Yu Chih Liang

Summary

Affiliation: Taipei Medical University
Country: Taiwan

Publications

  1. pmc 15,16-Dihydrotanshinone I, a Compound of Salvia miltiorrhiza Bunge, Induces Apoptosis through Inducing Endoplasmic Reticular Stress in Human Prostate Carcinoma Cells
    Mao Te Chuang
    Department of Surgery, St Martin de Porres Hospital, Chia Yi City 60069, Taiwan
    Evid Based Complement Alternat Med 2011:865435. 2011
  2. pmc The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells
    Li Chieh Wang
    Department of Pediatrics, National Taiwan University Hospital, Taipei 100, Taiwan, Republic of
    BMC Immunol 10:39. 2009
  3. ncbi request reprint Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression
    Jean Dean Liu
    College of Medicine, Taipei Medical University, Taipei, Taiwan
    Life Sci 74:2451-63. 2004
  4. ncbi request reprint Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells
    Shyr Yi Lin
    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    Mol Carcinog 35:21-8. 2002
  5. ncbi request reprint Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells
    Shu Huei Tsai
    Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
    J Cell Biochem 84:750-8. 2002
  6. ncbi request reprint In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest
    Wen Sen Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Int J Cancer 106:125-37. 2003
  7. ncbi request reprint The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1
    Yenn Hwei Chou
    Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Int J Biochem Cell Biol 37:604-15. 2005
  8. ncbi request reprint Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol
    Chiung Ho Liao
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Mol Carcinog 41:140-9. 2004
  9. ncbi request reprint Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells
    Chia Jen Tseng
    Graduate Institute of Biomedical Technology, Taipei Medical University, No 250, Wu Hsing Street, Taipei 110, Taiwan, ROC
    Toxicology 175:123-42. 2002
  10. ncbi request reprint Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells
    Jean Dean Liu
    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    Mol Carcinog 37:16-24. 2003

Collaborators

Detail Information

Publications64

  1. pmc 15,16-Dihydrotanshinone I, a Compound of Salvia miltiorrhiza Bunge, Induces Apoptosis through Inducing Endoplasmic Reticular Stress in Human Prostate Carcinoma Cells
    Mao Te Chuang
    Department of Surgery, St Martin de Porres Hospital, Chia Yi City 60069, Taiwan
    Evid Based Complement Alternat Med 2011:865435. 2011
    ..Results suggest that DHTS can induce apoptosis of prostate carcinoma cells via induction of ER stress and/or inhibition of proteasome activity, and may have therapeutic potential for prostate cancer patients...
  2. pmc The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells
    Li Chieh Wang
    Department of Pediatrics, National Taiwan University Hospital, Taipei 100, Taiwan, Republic of
    BMC Immunol 10:39. 2009
    ..In this study, the effect of caffeic acid phenethyl ester (CAPE), the most extensively studied components in propolis, on the functions of human monocyte-derived dendritic cells (MoDCs) was investigated...
  3. ncbi request reprint Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression
    Jean Dean Liu
    College of Medicine, Taipei Medical University, Taipei, Taiwan
    Life Sci 74:2451-63. 2004
    ..These results suggest that thiol antioxidant and reducing agents attenuate the expression of HO-1 induced by 15d-PGJ(2), and that the cellular thiol-disulfide redox status may be linked to HO-1 activation...
  4. ncbi request reprint Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells
    Shyr Yi Lin
    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    Mol Carcinog 35:21-8. 2002
    ....
  5. ncbi request reprint Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells
    Shu Huei Tsai
    Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
    J Cell Biochem 84:750-8. 2002
    ..Arsenite could induce IKK activity, which leads to the phosphorylation and degradation of IkappaB in ECV304 cells. Therefore, it appears that IKK signaling pathway is involved in arsenite-mediated Cox-2 expression...
  6. ncbi request reprint In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest
    Wen Sen Lee
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Int J Cancer 106:125-37. 2003
    ..These findings demonstrate for the first time that TB can inhibit the proliferation of tumor cells in vitro and in vivo...
  7. ncbi request reprint The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1
    Yenn Hwei Chou
    Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Int J Biochem Cell Biol 37:604-15. 2005
    ..Overall, it is possible that HSF-1 negatively regulates HO-1 gene expression, and that the HSE present in the -389 to -362 region mediates HSF-1-induced repression of human HO-1 gene expression...
  8. ncbi request reprint Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol
    Chiung Ho Liao
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    Mol Carcinog 41:140-9. 2004
    ..The NF-kappa B signaling pathway leads to inflammatory reaction and our results suggest that garcinol suppresses the expression of iNOS in this pathway...
  9. ncbi request reprint Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells
    Chia Jen Tseng
    Graduate Institute of Biomedical Technology, Taipei Medical University, No 250, Wu Hsing Street, Taipei 110, Taiwan, ROC
    Toxicology 175:123-42. 2002
    ..The results from the present study highlight the molecular mechanisms underlying of the PDP-induced anti-cancer activity...
  10. ncbi request reprint Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells
    Jean Dean Liu
    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    Mol Carcinog 37:16-24. 2003
    ..These results suggested that CyPGs, such as 15d-PGJ(2) and PGA(1), activated JNK signaling pathway, and that JNK activation may be involved in 15d-PGJ(2)- and PGA(1)-induced apoptosis...
  11. ncbi request reprint Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest
    Chih Hsiung Wu
    School of Medicine, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 180:22-35. 2002
    ..Our study provides the novel mechanisms of antitumor effects of MIC and such results may have significant applications for cancer chemotherapy...
  12. doi request reprint 5,5-Diphenyl-2-thiohydantoin-N10 (DPTH-N10) suppresses proliferation of cultured colon cancer cell line COLO-205 by inhibiting DNA synthesis and activating apoptosis
    Tong Sheng Lee
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 382:43-50. 2010
    ....
  13. ncbi request reprint Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages
    Ai Hsiang Lo
    Institute of Biochemistry, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan
    Carcinogenesis 23:983-91. 2002
    ..These results suggest that carnosol suppresses the NO production and iNOS gene expression by inhibiting NF-kappaB activation, and provide possible mechanisms for its anti-inflammatory and chemopreventive action...
  14. ncbi request reprint N-Hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells
    Ling Yu Liu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
    Chem Biol Interact 217:1-8. 2014
    ..These results suggest that WJ1376-1 and WJ1398-1 inhibit cell migration and invasion by suppressing TGF-βRI phosphorylation and subsequently hindering both Smad2 and phosphatidylinositol 3-kinase/Akt signaling pathways. ..
  15. ncbi request reprint Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways
    Chien Ho Chen
    School of Medical Laboratory Science and Biotechnology, College of Medicine, Taipei Medical University, No 250 Wu Hsing Street, Taipei 11014, Taiwan, ROC
    Biochem Pharmacol 72:1001-9. 2006
    ..These results suggest that modulation of iNOS and COX-2 expressions by dietary pectin may be important in cancer chemoprevention and anti-inflammation...
  16. ncbi request reprint Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin
    Der Zen Liu
    Graduate Institutes of Biomedical Materials, Taipei Medical University, Taipei, Taiwan
    Biochim Biophys Acta 1773:869-79. 2007
    ..We propose that the inhibition of PI(3)K by wortmannin in mouse macrophages enhances the PI-PLC downstream signals, and subsequently increases the LPS induction of iNOS expression independently of Akt pathway...
  17. ncbi request reprint Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells
    Chun Ru Shih
    Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, ROC, Taipei, Taiwan
    Biochem Pharmacol 67:67-75. 2004
    ..The findings from the present study suggest that DPTH might have the potential to inhibit the occurrence of angiogenesis...
  18. doi request reprint Involvement of the JNK activation in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells
    Sung Po Hsu
    Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Biochem 108:860-6. 2009
    ..Taken together, our results suggest that JNK activation is involved in the TB-induced inhibition of ERK phosphorylation, p53 and p21 up-regulation and DNA synthesis inhibition in HUVEC...
  19. ncbi request reprint Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action
    Der Zen Liu
    Graduate Institutes of Biomedical Materials, Taipei Medical University, Taipei, Taiwan
    J Ethnopharmacol 113:45-53. 2007
    ..These results suggest that Taiwanofungus camphoratus exhibits an anti-inflammatory activity that might contribute to the prevention of neurodegenerative diseases...
  20. ncbi request reprint Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages
    Ming Shium Hsieh
    Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
    J Cell Biochem 89:791-9. 2003
    ....
  21. ncbi request reprint Inhibition of human vascular endothelial cells proliferation by terbinafine
    Pei Yin Ho
    Graduate Institute of Cellular and Molecular Biology, Taipei Medical University, Taipei, Taiwan
    Int J Cancer 111:51-9. 2004
    ..Capillary-like tube formation and chick embryo chorioallantoic membrane (CAM) assays further demonstrated the anti-angiogenic effect of TB. These findings demonstrate for the first time that TB can inhibit the angiogenesis...
  22. ncbi request reprint Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells
    Jean Dean Liu
    Department of Internal Medicine, School of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan
    Mol Carcinog 37:39-50. 2003
    ..Our study showed the molecular mechanisms for TF-induced cell growth inhibition and the occurrence of apoptosis in human cancer cells...
  23. ncbi request reprint Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation
    Sung Ho Chen
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Toxicol Sci 102:138-49. 2008
    ..Their clinical implications in the etiology of neurodegenerative diseases deserve further investigation...
  24. doi request reprint An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways
    Yu Li Lin
    Department of Medical Research, Institute of Microbiology and Biochemistry, National Taiwan University Hospital, Taipei, Taiwan, Republic of China
    J Leukoc Biol 86:877-89. 2009
    ..In conclusion, our experiments demonstrated that rLZ-8 can effectively promote the activation and maturation of immature DCs, preferring a Th1 response, suggesting that rLZ-8 may possess a potential effect in regulating immune responses...
  25. ncbi request reprint Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells
    Kuo Ching Yang
    Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, China
    World J Gastroenterol 11:3040-5. 2005
    ..To explore both the in vitro and in vivo effects of denbinobin against colon cancer cells and clarify its underlying signal pathways...
  26. ncbi request reprint Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation
    Yuan Soon Ho
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 205:133-48. 2005
    ..In summary, our findings demonstrate for the first time that NNK could stimulate normal human bronchial cell proliferation through activation of the NFkappaB, which in turn up-regulated the cyclin D1 expression...
  27. ncbi request reprint YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway
    Hun Kung Hsu
    Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan, ROC
    Biochem Pharmacol 66:263-71. 2003
    ..This YC-1-induced antiproliferation effect in HUVEC is via a cyclic GMP-independent pathway...
  28. ncbi request reprint Anti-proliferation effect of 3-amino-2-imino-3,4-dihydro-2H-1,3-benzothiazin-4-one (BJ-601) on human vascular endothelial cells: G0/G1 p21-associated cell cycle arrest
    Chung Hsun Yu
    Graduate Institute Cellular and Molecular Biology, Taipei Medical University, Taipei, Taiwan, ROC
    Biochem Pharmacol 67:1907-16. 2004
    ..In conclusion, these data suggest that BJ-601 inhibits HDMVECs proliferation by increasing the level of p21 protein, which in turn inhibits CDK2 kinase activity, and finally causes retardation of the cell cycle at the G0/G1 phase...
  29. doi request reprint Neuroprotective activity of Vitis thunbergii var. taiwaniana extracts in vitro and in vivo
    Chung Kwe Wang
    Department of Primary Care Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    J Med Food 13:170-8. 2010
    ..The results suggest that VTT extracts have a potential to prevent neurodegeneration through the antioxidative activity by their ability to inhibit NO and hydrogen peroxide production...
  30. doi request reprint Inhibition of the ERK phosphorylation plays a role in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells
    Pei Yin Ho
    Graduate Institute of Cell and Molecular Biology, Taipei Medical University, Taipei, Taiwan
    Toxicol Appl Pharmacol 229:86-93. 2008
    ..Taken together, our results suggest that TB might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21 expression and cell-cycle arrest...
  31. doi request reprint Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1
    Li Ching Chen
    Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei, Taiwan
    J Agric Food Chem 57:7331-7. 2009
    ..Magnolol at a concentration of 100 microM induced DNA fragmentation in U373. Our findings suggest the potential applications of magnolol in the treatment of human brain cancers...
  32. doi request reprint Cytotoxicity of (-)-vitisin B in human leukemia cells
    Shing Sheng Wu
    Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
    Drug Chem Toxicol 36:313-9. 2013
    ..These results suggest that (-)-vitisin B-induced apoptosis of leukemia cells might be mediated through activation of JNK and Fas death-signal transduction...
  33. doi request reprint Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways
    Yi Cheng Lin
    Department of Orthopedics, Mackay Memorial Hospital, Taipei, Taiwan, ROC
    Rheumatol Int 28:1009-16. 2008
    ..The chondroprotective effect of GLN through the decrease in MMP-3 production and stimulation of proteoglycan synthesis may follow another potential signaling pathway of Akt...
  34. pmc TGF-beta inhibits IL-1beta-activated PAR-2 expression through multiple pathways in human primary synovial cells
    Shin Han Tsai
    Department of Neurosurgery, Department of Emergency and Critical Care Medicine, Taipei Medical University Shuang Ho Hospital, Taipei, Taiwan, Republic of China
    J Biomed Sci 16:97. 2009
    ..Because IL-1beta-induced PAR-2 expressed in hPSCs might play a significantly important role in early phase of OA, PAR-2 repression by exogenous TGF-beta or other agents might be an ideal therapeutic target to prevent OA from progression...
  35. ncbi request reprint Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages
    Chun Mao Lin
    College of Medicine, Taipei Medical University, Taipei, Taiwan
    Planta Med 71:748-53. 2005
    ..These results suggest that isovitexin, a food phytochemical contained in dietary rice products, might have biological significance...
  36. ncbi request reprint N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo
    Ling Yu Liu
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Chem Res Toxicol 26:1683-91. 2013
    ....
  37. ncbi request reprint 15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3
    Fat Moon Suk
    School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing St, Taipei 11031, Taiwan, ROC
    Anticancer Res 33:3225-31. 2013
    ..These results suggest that DHTS has a strong therapeutic or preventive potential against cancer. In addition, ATF3 has a dual role in DHTS-induced apoptosis, depending on the degree of malignancy of colorectal cancer. ..
  38. doi request reprint Liposome encapsulation reduces cantharidin toxicity
    Chun Chao Chang
    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    Food Chem Toxicol 46:3116-21. 2008
    ..These results suggest that the systemic toxicity of cantharidin can be mitigated by liposome encapsulation; however, that did not decrease its antitumor activity...
  39. ncbi request reprint Taiwanofungus camphoratus activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats
    Fat Moon Suk
    Department of Internal Medicine, Taipei Medical University Hospital and Wan Fang Hospital, Taipei, 11014, Taiwan
    Biosci Biotechnol Biochem 72:1704-13. 2008
    ..These results suggest that T. camphoratus might contain PPARgamma ligands and result in a hypotriglyceridemic effect, and that it also exhibits a liver protective activity...
  40. ncbi request reprint Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation
    Yi Hsin Hsu
    Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    J Cell Biochem 93:929-39. 2004
    ..The cytokine-triggered induction of eotaxin-1 further results in enhanced expressions of its own receptor of CCR3, CCR5, and MMPs, suggesting that eotaxin-1 plays an important role in cartilage degradation in OA...
  41. ncbi request reprint Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells
    Yu Li Lin
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    J Leukoc Biol 82:1473-80. 2007
    ..PlGF might play a major role in the pathogenesis of tumors and act as an effector molecule to skew T cell response to the Th2 phenotype, which might be more beneficial for pregnancy...
  42. doi request reprint 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells
    Fat Moon Suk
    Department of Internal Medicine, Taipei Medical University Hospital and Wan Fang Hospital, Taipei, Taiwan
    Toxicol Lett 187:22-7. 2009
    ..15d-PGJ(2) might have a beneficent effect on prevention of liver fibrosis induced by environmental toxicants...
  43. ncbi request reprint Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory skin edema and ornithine decarboxylase activity by theaflavin-3,3'-digallate in mouse
    Yu Chih Liang
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
    Nutr Cancer 42:217-23. 2002
    ..These results suggested that TF-3 was a potential inhibitor of ODC activity and TPA-induced edema and might be effective in cancer chemoprevention...
  44. ncbi request reprint Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase
    Yu Chih Liang
    School of Medical Technology, Taipei Medical University, Taipei, Taiwan, China
    World J Gastroenterol 11:2557-63. 2005
    ..The purpose of this study was to investigate the role of FACL4 in the human hepatocellular carcinoma (HCC) tumorigenesis and the specific signal pathways involved in this process...
  45. ncbi request reprint Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-chih) in spontaneously hypertensive rats
    Der Zen Liu
    Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taiwan
    Biosci Biotechnol Biochem 71:23-30. 2007
    ..However, wild CC and its MS extract were not as effective as the SSC type in reducing SHR blood pressure and had no effect on WKY rats. SSC-type CC might be developed into a health food with the ability to regulate blood pressure...
  46. doi request reprint Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway
    Wen Bin Zhong
    Department of Physiology, Medical College, Taipei Medical University, Taipei 110, Taiwan
    Biochem Pharmacol 82:1663-72. 2011
    ..These data suggest that lovastatin merits further investigation as multipotent therapy for treatment ATC...
  47. ncbi request reprint Molecular modeling of flavonoids that inhibits xanthine oxidase
    Chun Mao Lin
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, Taiwan, ROC
    Biochem Biophys Res Commun 294:167-72. 2002
    ..Isovitexin showed the weakest inhibitory effect among the compounds tested. The bulky group of sugar in isovitexin may hamper its interaction with xanthine oxidase...
  48. ncbi request reprint Potential mechanism of blood vessel protection by resveratrol, a component of red wine
    Huei Mei Huang
    Graduate Institute of Cell and Molecular Biology, Center for Stem Cells Research at Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Ann N Y Acad Sci 1042:349-56. 2005
    ..Deletion of NF-kappaB binding sites in the promoter region strongly reduced luciferase activity. Collectively, we suggest that resveratrol-mediated HO-1 expression occurs, at least in part, through the NF-kappaB pathway...
  49. ncbi request reprint Molecular mechanism of progesterone-induced antiproliferation in rat aortic smooth muscle cells
    Wen Sen Lee
    Department of Physiology, School of Medicine, Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Endocrinology 144:2785-90. 2003
    ..In conclusion, these data suggest that progesterone inhibits RASMCs proliferation by increasing the levels of p21 and p27 protein, which in turn inhibit CDK2 kinase activity, and finally interrupt the cell cycle...
  50. ncbi request reprint Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts
    Hsien Tsung Lu
    Department of Orthopedics and Traumatology, Taipei Medical University Hospital, Taipei, Taiwan, ROC
    J Cell Biochem 104:38-50. 2008
    ....
  51. doi request reprint Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex
    Sung Ho Chen
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Eur J Pharmacol 594:9-17. 2008
    ..Based on these findings; we conclude that PDTC/Cu complex-induced apoptosis is mediated by activation of JNK, NF-kappaB, AP-1 and caspase 3. Due to its high potency, PDTC may be useful as a therapeutic anti-cancer drug...
  52. ncbi request reprint Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis
    Yow Jen Lo
    College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC
    Rheumatol Int 27:1099-111. 2007
    ....
  53. ncbi request reprint Effect of lipopolysaccharide on diarrhea and gastrointestinal transit in mice: roles of nitric oxide and prostaglandin E2
    Yu Chih Liang
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan, China
    World J Gastroenterol 11:357-61. 2005
    ....
  54. ncbi request reprint Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats
    Sheng Hsuan Chen
    Department and Research Center of Gastroenterology, Taipei Medical University Hospital, Taipei 110, Taiwan, China
    World J Gastroenterol 11:3746-50. 2005
    ..To evaluate the preventive effect of Ginkgo biloba extract (GbE) on ethanol-induced gastric mucosal injuries in rats...
  55. doi request reprint Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells
    Wei Hwa Lee
    Department of Pathology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
    J Agric Food Chem 59:12874-81. 2011
    ..Therefore, osthole might have potential as an antidiabetic agent for treating diabetes...
  56. ncbi request reprint Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways
    Yu Li Lin
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    J Leukoc Biol 78:533-43. 2005
    ..Taken together, our data demonstrate that PS-G can effectively promote the activation and maturation of immature DC, suggesting that PS-G may possess a potential in regulating immune responses...
  57. doi request reprint A novel phycobiliprotein alleviates allergic airway inflammation by modulating immune responses
    Chun Jung Chang
    Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan, No 7 Chung Shan South Road, Taipei, Taiwan
    Am J Respir Crit Care Med 183:15-25. 2011
    ..it has been claimed that phycocyanin exhibits pharmaceutical functions in inhibiting histamine release and leukotriene biosynthesis. In allergic asthma, these inflammatory mediators are crucial for disease progression...
  58. doi request reprint β-Sitosterol inhibits cell cycle progression of rat aortic smooth muscle cells through increases of p21cip1 protein
    Ming Hsien Chien
    Taipei Medical University Wang Fang Hospital, Taipei, Taiwan
    J Agric Food Chem 58:10064-9. 2010
    ..In conclusion, β-sitosterol inhibited VSMC proliferation by increasing the levels of p21cip1 protein, which in turn inhibited the CDK2 activity, and finally interrupted the progress of the cell cycle...
  59. doi request reprint Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10)
    Yuan Liu
    Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Cancer Lett 271:294-305. 2008
    ..Capillary-like tube formation, aortic ring culture, and chick embryo chorioallantoic membrane (CAM) assays further demonstrated the anti-angiogenic effect of DPTH-N10...
  60. ncbi request reprint Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells
    Yu Chih Liang
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No 1, Section 1 Jen Ai Road, Taipei, Taiwan
    Biochem Pharmacol 65:1053-60. 2003
    ....
  61. ncbi request reprint The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells
    An Ming Wang
    Institute of Biopharmaceutical Sciences, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Cell Biochem 106:682-92. 2009
    ..Taken together, this system could be beneficial for screening of drugs with potential to treat Notch signal pathway-associated diseases...
  62. pmc NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity
    Wei Jan Huang
    Graduate Institute of Pharmacognosy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
    Evid Based Complement Alternat Med 2012:781417. 2012
    ..Finally, we showed that NBM-HD-1 exhibited potent antitumor activity in a xenograft model. In conclusion, this study demonstrated that this compound, NBM-HD-1, is a novel and potent HDACi with anticancer activity in vitro and in vivo...
  63. ncbi request reprint Effects of sphondin, isolated from Heracleum laciniatum, on IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells
    Ling Ling Yang
    Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei, Taiwan
    Life Sci 72:199-213. 2002
    ..We conclude that sphondin may have the therapeutic potential as an anti-inflammatory drug on airway inflammation...