Shih Jen Tsai

Summary

Affiliation: Taipei Veterans General Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Association analysis of polymorphism in the promoter region of the alpha2a-adrenoceptor gene with schizophrenia and clozapine response
    S J Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Schizophr Res 49:53-8. 2001
  2. pmc Physiologic and laboratory correlates of depression, anxiety, and poor sleep in liver cirrhosis
    Fang Yuan Ko
    Section of Liver Cirrhosis, Shuguang Hospital and Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai, 201203, China
    BMC Gastroenterol 13:18. 2013
  3. pmc Web-based tools can be used reliably to detect patients with major depressive disorder and subsyndromal depressive symptoms
    Chao Cheng Lin
    Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
    BMC Psychiatry 7:12. 2007
  4. pmc The influence of serotonin transporter polymorphisms on cortical activity: a resting EEG study
    Tien Wen Lee
    Department of Psychiatry, Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, Taoyuan County, Taiwan
    BMC Neurosci 12:33. 2011
  5. ncbi request reprint Distribution of androgen receptor CAG repeat polymorphism in Chinese schizophrenia and its correlation with age at onset
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, 11217, Taipei, Taiwan, ROC
    Psychoneuroendocrinology 31:270-4. 2006
  6. ncbi request reprint The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, and Division of Psychiatry, School of Medicine, National Yang Ming University, No 201 Shih Pai Road, Section 2, Taipei 11217, Taiwan
    Med Hypotheses 66:319-22. 2006
  7. ncbi request reprint Deltamethrin, a pyrethroid insecticide, could be a potential antidepressant agent
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 66:605-8. 2006
  8. ncbi request reprint The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a chinese population
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 21:139-43. 2006
  9. ncbi request reprint Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 50:37-40. 2004
  10. ncbi request reprint Lithium and antidepressants: potential agents for the treatment of Rett syndrome
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Division of Psychiatry, School of Medicine, National Yang Ming University, No 201 Shih Pai Road, Section 2, Taipei 11217, Taiwan
    Med Hypotheses 67:626-9. 2006

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Association analysis of polymorphism in the promoter region of the alpha2a-adrenoceptor gene with schizophrenia and clozapine response
    S J Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Schizophr Res 49:53-8. 2001
    ....
  2. pmc Physiologic and laboratory correlates of depression, anxiety, and poor sleep in liver cirrhosis
    Fang Yuan Ko
    Section of Liver Cirrhosis, Shuguang Hospital and Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai, 201203, China
    BMC Gastroenterol 13:18. 2013
    ..This study therefore measured both biochemistry data and heart rate variability (HRV) analyses, and aimed to identify the physiologic correlates of depression, anxiety, and poor sleep in cirrhosis...
  3. pmc Web-based tools can be used reliably to detect patients with major depressive disorder and subsyndromal depressive symptoms
    Chao Cheng Lin
    Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
    BMC Psychiatry 7:12. 2007
    ..Therefore the aim of this study was to evaluate the test-retest reliability and criterion validity of a Web-based system, the Internet-based Self-assessment Program for Depression (ISP-D)...
  4. pmc The influence of serotonin transporter polymorphisms on cortical activity: a resting EEG study
    Tien Wen Lee
    Department of Psychiatry, Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, Taoyuan County, Taiwan
    BMC Neurosci 12:33. 2011
    ..This study examined the modulatory effects of 5-HTTLPR (L-allele carriers vs. non-carriers) and 5-HTTVNTR (10-repeat allele carriers vs. non-carriers) polymorphism on regional neural activity in a young female population...
  5. ncbi request reprint Distribution of androgen receptor CAG repeat polymorphism in Chinese schizophrenia and its correlation with age at onset
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, 11217, Taipei, Taiwan, ROC
    Psychoneuroendocrinology 31:270-4. 2006
    ..Nevertheless, given that androgens affect cognitive function, violent behavior and mood, the effect of the AR CAG polymorphism on the clinical manifestations of schizophrenia may warrant further exploration...
  6. ncbi request reprint The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, and Division of Psychiatry, School of Medicine, National Yang Ming University, No 201 Shih Pai Road, Section 2, Taipei 11217, Taiwan
    Med Hypotheses 66:319-22. 2006
    ..Attempts to confirm the tPA/plasminogen hypothesis may lead to new directions in the study of the pathogenesis of MDD and the development of a novel intervention of this disorder...
  7. ncbi request reprint Deltamethrin, a pyrethroid insecticide, could be a potential antidepressant agent
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 66:605-8. 2006
    ..Further evaluation of the therapeutic and toxic effects of this drug in animal models is needed before clinical trials can begin...
  8. ncbi request reprint The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a chinese population
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 21:139-43. 2006
    ..002). These results suggest that BDNF genetic variation may possibly affect the risk for AD, particularly in subjects who are negative for APOE4...
  9. ncbi request reprint Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 50:37-40. 2004
    ..Further exploration of other genetic variants implicated in clozapine-induced BWC is important, however, in order to predict and reduce clozapine-associated weight gain...
  10. ncbi request reprint Lithium and antidepressants: potential agents for the treatment of Rett syndrome
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Division of Psychiatry, School of Medicine, National Yang Ming University, No 201 Shih Pai Road, Section 2, Taipei 11217, Taiwan
    Med Hypotheses 67:626-9. 2006
    ..Several points regarding the use of these agents in RTT are discussed. Further evaluation of the therapeutic effects of these drugs in RTT animal models is needed before clinical trials can begin...
  11. ncbi request reprint Association study of polymorphisms in glycine transporter with schizophrenia
    S J Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neural Transm 113:1545-9. 2006
    ..Further studies with other GlyT1 variants, relating either to schizophrenia, psychotic symptoms or to therapeutic response in schizophrenia, are suggested...
  12. ncbi request reprint Increased central brain-derived neurotrophic factor activity could be a risk factor for substance abuse: Implications for treatment
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, Taipei 11217, Taiwan
    Med Hypotheses 68:410-4. 2007
    ..Several strategies to decrease central BDNF activity that have potential use in the treatment of drug addiction are proposed...
  13. ncbi request reprint TrkB partial agonists: potential treatment strategy for epilepsy, mania, and autism
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 66:173-5. 2006
    ....
  14. ncbi request reprint Repetitive transcranial magnetic stimulation: a possible novel therapeutic approach to eating disorders
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taiwan Division of Psychiatry, School of Medicine, National Yang Ming University, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 65:1176-8. 2005
    ..Further investigation into the dose, duration and type of rTMS stimulus is needed to verify the efficacy of this intervention in eating disorders...
  15. ncbi request reprint Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young chinese females
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 50:153-6. 2004
    ..Similar to the results of a recent meta-analytic review, however, no association was demonstrated between this DRD4 polymorphism and novelty seeking in our young Chinese female sample population...
  16. ncbi request reprint Association study of serotonin 1B receptor (A-161T) genetic polymorphism and suicidal behaviors and response to fluoxetine in major depressive disorder
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 50:235-8. 2004
    ..Our findings suggest that 5-HT1B A-161T genetic polymorphism does not play a major role in the susceptibility to MDD, nor is it related to suicidal attempt or the therapeutic response to fluoxetine in MDD...
  17. ncbi request reprint Dopamine receptor downregulation: an alternative strategy for schizophrenia treatment
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital and School of Medicine, National Yang Ming University, No 201 Shih Pai Road, Sec 2, Taipei 11217, Taiwan, ROC
    Med Hypotheses 63:1047-50. 2004
    ..It is suggested that the development of agents that increase DR downregulation could be an alternative strategy for schizophrenia treatment...
  18. ncbi request reprint Adenosine A2a receptor/dopamine D2 receptor hetero-oligomerization: a hypothesis that may explain behavioral sensitization to psychostimulants and schizophrenia
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, 11217 Taipei, Taiwan, ROC
    Med Hypotheses 64:197-200. 2005
    ..The proposed A2aAR/DRD2 hetero-oligomerization model may suggest new directions in the understanding and treatment of schizophrenia...
  19. ncbi request reprint Central N-acetyl aspartylglutamate deficit: a possible pathogenesis of schizophrenia
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, and Division of Psychiatry, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Med Sci Monit 11:HY39-45. 2005
    ..The central NAAG deficit model of schizophrenia could explain the disease process, from the perspectives of both neurodevelopment and neurodegeneration, and may point to potential treatments for schizophrenia...
  20. ncbi request reprint Is autism caused by early hyperactivity of brain-derived neurotrophic factor?
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, No 201 Shin Pai Road, Sec 2, 11217 Taipei, Taiwan, ROC
    Med Hypotheses 65:79-82. 2005
    ..Attempts to prove the BDNF hyperactivity hypothesis may lead investigators in a new direction for the study of the pathogenesis of autism and the development of an effective intervention of this disorder...
  21. ncbi request reprint A study of the association of (Val66Met) polymorphism in the brain-derived neurotrophic factor gene with alcohol dependence and extreme violence in Chinese males
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Neurosci Lett 381:340-3. 2005
    ..Based on these findings, it seems reasonable to suggest that this BDNF-gene Val66Met polymorphism is unlikely to play a major role in the genetic susceptibility to the traits of alcohol-dependence or violence proneness...
  22. ncbi request reprint Possible involvement of brain-derived neurotrophic factor in the antinociceptive effect of antidepressants in neuropathic pain
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217, Taipei, Taiwan
    Med Hypotheses 65:530-3. 2005
    ..Exploration of this hypothesis could provide a new direction in the treatment of neuropathic pain, as well as other pain disorders...
  23. ncbi request reprint Possible involvement of the BDNF-dependent pathway in treatment-emergent suicidality or decreased response to antidepressants
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 65:942-6. 2005
    ..Further exploration of these hypotheses would help to design specific treatment strategies for depressed patients who have experienced unfavourable responses to antidepressant treatment...
  24. ncbi request reprint Signal transducer and activator of transcription 6 (STAT6) and attention-deficit hyperactivity disorder: a speculative hypothesis
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, and Division of Psychiatry, School of Medicine, National Yang Ming University, Taiwan
    Med Hypotheses 67:1342-4. 2006
    ..Several proposals to test this hypothesis are suggested; attempts to prove the STAT6-ADHD hypothesis may provide a new direction that elucidates the pathogenesis of and a treatment for ADHD...
  25. ncbi request reprint The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital and Division of Psychiatry, School of Medicine, National Yang Ming University, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 68:180-3. 2007
    ....
  26. ncbi request reprint Association study of brain-derived neurotrophic factor and apolipoprotein E polymorphisms and cognitive function in aged males without dementia
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, No 201, Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Neurosci Lett 433:158-62. 2008
    ..Our findings suggest a possible association between APOE-epsilon4 and specific cognitive domains in the aged male, whereas the functional genetic variant of BDNF (BDNF-G196A) played no significant role in normal cognitive ageing...
  27. doi request reprint Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    J Affect Disord 113:183-7. 2009
    ..Essential in dopamine degradation, it was suggested that catechol-O-methyltransferase (COMT) might be involved in the action of antidepressants and may therefore be a promising candidate for antidepressant pharmacogenetic studies...
  28. ncbi request reprint Brain-derived neurotrophic factor and antidepressant action: another piece of evidence from pharmacogenetics
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Pharmacogenomics 9:1353-8. 2008
    ..Several suggestions for further work are discussed below...
  29. doi request reprint Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Pharmacogenet Genomics 18:869-75. 2008
    ..Evidence suggests that plasminogen activator inhibitor type 1 gene (SERPINE1) is a stress-related gene and serum plasminogen activator inhibitor type 1 levels are increased in patients with major depressive disorders (MDD)...
  30. doi request reprint Interleukin-1 beta (C-511T) genetic polymorphism is associated with cognitive performance in elderly males without dementia
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurobiol Aging 31:1950-5. 2010
    ....
  31. doi request reprint Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 33:637-41. 2009
    ..Our findings show that TPH2 genetic variants may play a role in MDD susceptibility and in acute therapeutic response to selective serotonin reuptake inhibitors...
  32. doi request reprint Haplotype analysis of single nucleotide polymorphisms in the vascular endothelial growth factor (VEGFA) gene and antidepressant treatment response in major depressive disorder
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Psychiatry Res 169:113-7. 2009
    ..Our findings suggested that VEGFA genetic variants do not play a major role in the response to selective serotonin reuptake inhibitors...
  33. doi request reprint Recent molecular genetic studies and methodological issues in suicide research
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 35:809-17. 2011
    ..A better understanding of the SB genes by combining whole genome approaches with case-control association studies, may potentially lead to developing effective screening, prevention, and management of SB...
  34. doi request reprint Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder
    S J Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Pharmacogenomics J 8:384-90. 2008
    ....
  35. ncbi request reprint Sipatrigine could have therapeutic potential for major depression and bipolar depression through antagonism of the two-pore-domain K+ channel TREK-1
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
    Med Hypotheses 70:548-50. 2008
    ..Further evaluation of its antidepressant therapeutic and toxic effects in animal models is needed before clinical application...
  36. ncbi request reprint TrkB partial agonists: potential treatment strategy for major depression
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 68:674-6. 2007
    ....
  37. ncbi request reprint Attention-deficit hyperactivity disorder may be associated with decreased central brain-derived neurotrophic factor activity: clinical and therapeutic implications
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang Ming University, Taiwan
    Med Hypotheses 68:896-9. 2007
    ..This hypothesis may have some implications for clinical findings in ADHD (for example, the co-morbidity between ADHD and major depression), and provide a new direction for the development of medication for ADHD treatment...
  38. ncbi request reprint Association study of adenosine A2a receptor (1976C>T) genetic polymorphism and mood disorders and age of onset
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Psychiatr Genet 16:185. 2006
    ..The distribution of the A2aAR genotypes and alleles did not differ significantly comparing the two groups, suggesting that it is unlikely that the A2aAR 1976C>T polymorphism plays a major role in the development of mood disorders...
  39. ncbi request reprint Association study of polymorphisms in post-synaptic density protein 95 (PSD-95) with schizophrenia
    S J Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neural Transm 114:423-6. 2007
    ..Further genetic studies in schizophrenia with other PSD-95-like molecules that interact with the glutamate system are suggested...
  40. ncbi request reprint Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 68:1296-9. 2007
    ..The potential use of statins in these diseases may warrant further exploration...
  41. ncbi request reprint Glatiramer acetate could be a potential antidepressant through its neuroprotective and anti-inflammatory effects
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Section 2, Taipei 11217, Taiwan
    Med Hypotheses 69:145-8. 2007
    ..It is also suggested that immediate GA treatment after stress may prevent the development of stress-related psychiatric disorders such as MDD and post-traumatic stress disorder...
  42. ncbi request reprint No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 31:752-5. 2007
    ..However, association between schizophrenia and other polymorphisms in the GRIP1 gene cannot be totally ruled out as the whole gene was not covered by the two polymorphisms studied...
  43. ncbi request reprint Glatiramer acetate could be a potential therapeutic agent for Parkinson's disease through its neuroprotective and anti-inflammatory effects
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 69:1219-21. 2007
    ....
  44. ncbi request reprint Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, 11217 Taipei, Taiwan
    Med Hypotheses 68:1144-6. 2007
    ..The potential therapeutic effect of Semax in Rett syndrome by increasing central BDNF activity may be of interest for further exploration in animal models of Rett syndrome...
  45. ncbi request reprint Association study of a functional catechol-O-methyltransferase genetic polymorphism with age of onset, cognitive function, symptomatology and prognosis in chronic schizophrenia
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 49:196-200. 2004
    ....
  46. ncbi request reprint Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia
    S J Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan
    Psychiatr Genet 10:149-51. 2000
    ..409), with these negative findings suggesting that, for Chinese populations, the (AAT)n triplet repeat in the promoter region of the CNR1 gene is not directly involved in the pathogenesis of schizophrenic disorders...
  47. ncbi request reprint Is mania caused by overactivity of central brain-derived neurotrophic factor?
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, 11217, Taipei, Taiwan, ROC
    Med Hypotheses 62:19-22. 2004
    ..Further, exploration of this hypothesis can provide a new direction in the treatment of the bipolar affective disorder...
  48. ncbi request reprint Personality traits in young female apolipoprotein E (apoE) epsilon4 and non-epsilon4 carriers
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, ROC
    Am J Med Genet B Neuropsychiatr Genet 124:58-60. 2004
    ..No significant differences were demonstrated comparing the scores for the two groups. Our findings suggest that the investigated apoE polymorphism does not play a major role in personality trait factors, as assessed by TPQ...
  49. ncbi request reprint Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, No 201 Shih Pai Road, Sec 2, 11217, Taipei, Taiwan, Republic of China
    Neurosci Lett 338:123-6. 2003
    ....
  50. ncbi request reprint Association study of oestrogen receptor alpha gene polymorphism and suicidal behaviours in major depressive disorder
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Psychiatr Genet 13:19-22. 2003
    ..A population-based association study was used to test the hypothesis that the genetic variants ( II and I polymorphisms) of the oestrogen receptor alpha gene (ER-alpha) confer susceptibility to MDD...
  51. ncbi request reprint Attention-deficit hyperactivity disorder and brain-derived neurotrophic factor: a speculative hypothesis
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, ROC
    Med Hypotheses 60:849-51. 2003
    ..It is proposed here that BDNF may play a role in the therapeutic action and pathogenesis of ADHD. This hypothesis may provide a new direction for the treatment and the pathogenesis of ADHD...
  52. ncbi request reprint Lack of association between the interleukin-1alpha gene C(-889)T polymorphism and Alzheimer's disease in a Chinese population
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Neurosci Lett 343:93-6. 2003
    ..Further studies of the associations between other IL-1A genetic polymorphisms and AD are needed to fully elaborate the involvement of this gene in AD...
  53. ncbi request reprint No association of tumor necrosis factor alpha gene polymorphisms with schizophrenia or response to clozapine
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Schizophr Res 65:27-32. 2003
    ..The results of these investigations suggest that the TNF-alpha gene -308G/A variants do not play a major role in susceptibility to, clinical manifestations for, or clozapine response in, schizophrenia...
  54. ncbi request reprint Dopamine receptor hetero-oligomerization: a hypothesis for behavioral sensitization to psychostimulants
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, ROC
    Med Hypotheses 61:18-20. 2003
    ..The proposed receptor hetero-oligomerization model may provide a new direction in the exploration of the functionally critical sensitization phenomenon...
  55. ncbi request reprint Brain-derived neurotrophic factor: a bridge between major depression and Alzheimer's disease?
    Shih Jen Tsai
    Veterans General Hospital, Taipei, Taiwan ROC
    Med Hypotheses 61:110-3. 2003
    ....
  56. ncbi request reprint Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, ROC
    Psychiatr Genet 12:165-8. 2002
    ..007). Our findings suggest that the 5HTT genetic polymorphism may be associated with HA scores; however, the effect is influenced by ethnicity and gender...
  57. ncbi request reprint Norepinephrine transporter and alpha(2c) adrenoceptor allelic variants and personality factors
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, Republic of China
    Am J Med Genet 114:649-51. 2002
    ..Our negative findings suggest that the investigated polymorphisms of the norepinephrine transporter and the alpha(2c) adrenoceptor do not play a major role in the reward-dependence personality trait as assessed by TPQ...
  58. ncbi request reprint Down-regulation of the Trk-B signal pathway: the possible pathogenesis of major depression
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, 11217, Taipei, Taiwan, ROC
    Med Hypotheses 62:215-8. 2004
    ..Further, several possible mechanisms of Trk-B pathway down-regulation, and the implications for this down-regulation in MDD are discussed...
  59. ncbi request reprint Association study between cannabinoid receptor gene (CNR1) and pathogenesis and psychotic symptoms of mood disorders
    S J Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan ROC
    Am J Med Genet 105:219-21. 2001
    ..The results showed that the triplet repeat polymorphism in the promoter region of the CNR1 gene was not likely to be involved in the pathogenesis or in the psychotic symptoms of mood disorders...
  60. ncbi request reprint Reduced regional [14C]2-deoxyglucose uptake in response to long-term clozapine administration in rats
    S J Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, ROC
    Neuropsychobiology 44:36-40. 2001
    ..The pattern of 2-DG uptake changes after long-term clozapine administration may provide information for the regions related to the therapeutic effect of clozapine...
  61. ncbi request reprint Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 49:13-6. 2004
    ..In contrast to a recent report, however, this polymorphism does not appear to be associated with the neuroticism-related personality trait...
  62. ncbi request reprint Allelic variants of the alpha1a adrenoceptor and the promoter region of the alpha2a adrenoceptor and temperament factors
    S J Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, Republic of China
    Am J Med Genet 105:96-8. 2001
    ..Our negative findings suggest that polymorphisms of the alpha1a adrenoceptor and of the promoter region of the alpha2a-adrenoceptor have no major effect on the reward-dependence personality trait as assessed by TPQ...
  63. ncbi request reprint Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 49:10-2. 2004
    ..Further studies with genetic variations in BDNF relating either to AD-associated depression or to the AD treatment response are suggested...
  64. ncbi request reprint No association for D2 and D4 dopamine receptor polymorphisms and methamphetamine abuse in Chinese males
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, ROC
    Psychiatr Genet 12:29-33. 2002
    ....
  65. ncbi request reprint Association study of serotonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior
    S J Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, School of Medicine, National Yang Ming University, Taiwan, ROC
    Neurosci Lett 271:135-7. 1999
    ..However, genotype distribution was significantly different between schizophrenic patients and control subjects. This suggests that the 5-HT6 gene may play a role in the pathogenesis of schizophrenic disorders...
  66. ncbi request reprint Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 48:68-71. 2003
    ..Our negative findings suggest that the TPH A218C and HTR1B polymorphisms do not play major roles in the determination of TPQ personality traits...
  67. ncbi request reprint Association study of serotonin transporter gene VNTR polymorphism and mood disorders, onset age and suicide attempts in a Chinese sample
    Feng Chang Yen
    Divison of Psychiatry, Cheng Hsin Rehabilitation and Medical Center, Veterans General Hospital, Taipei, Taiwan
    Neuropsychobiology 48:5-9. 2003
    ..These negative findings suggest that 5-HTTVNTR does not play a major role in the pathogenesis of mood disorder in Chinese populations...
  68. ncbi request reprint An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, No 201 Shih Pai Road, Sec 2, 11217 Taipei, Taiwan, ROC
    Neurosci Lett 349:206-8. 2003
    ..Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment...
  69. ncbi request reprint Association study for Parkinson's disease and a dopamine transporter gene polymorphism (1215A/G)
    Chien Nan Lin
    Provisional Chia Nan Psychiatric Center, Tainan, Taiwan, ROC
    Eur Neurol 48:207-9. 2002
    ..Other DAT genetic variants, and the association of these variants with PD symptomatology or treatment response, may merit further investigation...
  70. ncbi request reprint Association for serotonin transporter gene variable number tandem repeat polymorphism and schizophrenic disorders
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Neuropsychobiology 45:131-3. 2002
    ..043). This positive finding further supports the proposition that the 5-HTT-VNTR allele 12 is a risk factor for schizophrenic disorders in Chinese populations, although the effect is weak...
  71. ncbi request reprint Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neurosci Lett 353:75-7. 2003
    ..Other BDNF genetic variants, and the association of these variants with PD symptomatology or treatment response, may merit further investigation...
  72. ncbi request reprint Association study of onset age, attempted suicide, aggressive behavior, and schizophrenia with a serotonin 1B receptor (A-161T) genetic polymorphism
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 49:1-4. 2004
    ..These findings suggest that the investigated 5-HT1B genetic polymorphism does not play a major role in the pathogenesis of schizophrenic disorders...
  73. doi request reprint Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response
    Ruu Fen Tzang
    Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan
    Neurosci Lett 447:92-5. 2008
    ..Our findings suggest that p11 genetic variants do not play a major role in the MDD susceptibility, antidepressant therapeutic response or the risk of suicide attempt in MDD...
  74. ncbi request reprint Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior
    Chen Jee Hong
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Neuropsychobiology 48:186-9. 2003
    ....
  75. doi request reprint Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia
    Mu En Liu
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Neurosci Lett 436:193-5. 2008
    ..These findings suggest that the COMT Val158Met genotype may contribute to differences in normal cognitive aging, particularly in the area of general attention...
  76. ncbi request reprint Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients
    Ding Lieh Liao
    Department of General Psychiatry, Pali Psychiatric Hospital, Central Taiwan Office, Taipei, Taiwan, ROC
    Neuropsychobiology 48:72-6. 2003
    ..This study investigated the association of type I muscarinic receptor (CHRM1) genetic polymorphisms with the clinical characteristics of chronic schizophrenic inpatients...
  77. ncbi request reprint Possible association between serotonin transporter promoter region polymorphism and extremely violent crime in Chinese males
    Ding Lieh Liao
    Department of General Psychiatry, Pali Psychiatric Hospital, Central Taiwan Office, Taipei, Taiwan, ROC
    Neuropsychobiology 50:284-7. 2004
    ..Our findings demonstrate that carriage of the low-activity S allele is associated with extremely violent criminal behavior in Chinese males, and suggests that the 5-HTT may be implicated in the mechanisms underlying violent behaviors...
  78. ncbi request reprint Association analysis for serotonin transporter promoter polymorphism and auditory evoked potentials for major depression
    Tai Jui Chen
    Kai Suan Psychiatric Hospital, Kaohsiung, Taiwan, ROC
    Neuropsychobiology 46:57-60. 2002
    ..4% of the variance in P2 latency. Our findings suggest a relationship between the 5-HTTLPR polymorphism and AEP P2 latency, and further studies of other genetic polymorphisms in the serotonergic system may help to predict this latency...
  79. ncbi request reprint Association analysis for dopamine D3 receptor, dopamine D4 receptor and dopamine transporter genetic polymorphisms and P300 event-related potentials for normal young females
    Shih Jen Tsai
    Division of Psychiatry, School of Medicine, National Yang Ming University, Taipei Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan
    Psychiatr Genet 13:51-3. 2003
    ..We tested the genetic effects of the dopaminergic system in P300 components by association study...
  80. ncbi request reprint Association study of a functional MAOA-uVNTR gene polymorphism and cognitive function in healthy females
    Younger W Y Yu
    Yu s Psychiatric Clinic, Taiwan, ROC
    Neuropsychobiology 52:77-82. 2005
    ..Therefore, we suggest that our study should be replicated and that the testing method, sex, disease and ethnicity should also be considered in future studies...
  81. ncbi request reprint Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1510-3. 2007
    ..Further studies with SLC25A12 variants relating to brain NAA levels in patients with schizophrenia are suggested...
  82. ncbi request reprint Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease
    Hsiu Chih Liu
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 19:42-5. 2005
    ..We propose that other genetic variations of CHRM1, relating either to AD or to the therapeutic response for AD, may need further investigation...
  83. ncbi request reprint Family-based association study between G72/G30 genetic polymorphism and schizophrenia
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
    Neuroreport 17:1067-9. 2006
    ..Our family-based association study supports the suggestion that the G72/G30 gene may be implicated in susceptibility to schizophrenia and there may be an interaction between this gene and sex in the pathogenesis of schizophrenia...
  84. ncbi request reprint Association study of PICK1 rs3952 polymorphism and schizophrenia
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, 11217, Taipei, Taiwan, ROC
    Neuroreport 15:1965-7. 2004
    ..Results demonstrated that the PICK1 rs3952 genotype and allele distribution was significantly different between the two groups. The positive association suggests that the PICK1 gene may play a role in the pathogenesis of schizophrenia...
  85. doi request reprint Interleukin-1 beta -511C/T genetic polymorphism is associated with age of onset of geriatric depression
    Jen Ping Hwang
    Department of Psychiatry, Taipei Veterans General Hospital, No 201, Shih Pai Road, Sec 2, Taipei, 11217, Taiwan
    Neuromolecular Med 11:322-7. 2009
    ..Further study is warranted to confirm this finding and to assess its generalization to other ethnic groups...
  86. ncbi request reprint Support for the involvement of the KCNK2 gene in major depressive disorder and response to antidepressant treatment
    Ying Jay Liou
    Institute of Clinical Medicine, National Yang Ming University, Taipei Veterans General Hospital, Taiwan, Republic of China
    Pharmacogenet Genomics 19:735-41. 2009
    ..The aim of this study was to examine the associations between genetic variations in the human KCNK2 gene and major depressive disorder (MDD) and response to antidepressant treatment...
  87. doi request reprint Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population
    Ying Chieh Wang
    Department of Psychiatry, Yuli Veterans Hospital, Hualien City, Taiwan, ROC
    Biol Psychiatry 64:1093-6. 2008
    ..The study investigated the possible association of NRG3 gene and schizophrenia in a Han Chinese population...
  88. doi request reprint Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression
    Eugene Lin
    Vita Genomics, Inc, Taipei, Taiwan
    Rejuvenation Res 12:387-93. 2009
    ..Analyses using logistic regression models confirmed the gene-gene interactions. The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner...
  89. ncbi request reprint Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes
    Chih Ya Cheng
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Eur Neurol 47:26-9. 2002
    ..88. Our findings further support previous reports of an association between ACE polymorphism and AD. The implication of the ACE I/D polymorphism in the pathogenesis of AD warrants further exploration...
  90. ncbi request reprint Association study of androgen receptor CAG repeat polymorphism and male violent criminal activity
    Daniel Cheng
    Department of Psychiatry, General Psychiatry Section, Taipei Veterans General Hospital, No 201 Shih Pai Road Sec 2, Taipei 11217, Taiwan, ROC
    Psychoneuroendocrinology 31:548-52. 2006
    ..Our findings suggest that the AR CAG repeat polymorphism does not play a major role in the susceptibility of male violent criminal activity...
  91. ncbi request reprint Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response
    Younger W Y Yu
    Yu s Psychiatric Clinic, Kaohsiung, Taiwan, ROC
    Neuropsychopharmacology 28:1182-5. 2003
    ..Further study with a larger sample is needed to clarify the role of the IL-1beta genetic polymorphisms in the symptoms and treatment effects in MDD...
  92. ncbi request reprint Association study of a brain-derived neurotrophic factor (Val66Met) genetic polymorphism and panic disorder
    Pok Lam
    Department of Psychiatry, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    Neuropsychobiology 49:178-81. 2004
    ..Further studies exploring the relationship between genetic variations of BDNF and the cerebral atrophy associated with, and antidepressant treatment response in, panic disorder may be appropriate...
  93. ncbi request reprint Polymorphisms in glycine transporter with schizophrenia
    Shih Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
    Neuropsychopharmacol Hung 8:17-21. 2006
    ..Further studies with other GIyT1 variants, relating either to schizophrenia, psychotic symptoms or to therapeutic response in schizophrenia, are suggested...
  94. ncbi request reprint Association study of A2a adenosine receptor genetic polymorphism in panic disorder
    Pok Lam
    Department of Psychiatry, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan ROC
    Neurosci Lett 378:98-101. 2005
    ..The 1976C > T polymorphism may be in linkage disequilibrium with a functional variant that affects panic disorder, and the extent of this linkage disequilibrium is not similar for all ethnic populations...
  95. ncbi request reprint Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan, ROC
    Am J Med Genet B Neuropsychiatr Genet 123:19-22. 2003
    ..This finding suggests the BDNF polymorphism investigated plays no major role in the pathogenesis of MDD...
  96. ncbi request reprint Association analysis for neuronal nitric oxide synthase gene polymorphism with major depression and fluoxetine response
    Younger W Y Yu
    Yu s Psychiatric Clinic, Kaohsiung, Taipei, Taiwan, ROC
    Neuropsychobiology 47:137-40. 2003
    ..However, the association between other NOS variants and MDD or antidepressant response, including sexual dysfunction, may warrant further investigation...
  97. ncbi request reprint Association analysis for the genetic variants of the NMDA receptor subunit 2b and Alzheimer's disease
    Shih Jen Tsai
    School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    Dement Geriatr Cogn Disord 13:91-4. 2002
    ..We propose that other genetic variations of the NMDA subunits, relating either to AD or to the therapeutic response for NMDA partial agonists, may need further investigation...
  98. ncbi request reprint Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response
    Younger W Y Yu
    Yu s Psychiatric Clinic, Kaohsiung, Taiwan, ROC
    Neuropsychopharmacology 30:1719-23. 2005
    ....
  99. ncbi request reprint Genetic variant of the histamine-1 receptor (glu349asp) and body weight change during clozapine treatment
    Chen Jee Hong
    Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan
    Psychiatr Genet 12:169-71. 2002
    ....
  100. ncbi request reprint Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder
    Chen Jee Hong
    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neurosci Lett 355:69-72. 2004
    ..Determination of the functional impact of the -2 bp variant in the nervous system and, in particular, the effect of harboring more than two alleles of the -2 bp deletion needs further exploration...
  101. ncbi request reprint X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset
    Sheue Jane Hou
    Division of Psychiatry, Cheng Hsin Rehabilitation and Medical Center, Taipei, Taiwan, ROC
    Neurosci Lett 367:232-4. 2004
    ..These negative findings suggest that the XBP1 C--116G polymorphism does not play a major role in the pathogenesis of bipolar disorders in Chinese populations...