Chueh Chuan Yen

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. pmc Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Oncotarget 5:716-25. 2014
  2. doi request reprint Integrating bioinformatics and clinicopathological research of gastrointestinal stromal tumors: identification of aurora kinase A as a poor risk marker
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann Surg Oncol 19:3491-9. 2012
  3. doi request reprint PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Surg Oncol 103:761-7. 2011
  4. ncbi request reprint Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma
    Chueh Chuan Yen
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Oncol 35:775-88. 2009
  5. ncbi request reprint Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed
    Chueh Chuan Yen
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, China
    World J Gastroenterol 11:1267-72. 2005
  6. ncbi request reprint Concurrent chemoradiotherapy followed by metastasectomy converts to survival benefit in stage IV rectum cancer
    Jen Kou Lin
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Gastrointest Surg 16:1888-96. 2012
  7. ncbi request reprint Decreased FHIT protein expression correlates with a worse prognosis in patients with diffuse large B-cell lymphoma
    Po Min Chen
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, No 201 Shih Pai Road, Section 2, Taipei 112, Taiwan, R O C
    Oncol Rep 11:349-56. 2004
  8. doi request reprint Follow-up after primary treatment of soft tissue sarcoma of extremities: impact of frequency of follow-up imaging on disease-specific survival
    Yi Sheng Chou
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Surg Oncol 106:155-61. 2012
  9. ncbi request reprint Temsirolimus enhances the efficacy of cetuximab in colon cancer through a CIP2A-dependent mechanism
    Hsei Wei Wang
    National Yang Ming University School of Medicine, Taipei, Taiwan
    J Cancer Res Clin Oncol 140:561-71. 2014
  10. ncbi request reprint Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma
    Po Kuei Hsu
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei City, Taiwan National Yang Ming University School of Medicine, Taipei City, Taiwan Institute of Clinical Medicine, National Yang Ming University, Taipei City, Taiwan
    J Thorac Cardiovasc Surg 147:1612-1618.e4. 2014

Collaborators

Detail Information

Publications71

  1. pmc Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Oncotarget 5:716-25. 2014
    ..15d-PGJ2 is a potential therapeutic agent for OS, exerting cytotoxicity mediated through both AKT and PKA-PLK1 inhibition, and these results form the basis for further analysis of its role in animal studies and clinical applications. ..
  2. doi request reprint Integrating bioinformatics and clinicopathological research of gastrointestinal stromal tumors: identification of aurora kinase A as a poor risk marker
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann Surg Oncol 19:3491-9. 2012
    ..For completely resected primary gastrointestinal stromal tumors (GISTs), mitotic rate, tumor size, and tumor location are important risk factors for recurrence. However, molecular markers for recurrence are still lacking...
  3. doi request reprint PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Surg Oncol 103:761-7. 2011
    ..We evaluated the clinicopathological associations and prognostic implications of promyelocytic leukemia gene (PML) expressions in patients with esophageal squamous cell carcinomas (ESCC) receiving primary surgery...
  4. ncbi request reprint Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma
    Chueh Chuan Yen
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Oncol 35:775-88. 2009
    ..The study also demonstrated that CN and LOH analyses were able to detect distinct subsets of genetic abnormalities in OS...
  5. ncbi request reprint Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed
    Chueh Chuan Yen
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, China
    World J Gastroenterol 11:1267-72. 2005
    ..However, amplification patterns of these genes in EC-SCC have never been reported. The possible association of copy number changes of these genes with pathologic characteristics is still not clear...
  6. ncbi request reprint Concurrent chemoradiotherapy followed by metastasectomy converts to survival benefit in stage IV rectum cancer
    Jen Kou Lin
    School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Gastrointest Surg 16:1888-96. 2012
    ..To investigate the impact of concurrent chemoradiotherapy (CCRT) on stage IV rectum cancer...
  7. ncbi request reprint Decreased FHIT protein expression correlates with a worse prognosis in patients with diffuse large B-cell lymphoma
    Po Min Chen
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, No 201 Shih Pai Road, Section 2, Taipei 112, Taiwan, R O C
    Oncol Rep 11:349-56. 2004
    ..Our result indicates that abnormal FHIT mRNA expression is noted frequently in NHL cell lines and a certain proportion of NHL patients, and decreased FHIT protein expression indicates a significantly worse prognosis in DLBCLs...
  8. doi request reprint Follow-up after primary treatment of soft tissue sarcoma of extremities: impact of frequency of follow-up imaging on disease-specific survival
    Yi Sheng Chou
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Surg Oncol 106:155-61. 2012
    ..We explored the impact of frequency of surveillance imaging on disease-specific survival (DSS) in patients with extremity soft tissue sarcoma (STS)...
  9. ncbi request reprint Temsirolimus enhances the efficacy of cetuximab in colon cancer through a CIP2A-dependent mechanism
    Hsei Wei Wang
    National Yang Ming University School of Medicine, Taipei, Taiwan
    J Cancer Res Clin Oncol 140:561-71. 2014
    ..We investigated the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in the synergism between temsirolimus and cetuximab in colon cancer...
  10. ncbi request reprint Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma
    Po Kuei Hsu
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei City, Taiwan National Yang Ming University School of Medicine, Taipei City, Taiwan Institute of Clinical Medicine, National Yang Ming University, Taipei City, Taiwan
    J Thorac Cardiovasc Surg 147:1612-1618.e4. 2014
    ..CRNN gene expression is downregulated in esophageal squamous cell carcinoma (ESCC), although its clinical implications in esophageal cancer remain unclear...
  11. ncbi request reprint Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction
    Chueh Chuan Yen
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Int J Oncol 23:871-81. 2003
    ..001). Combination of CGH, SKY and FISH could reveal detailed chromosomal changes associated with esophageal cancer cells, and Q-PCR could assess the change of the candidate genes in clinical samples in a high throughput way...
  12. doi request reprint Evaluation of prognosis for carcinoma of unknown origin in elderly patients
    Hsueh Ju Lu
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Oncology 83:24-30. 2012
    ..Carcinoma of unknown origin has a poor outcome and usually occurs in elderly patients. In this article, we analyzed the prognostic factors in elderly patients with cancer of unknown primary site (CUP) for treatment considerations...
  13. ncbi request reprint Outcome of colorectal carcinoma in patients under 40 years of age
    Jen Tsun Lin
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, 201 Sec 2 Shi Pai Road, Shi Pai, Taipei 112, Taiwan
    J Gastroenterol Hepatol 20:900-5. 2005
    ..Colorectal carcinoma in patients under 40 years of age usually has a poor prognosis. Controversies still exist regarding the features and the prognosis of colorectal cancer in young patients...
  14. ncbi request reprint Irinotecan (CPT11) plus high-dose 5-fluorouracil (5-FU) and leucovorin (LV) as salvage therapy for metastatic colorectal cancer (MCRC) after failed oxaliplatin plus 5-FU and LV: a pilot study in Taiwan
    Cheng Jeng Tai
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, 201 Shih Pai Road, Sec 2, Pei Tou, 112 Taipei, Taiwan
    Jpn J Clin Oncol 33:136-40. 2003
    ..We conducted this pilot study to evaluate the efficacy and tolerance of combination treatment with irinotecan and 5-fluorouracil (5-FU) for patients in whom combination treatment with oxaliplatin with 5-FU + leucovorin has failed...
  15. ncbi request reprint CA19-9 as the most significant prognostic indicator of metastatic colorectal cancer
    Wei Shu Wang
    Division of Medical Oncology, Department of Medicine, Veterans General Hospital Taipei, Taipei 11217, Taiwan, ROC
    Hepatogastroenterology 49:160-4. 2002
    ..However, these reports are contradictory and lack definite conclusions. This study was carried out in an effort to evaluate the prognostic significance of serum CA19-9 levels in patients with metastatic colorectal cancer in Taiwan...
  16. ncbi request reprint Higher fungal infection rate in elderly patients (more than 80 years old) suffering from diffuse large B cell lymphoma and treated with rituximab plus CHOP
    Peng Chan Lin
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann Hematol 86:95-100. 2007
    ..Adding rituximab to the standard CHOP regimen in elderly DLBCL patients might increase the incidence of fungal infection especially in those older than 80 years old...
  17. ncbi request reprint High prevalence of SV40 infection in patients with nodal non-Hodgkin's lymphoma but not acute leukemia independent of contaminated polio vaccines in Taiwan
    Po Min Chen
    Division of Medical Oncology, Department of Medicine, Taipei Veteran General Hospital, Taipei, Taiwan, Republic of China
    Cancer Invest 24:223-8. 2006
    ..0001). Prospective studies are needed to determine the prevalence of SV40 infections in our and other human populations and to explore the means of transmission of the virus...
  18. doi request reprint The efficacy of chemotherapy in patients with high-grade metastatic colon cancer
    Chia Jen Liu
    Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Hepatogastroenterology 58:1495-501. 2011
    ....
  19. doi request reprint CIP2A is a predictor of poor prognosis in colon cancer
    Hao Wei Teng
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Gastrointest Surg 16:1037-47. 2012
    ..The cancerous inhibitor of protein phosphatase 2A (CIP2A) oncoprotein is overexpressed in colon cancer tissue compared to normal colon mucosa. We investigated the impact of CIP2A on colon cancer...
  20. ncbi request reprint Low incidence of BCL-6 gene alterations for diffuse large B-cell lymphomas in Taiwan Chinese
    Po Min Chen
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, No 201, Section 2, Shih Pai Road, Taipei 112, Taiwan, Republic of China
    Cancer 94:2635-44. 2002
    ....
  21. doi request reprint Effective salvage therapy of imatinib-resistant gastrointestinal stromal tumor with combination of imatinib and pegylated liposomal doxorubicin
    Yao Yu Hsieh
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 74:272-4. 2011
    ..Surprisingly, combination of imatinib with pegylated liposomal doxorubicin produced a substantial response and resulted in a 5-month progression free period for this imatinib-resistant gastrointestinal stromal tumor...
  22. ncbi request reprint N-acetylcysteine has neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients: preliminary data
    Peng Chan Lin
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taiwan, Republic of China
    Support Care Cancer 14:484-7. 2006
    ..We concluded that oral N-acetylcysteine reduces the incidence of oxaliplatin-induced neuropathy in colon cancer patients receiving oxaliplatin-based adjuvant chemotherapy...
  23. ncbi request reprint Unusually high incidence of upper urinary tract urothelial carcinoma in Taiwan
    Muh Hwa Yang
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, Republic of China
    Urology 59:681-7. 2002
    ....
  24. ncbi request reprint Extended lamivudine therapy against hepatitis B virus infection in hematopoietic stem cell transplant recipients
    Liang Tsai Hsiao
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Biol Blood Marrow Transplant 12:84-94. 2006
    ..016-0.908; P = .040). In conclusion, extended lamivudine therapy is safe and effective for the prevention of HBV reactivation in an HSCT setting and significantly decreases reactivation hepatitis after transplantation...
  25. ncbi request reprint Non-Hodgkin lymphoma in elderly patients: experience at Taipei Veterans General Hospital
    Li Yuan Bai
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Cancer 98:1188-95. 2003
    ..The annual incidence of non-Hodgkin lymphoma (NHL) has increased over the past two decades in all age groups, including the elderly. Establishing guidelines for proper care for this segment of the population requires further information...
  26. ncbi request reprint EIA versus RIA in detecting carcinoembryonic antigen level of patients with metastatic colorectal cancer
    Wei Shu Wang
    Division of Medical Oncology, Department of Medicine, Veterans General Hospital, Taipei, Taiwan
    Hepatogastroenterology 51:136-41. 2004
    ..Because EIA has the advantage of avoiding the use of radioisotopes, the potential of using EIA instead of RIA in detecting CEA of patients with colorectal cancer is of interest to us...
  27. ncbi request reprint Tumor marker CEA in monitoring of response to tegafur-uracil and folinic acid in patients with metastatic colorectal cancer
    Wei Shu Wang
    Department of Medicine, Division of Medical Oncology, Veterans General Hospital, Taipei, Taiwan
    Hepatogastroenterology 49:388-92. 2002
    ..This study was carried out in an effort to evaluate the correlation between serial change on imaging and on CEA (carcinoembryonic antigen) levels for assessing chemotherapeutic response of patients with metastatic colorectal cancer...
  28. doi request reprint BRAF mutation is a prognostic biomarker for colorectal liver metastasectomy
    Hao Wei Teng
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Surg Oncol 106:123-9. 2012
    ..We aimed to determine the impact of KRAS and BRAF mutation as determined from liver metastases specimens on overall survival (OS) in patients following colorectal liver metastasectomy...
  29. doi request reprint Brain, the last fortress of sarcoma: similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma
    Yi Sheng Chou
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Surg Oncol 104:765-70. 2011
    ..Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized...
  30. ncbi request reprint All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia
    Jen Tsun Lin
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, National Yang Ming University, School of Medicine, Taipei, Taiwan
    Adv Ther 20:337-43. 2003
    ..As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL...
  31. ncbi request reprint Chryseobacterium indologenes bacteremia in a bone marrow transplant recipient with chronic graft-versus-host disease
    Jen Tsun Lin
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan
    Scand J Infect Dis 35:882-3. 2003
    ..Our case indicates that C. indologenes infection can occur in patients with GVHD after allogeneic BMT and might be treated with a single agent, piperacillin/tazobactam without the removal of intravascular catheter...
  32. ncbi request reprint Detection of reactivation and genetic mutations of the hepatitis B virus in patients with chronic hepatitis B infections receiving hematopoietic stem cell transplantation
    Po Min Chen
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital Department of Medicine, Taipei, Republic of China
    Transplantation 74:182-8. 2002
    ..This study elucidates the profiles for hepatitis B virus (HBV) reactivation and genetic mutation of the core promoter and precore regions for HBV-carriers receiving hematopoietic stem cell transplantation (HSCT)...
  33. doi request reprint Duloxetine improves oxaliplatin-induced neuropathy in patients with colorectal cancer: an open-label pilot study
    Ya Hsu Yang
    Department of Psychiatry, Taipei City Hospital Renai Branch, Taipei, Taiwan
    Support Care Cancer 20:1491-7. 2012
    ..This open-label pilot study is aimed to evaluate the efficacy and tolerability of the antidepressant duloxetine, which is effective for diabetic neuropathic pain, in the treatment of chronic oxaliplatin-induced peripheral neuropathy (OIPN)...
  34. ncbi request reprint Prognostic significance of clonal diversity of immunoglobulin gene rearrangements in patients with diffuse large B-cell lymphoma
    Muh Hwa Yang
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, No 201 Sec 2 Shih Pai Rd, Taipei 112, Taiwan
    Oncol Rep 13:503-8. 2005
    ..It is also a factor of poor prognosis in DLBCL, especially for high-intermediate risk category...
  35. ncbi request reprint Stevens-Johnson syndrome after treatment with STI571: a case report
    Liang Tsai Hsiao
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei 112, Taiwan
    Br J Haematol 117:620-2. 2002
    ..This report may serve to remind the clinician about the possible severe cutaneous side-effects of STI571 before instituting more extensive clinical application of this agent in the future...
  36. ncbi request reprint Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome
    Peter Mu Hsin Chang
    Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan, R O C
    Int J Oncol 33:549-54. 2008
    ..We suggest that overexpression of DcR3 is associated with a worse prognosis in DLBCL and the possible mechanism may act through the increase of chemo-resistance of lymphoma cells...
  37. ncbi request reprint Sequential therapy with capecitabine followed by vinorelbine/cisplatin in patients with anthracycline/taxane-refractory metastatic breast cancer
    Peng Chan Lin
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 69:304-9. 2006
    ..In this study, we analyzed the efficacy and toxicity of sequential therapy with capecitabine followed by biweekly vinorelbine plus cisplatin in 37 patients with anthracycline and taxane-refractory MBC in Taipei Veterans General Hospital...
  38. ncbi request reprint Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma
    Wei Shu Wang
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan, China
    World J Gastroenterol 11:2166-70. 2005
    ..To evaluate the correlations of plasma von Willebrand factor (vWF) level with the distant metastasis and prognosis of patients with colorectal cancer...
  39. doi request reprint A new classification scheme for recurrent or metastatic colon cancer after liver metastasectomy
    Yen Ning Hsu
    Division of Hematology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC
    J Chin Med Assoc 74:493-9. 2011
    ..Metastasectomy is the standard treatment for patients with resectable liver metastasis from colon cancer. This study aimed to determine the impact of initial stage on overall survival (OS) after metastasectomy...
  40. doi request reprint Soft tissue sarcoma of extremities: the prognostic significance of adequate surgical margins in primary operation and reoperation after recurrence
    Chun Yu Liu
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann Surg Oncol 17:2102-11. 2010
    ..This study aimed to explore the impact of clinicopathological factors on outcome and to define an "oncological safe margin" in these patients...
  41. doi request reprint Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma
    Hao Wei Teng
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Surg Oncol 103:773-81. 2011
    ..We aimed to study the prevalence and prognostic influence of epidermal growth factor receptor (EGFR) and its downstream effectors in synovial sarcoma (SS)...
  42. doi request reprint High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin's lymphoma
    Ming Huang Chen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann Hematol 87:475-80. 2008
    ..B cell NHL patients, even HBsAg-negative B cell NHL patients, but not T cell NHL patients, have a higher incidence of HBV infection than patients with solid tumors. Our findings support the etiologic role of HBV infection in B cell NHL...
  43. ncbi request reprint High serum hepatocyte growth factor level in patients with non-Hodgkin's lymphoma
    Liang Tsai Hsiao
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taiwan
    Eur J Haematol 70:282-9. 2003
    ..The pathogenic role of HGF in NHL patients was further highlighted by a modest expression of HGF in most of the diffuse large B cell lymphoma...
  44. ncbi request reprint Pulmonary function changes in long-term survivors of chronic myelogenous leukemia after allogeneic bone marrow transplantation: a Taiwan experience
    Tzeon Jye Chiou
    Section of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, No 201, Sec 2, Shih Pai Road, Taipei 112, Taiwan, ROC
    Cancer Invest 20:880-8. 2002
    ..The primary negative presentation with the development of oxygenation defect had no clinical significance in most patients. The influences on the impairment of pulmonary function were multifactorial...
  45. ncbi request reprint A dose-escalating pilot study of sterically stabilized, pegylated liposomal doxorubicin (Lipo-Dox) in patients with metastatic breast cancer
    Ta Chung Chao
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, National Yang Ming University, School of Medicine, Taipei, Taiwan, ROC
    Cancer Invest 21:837-47. 2003
    ....
  46. pmc Evaluation of prognostic factors and the role of chemotherapy in unfavorable carcinoma of unknown primary site: a 10-year cohort study
    Kuo Wei Chen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    BMC Res Notes 5:70. 2012
    ..Carcinoma of unknown primary site (CUP) has a poor prognosis and the prognostic factors in these patients are not well established. Furthermore, there are no selection criteria for patients who should benefit from chemotherapy...
  47. doi request reprint Pneumothorax after bevacizumab-containing chemotherapy: a case report
    Sheng Hsiang Yang
    Division of Hematology Oncology, Department of Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei 112, Taiwan
    Jpn J Clin Oncol 41:269-71. 2011
    ..In patients who had chest discomfort after bevacizumab-containing therapy, pneumothorax should never be overlooked as one of the differential diagnoses...
  48. ncbi request reprint Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia
    Po Min Chen
    Division of Hematology Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan R O C
    Int J Oncol 32:1335-41. 2008
    ..These results suggest that down-regulation of Notch-1 expression decreases PU.1/MCSFR expression and disrupts the Notch-1/PU.1 complex, which may impede the PU.1-mediated myeloid signaling and contribute to the leukemogenesis of AML...
  49. doi request reprint A novel E1B-55kD-deleted oncolytic adenovirus carrying mutant KRAS-regulated hdm2 transgene exerts specific antitumor efficacy on colorectal cancer cells
    Chin Cheng Liu
    Institute of Biochemistry and Molecular Biology, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Mol Cancer Ther 9:450-60. 2010
    ..Ad-KRhdm2 has shown its therapeutic potential in KRAS(aMut) cancer cells and warrants further clinical trials...
  50. ncbi request reprint An intron promotes the anti-bcr-abl activities of a retrovirally expressed ribozyme in chronic myeloid leukemia cells
    Jin Hwang Liu
    Division of Medical Oncology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan, ROC
    Biochem Biophys Res Commun 318:764-72. 2004
    ..Noticeably, the improvement is contributed in part by subcellular co-localization...
  51. ncbi request reprint Sonographically guided core needle biopsy of soft tissue neoplasms
    Juhn Cherng Liu
    Department of Radiology, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei, Taiwan, Republic of China
    J Clin Ultrasound 32:294-8. 2004
    ..This study was conducted to evaluate the usefulness of sonography (US)-guided needle biopsy in the diagnosis of soft tissue masses...
  52. ncbi request reprint Rituximab therapy increased post-transplant cytomegalovirus complications in Non-Hodgkin's lymphoma patients receiving autologous hematopoietic stem cell transplantation
    Ming Yang Lee
    Division of Hemato Oncology, Department of Medicine, Chia Yi Christian Hospital, Chia Yi, Taiwan, ROC
    Ann Hematol 87:285-9. 2008
    ..7% vs 0%, p = 0.131, Fisher exact test, two-sided). The NHL patients receiving rituximab therapy had higher risk to develop CMV infectious complications after autologous HSCT...
  53. doi request reprint Pml and TAp73 interacting at nuclear body mediate imatinib-induced p53-independent apoptosis of chronic myeloid leukemia cells
    Jin Hwang Liu
    Division of Hematology and Oncology, Taipei Veterans General Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Int J Cancer 125:71-7. 2009
    ..A novel p53-independent proapoptotic mechanism using p38 MAPK /pml/TAp73 axis with a step processing at PML-NB and probably with chk2 and bax being involved is hereby evident in some imatinib-treated CML cells...
  54. ncbi request reprint Prognostic factors and treatment efficacy in patients with primary diffuse large B-cell lymphoma of the bone: single institute experience over 11 years
    Yao Chung Liu
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taiwan
    Intern Med 53:95-101. 2014
    ..In our study, a favorable response and lower risk of emergent surgery were observed following the administration of systemic chemotherapy with or without rituximab...
  55. ncbi request reprint Paclitaxel in a novel formulation containing less Cremophor EL as first-line therapy for advanced breast cancer: a phase II trial
    Ta Chung Chao
    Division of Medical Oncology, Department of Medicine, Taipei Veteran General Hospital, Taipei 112, Taiwan, R O C
    Invest New Drugs 23:171-7. 2005
    ..These phase II trial results demonstrate that a 60% reduction of CrEL by Genetaxyl's formulation does not affect the activity of paclitaxel and could allow for better control of several CrEL-related toxicities...
  56. doi request reprint Color Doppler ultrasonography evaluation for chemotherapy treatment response of osteogenic sarcoma
    Yen Huai Lin
    Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan
    Ultrasound Med Biol 38:202-8. 2012
    ..For individuals with osteogenic sarcoma who still have a higher difference in PSV between the diseased and contralateral limbs after chemotherapy, another course of chemotherapy after surgery and close follow-up should be considered...
  57. ncbi request reprint Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients
    Wei Shu Wang
    National Yang Ming University School of Medicine, Taipei, Taiwan, Republic of China
    Oncologist 12:312-9. 2007
    ..8%), or survival. These data indi-cate that oral glutamine significantly reduces the incidence and severity of peripheral neuropathy of MCRC patients receiving oxaliplatin without affecting response to chemotherapy and survival...
  58. ncbi request reprint TPX2 expression is associated with cell proliferation and patient outcome in esophageal squamous cell carcinoma
    Po Kuei Hsu
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    J Gastroenterol 49:1231-40. 2014
    ..Using high-throughput data analysis, we examined molecular changes involved in ESCC pathogenesis and investigated their clinical relevance...
  59. pmc Incidence patterns of primary bone cancer in taiwan (2003-2010): a population-based study
    Giun Yi Hung
    Division of Pediatric Hematology and Oncology, Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Ann Surg Oncol 21:2490-8. 2014
    ..Primary bone cancer (BC) incidence by age has not been surveyed in Asia...
  60. doi request reprint Diffusion capacity predicts long-term survival after allogeneic bone marrow transplantation for acute lymphoblastic leukemia
    Peter Mu Hsin Chang
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 71:234-40. 2008
    ..The aim of this study was to evaluate changes in pulmonary function measures as predictors of outcome in acute lymphoblastic leukemia (ALL) patients after myeloablative allogeneic bone marrow transplantation (BMT)...
  61. ncbi request reprint Prurigo nodularis as initial presentation of metastatic transitional cell carcinoma of the bladder
    Jen Tsun Lin
    Division of Medical Oncology, Department of Medicine and Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Urol 168:631-2. 2002
  62. ncbi request reprint Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: different cytogenetic changes are correlated with genders and smoking habits
    Chueh Chuan Yen
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Lung Cancer 57:292-301. 2007
    ..The role of LDHC in the carcinogenesis of smoking-related lung adenocarcinoma, especially in male patients with pleural effusions, deserves further investigations...
  63. ncbi request reprint Primary renal synovial sarcoma with inferior vena cava and right atrium invasion
    Paul Chih Hsueh Chen
    Department of Pathology, Division of Medical Oncology, Veterans General Hospital and Yang Ming University, Taipei, Taiwan
    Int J Urol 10:657-60. 2003
    ..Our case shows that synovial sarcoma should be considered in the differential diagnosis of renal tumors, especially in adolescents and young adults. Proper molecular analysis should be undertaken to attain a definitive diagnosis...
  64. ncbi request reprint Stage IV thymic carcinoma: a study of 20 patients
    Jen Tsun Lin
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Am J Med Sci 330:172-5. 2005
    ..This study was performed to investigate the clinical factors, tumor characteristics, treatment approach, and prognosis of patients with Stage IV thymic carcinoma (WHO type C)...
  65. doi request reprint Prognostic factors of Chinese patients with primary pulmonary non-Hodgkin's lymphoma: the single-institute experience in Taiwan
    Yu Hui Hu
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann Hematol 88:839-46. 2009
    ..The two prognostic factors provided additional information in managing these patients...
  66. doi request reprint The prognosis of patients with primary osteosarcoma who have undergone unplanned therapy
    Ta I Wang
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital 201, Section 2, Shih Pai Road, Taipei 112, Taiwan
    Jpn J Clin Oncol 41:1244-50. 2011
    ..Erroneous treatment may cause local contamination and systemic seeding in patients. The purpose of this study was to compare outcomes of planned and unplanned treatment for osteosarcoma...
  67. ncbi request reprint Overexpression of cyclin D1 in accelerated-phase chronic myeloid leukemia
    Jin Hwang Liu
    Division of Medical Oncology and Hematology Taipei Veterans General Hospital and National Yang Ming University School of Medicine Taipei Taiwan
    Leuk Lymphoma 45:2419-25. 2004
    ..These results suggest that the expression level of cyclin D1 RNA in bone marrow cells is predictive of the phase evolution in CML and may be helpful in treatment decision-making...
  68. ncbi request reprint Pathology quiz case: Metastatic osteosarcoma of the external auditory canal
    Chia Huei Chu
    Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Arch Otolaryngol Head Neck Surg 132:109-10. 2006
  69. ncbi request reprint Prognostic-factors-based risk-stratification model for invasive urothelial carcinoma of the urinary bladder in Taiwan
    Muh Hwa Yang
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, People s Republic of China, Taipei, Taiwan
    Urology 59:232-8; discussion 238-9. 2002
    ..The incidence of recurrent disease is significantly higher for patients with poor renal function before treatment or advanced T stage and those undergoing transurethral tumor resection instead of radical cystectomy...
  70. doi request reprint Magnetic resonance imaging guided biopsy of musculoskeletal lesions
    Hung Ta H Wu
    Department of Radiology, Taipei Veterans General Hospital, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 75:160-6. 2012
    ..The purpose of this study was to clinically test and evaluate the efficacy of the magnetic resonance imaging (MRI)-guidance techniques for obtaining musculoskeletal biopsies using the appropriate imaging modalities and instruments...
  71. doi request reprint Malignant lymphoma in an atomic-bomb survivor
    Cheng Chia Lee
    Department of Orthopedics and Traumatology, Taipei Veterans General Hospital, Department of Surgery, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 72:388-93. 2009
    ..In addition, the authors suggest that atomic bomb survivors should be followed-up carefully throughout their entire life...