Joen Rong Sheu

Summary

Affiliation: Taipei Medical University
Country: Taiwan

Publications

  1. pmc Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Rd, Taipei 11101, Taiwan
    J Biomed Sci 20:4. 2013
  2. ncbi request reprint Mechanisms involved in agonist-induced hyperaggregability of platelets from normal pregnancy
    Joen Rong Sheu
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical University, Taipei, Taiwan, ROC
    J Biomed Sci 9:17-25. 2002
  3. ncbi request reprint Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation
    J R Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
    Platelets 14:189-96. 2003
  4. ncbi request reprint Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments
    Joen R Sheu
    Department of Pharmacology, Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Exp Biol Med (Maywood) 228:1321-8. 2003
  5. ncbi request reprint Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets
    Joen Rong Sheu
    Graduate Institutes of Medical Sciences and Pharmacology, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Agric Food Chem 52:4414-8. 2004
  6. pmc Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies
    Joen R Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Br J Pharmacol 143:193-201. 2004
  7. ncbi request reprint Mechanisms involved in the antiplatelet activity of magnesium in human platelets
    Joen Rong Sheu
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Br J Haematol 119:1033-41. 2002
  8. ncbi request reprint Morphine-potentiated agonist-induced platelet aggregation through alpha2-adrenoceptors in human platelets
    Joen Rong Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Cardiovasc Pharmacol 40:743-50. 2002
  9. pmc Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation
    Ye Ming Lee
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 17:45. 2010
  10. ncbi request reprint Mechanisms involved in the antiplatelet activity of midazolam in human platelets
    Joen R Sheu
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Anesthesiology 96:651-8. 2002

Collaborators

Detail Information

Publications91

  1. pmc Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Rd, Taipei 11101, Taiwan
    J Biomed Sci 20:4. 2013
    ..Brazilin, isolated from the heartwood of Caesalpinia sappan L., has been shown to possess multiple pharmacological properties...
  2. ncbi request reprint Mechanisms involved in agonist-induced hyperaggregability of platelets from normal pregnancy
    Joen Rong Sheu
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical University, Taipei, Taiwan, ROC
    J Biomed Sci 9:17-25. 2002
    ....
  3. ncbi request reprint Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation
    J R Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
    Platelets 14:189-96. 2003
    ..These results suggest that kinetin has an effective anti-platelet effect and that it may be a potential therapeutic agent for arterial thrombosis...
  4. ncbi request reprint Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments
    Joen R Sheu
    Department of Pharmacology, Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Exp Biol Med (Maywood) 228:1321-8. 2003
    ..The results strongly indicate that metallothionein provides protection against thromboembolism...
  5. ncbi request reprint Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets
    Joen Rong Sheu
    Graduate Institutes of Medical Sciences and Pharmacology, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Agric Food Chem 52:4414-8. 2004
    ....
  6. pmc Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies
    Joen R Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Br J Pharmacol 143:193-201. 2004
    ..These results strongly indicate that MMP-9 is a potent inhibitor of aggregation. It may play an important role as a negative feedback regulator during platelet activation...
  7. ncbi request reprint Mechanisms involved in the antiplatelet activity of magnesium in human platelets
    Joen Rong Sheu
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Br J Haematol 119:1033-41. 2002
    ..2) Magnesium sulphate might also trigger the formation of cyclic AM, ultimately resulting in inhibition of the phosphorylation of P47 and intracellular Ca+2 mobilization...
  8. ncbi request reprint Morphine-potentiated agonist-induced platelet aggregation through alpha2-adrenoceptors in human platelets
    Joen Rong Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Cardiovasc Pharmacol 40:743-50. 2002
    ....
  9. pmc Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation
    Ye Ming Lee
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 17:45. 2010
    ..Although the inhibitory effect of simvastatin in platelet activation has been studied; the detailed signal transductions by which simvastatin inhibit platelet activation has not yet been completely resolved...
  10. ncbi request reprint Mechanisms involved in the antiplatelet activity of midazolam in human platelets
    Joen R Sheu
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Anesthesiology 96:651-8. 2002
    ..Midazolam is widely used as a sedative and anesthetic induction agent. The aim of this study was to systematically examine the inhibitory mechanisms of midazolam in platelet aggregation...
  11. ncbi request reprint The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways
    J R Sheu
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical University, Taipei 110, Taiwan
    Clin Lab Haematol 24:121-9. 2002
    ....
  12. ncbi request reprint Antithrombotic effects of magnesium sulfate in in vivo experiments
    Joen R Sheu
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Int J Hematol 77:414-9. 2003
    ..In conclusion, these results suggest that magnesium sulfate has an effective antithrombotic activity in vivo, and treatment with magnesium sulfate may lower the risk of thromboembolic-related disorders...
  13. ncbi request reprint Mechanisms involved in the antiplatelet activity of ketamine in human platelets
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    J Biomed Sci 11:764-72. 2004
    ....
  14. ncbi request reprint Mechanisms of antiplatelet and antithrombotic activity of midazolam in in vitro and in vivo studies
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Eur J Pharmacol 487:159-66. 2004
    ..These lead to lower intracellular Ca(+2) mobilization and phosphorylation of P47...
  15. ncbi request reprint alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation
    George Hsiao
    Graduate Institute of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
    J Agric Food Chem 53:5179-86. 2005
    ..These results strongly indicate that alpha-NF appears to represent a novel and potent antiplatelet agent for treatment of arterial thromboembolism...
  16. pmc YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells
    Ming Shyan Chang
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Br J Pharmacol 136:558-67. 2002
    ....
  17. ncbi request reprint Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Lab Clin Med 146:216-26. 2005
    ..The results may imply that tomato-based foods are especially beneficial in the prevention of platelet aggregation and thrombosis...
  18. ncbi request reprint YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells
    Ming Shyan Chang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Mol Pharmacol 66:561-71. 2004
    ....
  19. ncbi request reprint Inhibitory mechanisms of low concentrations of oxidized low-density lipoprotein on platelet aggregation
    Duen Suey Chou
    Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan, ROC
    J Biomed Sci 13:333-43. 2006
    ..This study further provides new insights concerning the effects of low concentrations of oxLDL on platelet aggregation...
  20. ncbi request reprint Involvement of the antiplatelet activity of magnesium sulfate in suppression of protein kinase C and the Na+/H+ exchanger
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Biomed Sci 11:19-26. 2004
    ..2) On the other hand, magnesium sulfate inhibits the Na+/H+ exchanger, leading to reduced intracellular Ca+2 mobilization, and ultimately to inhibition of platelet aggregation and the ATP-release reaction...
  21. ncbi request reprint Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, Taiwan, Republic of China
    Planta Med 72:411-7. 2006
    ..Thus, TMPZ treatment may represent an ideal approach to lowering the risk of or improving function in ischemia-reperfusion brain injury-related disorders...
  22. ncbi request reprint Inhibitory mechanisms of YC-1 and PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages
    George Hsiao
    Graduate Institute of Pharmacology, Taipei Medical University, 250 Wu Shing Street, Taipei 110, Taiwan, ROC
    Biochem Pharmacol 67:1411-9. 2004
    ..YC-1 may be mediated by increasing cyclic GMP, followed by, at least partly, inhibition of JNK/SAPK and NF-kappaB activations, thereby leading to inhibition of iNOS expression...
  23. ncbi request reprint Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo
    George Hsiao
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan, ROC
    Eur J Pharmacol 465:281-7. 2003
    ..Treatment with kinetin may lower the risk of thromboembolic-related disorders. Therefore, kinetin may be a potential therapeutic agent for arterial thrombosis, but its toxicity must be further assessed...
  24. doi request reprint Arsenic trioxide-mediated antiplatelet activity: pivotal role of the phospholipase C gamma 2-protein kinase C-p38 MAPK cascade
    Kuan H Lin
    Graduate Institute of Medical Sciences, Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Transl Res 155:97-108. 2010
    ....
  25. ncbi request reprint Morphine-potentiated platelet aggregation in in vitro and platelet plug formation in in vivo experiments
    George Hsiao
    Department of Pharmacology, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Biomed Sci 10:292-301. 2003
    ..This leads to increased intracellular Ca(2+) mobilization, and finally potentiation of platelet aggregation and of the ATP release reaction...
  26. doi request reprint A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP
    Wan Jung Lu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    J Mol Med (Berl) 89:1261-73. 2011
    ....
  27. ncbi request reprint Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways
    Ming Shyan Chang
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    Cell Signal 17:299-310. 2005
    ..Taken together, these results indicate that PMA might activate PKC to elicit activation of the Ras/Raf-1/ERK1/2 pathway, which in turn initiates NF-kappaB activation, and finally induces COX-2 expression and PGE2 release in A549 cells...
  28. ncbi request reprint Low concentration of oxidized low density lipoprotein suppresses platelet reactivity in vitro: an intracellular study
    Duen Suey Chou
    Graduate Institutes of Medical Sciences and Pharmacology, Taipei Medical University, Taipei 110, Taiwan
    Lipids 39:433-40. 2004
    ..This study provides new insights concerning the effect of oxLDL in platelet aggregation...
  29. ncbi request reprint Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells
    Bing Chang Chen
    School of Respiratory Therapy, Taipei Medical University, Taiwan
    J Immunol 173:5219-28. 2004
    ....
  30. doi request reprint Inhibitory signaling of 17β-estradiol in platelet activation: the pivotal role of cyclic AMP-mediated nitric oxide synthase activation
    Gong Jhe Wu
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Eur J Pharmacol 649:140-9. 2010
    ....
  31. ncbi request reprint C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis
    George Hsiao
    Graduate Institute of Pharmacology, and Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    J Agric Food Chem 53:7734-40. 2005
    ..These results strongly indicate that C-PC appears to represent a novel and potential antiplatelet agent for treatment of arterial thromboembolism...
  32. ncbi request reprint Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B
    Bing Chang Chen
    School of Respiratory Therapy, Graduate Institute of Biomedical Technology, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Immunol 177:681-93. 2006
    ..However, PGN-induced NO release is not involved in the signaling pathway of PGN-induced IL-6 production...
  33. ncbi request reprint Suppressive effects of ketamine on macrophage functions
    Yi Chang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 204:27-35. 2005
    ....
  34. ncbi request reprint Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets
    Tyng Guey Chen
    Department of Anesthesiology, Wan Fang Hospital Taipei Medical University, Taiwan, ROC
    Chin J Physiol 50:121-6. 2007
    ..These results strongly indicate that CAPE appears to represent a novel and potent antiplatelet agent for treatment of arterial thromboembolism...
  35. ncbi request reprint ESR spin trapping of a carbon-centered free radical from agonist-stimulated human platelets
    Duen Suey Chou
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Free Radic Biol Med 39:237-48. 2005
    ..005 radical but could not restore platelet aggregatory activity. These results suggest that the carbon-centered radical is a self-destructing free radical formed during peroxide-mediated deactivation of PGHS in human platelets...
  36. doi request reprint Histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide attenuates plasminogen activator inhibitor-1 expression in human pleural mesothelial cells
    Chi Li Chung
    Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan
    Am J Respir Cell Mol Biol 46:437-45. 2012
    ..Given the down-regulating effect of CBHA on PAI-1 expression, HDAC inhibitors should be tested further in animal models as potential therapeutic agents for pleural fibrosis...
  37. doi request reprint Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 and JAK2 phosphorylation
    Cheng Ying Hsieh
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    Free Radic Biol Med 49:881-93. 2010
    ..PMC treatment may represent a novel approach for lowering the risk of or improving function in abnormal VSMC proliferation-related vascular diseases...
  38. ncbi request reprint Lipoteichoic acid-induced cyclooxygenase-2 expression requires activations of p44/42 and p38 mitogen-activated protein kinase signal pathways
    Chien Huang Lin
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan, ROC
    Eur J Pharmacol 450:1-9. 2002
    ..Both events required activation of upstream tyrosine kinase and PKC...
  39. ncbi request reprint Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions
    George Hsiao
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Biochem Pharmacol 73:682-93. 2007
    ..Thus, PMC treatment may represent a novel approach to lowering the risk or improving function in ischemia-reperfusion brain injury-related disorders...
  40. ncbi request reprint Antithrombotic effect of PMC, a potent alpha-tocopherol analogue on platelet plug formation in vivo
    G Hsiao
    Graduate Institute of Medical Sciences, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    Br J Haematol 117:699-704. 2002
    ..These results suggest that PMC has an effective antiplatelet effect in vivo and may be a potential therapeutic agent for arterial thrombosis, but must be assessed further for toxicity...
  41. ncbi request reprint A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells
    George Hsiao
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, 250 Wu Shing Street, Taiwan, ROC
    Biochem Pharmacol 65:1383-92. 2003
    ....
  42. doi request reprint Expression of amyloid beta peptide in human platelets: pivotal role of the phospholipase Cgamma2-protein kinase C pathway in platelet activation
    Ming Yi Shen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Pharmacol Res 57:151-8. 2008
    ....
  43. ncbi request reprint Decline in titin content in rat skeletal muscle after denervation
    Sy Ping Chen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Muscle Nerve 32:798-807. 2005
    ..Our study provides evidence that titin is more sensitive to degradation than MHC and actin after denervation. Moreover, the titin decline results in the loss of titin-based sarcomeric integrity in atrophic muscle...
  44. ncbi request reprint Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study
    Duen Suey Chou
    Graduate Institutes of Pharmacology and Medical Sciences, Taipei Medical University, No 250 Wu Hsing Street, Taipei 110, Taiwan
    J Agric Food Chem 55:649-55. 2007
    ..The results of this study led to the proposal that baicalein induces hydroxyl radical formation via 12-lipoxygenase and induces semiquinone radical formation via PGHS-peroxidase in human platelets...
  45. pmc Clinical importance of angiogenic cytokines, fibrinolytic activity and effusion size in parapneumonic effusions
    Chi Li Chung
    Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    PLoS ONE 8:e53169. 2013
    ..To investigate the relationship among angiogenic cytokines, fibrinolytic activity and effusion size in parapneumonic effusion (PPE) and their clinical importance...
  46. doi request reprint Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells
    Ya Fen Hsu
    Division of General Surgery, Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Biochim Biophys Acta 1820:104-15. 2012
    ..HDAC inhibition induces growth arrest and cell death in various transformed cell; however, the mechanisms by which this reduces cell viability in colorectal cancer cells remain unexplained...
  47. ncbi request reprint Induction of nitric oxide synthase in RAW 264.7 macrophages by lipoteichoic acid from Staphylococcus aureus: involvement of protein kinase C- and nuclear factor-kB-dependent mechanisms
    Chen Tzu Kuo
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 10:136-45. 2003
    ..These results suggest that LTA might activate PC-PLC and PI-PLC to induce PKC activation, which in turn initiates NF-kappaB activation, and finally induces iNOS expression and NO release in RAW 264.7 macrophages...
  48. ncbi request reprint Antioxidative and hepatoprotective effects of Antrodia camphorata extract
    George Hsiao
    Department of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Agric Food Chem 51:3302-8. 2003
    ..These results suggest that A. camphorata extract exerts effective protection against chronic chemical-induced hepatic injury in vivo, by mediating antioxidative and free radical scavenging activities...
  49. ncbi request reprint Inhibitory mechanisms of gabapentin, an antiseizure drug, on platelet aggregation
    Chi Feng Pan
    Graduate Institute of Medical Sciences and Topnotch Stroke Research Center, Taipei Medical University, Taipei, Taiwan
    J Pharm Pharmacol 59:1255-61. 2007
    ..Thus, it is possible that gabapentin treatment, alone or in combination with other antiplatelet drugs, may induce or potentiate inhibition of platelet aggregation, which may affect haemostasis in-vivo...
  50. doi request reprint MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide
    Ya Fen Hsu
    Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Biochim Biophys Acta 1810:1160-9. 2011
    ..In the present study, we explored the actions of trichostatin A (TSA), a potent HDAC inhibitor, on lipopolysaccharide (LPS)-induced cyclooxygenase (COX)-2 expression in human umbilical vascular endothelial cells (HUVECs)...
  51. ncbi request reprint Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis
    Ruei Ming Chen
    Department of Anesthesiology, Wan Fang Hospital, College of Medicine, Taipei Medical University, No 111, Sec 3, Hsing Lung Road, Taipei 116, Taiwan
    Anesthesiology 98:1178-85. 2003
    ..Propofol is an intravenous anesthetic agent that may impair host defense system. The aim of this study was to evaluate the effects of propofol on macrophage functions and its possible mechanism...
  52. doi request reprint Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells
    Yung Chen Chou
    Graduate Institute of Medical Sciences and Department of Pharmacology, Taipei Medical University, 250 Wu Hsing Street, Taipei 110 31, Taiwan
    Chem Biol Interact 184:403-12. 2010
    ..Further studies are needed to verify its anti-inflammatory effects...
  53. doi request reprint Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), in ischemic stroke of rats
    Ting Lin Yen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Agric Food Chem 60:1937-44. 2012
    ..Therefore, this novel role of xanthohumol may represent high therapeutic potential for treatment or prevention of ischemia-reperfusion injury-related disorders...
  54. ncbi request reprint Platonin, a photosensitizing dye, improves circulatory failure and mortality in rat models of endotoxemia
    George Hsiao
    Department of Pharmacology, Taipei Medical University, Taiwan
    Biol Pharm Bull 25:995-9. 2002
    ..This protective effect of platonin may be mediated, at least partly, by the reduced drop in MAP and the inhibition of NO and free radical formation in rat models of endotoxemia...
  55. ncbi request reprint Inducibility of abnormal automaticity and triggered activity in myocardial sleeves of canine pulmonary veins
    Tsui Min Wang
    Graduate Institute of Medical Science, Taipei Medical University, Taipei, Taiwan
    Int J Cardiol 104:59-66. 2005
    ..To study the cellular mechanisms governing cardiac atrial arrhythmias initiated by ectopic focus (or foci) from pulmonary veins (PVs)...
  56. doi request reprint Involvement of p38 MAPK phosphorylation and nitrate formation in aristolochic acid-mediated antiplatelet activity
    Ming Yi Shen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Planta Med 74:1240-5. 2008
    ..These results imply that Aristolochia fangchi treatment alone or in combination with other antiplatelet drugs, may result in alteration of hemostasis in vivo...
  57. ncbi request reprint Proinflammatory cytokines, transforming growth factor-beta1, and fibrinolytic enzymes in loculated and free-flowing pleural exudates
    Chi Li Chung
    Department of Chest Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    Chest 128:690-7. 2005
    ....
  58. doi request reprint Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats
    Yen Mei Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    J Cardiovasc Pharmacol 58:133-42. 2011
    ..The suppression of nuclear factor-κB and p38 mitogen-activated protein kinase activation and the inhibition of monocyte chemoattractant protein-1 expression contribute to the beneficial effects of wogonin...
  59. ncbi request reprint Scoparone inhibits tissue factor expression in lipopolysaccharide-activated human umbilical vein endothelial cells
    Yen Mei Lee
    Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, ROC
    J Biomed Sci 10:518-25. 2003
    ..Our results demonstrate that the inhibition of scoparone on LPS-induced TF expression in HUVECs may mediate by the mechanisms suppressing superoxide anion formation and TF transcription...
  60. pmc A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activation
    Chao Chien Chang
    Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 11031, Taiwan
    J Biomed Sci 18:93. 2011
    ..Therefore, we further investigated the inhibitory roles of sesamol in NF-κB-mediated platelet function...
  61. doi request reprint Hypertonicity-enhanced TNF-α release from activated human monocytic THP-1 cells requires ERK activation
    Yung Chen Chou
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan corrected
    Biochim Biophys Acta 1810:475-84. 2011
    ..As hypertonicity inhibits endocytosis, we evaluated the mechanism of hypertonicity-induced TNF-α release from activated human monocytic THP-1 cells...
  62. doi request reprint Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses
    Yen Mei Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
    J Ethnopharmacol 135:179-85. 2011
    ..To evaluate the protective effect of baicalein on myocardial dysfunction caused by endotoxaemia in rats and to explore the possible mechanisms...
  63. ncbi request reprint Repeated thoracenteses affect proinflammatory cytokines, vascular endothelial growth factor, and fibrinolytic activity in pleural transudates
    Chi Li Chung
    Department of Chest Medicine, Taipei Medical University Hospital, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Am J Med Sci 334:452-7. 2007
    ..Repeated thoracenteses is indicated in patients with refractory, symptomatic transudative effusions. However, their effect on cytokines and fibrinolytic activity in pleural transudates remains unclear...
  64. doi request reprint A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis
    Ting Lin Yen
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Pharm Biol 51:1150-7. 2013
    ..Conclusions: These data suggest that andrographolide may disrupt BBB integrity, thereby deteriorating MCAO/reperfusion-induced brain injury, which are, in part, associated with its capacity to arrest cell-cycle and induce CEC apoptosis. ..
  65. doi request reprint A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies
    Thanasekaran Jayakumar
    Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    J Nutr Biochem 24:1086-95. 2013
    ..Therefore, this novel role of sulforaphane may represent a high therapeutic potential for treatment or prevention of cardiovascular diseases...
  66. ncbi request reprint Tetramethylpyrazine suppresses HIF-1alpha, TNF-alpha, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei 110, Taiwan, China
    Acta Pharmacol Sin 28:327-33. 2007
    ..To examine the detailed mechanisms underlying the inhibitory effect of tetramethylpyrazine (TMPZ) in inflammatory and apoptotic responses induced by middle cerebral artery occlusion (MCAO) in rats...
  67. doi request reprint p53 in trichostatin A induced C6 glioma cell death
    Ya Fen Hsu
    Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Biochim Biophys Acta 1810:504-13. 2011
    ..HDAC inhibitors have thus emerged as a new class of anti-tumor agents for various types of tumors. However, the mechanisms by which HDAC inhibition-induced cell death remain to be fully defined...
  68. pmc Novel bioactivity of ellagic Acid in inhibiting human platelet activation
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei 111, Taiwan School of Medicine, Fu Jen Catholic University, Taipei 242, Taiwan Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Evid Based Complement Alternat Med 2013:595128. 2013
    ..It appears to initially inhibit the PLCγ2-PKC cascade and/or hydroxyl radical formation, followed by decreased phosphorylation of MAPKs and Akt, ultimately inhibiting platelet aggregation...
  69. doi request reprint Platonin inhibited PDGF-BB-induced proliferation of rat vascular smooth muscle cells via JNK1/2-dependent signaling
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Acta Pharmacol Sin 32:1337-44. 2011
    ..To examine the inhibitory actions of the immunoregulator platonin against proliferation of rat vascular smooth muscle cells (VSMCs)...
  70. ncbi request reprint Detection of myofibrillar proteins using a step gradient minigel with an ambiguous interface
    Sy Ping Chen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Anal Biochem 338:270-7. 2005
    ..This gel system is simple to prepare and easy to use, and it is a reliable method for analyzing myofibrillar proteins or other protein mixtures with broad molecular masses...
  71. ncbi request reprint Genistein and tyrphostin AG 556 block the action potential shortening in septic shock
    Chern En Chiang
    Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan, ROC
    Zhonghua Yi Xue Za Zhi (Taipei) 65:570-9. 2002
    ..Because the increase in NO production and the decrease of APD appear to be downstream late events in endotoxic shock, we hypothesized that a common signaling pathway might mediate these effects...
  72. ncbi request reprint Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo
    Yen Mei Lee
    Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan
    J Pineal Res 33:72-80. 2002
    ..The pronounced cardioprotective activity of melatonin may be mediated by its antioxidant activity and by its capacity for neutrophil inhibition in myocardial I/R...
  73. doi request reprint Aristolochic acid downregulates monocytic matrix metalloproteinase-9 by inhibiting nuclear factor-κB activation
    Chih Jen Wu
    Division of Nephrology, Mackay Memorial Hospital and Mackay Medicine, Nursing and Management College, Taipei, Taiwan
    Chem Biol Interact 192:209-19. 2011
    ..These results also imply that AA may be involved in alteration of matrix homeostasis during renal fibrosis in vivo...
  74. doi request reprint Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration
    Ming Jen Hsu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Biochim Biophys Acta 1800:290-6. 2010
    ..Understanding these death signaling processes will aid in the development of more effective strategies to slow down age-dependent cerebrovascular degeneration caused by progressive cerebrovascular Abeta deposition...
  75. doi request reprint Traditional Chinese medicine, Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats
    Jie Jen Lee
    Department of Surgery, Mackay Memorial Hospital and Mackay Medical College, Taipei, Taiwan
    J Ethnopharmacol 134:824-30. 2011
    ..In the present study, we evaluated the protective effect of the combination of XFZYD with or without rt-PA in a rat model of thromboembolic stroke...
  76. doi request reprint Cinnamophilin isolated from Cinnamomum philippinense protects against collagen degradation in human chondrocytes
    Yung Chang Lu
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Phytother Res 27:892-9. 2013
    ..Furthermore, these findings suggest that cinnamophilin may have the potential for chondroprotection against collagen matrix breakdown in cartilage of diseased tissues such as those found in arthritic disorders...
  77. doi request reprint Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells
    Yung Chang Lu
    Department of Orthopaedic Surgery, Mackay Memorial Hospital, Department of Leisure Sports and Health Management, College of Humanities and Sciences, St John s University, Taipei, Taiwan
    J Agric Food Chem 59:4969-78. 2011
    ..This study also showed that sesamol attenuates destructive factor expression in vivo, providing a potential strategy for the chondroprotective therapy in OA...
  78. pmc Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets
    Wei Fan Chen
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Haematologica 98:793-801. 2013
    ..Our results showed a novel physiological significance of PAR4-nSMase/ceramide-p38 MAPK-NF-κB cascade in platelet activation...
  79. pmc Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide
    Thanasekaran Jayakumar
    Department of Pharmacology, Taipei Medical University, Taipei 110, Taiwan
    Evid Based Complement Alternat Med 2013:846740. 2013
    ..Therefore, this paper is intended to provide evidence reported in relevant literature on qualitative research to assist scientists in isolating and characterizing bioactive compounds...
  80. pmc Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats
    Yi Chang
    Department of Anesthesiology, Shin Kong Wu Ho Su Memorial Hospital and School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    J Biomed Sci 16:9. 2009
    ..Thus, puerarin treatment may represent a novel approach to lowering the risk of or improving function in ischemia-reperfusion brain injury-related disorders...
  81. doi request reprint Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase
    Duen Suey Chou
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    Free Radic Biol Med 46:1197-203. 2009
    ..On the basis of these data, we conclude that ROS formation catalyzed by 12-LOX is one possible mechanism of growth inhibition by baicalein in B16F10 melanoma cells...
  82. pmc Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling
    Jen Jui Wang
    Department of Anesthesiology, West Garden Hospital, Taipei, Taiwan
    Arch Med Sci 9:332-9. 2013
    ..The aim of this study was to examine the mechanisms of action of midazolam on MMP expression via nuclear factor κB (NF-κB) signaling in activated chondrosarcoma cells maintained in vitro...
  83. doi request reprint The role of cyclooxygenase-derived oxidative stress in surgically induced lymphedema in a mouse tail model
    Ting Chen Chang
    Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Pharm Biol 51:573-80. 2013
    ..Oxidative stress may contribute to lymphedema and subsequent tissue damage. However, the causal role of oxidative stress in lymphedema remains unclear...
  84. ncbi request reprint Oxidative stress induces vascular heme oxygenase-1 expression in ovariectomized rats
    Yen Mei Lee
    Department of Pharmacology, National Defense Medical Center, Nei Hu, Taipei, Taiwan
    Free Radic Biol Med 39:108-17. 2005
    ..The NO/iNOS system contributes to the induction of HO-1, which may subsequently suppress iNOS activity to modulate vasculoprotective effects after menopause...
  85. ncbi request reprint Peptidoglycan induces nuclear factor-kappaB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages
    Bing Chang Chen
    School of Respiratory Therapy, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Biol Chem 279:20889-97. 2004
    ..Our data demonstrate for the first time that PGN activates the Ras/Raf-1/ERK pathway, which in turn initiates IKKalpha/beta and NF-kappaB activation, and ultimately induces COX-2 expression in RAW 264.7 macrophages...
  86. doi request reprint Modulation of biocompatibility on poly(vinylidene fluoride) and polysulfone by oxygen plasma treatment and dopamine coating
    Dave Mangindaan
    Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan
    J Biomed Mater Res A 100:3177-88. 2012
    ..Moreover, the simple immobilization of polymers in dopamine solution resulted in hydrophilic surface coating with stability that caused threefold and twofold increases of biocompatibility on PVDF and PSf correspondingly...
  87. pmc Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways
    Ming Yi Shen
    Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, Taiwan
    Evid Based Complement Alternat Med 2012:982396. 2012
    ..Overall, the data demonstrate the preventive effect and molecular mechanism of action of catenarin on T1D, suggesting its novel use as a prophylactic agent in T1D...
  88. doi request reprint Dynasore, a dynamin inhibitor, induces PAI-1 expression in MeT-5A human pleural mesothelial cells
    Chi Li Chung
    Department of Chest Medicine, Taipei Medical University Hospital and School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Am J Respir Cell Mol Biol 40:692-700. 2009
    ..Given the profibrotic effect of dynasore, further in vivo studies may be conducted to evaluate its potential as a pleurodesing agent...
  89. ncbi request reprint Renal ischemia/reperfusion injury inhibits differentiation of dendritic cells derived from bone marrow monocytes in rats
    Chih Jen Wu
    Division of Nephrology, Mackay Memorial Hospital, Taipei, Taiwan
    Life Sci 78:1121-8. 2006
    ..This decrease may reflect a stress-induced downshift in the capacity of BMMos to differentiate into DCs and a parallel upshift in the capacity of DCs to infiltrate the kidney...
  90. ncbi request reprint Comparison of the binding character of triflavin on resting and activated alpha(IIb)beta(3) integrin in human platelets by electron microscopy
    Woei Jer Chuang
    Department of Biochemistry, National Cheng Kung University, Medical College, Tainan, Taiwan
    Thromb Res 109:37-46. 2003
    ....
  91. ncbi request reprint Inhibitory mechanisms of activated matrix metalloproteinase-9 on platelet activation
    Ye Ming Lee
    Department of Surgery, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan
    Eur J Pharmacol 537:52-8. 2006
    ..This study further provides new insights concerning the effects of activated MMP-9 on platelet aggregation...