Research Topics
Genomes and GenesSpecies | Chin Chen PanSummaryAffiliation: Taipei Veterans General Hospital Country: Taiwan Publications
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Detail Information
Publications
Tubulocystic clear cell adenocarcinoma arising within the prostateC C Pan
Department of Pathology, National Yang Ming University and Veterans General Hospital Tapiei, Taiwan, ROC
Am J Surg Pathol 24:1433-6. 2000..The clinical as well as the pathologic features are consistent with a clear cell adenocarcinoma as seen in the female genital tract rather than a typical prostatic adenocarcinoma...- An easy method for manual construction of high-density tissue arraysChin Chen Pan
Department of Pathology, National Yang Ming University and Veterans General Hospital, Taipei, Taiwan
Appl Immunohistochem Mol Morphol 12:370-2. 2004..The results were generally in agreement with those in previous reports. The authors offer a satisfactory alternative method for building custom arrays for any laboratory that is unable to afford a tissue array apparatus... - Differential immunoprofiles of hepatocellular carcinoma, renal cell carcinoma, and adrenocortical carcinoma: a systemic immunohistochemical survey using tissue array techniqueChin Chen Pan
Department of Pathology, National Yang Ming University, Taipei Veterans General Hospital, Taiwan
Appl Immunohistochem Mol Morphol 13:347-52. 2005..Proper selection of immunohistochemical stains aid in the differential diagnosis of the three neoplasms. Using the tissue array technique, the authors also showed an effective model for comprehensive antibody testing... - KIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomasChin Chen Pan
Department of Pathology, National Yang Ming University and Taipei Veterans General Hospital, Taiwan
J Pathol 202:375-81. 2004..The overexpression of KIT in thymic carcinomas has potential diagnostic utility in differentiating these tumours from thymomas and carcinomas arising from other sites, which express KIT infrequently... - Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasmChin Chen Pan
Department of Pathology, National Yang Ming University, Taipei, Taiwan Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan
Hum Pathol 37:606-12. 2006..From a molecular genetic perspective, the recurrent chromosomal alterations in both renal and extrarenal tumors further support the concept of PEComa as a distinctive tumor entity regardless of anatomic location... - Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipomaC C Pan
Department of Pathology, Taipei Veterans General Hospital and National Yang Ming University, Taiwan
J Pathol 214:387-93. 2008..Our observations of frequent deletion of TSC2 and the mTOR signalling pathway provide evidence that the oncogenetic lineage of PEComa, as a distinct TSC2-linked neoplasm, is similar to that of angiomyolipoma... 
Immunohistochemical and molecular genetic profiling of acquired cystic disease-associated renal cell carcinomaChin Chen Pan
Department of Pathology, Taipei Veterans General Hospital and National Yang Ming University, No 201, Shi Pai Rd, Sec 2, Taipei 11217, Taiwan
Histopathology 55:145-53. 2009....- Expression of apoptosis-related markers and HER-2/neu in thymic epithelial tumoursC C Pan
Department of Pathology, National Yang Ming University, and Veterans General Hospital Taipei, Taiwan
Histopathology 43:165-72. 2003.... - Clear cell myomelanocytic tumor of the urinary bladderChin Chen Pan
Department of Pathology, National Yang Ming University and Veterans General Hospital Taipei, Taiwan
Am J Surg Pathol 27:689-92. 2003..This case, in association with the expanding list of perivascular epithelioid cell tumor reported in different sites, suggests that this type of neoplasm may be ubiquitous... - Malignant perivascular epithelioid cell tumor involving the prostateChin Chen Pan
Department of Pathology, National Yang Ming University, and Veterans General Hospital Taipei, Taipei, Taiwan
Arch Pathol Lab Med 127:E96-8. 2003..Immunohistochemically, the tumor cells were positive for HMB-45 but negative for epithelial markers, Melan-A, and S100 protein. The tumor behaved in a malignant fashion, and the patient died of the disease 4 years after diagnosis... - Spindle cell and mixed spindle/lymphocytic thymomas: an integrated clinicopathologic and immunohistochemical study of 81 casesC C Pan
Department of Pathology, National Yang Ming University and Veterans General Hospital Taipei, Taiwan
Am J Surg Pathol 25:111-20. 2001..When interpreted within the context of staging, spindle cell and mixed spindle/lymphocytic thymomas presenting in stages I and II most likely behave in an indolent fashion... - Thymoma is associated with an increased risk of second malignancyC C Pan
Department of Pathology, Veterans General Hospital Taipei, No 201, Sec 2, Shih Pai Road, Taipei, 11217 Taiwan
Cancer 92:2406-11. 2001..An association between thymoma and second malignancy has been suggested but has not been validated. Whether the relation is due to treatment or to other thymoma-associated conditions is unclear... - The diagnostic utility of MOC31, BerEP4, RCC marker and CD10 in the classification of renal cell carcinoma and renal oncocytoma: an immunohistochemical analysis of 328 casesC C Pan
Department of Pathology, National Yang Ming University, and Taipei Veterans General Hospital, Taipei, Taiwan
Histopathology 45:452-9. 2004..To demonstrate the diagnostic utility of MOC31, BerEP4, renal cell carcinoma marker (RCC Ma) and CD10 in the classification of RCC and renal oncocytoma, based upon a comprehensive immunohistochemical analysis... - Constructing prognostic model incorporating the 2004 WHO/ISUP classification for patients with non-muscle-invasive urothelial tumours of the urinary bladderChin Chen Pan
Department of Pathology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
J Clin Pathol 63:910-5. 2010.... - Detection of chromosome copy number alterations in metanephric adenomas by array comparative genomic hybridizationChin Chen Pan
Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan
Mod Pathol 23:1634-40. 2010..Our series demonstrates that the genetic profile of metanephric adenoma is fundamentally distinct from those of papillary renal cell carcinoma and Wilms' tumor... - Prognostic significance of the 2004 WHO/ISUP classification for prediction of recurrence, progression, and cancer-specific mortality of non-muscle-invasive urothelial tumors of the urinary bladder: a clinicopathologic study of 1,515 casesChin Chen Pan
Department of Pathology, Taipei Veterans General Hospital, No 201, Shi Pai Rd, Sec 2, Taipei, 11217 Taiwan
Am J Clin Pathol 133:788-95. 2010.... - PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgeryChueh Chuan Yen
Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
J Surg Oncol 103:761-7. 2011..We evaluated the clinicopathological associations and prognostic implications of promyelocytic leukemia gene (PML) expressions in patients with esophageal squamous cell carcinomas (ESCC) receiving primary surgery... - Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressedChueh Chuan Yen
Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, China
World J Gastroenterol 11:1267-72. 2005..However, amplification patterns of these genes in EC-SCC have never been reported. The possible association of copy number changes of these genes with pathologic characteristics is still not clear... - Prognostic significance in substaging ofT1 urinary bladder urothelial carcinoma on transurethral resectionWei Chin Chang
Department of Pathology, Taipei Veterans General Hospital, Taiwan
Am J Surg Pathol 36:454-61. 2012.... - Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancerYu Chuen Huang
Division of Preventive Medicine, Institute of Public Health, National Yang Ming University, Taipei, Taiwan
Clin Cancer Res 13:1412-20. 2007..Here, we report on our efforts to characterize the haplotypes, loss of heterozygosity (LOH), and expression levels of the GNMT in prostate cancer... - Unusual visualization of an adrenal carcinoma on NP-59 scintiscanFan Fen Wang
Division of Endocrinology and Metabolism, Taipei Municipal Yang Ming Hospital, Taipei, Taiwan
J Formos Med Assoc 105:340-5. 2006..Visualization of an adrenal tumor on NP-59 scintiscan is an unusual finding, which cannot exclude the possibility of malignancy... - Sunitinib-induced nephrotic syndrome in association with drug response in a patient with Xp11.2 translocation renal cell carcinomaYao Chung Liu
Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, No 201, Sec 2, Shih Pai Road, Taipei 112, Taiwan
Jpn J Clin Oncol 41:1277-81. 2011..Our case highlighted the favorable response of a particular non-clear cell type renal cell carcinoma to sunitinib and the specific toxicity associated with the antiangiogenic effect of sunitinib... - Malignant renal epithelioid angiomyolipoma with aggressive behavior and distant metastasisWen Chiung Lin
Department ofRadiology, Taipei Veterans General Hospital, Taiwan, ROC
J Chin Med Assoc 66:303-6. 2003..We have observed that AML of epithelioid subtype with tumoral necrosis may suggest the malignant change... - Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladderChih Hao Sun
Department of Pathology, ChiaYi Veterans Hospital, Chiayi, Taiwan
Histopathology 58:1054-63. 2011..However, its clinical relevance has not been substantially validated in human samples. The aim of this study was to assess the expression of the pathway in a large cohort of bladder cancers using the tissue microarray technique... - Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytomaChin-Chen Pan
Department of Pathology, National Yang-Ming University, Taipei, Taiwan
Am J Clin Pathol 121:878-83. 2004..However, the therapeutic relevance of KIT overexpression in these tumors is uncertain owing to the lack of mutations that would lead to constitutive activation of the protein... - Risk of oral cancer associated with human papillomavirus infection, betel quid chewing, and cigarette smoking in Taiwan--an integrated molecular and epidemiological study of 58 casesPaul Chih-Hsueh Chen
Department of Pathology, Veterans General Hospital, Taipei and National Yang, Ming University, Taiwan
J Oral Pathol Med 31:317-22. 2002..CONCLUSIONS: Our results showed that HPV16 and betel quid chewing were two major risk factors for OSCC in Taiwan, indicating that they act through different mechanisms in the pathogenesis of OSCC... - Giant bilateral perinephric tumour and overt proteinuriaMing-Yu Lai
Division of Nephrology, Department of Radiology, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei 11217, Taiwan
Nephrol Dial Transplant 22:2089-90. 2007 - Sonographic features of primary testicular granulocytic sarcomaSee-Ying Chiou
Department of Radiology, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China
J Ultrasound Med 22:1413-6. 2003 - Her2 amplification distinguishes a subset of non-muscle-invasive bladder cancers with a high risk of progressionPaul Chih Hsueh Chen
Department of Pathology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
J Clin Pathol 66:113-9. 2013..Few studies have examined Her2 status in non-muscle invasive bladder cancer (NMIBC) using fluorescence in situ hybridisation (FISH)... - XP11.2 translocation renal cell carcinoma: clinical experience of Taipei Veterans General HospitalChia Chen Hung
Division of Urology, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
J Chin Med Assoc 74:500-4. 2011..These rare cancers occur predominantly in children and young adults and comprise about one-third of pediatric RCCs. In the present study, we review the clinical course of Xp11.2 translocation renal cell carcinoma in our institution... - Risk of oral nonmalignant lesions associated with human papillomavirus infection, betel quid chewing, and cigarette smoking in Taiwan: an integrated molecular and epidemiologic studyPaul Chih Hsueh Chen
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
Arch Pathol Lab Med 130:57-61. 2006.... - Expression of calretinin and other mesothelioma-related markers in thymic carcinoma and thymomaChin-Chen Pan
Department of Pathology, National Yang-Ming University and Veterans General Hospital, Taipei, Taiwan
Hum Pathol 34:1155-62. 2003.... - Mosaic or chimera? Revisiting an old hypothesis about the cause of the 46,XX/46,XY hermaphroditeDau Ming Niu
Department of Pediatrics, Veterans General Hospital Taipei, Institute of Clinical Medicine and Genome Research Center, Taiwan
J Pediatr 140:732-5. 2002..A cell lineage in a hermaphrodite infant showing a 46,XX/46,XY karyotype was analyzed to determine the genetic contribution from both parents and identify the underlying mechanism... - Trends in prostate needle biopsy diagnosis. A ten year experience of a medical center in TaiwanYing Ju Kuo
Department of Pathology and Laboratory Medicine, Taipei Veterans General, Taiwan
Pathol Int 62:191-8. 2012.... - Malignant ganglioneuroma arising from mediastinal mixed germ cell tumorPi Yu Chen
Department of Pathology, Chia Yi Veterans General Hospital, Taiwan, ROC
J Chin Med Assoc 70:76-9. 2007..To our knowledge, this is the first reported case of a malignant ganglioneuroma arising from mediastinal mixed germ cell tumor... - Detection of Epstein-Barr virus genome within thymic epithelial tumours in Taiwanese patients by nested PCR, PCR in situ hybridization, and RNA in situ hybridizationPaul Chih-Hsueh Chen
Department of Pathology, National Yang-Ming University and Veterans General Hospital-Taipei, Taiwan
J Pathol 197:684-8. 2002..Thymomas are not related to EBV, even in this endemic area. Thymic carcinomas, especially the lymphoepithelioma-like thymic carcinomas, are more often associated with the virus... - Primary renal synovial sarcoma with inferior vena cava and right atrium invasionPaul Chih-Hsueh Chen
Department of Pathology, Division of Medical Oncology, Veterans General Hospital and Yang-Ming University, Taipei, Taiwan
Int J Urol 10:657-60. 2003..Our case shows that synovial sarcoma should be considered in the differential diagnosis of renal tumors, especially in adolescents and young adults. Proper molecular analysis should be undertaken to attain a definitive diagnosis... - Comparative genomic hybridization analysis of thymic neuroendocrine tumorsChin-Chen Pan
Department of Pathology, National Yang-Ming University, Taipei, Taiwan
Mod Pathol 18:358-64. 2005..Consequently, we consider that a distinctive cytogenetic mechanism is at work in the development of thymic neuroendocrine tumors, which is different from that of foregut carcinoid tumors... - Pheochromocytoma and adrenocortical adenoma in the same glandWei Ren Hwang
Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
J Chin Med Assoc 70:289-93. 2007..After right adrenalectomy, a small adrenal cortical adenoma and a large pheochromocytoma were noted. This is an extremely rare case of an adrenal incidentaloma consisting of both medullary and cortical tumors in the same gland... - Diagnosing minimal adenocarcinoma on prostate needle biopsy by real-time dynamic telepathology through the internet: evaluation of an economic technology for remote consultationChin-Chen Pan
Department of Pathology, National Yang-Ming University and Veterans General Hospital-Taipei, Taiwan
Hum Pathol 33:242-6. 2002..Our results demonstrate that this method is effective for teleconsultation. Similar systems using the internet can be easily set up by ordinary pathology laboratories to facilitate remote consultation... - Cytoplasmic immunoreactivity for thyroid transcription factor-1 in hepatocellular carcinoma: a comparative immunohistochemical analysis of four commercial antibodies using a tissue array techniqueChin-Chen Pan
Department of Pathology, National Yang-Ming University, Taipei Veterans General Hospital, Taiwan, Republic of China
Am J Clin Pathol 121:343-9. 2004..In general, the Novocastra antibody with EDTA HIER is superior for its consistent nuclear positivity and absence of erratic cytoplasmic staining... - Primary sweat gland carcinosarcoma of the scrotal skinTzu-Ping Lin
Division of Urology, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan, ROC
J Cutan Pathol 31:678-82. 2004..The tumor behaved aggressively. Local recurrence and distant metastases to lungs and brain occurred 6 months and 18 months later. The patient died of the disease 20 months after the initial diagnosis... - Epstein-Barr virus-associated lymphoepithelioma-like carcinoma of the esophagusPaul Chih-Hsueh Chen
Department of Pathology, Veterans General Hospital, Taipei, Taiwan
Hum Pathol 34:407-11. 2003..Due to its distinct histological features, the association with EBV, and possible prognostic implication, LELC of the esophagus should be precisely diagnosed and discerned from the usual poorly differentiated carcinoma... - Nephrogenic adenoma arising in a renal cortical cystYi-Chun Chiu
Division of Urology, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
J Chin Med Assoc 68:444-6. 2005..A MEDLINE search of the literature from 1960 to the present revealed no previous documentation of a nephrogenic adenoma arising from a renal cortical cyst. Herein, we present such a case arising in a renal cortical cyst... - A distinct expression pattern and point mutation of c-KIT in papillary renal cell carcinomasChin-Chen Pan
Mod Pathol 17:1440-1; author reply 1442-4. 2004 - Spontaneous cholecystocutaneous fistula presenting with a cellulitis and portal vein thrombosisShen-Shong Chang
J Clin Gastroenterol 34:99-100. 2002