Shih Chieh Hung
Affiliation: Taipei Veterans General Hospital
Lin Y, Yet S, Hsu Y, Wang G, Hung S. Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function. Stem Cells Transl Med. 2015;4:44-55 pubmed publisher
..Activation of the Akt/eNOS pathway in endothelium by IL8/MIP-2 is involved in the protective effect of MSCs. The study helps support the use and clarify the mechanism of MSCs for ameliorating atherosclerosis. ..
Lin S, Chiu F, Wang Y, Yen M, Kao S, Hung S. RB maintains quiescence and prevents premature senescence through upregulation of DNMT1 in mesenchymal stromal cells. Stem Cell Reports. 2014;3:975-86 pubmed publisher
..These results demonstrate that RB expressed in early-passage MSCs upregulates DNMT1 expression and inhibits senescence in MSCs. Therefore, genetic modification of RB could be a way to improve the efficiency of MSCs in clinical use. ..
Hung S, Pochampally R, Hsu S, Sanchez C, Chen S, Spees J, et al
. Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PLoS ONE. 2007;2:e416 pubmed
..The results suggest that short-term culture of MSCs under hypoxic conditions may provide a general method of enhancing their engraftment in vivo into a variety of tissues. ..
Lee K, Lin H, Huang Y, Hung S. Allo-transplantation of mesenchymal stem cells attenuates hepatic injury through IL1Ra dependent macrophage switch in a mouse model of liver disease. J Hepatol. 2015;63:1405-12 pubmed publisher
..Allo-transplantation of MSCs reduces Con A liver injury by increasing IL10 production through an IL1Ra dependent macrophage switch. ..
Hung S, Cheng H, Pan C, Tsai M, Kao L, Ma H. In vitro differentiation of size-sieved stem cells into electrically active neural cells. Stem Cells. 2002;20:522-9 pubmed
..These findings suggest that SS cells may be an alternative source of undifferentiated cells for cell therapy and gene therapy in neural dysfunction...