De Ming Yang

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Dynamics of mitochondria and mitochondrial Ca2+ near the plasma membrane of PC12 cells: a study by multimode microscopy
    De Ming Yang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Republic of China
    Ann N Y Acad Sci 1042:163-7. 2005
  2. ncbi request reprint An automated tracking system to measure the dynamic properties of vesicles in living cells
    Tien Chuan Ku
    Department of Biomedical Engineering, Chung Yuan Christian University, Jhongli, Taiwan
    Microsc Res Tech 70:119-34. 2007
  3. ncbi request reprint An evanescent approach for mitochondrial function assay of living cells
    De Ming Yang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
    Nanomedicine 1:286-92. 2005
  4. ncbi request reprint Detection of the interaction between SNAP25 and rabphilin in neuroendocrine PC12 cells using the FLIM/FRET technique
    Jiung De Lee
    Institute of Biophotonics, School of Medical Technology and Engineering, National Yang Ming University, Taipei, Taiwan, Republic of China
    Microsc Res Tech 71:26-34. 2008
  5. doi request reprint Orai1-STIM1 formed store-operated Ca2+ channels (SOCs) as the molecular components needed for Pb2+ entry in living cells
    Yu Fen Chang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan, Republic of China
    Toxicol Appl Pharmacol 227:430-9. 2008
  6. doi request reprint Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1
    Chien Chang Huang
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan, R O C
    Traffic 12:1356-70. 2011
  7. doi request reprint Visualization of the Orai1 homodimer and the functional coupling of Orai1-STIM1 by live-cell fluorescence lifetime imaging
    Ping Chun Huang
    Department of Medical Research and Education, Taipei Veterans General Hospital Taipei, Taiwan, Republic of China
    Microsc Microanal 16:313-26. 2010
  8. ncbi request reprint Effects of clodronate on cancer growth and Ca2+ signaling of human thyroid carcinoma cell lines
    De Ming Yang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Anticancer Res 24:1617-23. 2004
  9. doi request reprint Dominant role of Orai1 with STIM1 on the cytosolic entry and cytotoxicity of lead ions
    Tai Yu Chiu
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan, Republic of China
    Toxicol Sci 110:353-62. 2009
  10. doi request reprint Potential effect of resistin on the ET-1-increased reactions of blood pressure in rats and Ca2+ signaling in vascular smooth muscle cells
    Tung Yueh Chuang
    Department and Institute of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 227:1610-8. 2012

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Dynamics of mitochondria and mitochondrial Ca2+ near the plasma membrane of PC12 cells: a study by multimode microscopy
    De Ming Yang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Republic of China
    Ann N Y Acad Sci 1042:163-7. 2005
    ..The results provide direct evidence to support the hypothesis that mitochondria in different subcellular localization show differential responses to the influx of extracellular Ca2+...
  2. ncbi request reprint An automated tracking system to measure the dynamic properties of vesicles in living cells
    Tien Chuan Ku
    Department of Biomedical Engineering, Chung Yuan Christian University, Jhongli, Taiwan
    Microsc Res Tech 70:119-34. 2007
    ..In conclusion, the novel tracking system, PTrack, should facilitate automated quantification of the dynamic properties of vesicles that are important when classifying vesicular protein locations...
  3. ncbi request reprint An evanescent approach for mitochondrial function assay of living cells
    De Ming Yang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
    Nanomedicine 1:286-92. 2005
    ..This system permits further analysis of functions of mitochondria and other organelles with more precision than is possible using a traditional platform...
  4. ncbi request reprint Detection of the interaction between SNAP25 and rabphilin in neuroendocrine PC12 cells using the FLIM/FRET technique
    Jiung De Lee
    Institute of Biophotonics, School of Medical Technology and Engineering, National Yang Ming University, Taipei, Taiwan, Republic of China
    Microsc Res Tech 71:26-34. 2008
    ..Finally, these two proteins dissociated after stimulation. To our knowledge, this is the first report to demonstrate the interaction of SNAP25 and rabphilin in situ using the FLIM-FRET technique within neuroendocrine cells...
  5. doi request reprint Orai1-STIM1 formed store-operated Ca2+ channels (SOCs) as the molecular components needed for Pb2+ entry in living cells
    Yu Fen Chang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan, Republic of China
    Toxicol Appl Pharmacol 227:430-9. 2008
    ..In summary, our results suggest that SOCs are responsible for Pb2+ permeation and that the Orai1-STIM1 protein complex formed by functional SOCs is one of the molecular components involved in Pb2+ entry...
  6. doi request reprint Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1
    Chien Chang Huang
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan, R O C
    Traffic 12:1356-70. 2011
    ..Munc18-1 acts downstream of Munc13-1/RIM/Rab3A and interacts with syntaxin 1a allowing vesicle priming. Furthermore, Munc18-1 promotes Rab3A dissociation from vesicles, which then results in fusion...
  7. doi request reprint Visualization of the Orai1 homodimer and the functional coupling of Orai1-STIM1 by live-cell fluorescence lifetime imaging
    Ping Chun Huang
    Department of Medical Research and Education, Taipei Veterans General Hospital Taipei, Taiwan, Republic of China
    Microsc Microanal 16:313-26. 2010
    ..In summary, we show the detailed interactions Orai1-Orai1 and Orai1-STIM1 within intact living cells by using the FLIM-FRET technique...
  8. ncbi request reprint Effects of clodronate on cancer growth and Ca2+ signaling of human thyroid carcinoma cell lines
    De Ming Yang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Anticancer Res 24:1617-23. 2004
    ..The results from this study implied that clodronate-mediated cell growth inhibition in slow growing thyroid cancer cells might correlate with a Ca2+ signaling pathway...
  9. doi request reprint Dominant role of Orai1 with STIM1 on the cytosolic entry and cytotoxicity of lead ions
    Tai Yu Chiu
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan, Republic of China
    Toxicol Sci 110:353-62. 2009
    ..In summary, the data suggest that Orai1, together with STIM1, plays a critical role in Pb(2+) entry and the toxicity of Pb(2+)...
  10. doi request reprint Potential effect of resistin on the ET-1-increased reactions of blood pressure in rats and Ca2+ signaling in vascular smooth muscle cells
    Tung Yueh Chuang
    Department and Institute of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 227:1610-8. 2012
    ..Resistin appears to exert effects on ET-1-induced Ca(2+) increases by enhancing the activity of ERK-dependent SOCE (STIM1-partcipated), and may accelerate and prolong ET-1-increased blood pressure via the same pathway...
  11. doi request reprint In-depth fluorescence lifetime imaging analysis revealing SNAP25A-Rabphilin 3A interactions
    Jiung De Lee
    Department of Medical Research and Education, Taipei Veterans General Hospital, National Yang Ming University, Taipei 11217, Taiwan, Republic of China
    Microsc Microanal 14:507-18. 2008
    ..In summary, we have demonstrated that the 2PE-FLIM/FRET technique is a powerful tool to reveal dynamic SNAP25A/RPH3A interactions in single neuroendocrine cells...
  12. doi request reprint Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells
    Ling Ming Tseng
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Pharmacol Exp Ther 341:410-23. 2012
    ..In summary, these results show that the STAT3 pathway plays a key role in mediating CSC properties in ATC-CD133+ cells. Targeting STAT3 with cucurbitacin I in ATC may provide a new approach for therapeutic treatment in the future...
  13. ncbi request reprint A domain directly C-terminal to the major homology region of human immunodeficiency type 1 capsid protein plays a crucial role in directing both virus assembly and incorporation of Gag-Pol
    An I Chien
    Department of Medical Research and Education, Taipei Veterans General Hospital, 201, Sec 2, Shih Pai Road, Taipei 11217, Taiwan
    Virology 348:84-95. 2006
    ....
  14. pmc Live-cell dynamic sensing of Cd(2+) with a FRET-based indicator
    Tai Yu Chiu
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    PLoS ONE 8:e65853. 2013
    ..57 was constructed for reliable and convenient investigations to determine the Cd(2+) concentration within living cells, including the identification of the entry pathway of Cd(2+) and sub-cellular sequestration...
  15. doi request reprint A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways
    Kun Ling Tsai
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    J Nutr Biochem 23:458-68. 2012
    ..However, its molecular mechanisms on endothelial cells remain still unclarified...
  16. ncbi request reprint An endothelin type A receptor-expressing cell to characterize endothelin-1 binding and screen antagonist
    Chi Chang Juan
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan, Republic of China
    Anal Biochem 379:27-31. 2008
    ..The COS-7(ET(A)R) established in this study will be a useful tool for screening ET-1 antagonists for treating hypertension...
  17. pmc miRNA-146a expression positively regulates tumor necrosis factor-α-induced interleukin-8 production in mesenchymal stem cells and differentiated lung epithelial-like cells
    Diahn Warng Perng
    Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Tissue Eng Part A 18:2259-67. 2012
    ..The expression of miRNA-146a and the response to stimuli may be modulated through mature differentiation of BM-MSC...
  18. doi request reprint Clodronate-induced cell apoptosis in human thyroid carcinoma is mediated via the P2 receptor signaling pathway
    De Ming Yang
    Departments of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    J Pharmacol Exp Ther 330:613-23. 2009
    ..In conclusion, we demonstrated that clodronate-induced PTC cell apoptosis and tumor inhibition are partially mediated by the P2Y receptor-cAMP cascade...
  19. ncbi request reprint A novel in vitro retinal differentiation model by co-culturing adult human bone marrow stem cells with retinal pigmented epithelium cells
    Shih Hwa Chiou
    Department of Ophthalmology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Biochem Biophys Res Commun 326:578-85. 2005
    ..The latter system provides an ex vivo expansion model of culturing photoreceptors for the treatment of retinal degeneration diseases...
  20. pmc When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?
    Yi Chao Lee
    Ph D Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, Republic of China
    PLoS ONE 7:e38865. 2012
    ..Taken together, zeatin riboside might have therapeutic potential as a novel neuroprotectant and a lead for treating neurodegenerative disorders...
  21. ncbi request reprint Scattering polarization by anisotropic biomolecules
    Tsu Wei Nee
    Institute of Biophotonics, National Yang Ming University, Taipei, Taiwan, China twnee ym edu tw
    J Opt Soc Am A Opt Image Sci Vis 25:1030-8. 2008
    ..The medium dielectric constant of the model ellipsoid provides a theoretic background for correlating the optical polarization properties of a biomolecule to its microscopic electronic structure...