Chia Kwung Fan


Affiliation: Taipei Medical University
Country: Taiwan


  1. Chou C, Fan C. Significant apoptosis rather autophagy predominates in astrocytes caused by Toxocara canis larval excretory-secretory antigens. J Microbiol Immunol Infect. 2018;: pubmed publisher
    ..We concluded that TcES Ag may trigger astrocytes apoptosis predominantly through intrinsic and extrinsic pathways rather autophagy, revealing a novel role of astrocytes in the pathogenesis of CT. ..
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    Fan C, Liao C, Wu M, Su K, Han B. Seroepidemiology of Toxoplasma gondii infection among Chinese aboriginal and Han people residing in mountainous areas of northern Thailand. J Parasitol. 2003;89:1239-42 pubmed
    ..1, 95% CI = 0.0 to 0.4, P < 0.001). Ethnically, Yau aboriginal populations had a significantly higher seroprevalence than did the Akka aborigines and Han people (P < 0.001). ..
  3. Dlamini S, Liao C, Dlamini Z, Siphepho J, Cheng P, Chuang T, et al. Knowledge of human social and behavioral factors essential for the success of community malaria control intervention programs: The case of Lomahasha in Swaziland. J Microbiol Immunol Infect. 2017;50:245-253 pubmed publisher
    ..Malpractices are more commonly observed among men, boys, and those who drink alcohol. This study suggests a thorough community diagnosis before all intervention programs for malaria control are instituted. ..
  4. Fan C, Holland C, Loxton K, Barghouth U. Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?. Clin Microbiol Rev. 2015;28:663-86 pubmed publisher
    ..canis larvae in the brain and the progression of Alzheimer's disease (AD) due to enhanced AD-associated neurodegenerative biomarker expression. ..
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    Fan C, Su K, Tsai Y. Serological survey of Toxoplasma gondii infection among slaughtered pigs in northwestern Taiwan. J Parasitol. 2004;90:653-4 pubmed
    ..4%, 128/288) previously reported about 10 yr ago using the LA test. Nevertheless, it is important to avoid eating raw or undercooked pork in order to prevent the acquisition of T. gondii infection among people in Taiwan. ..
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    Fan C, Su K, Wu G, Chiou H. Seroepidemiology of Toxoplasma gondii infection among two mountain aboriginal populations and Southeast Asian laborers in Taiwan. J Parasitol. 2002;88:411-4 pubmed
    ..gondii infection than those who had never consumed raw meat. Ethnically, a significant difference in seroprevalence was observed between Indonesians and Paiwans, Atayals, Thais, and Filipinos (P < 0.001). ..
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    Fan C, Hung C, Lin Y, Li M, Su K. Enhanced expression of transforming growth factor-beta1 in inflammatory cells and secretory granules in Paneth cells in the small intestine of mice infected with Toxocara canis. Parasitol Res. 2004;94:397-404 pubmed
    ..The significance of both effectors might be related to the host's defense against larval invasion in the intestinal phase of toxocaral infection. ..
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    Fan C, Hung C, Su K, Sung F, Chiou H, Gil V, et al. Seroprevalence of Toxoplasma gondii infection among pre-schoolchildren aged 1-5 years in the Democratic Republic of Sao Tome and Principe, Western Africa. Trans R Soc Trop Med Hyg. 2006;100:446-9 pubmed
    ..Whether the DRSTP pre-schoolchildren acquire T. gondii infection through constant exposure to the parasite from their daily activities owing to poor environmental hygiene should be further evaluated. ..
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    Fan C, Hung C, Su K, Chiou H, Gil V, Ferreira M, et al. Seroprevalence of Toxoplasma gondii infection among inhabitants in the Democratic Republic of Sao Tome and Principe. Trans R Soc Trop Med Hyg. 2007;101:1157-8 pubmed
    ..The older age group (> or =45 years) had significantly higher seroprevalence (80.0%, 28/35) than the younger age group (<15 years) (20.0%, 3/15) (chi(2)=16.04, P<0.001). ..

More Information


  1. Fan C, Lee L, Liao C, Huang Y, Lee Y, Chang Y, et al. Toxoplasma gondii infection: relationship between seroprevalence and risk factors among primary schoolchildren in the capital areas of Democratic Republic of São Tomé and Príncipe, West Africa. Parasit Vectors. 2012;5:141 pubmed publisher
    ..Measures such as improving environmental hygiene and intensive educational intervention to both PSC and their parents should be performed immediately so as to reduce T. gondii infection of DRSTP inhabitants including PSC and adults. ..
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    Fan C, Su K. Cross-reactions with Ascaris suum antigens of sera from mice infected with A. suum, Toxocara canis, and Angiostrongylus cantonensis. Parasitol Int. 2004;53:263-71 pubmed
    ..suum-induced VLM with serum IgG as tested by ELISA. Moreover, it was the first report to test the possibly antigenic cross-reactivity between A. suum and A. cantonensis. ..
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    Fan C, Hung C, Du W, Liao C, Su K. Seroepidemiology of Toxocara canis infection among mountain aboriginal schoolchildren living in contaminated districts in eastern Taiwan. Trop Med Int Health. 2004;9:1312-8 pubmed
    ..canis infection than those who did not. Children who habitually washed their hands before eating (OR=0.57, 95% CI: 0.33-0.97, P=0.04) had a lower chance of acquiring T. canis infection than those who did not. ..
  4. Maseko T, Mkhonta N, Masuku S, Dlamini S, Fan C. Schistosomiasis knowledge, attitude, practices, and associated factors among primary school children in the Siphofaneni area in the Lowveld of Swaziland. J Microbiol Immunol Infect. 2018;51:103-109 pubmed publisher
    ..This study suggests that empowering children with knowledge and attempting to modify their water contact, and improved human waste disposal practices are necessary for schistosomiasis control. ..
  5. Sowemimo O, Lee Y, Asaolu S, Chuang T, Akinwale O, Badejoko B, et al. Seroepidemiological study and associated risk factors of Toxocara canis infection among preschool children in Osun State, Nigeria. Acta Trop. 2017;173:85-89 pubmed publisher
    ..The results also provide baseline data for effective prevention strategies of toxocariasis in Southwest Nigeria and the study recommends prompt interventional measures, particularly health education on personal hygiene. ..
  6. Chou C, Lee Y, Liao C, Huang Y, Fan C. Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess A? accumulation in the hippocampus of mice with persistent cerebral toxocariasis. Parasit Vectors. 2017;10:620 pubmed publisher
    ..We thus postulate that progressive CT may still progress to neurodegeneration due to enhanced NDAF expressions, persistent UPS impairment and excess A? accumulation in the hippocampus. ..
  7. Liao C, Fan C, Kao T, Ji D, Su K, Lin Y, et al. Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice. BMC Infect Dis. 2008;8:84 pubmed publisher
    ..Since the pathogenesis of murine toxocariasis is very similar to that in humans, it appears appropriate to use a murine model to investigate the pathogenesis of CT...
  8. Gyang V, Chuang T, Liao C, Lee Y, Akinwale O, Orok A, et al. Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria. J Microbiol Immunol Infect. 2019;52:106-113 pubmed publisher
  9. Liao C, Cheng P, Chuang T, Chiu K, Chiang I, Kuo J, et al. Prevalence of Pediculus capitis in schoolchildren in Battambang, Cambodia. J Microbiol Immunol Infect. 2017;: pubmed publisher
    ..P. capitis infestation is currently a common parasitic dermatosis and a critical public health concern in underdeveloped countries...
  10. Gyang P, Akinwale O, Lee Y, Chuang T, Orok A, Ajibaye O, et al. Seroprevalence, disease awareness, and risk factors for Toxocara canis infection among primary schoolchildren in Makoko, an urban slum community in Nigeria. Acta Trop. 2015;146:135-40 pubmed publisher
    ..Our findings suggest the need for prompt interventional measures, particularly health education on personal hygiene. ..
  11. Liao C, Chuang T, Huang Y, Chou C, Chiang C, Lee F, et al. Intestinal parasitic infections: Current prevalence and risk factors among schoolchildren in capital area of the Republic of Marshall Islands. Acta Trop. 2017;176:242-248 pubmed publisher
    ..05). Schoolchildren who lived in urban area than rural area had higher chance to acquire pathogenic IPIs (p=0.03). However, none of risk factors were identified to be associated with pathogenic IPIs. ..