacteric symptoms, bone turnover markers, serum lipid profiles and the safety of Kliogest...
  24. ncbi request reprint Interleukin-8 can stimulate progesterone secretion from a human trophoblast cell line, BeWo
    Kuan Hao Tsui
    Department of Obstetrics and Gynecology, Veterans General Hospital, 201 Section 2, Shih Pai Road, Taipei, Taiwan 112, Republic of China
    In Vitro Cell Dev Biol Anim 40:331-6. 2004
    ..Our results demonstrate that IL-8 may play an important role in the endometrium-embryo interactions by stimulating trophoblast secretion of P4 for maintenance of a successful pregnancy...
  25. ncbi request reprint Improved cervical cancer screening in premenopausal women by combination of Pap smear and speculoscopy
    Nae Fang Twu
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan
    Eur J Obstet Gynecol Reprod Biol 133:114-8. 2007
    ..This study was done to evaluate the efficacy of the Pap smear, speculoscopy, and a combination of Pap smear and speculoscopy (PapSure examination) in pre- and postmenopausal women...
  26. doi request reprint Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer
    Nae Fang Twu
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur J Obstet Gynecol Reprod Biol 142:57-63. 2009
    ..However, the expression of Aurora kinases in normal and neoplastic cervical tissues remains undetermined...
  27. ncbi request reprint Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang Ming University, Taiwan
    Anal Quant Cytol Histol 24:1-6. 2002
    ..To use comparative genomic hybridization (CGH) to analyzefrozen tissuesfrom adenomyosis cases to discover and map genomic regions for chromosomal gains and losses...
  28. ncbi request reprint Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis
    Yu Ching Chou
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, 201 Section 2, Shih Pai Road, Taipei 11217, Taiwan
    Eur J Obstet Gynecol Reprod Biol 124:101-5. 2006
    ..The purpose of this study was to examine if COX-2, CK7 and CK20 are involved in the malignant transformation of endometriosis...
  29. ncbi request reprint The power Doppler velocity index, pulsatility index, and resistive index can assist in making a differential diagnosis of primary ovarian carcinoma and Krukenberg tumors: a preliminary study
    Chih Yao Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    J Ultrasound Med 26:921-6; quiz 927-9. 2007
    ....
  30. ncbi request reprint Effect of a selective nonsteroidal anti-inflammatory drug, celecoxib, on the reproductive function of female mice
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan, R O C
    J Chin Med Assoc 70:245-8. 2007
    ..The aim of the present study was to determine if long-term use of a cyclooxygenase-2 (COX-2) inhibitor affects fertility or ovulation in female mice...
  31. ncbi request reprint Physiology and potential application of NKT cells: a minireview
    Jiun Yih Yeh
    Department of Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Chin J Physiol 52:275-9. 2009
    ..This minireview will focus on the physiology of NKT cells and potential clinical application...
  32. ncbi request reprint Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Gynecol Oncol 89:395-401. 2003
    ....
  33. ncbi request reprint Umbilicus as the only site of metastasis in recurrent ovarian cancer
    Hsiao Wen Tsai
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan, ROC
    J Chin Med Assoc 69:233-5. 2006
    ..Although an umbilical metastasis usually indicates advanced disease with disseminating peritoneal spread, it does not always imply inoperable or incurable disease. Intensive treatment can improve the outcome...
  34. ncbi request reprint Radioimmunotherapy and apoptotic induction on CK19-overexpressing human cervical carcinoma cells with Re-188-mAbCx-99
    Chih Hsien Chang
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Anticancer Res 25:2719-28. 2005
    ..The overexpression of Ck19 antigen occurs frequently in human carcinomas. The strategy and mechanism of radioimmunotherapy using Re-188-mAbCx-99 to Ck19 on human cervical carcinoma cells was investigated in this study...
  35. ncbi request reprint Fetal meconium peritonitis in the infant of a woman with fulminant hepatitis B. A case report
    Weng Hsiang Su
    Department of Obstetrics and Gynecology, Toayuang Yee Zen General Hospital, No 30, Lane 321, Yang Hsin North Road, Yang Mei, Toa Yuang, 326, Taiwan
    J Reprod Med 47:952-4. 2002
    ..Simultaneous fulminant maternal hepatitis B infection and fetal meconium peritonitis has never been reported before in the English-language literature...
  36. ncbi request reprint A simple method to accurately position Port-A-Cath without the aid of intraoperative fluoroscopy or other localizing devices
    Huann Cheng Horng
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    J Surg Oncol 95:582-6. 2007
    ..To evaluate the efficacy and acceptability of the Port-A-Cath (PAC) insertion method with (conventional group as II) and without (modified group as I) the aid of intraoperative fluoroscopy or other localizing devices...
  37. ncbi request reprint Prenatal diagnosis of occipital encephalocele, mega-cisterna magna, mesomelic shortening, and clubfeet associated with pure tetrasomy 20p
    Yi Cheng Wu
    Department of Obstetrics and Gynecology, Veterans General Hospital Taipei, 201 Shih Pai Road, Section 2, Taipei, Taiwan, ROC
    Prenat Diagn 23:124-7. 2003
    ..The pregnancy was terminated because of associated multiple anomalies and severe oligohydramnios. The postmortem examination confirmed the prenatal diagnosis...
  38. ncbi request reprint Natural progression of menstrual pain in nulliparous women at reproductive age: an observational study
    Chi Mou Juang
    Division of General Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, R O C
    J Chin Med Assoc 69:484-8. 2006
    ..Menstrual pain can be alleviated after childbirth. The purpose of this observational study was to evaluate the natural progression of menstrual pain among nulliparous women at their reproductive age...
  39. ncbi request reprint Effect of continuous administration of conjugated estrogen plus medroxyprogesterone acetate (Premelle) in postmenopausal women in Taiwan
    Tzay Shing Yang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:336-43. 2004
    ....
  40. ncbi request reprint Single-dose sertaconazole vaginal tablet treatment of vulvovaginal candidiasis
    Peng Hui Wang
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan, ROC
    J Chin Med Assoc 69:259-63. 2006
    ..The aim of the present study was to evaluate the efficacy, acceptability, and safety of single-dose sertaconazole vaginal tablet (500 mg) treatment compared with conventional 3-dose econazole vaginal tablet (150 mg) treatment for VVC...
  41. ncbi request reprint Nuchal translucence incorporated into a one-stage multifactorial screening model for Down syndrome prediction at second-trimester pregnancy
    Jeng Hsiu Hung
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
    Ultrasound Med Biol 29:1667-74. 2003
    ..The risk probability of Down syndrome could be readily calculated after inputting data for all four predictor variables...
  42. ncbi request reprint Regulatory T cells: potential target in anticancer immunotherapy
    Chi Mou Juang
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Veterans General Hospital, Taipei, Taiwan
    Taiwan J Obstet Gynecol 46:215-21. 2007
    ..The mechanism and the potential clinical application of regulatory T cells in cancer immunotherapy are discussed...
  43. ncbi request reprint Successful rescue of an early interstitial pregnancy after failed systemic methotrexate treatment: a case report
    Yu Shiou Lin
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan
    J Reprod Med 52:332-4. 2007
    ..Use of an ultrasound-guided local injection can be a good alternative to surgery...
  44. ncbi request reprint Successful pregnancy in a woman with symptomatic fibroids who underwent laparoscopic bipolar coagulation of uterine vessels
    Yi Jen Chen
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Fertil Steril 77:838-40. 2002
    ..To report a case of successful pregnancy after laparoscopic bipolar coagulation of uterine vessels (LBCUV)...
  45. ncbi request reprint The concentration of serum transforming growth factor beta-1 (TGF-beta1) is decreased in cervical carcinoma patients
    Hwa Shyi Wu
    Department of Obstetrics and Gynecology, Veterans General Hospital, Taipei, Taiwan, ROC
    Cancer Invest 20:55-9. 2002
    ..07 +/- 9.38 ng/mL) than in normal controls (49.13 +/- 8.81 ng/mL) (p < 0.04). It suggested that diminution of the production of TGF-beta1 has close association with the neoplastic transformation of cervical epithelium...