Wayne Huey Herng Sheu

Summary

Affiliation: Taichung Veterans General Hospital
Country: Taiwan

Publications

  1. ncbi request reprint Insulin sensitivity, proinflammatory markers and adiponectin in young males with different subtypes of depressive disorder
    Yi Jen Hung
    Division of Endocrinology and Metabolism, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Clin Endocrinol (Oxf) 67:784-9. 2007
  2. pmc Effects of Statins on Incident Dementia in Patients with Type 2 DM: A Population-Based Retrospective Cohort Study in Taiwan
    Jui Ming Chen
    Department of Endocrinology and Metabolism, Tungs Taichung Metroharbor Hospital, Taichung, Taiwan Department of Biomedical Informatics, Asia University, Taichung, Taiwan Department of Gerontechnology and Service Management, Nan Kai University of Technology, Nantou, Taiwan
    PLoS ONE 9:e88434. 2014
  3. pmc Metabolic syndrome and renal injury
    Yi Jing Sheen
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Hospital Department of Health, Executive Yuan, No 199, Sec 1, Sanmin Road, Taichung 403, Taiwan
    Cardiol Res Pract 2011:567389. 2011
  4. pmc Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Ta
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 407, Taiwan
    Cardiovasc Diabetol 11:43. 2012
  5. pmc Transculturalization of a diabetes-specific nutrition algorithm: Asian application
    Hsiu Yueh Su
    Department of Dietetics, Taipei Medical University Hospital, Taipei, Taiwan
    Curr Diab Rep 12:213-9. 2012
  6. ncbi request reprint C-reactive protein gene polymorphism 1009A>G is associated with serum CRP levels in Chinese men: a TCVGHAGE study
    Wayne H H Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Clin Chim Acta 382:117-23. 2007
  7. ncbi request reprint Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women
    Wayne Huey Herng Sheu
    Division of Endocrinology and Metabolism and Department of Medical Education and Research, Taiwan, ROC
    Life Sci 76:2137-45. 2005
  8. doi request reprint Addressing the burden of type 2 diabetes and cardiovascular disease through the management of postprandial hyperglycaemia: an Asian-Pacific perspective and expert recommendations
    Wayne H H Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Diabetes Res Clin Pract 92:312-21. 2011
  9. ncbi request reprint Effect of weight loss on proinflammatory state of mononuclear cells in obese women
    Wayne H H Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Institute of Medical Technology, National Chung Hsing University, Taichung, Taiwan
    Obesity (Silver Spring) 16:1033-8. 2008
  10. ncbi request reprint A relationship between serum ferritin and the insulin resistance syndrome is present in non-diabetic women but not in non-diabetic men
    Wayne Huey Herng Sheu
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Clin Endocrinol (Oxf) 58:380-5. 2003

Collaborators

Detail Information

Publications91

  1. ncbi request reprint Insulin sensitivity, proinflammatory markers and adiponectin in young males with different subtypes of depressive disorder
    Yi Jen Hung
    Division of Endocrinology and Metabolism, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Clin Endocrinol (Oxf) 67:784-9. 2007
    ..This study was designed to evaluate insulin sensitivity, proinflammatory markers and adiponectin concentration in young males with different subtypes of depressive disorder...
  2. pmc Effects of Statins on Incident Dementia in Patients with Type 2 DM: A Population-Based Retrospective Cohort Study in Taiwan
    Jui Ming Chen
    Department of Endocrinology and Metabolism, Tungs Taichung Metroharbor Hospital, Taichung, Taiwan Department of Biomedical Informatics, Asia University, Taichung, Taiwan Department of Gerontechnology and Service Management, Nan Kai University of Technology, Nantou, Taiwan
    PLoS ONE 9:e88434. 2014
    ..Results from a recent study indicated that statin users had lower chance of developing incident dementia. However there is little information on the potential benefits of statin use on dementia in patients with T2DM cohort...
  3. pmc Metabolic syndrome and renal injury
    Yi Jing Sheen
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Hospital Department of Health, Executive Yuan, No 199, Sec 1, Sanmin Road, Taichung 403, Taiwan
    Cardiol Res Pract 2011:567389. 2011
    ..Weight control, stick control of blood pressure, glucose, and lipids disorders may lead to lessening renal injury and even the subsequent CVD...
  4. pmc Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHIRe) Ta
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 407, Taiwan
    Cardiovasc Diabetol 11:43. 2012
    ..We hypothesized that central obesity contributes to a higher risk of new-onset diabetes than other metabolic abnormalities in the hypertensive families...
  5. pmc Transculturalization of a diabetes-specific nutrition algorithm: Asian application
    Hsiu Yueh Su
    Department of Dietetics, Taipei Medical University Hospital, Taipei, Taiwan
    Curr Diab Rep 12:213-9. 2012
    ..Following cultural adaptation, Asian and Asian-Indian versions of this algorithmic tool have emerged. The Asian version is presented in this report...
  6. ncbi request reprint C-reactive protein gene polymorphism 1009A>G is associated with serum CRP levels in Chinese men: a TCVGHAGE study
    Wayne H H Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Clin Chim Acta 382:117-23. 2007
    ..Since the relation between CRP concentration and cardiovascular diseases occurs across ethnicities, we determined whether CRP gene variants affect fasting hs-CRP concentrations in a cohort of Chinese men...
  7. ncbi request reprint Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women
    Wayne Huey Herng Sheu
    Division of Endocrinology and Metabolism and Department of Medical Education and Research, Taiwan, ROC
    Life Sci 76:2137-45. 2005
    ..Folic acid supplementation decreased serum homocysteine concentrations in those women who had higher serum homocysteine concentrations before participating in the weight reduction program...
  8. doi request reprint Addressing the burden of type 2 diabetes and cardiovascular disease through the management of postprandial hyperglycaemia: an Asian-Pacific perspective and expert recommendations
    Wayne H H Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Diabetes Res Clin Pract 92:312-21. 2011
    ..Additionally, frequent meal-based testing and effective PPHG management are essential to the management of IGT and type 2 diabetes...
  9. ncbi request reprint Effect of weight loss on proinflammatory state of mononuclear cells in obese women
    Wayne H H Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Institute of Medical Technology, National Chung Hsing University, Taichung, Taiwan
    Obesity (Silver Spring) 16:1033-8. 2008
    ..In conclusion, weight loss by 5% of initial weight in nondiabetic obese women led to significant improvement in activated intranuclear NF-kappaB binding as well as several transcriptions of proinflammatory genes regulated by NF-kappaB...
  10. ncbi request reprint A relationship between serum ferritin and the insulin resistance syndrome is present in non-diabetic women but not in non-diabetic men
    Wayne Huey Herng Sheu
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Clin Endocrinol (Oxf) 58:380-5. 2003
    ..Because serum ferritin levels differ significantly between men and women, variation in the role of ferritin in insulin resistance between the sexes, particularly in Asian populations, is still unknown...
  11. doi request reprint Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells
    Hsiu Chung Ou
    Division of Endocrinology and Metabolism, Dept of Internal Medicine, Taichung Veterans General Hospital, No 160, Sec 3, Taichung Kang Road, Taichung 407, Taiwan
    J Appl Physiol (1985) 106:1674-85. 2009
    ..05). Results from this study may provide insight into a possible molecular mechanism underlying GbE suppression of the oxLDL-mediated vascular endothelial dysfunction...
  12. ncbi request reprint Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells
    Hsiu Chung Ou
    Division of Endocrinology and Metabolism, Department of Education and Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
    Chem Biol Interact 161:1-13. 2006
    ..Our results suggest that honokiol may have clinical implications in the prevention of atherosclerotic vascular disease...
  13. ncbi request reprint Protective effects of eugenol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells
    Hsiu Chung Ou
    Division of Endocrinology and Metabolism, Department of Education and Medical Research, Taichung Veterans General Hospital, Institute of Biochemistry, Chung Shan Medical University, Taichung, Taiwan
    Food Chem Toxicol 44:1485-95. 2006
    ..Our results suggest that eugenol may protect against the oxLDL-induced dysfunction in endothelial cells...
  14. ncbi request reprint Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats
    Ya Yu Wang
    Division of Family Medicine Y Y W, Division of Endocrinology and Metabolism S Y L, Y H C, W H H S, Department of Medical Research C J C, Taichung Veterans General Hospital, Taichung, Taiwan and Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan Y Y W, K C T and School of Medicine, National Yang Ming University, Taipei, Taiwan Y Y W, S Y L, W H H S
    Endocrinology 155:1235-46. 2014
    ..These results suggest that acute ischemic stroke can activate proinflammatory pathways in the liver by the catecholamines and is associated with the development of hepatic insulin resistance. ..
  15. doi request reprint Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells
    Wen Jane Lee
    Department of Medical Research, Taichung Veterans General Hospital, Tunghai University, Taichung, Taiwan
    J Vasc Surg 52:1290-300. 2010
    ..In this study, we determined whether ellagic acid, a polyphenolic compound widely distributed in fruits and nuts, protects against oxLDL-induced endothelial dysfunction by modulating the LOX-1-mediated signaling pathway...
  16. ncbi request reprint Hypercholesterolemia, not metabolic syndrome, related to adhesion of monocytes to cultured endothelium in nondiabetic subjects
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Metabolism 54:1467-71. 2005
    ..Our study demonstrated that monocyte adhesion to endothelium has a stronger relationship with the plasma concentration LDL-C than with characteristics of metabolic syndrome...
  17. ncbi request reprint Activation of ubiquitin-proteasome pathway is involved in skeletal muscle wasting in a rat model with biliary cirrhosis: potential role of TNF-alpha
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Am J Physiol Endocrinol Metab 288:E493-501. 2005
    ..01). We conclude that the ubiquitin-proteasome system is involved in muscle wasting of rats with BDL-induced cirrhosis. TNF-alpha might play a role in mediating activation of this proteolytic pathway, probably through a local mechanism...
  18. pmc Performance of HbA1c and fasting plasma glucose in screening for diabetes in patients undergoing coronary angiography
    Jun Sing Wang
    Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Diabetes Care 36:1138-40. 2013
    ..The performance of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) was compared in screening for diabetes by an oral glucose tolerance test (OGTT) in patients undergoing coronary angiography (CAG)...
  19. ncbi request reprint Predictors of incident diabetes, metabolic syndrome in middle-aged adults: a 10-year follow-up study from Kinmen, Taiwan
    Wayne Huey Herng Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Diabetes Res Clin Pract 74:162-8. 2006
    ..The aim of this prospective study was to assess a population-based cohort for the predictors of incident diabetes and metabolic syndrome, which is most likely to lead to cardiovascular disease...
  20. pmc Coronary artery disease progression is associated with C-reactive protein and conventional risk factors but not soluble CD40 ligand
    Kae Woei Liang
    Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan
    Can J Cardiol 22:691-6. 2006
    ..The aim of the present study was to explore the roles of novel and conventional risk factors in CAD progression...
  21. ncbi request reprint Rosiglitazone improves insulin sensitivity in nonobese subjects with impaired glucose tolerance: the role of adiponectin and C-reactive protein
    Yi Jen Hung
    Division of Endocrinology and Metabolism, Tri Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan, ROC
    Metabolism 55:439-44. 2006
    ..The amelioration of insulin resistance may be a major determinant to predict the conversion of IGT independent of the changes in adiponectin and CRP...
  22. doi request reprint Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway
    Hsiu Chung Ou
    Department of Physical Therapy and Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan, ROC
    Toxicol Appl Pharmacol 248:134-43. 2010
    ..The inhibition of oxLDL-induced endothelial apoptosis by ellagic acid is due at least in part to its anti-oxidant activity and its ability to modulate the PI3K/Akt/eNOS signaling pathway...
  23. ncbi request reprint Rosiglitazone improves insulin sensitivity and glucose tolerance in subjects with impaired glucose tolerance
    Yi Jen Hung
    Division of Endocrinology and Metabolism, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Clin Endocrinol (Oxf) 62:85-91. 2005
    ..This study was designed to evaluate the effects of rosiglitazone (ROS) on insulin sensitivity, beta-cell function, and glycaemic response to glucose challenge and meal in subjects with impaired glucose tolerance (IGT)...
  24. doi request reprint Comparison of the efficacy and safety profiles of two fixed-dose combinations of antihypertensive agents, amlodipine/benazepril versus valsartan/hydrochlorothiazide, in patients with type 2 diabetes mellitus and hypertension: a 16-week, multicenter, rando
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan
    Clin Ther 34:1735-50. 2012
    ..Fixed-dose combination therapy is currently recommended for the treatment of hypertension due to the advantage of reducing the pill burden. However, the effects of combination therapy may be diverse because of the different components...
  25. ncbi request reprint Sesamin mitigates inflammation and oxidative stress in endothelial cells exposed to oxidized low-density lipoprotein
    Wen Jane Lee
    Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
    J Agric Food Chem 57:11406-17. 2009
    ..Results from this study may provide insight into possible molecular mechanisms underlying sesamin's beneficial effects against oxLDL-mediated vascular endothelial dysfunction...
  26. ncbi request reprint Diabetes exacerbates angiographic coronary lesion progression in subjects with metabolic syndrome independent of CRP levels
    Kae Woei Liang
    Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan
    Clin Chim Acta 388:41-5. 2008
    ..We investigated the predictors for angiographic coronary atherosclerosis progression in patients with metabolic syndrome and angina pectoris...
  27. doi request reprint Metabolic syndrome abating the beneficial effect of pravastatin treatment on adhesion of endothelium by monocytes in subjects with hypercholesterolemia
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Metabolism 58:416-20. 2009
    ..001-0.865, P = .041). Attenuating adhesion between monocytes and endothelium is altered by the presence of metabolic syndrome when hypercholesterolemia subjects receive pravastatin treatment...
  28. doi request reprint Effects of acarbose versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients inadequately controlled by metformin: a 24-week, randomized, open-label, parallel-group comparison
    Jun Sing Wang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Clin Ther 33:1932-42. 2011
    ..We hypothesize that treatment with acarbose could attenuate glycemic excursions and reduce oxidative stress in patients with T2DM...
  29. doi request reprint Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia
    Ya Yu Wang
    Division of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Mol Cell Endocrinol 367:50-6. 2013
    ..Our data suggest that cerebral ischemic insults might modify intracellular and extracellular environments, favoring hepatic gluconeogenesis and the consequences of hyperglycemia...
  30. doi request reprint Adiponectin, but not leptin or high-sensitivity C-reactive protein, is associated with blood pressure independently of general and abdominal adiposity
    Shih Hsien Sung
    Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Hypertens Res 31:633-40. 2008
    ..In conclusion, adiponectin, but not leptin or hs-CRP, was independently associated with blood pressure in a nondiabetic normotensive subgroup...
  31. doi request reprint Circulating adiponectin concentrations were related to free thyroxine levels in thyroid cancer patients after thyroid hormone withdrawal
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan
    Metabolism 59:195-9. 2010
    ..The relevant roles of adiponectin in the regulation of thyroid hormone metabolism require further investigation...
  32. ncbi request reprint Acarbose plus metformin fixed-dose combination outperforms acarbose monotherapy for type 2 diabetes
    Jun Sing Wang
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan
    Diabetes Res Clin Pract 102:16-24. 2013
    ..To compare the efficacy and safety of acarbose plus metformin fixed-dose combination (FDC) versus acarbose monotherapy for type 2 diabetes (T2D)...
  33. ncbi request reprint Comparison of brachial artery flow-mediated vasodilatation in symptomatic and asymptomatic patients with carotid arterial stenosis
    Hung Yi Hsu
    Section of Neurology, Department of Internal Medicine, Veterans General Hospital Taichung, Chung Shan Medical and Dental College, Taichung, Taiwan
    Am J Cardiol 90:814-6. 2002
  34. ncbi request reprint Early Improvements in insulin sensitivity and inflammatory markers are induced by pravastatin in nondiabetic subjects with hypercholesterolemia
    Wen Jane Lee
    Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Clin Chim Acta 390:49-55. 2008
    ..We investigated the effects of 2 doses of pravastatin (40 and 10 mg/day) on insulin sensitivity and serum inflammatory markers in nondiabetic hypercholesterolemic patients...
  35. ncbi request reprint Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population
    Ya Yu Wang
    Department of Family Medicine, Taichung Veterans General Hospital, National Yang Ming University School of Medicine, Taiwan
    J Gastroenterol Hepatol 20:1410-5. 2005
    ..The purpose of the present study was to assess the association of MS with adenomas of the rectosigmoid colon, a well-established precancerous lesion...
  36. ncbi request reprint Circulating hepatocyte growth factor level but not basic fibroblast growth factor level is elevated in angiography-proven symptomatic peripheral artery disease
    Jiunn Wen Lin
    Cardiovascular Center, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Angiology 58:420-8. 2007
    ..Circulating HGF level, but not bFGF level, is significantly elevated in patients with symptomatic angiographically documented PAD, especially in those with more extensive involvement...
  37. doi request reprint Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model
    Ya Yu Wang
    Division of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Am J Physiol Endocrinol Metab 300:E155-63. 2011
    ..These results suggest a potential role of adipose proinflammatory cytokines induced by the sympathetic nervous system in the pathogenesis of glucose metabolic disorder in rats with acute ischemic stroke...
  38. ncbi request reprint Relationship between several surrogate estimates of insulin sensitivity in non-diabetic patients with coronary artery disease
    Shih Ting Tseng
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    J Formos Med Assoc 104:94-100. 2005
    ..This study explored the relationship between several surrogate estimates of insulin sensitivity in non-diabetic patients with angiographic evidence of CAD...
  39. ncbi request reprint High total-to-HDL cholesterol ratio predicting deterioration of ankle brachial index in Asian type 2 diabetic subjects
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Diabetes Res Clin Pract 79:419-26. 2008
    ..We conducted a prospective study to determine the risk factors for decrease in ABI in Chinese subjects with type 2 diabetes during a 3-year period...
  40. ncbi request reprint Relationship of stressful life events, anxiety and depression to hyperthyroidism in an asian population
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Horm Res 60:247-51. 2003
    ....
  41. ncbi request reprint Circulating CD40 ligand is elevated only in patients with more advanced symptomatic peripheral arterial diseases
    Wen Jane Lee
    Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan
    Thromb Res 118:619-26. 2006
    ..To date, there is no report on the association of sCD40L with angiographic peripheral artery disease (PAD) disease severity...
  42. doi request reprint Association between metabolic syndrome (MS) and bone mineral loss: a cross-sectional study in Puli Township in Taiwan
    Yao Hsien Tseng
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Puli Veterans Hospital, No 1, Rongguang Rd, Puli Township, Nantou County 545, Taiwan
    Arch Gerontol Geriatr 49:S37-40. 2009
    ..001), lower triglycerides (p = 0.016) and more central obesity in men (p = 0.011) predicted bone mineral loss. The MS was not associated with bone mineral loss in either of sexes (p = 0.550 in men; p = 0.628 in women)...
  43. doi request reprint Obesity and diabetic hyperglycemia were associated with serum alanine aminotransferase activity in patients with hepatitis B infection
    Ya Yu Wang
    Division of Family Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Metabolism 59:486-91. 2010
    ....
  44. ncbi request reprint The short-/intermediate-term changes in novel vascular inflammatory markers after angioplasty plus stenting in patients with symptomatic advanced systemic arterial diseases
    Wen Lieng Lee
    Division of Cardiology, Department of Medicine, Taichung Veterans General Hospital, 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan, ROC
    Atherosclerosis 176:125-32. 2004
    ..In conclusion, cell adhesion molecules and hs-CRP did play a significant role in patients with advanced systemic arterial diseases who underwent PTA/stenting...
  45. doi request reprint Brain-derived neurotrophic factor not associated with metabolic syndrome but inversely correlated with vascular cell adhesion molecule-1 in men without diabetes
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Clin Chim Acta 413:944-8. 2012
    ..Because brain-derived neurotrophic factor (BDNF) plays an important role in neurons, we examined the relationship of BDNF to MetS, adipose tissue and biomarkers in men...
  46. ncbi request reprint Increased serum leptin concentrations correlate with soluble tumour necrosis factor receptor levels in patients with cirrhosis
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taiwan
    Clin Endocrinol (Oxf) 57:805-11. 2002
    ..In this study, we investigate the potential interaction of the TNF-alpha system with leptin in the development of malnutrition in liver cirrhosis...
  47. ncbi request reprint Stimulated resistin expression in white adipose of rats with bile duct ligation-induced liver cirrhosis: relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Mol Cell Endocrinol 232:1-8. 2005
    ..Further study is necessary to document the role of resistin in metabolic abnormalities of liver cirrhosis...
  48. ncbi request reprint Simvastatin reduces plasma concentration of high-sensitivity C-reactive protein in type 2 diabetic patients with hyperlipidemia
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, ROC
    J Diabetes Complications 16:382-5. 2002
    ..001). This study shows that plasma hs-CRP concentration can be reduced by 8-week administration of simvastatin in type 2 diabetic patients with hyperlipidemia...
  49. ncbi request reprint Characteristics predicting dyslipidemia in drug-naïve type 2 diabetes patients
    Shi Dou Lin
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC
    J Chin Med Assoc 69:404-8. 2006
    ..Plasma lipid concentrations are related to a variety of attributes in obese subjects, but these relationships have not been extensively examined in type 2 diabetes patients...
  50. ncbi request reprint Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells
    Hsiu Chung Ou
    Department of Education and Medical Research, Taichung Veterans General Hospital, No 160, Sec 3, Taichung Kang Road, Taichung, 407, Taiwan
    Arch Toxicol 81:421-32. 2007
    ..Our results suggest that magnolol may have clinical implications in the prevention of atherosclerotic vascular disease through decreasing the oxLDL-induced ROS production...
  51. ncbi request reprint Positive associations of bone mineral density with body mass index, physical activity, and blood triglyceride level in men over 70 years old: a TCVGHAGE study
    Yih Jing Tang
    Taichung Veterans General Hospital AGEing Research Group TCVGHAGE, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    J Bone Miner Metab 25:54-9. 2007
    ..Calcaneus bone mass is significantly and positively associated with BMI, blood triglycerides, and 6-min walking distance in older men...
  52. ncbi request reprint The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe
    Hung Yuan Li
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Am J Hypertens 21:471-6. 2008
    ..In order to minimize confounding effects from unidentified factors, a family-based design was employed to explore the relationship...
  53. doi request reprint In-hospital mortality risk estimation in patients with acute nonvariceal upper gastrointestinal bleeding undergoing hemodialysis: a retrospective cohort study
    Shuo Chun Weng
    Center of Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan
    Ren Fail 35:243-8. 2013
    ..Upper gastrointestinal bleeding (UGIB) is a major cause of clinical bleeding among patients with end-stage renal disease (ESRD). This study aimed to investigate the association between mortality and UGIB in patients with uremia...
  54. doi request reprint Common PCSK1 haplotypes are associated with obesity in the Chinese population
    Yi Cheng Chang
    Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
    Obesity (Silver Spring) 18:1404-9. 2010
    ..05, 0.003, 0.001, 0.04, and 0.04, respectively). These data indicate common PCSK1 genetic variants are associated with obesity in the Chinese population...
  55. pmc An elevated gap between admission and A1C-derived average glucose levels is associated with adverse outcomes in diabetic patients with pyogenic liver abscess
    Wen I Liao
    Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 8:e64476. 2013
    ....
  56. ncbi request reprint Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Metabolism 54:1524-8. 2005
    ..Low circulating free thyroxine levels, albeit normal, were associated with MS in a Chinese population. Further study is necessary to document the role of thyroid hormones in metabolic abnormalities of MS...
  57. ncbi request reprint Rosiglitazone inhibits endothelial proliferation and angiogenesis
    Wayne Huey Herng Sheu
    Division of Endocrinology and Metabolism, Department of Education and Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
    Life Sci 78:1520-8. 2006
    ..Our data suggest that both anti-proliferative and anti-angiogenic activities in endothelial cells might account for the greater than expected beneficial effects of rosiglitazone for the treatment and prevention of atherosclerosis...
  58. doi request reprint Metabolic syndrome exacerbating ankle-brachial index in asian type 2 diabetic patients
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Angiology 61:482-6. 2010
    ..001). Metabolic syndrome is also an independent risk factor for low ABI in participants with diabetes (P = .018). Thus, MetS is usually associated with lower ABI, most obvious in diabetic participants...
  59. pmc Peripheral arterial stiffness is independently associated with a rapid decline in estimated glomerular filtration rate in patients with type 2 diabetes
    Yi Jing Sheen
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Hospital, Department of Health, Executive Yuan, No 199, Section 1, Sanmin Road, Taichung 402, Taiwan
    Biomed Res Int 2013:309294. 2013
    ..We evaluated the associations of variables of arterial stiffness and the decline in estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes...
  60. ncbi request reprint Changes in flow-mediated dilatation, cytokines and carotid arterial stenosis during aggressive atorvastatin treatment in normocholesterolemic patients
    Hung Yi Hsu
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan, R O C
    J Chin Med Assoc 68:53-8. 2005
    ....
  61. ncbi request reprint Metabolic syndrome and its contribution to coronary artery disease in non-diabetic subjects
    Rong Tsung Lin
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan
    J Formos Med Assoc 103:317-20. 2004
    ..This study assessed the 5 risk factors of metabolic syndrome in non-diabetic individuals with angiographically-documented CAD...
  62. ncbi request reprint Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects--a randomized double-blind trial
    Hsiao Ling Chen
    Institute of Nutritional Science, School of Nutrition, Taichung, Taiwan, R O C
    J Am Coll Nutr 22:36-42. 2003
    ..6 g/day) for 28 days on blood lipid and glucose levels in hyperlipidemic type 2 diabetic patients and the possible mechanism for the reductions in blood lipid levels...
  63. ncbi request reprint Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris
    Kae Woei Liang
    Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan
    Int J Cardiol 129:76-80. 2008
    ..959, p=0.030) were all significant independent predictors of CAD progression. In conclusion, we found that a decreased circulating level of adiponectin is associated with angiographic CAD progression in patients with angina pectoris...
  64. doi request reprint Aspirin prevents resistin-induced endothelial dysfunction by modulating AMPK, ROS, and Akt/eNOS signaling
    Hsiu Chung Ou
    Department of Physical Therapy and Graduate, Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan, Republic of China
    J Vasc Surg 55:1104-15. 2012
    ....
  65. doi request reprint Ellagic acid inhibits oxidized low-density lipoprotein (OxLDL)-induced metalloproteinase (MMP) expression by modulating the protein kinase C-α/extracellular signal-regulated kinase/peroxisome proliferator-activated receptor γ/nuclear factor-κB (PKC-α/ERK/
    Mei Ying Kuo
    Department of Physical Therapy and Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan
    J Agric Food Chem 59:5100-8. 2011
    ....
  66. ncbi request reprint Effects of xylooligosaccharides in type 2 diabetes mellitus
    Wayne Huey Herng Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    J Nutr Sci Vitaminol (Tokyo) 54:396-401. 2008
    ..In conclusion, the dietary supplementation with XOS for 8 wk was effective in improving the blood sugar and lipids in type 2 diabetes, indicating that XOS-containing diets might be beneficial to DM subjects...
  67. ncbi request reprint Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women
    Jason Yen Ping Ho
    Department of Obstetrics and Gynecology, Taichung Veterans Hospital, Institute of Biomedical Sciences, National Chung Hsing University, Taiwan
    Hum Reprod 21:2715-20. 2006
    ..Recent studies have revealed that HRT may increase the risk for atherosclerotic vascular disease (ASVD)...
  68. ncbi request reprint Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism
    I Te Lee
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, No 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan, ROC
    J Bone Miner Metab 24:255-8. 2006
    ..In conclusion, administration of bisphosphonates in primary hyperparathyroidism can prevent the occurrence of hungry bone syndrome after parathyroidectomy...
  69. ncbi request reprint Graves' disease presented as painful goiter
    Chen Shun Chao
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Horm Res 57:53-6. 2002
    ..However, follow-up thyroid function tests still showed high serum thyroid hormone levels. The possible etiologies of a painful thyroid gland in Graves' disease will be discussed...
  70. ncbi request reprint Effects of alendronate combined with hormone replacement therapy on osteoporotic postmenopausal Chinese women
    Li Nien Tseng
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan 407, Republic of China
    Metabolism 55:741-7. 2006
    ..However, this study does not indicate whether HRT plus alendronate has any greater effect on BMD than alendronate alone...
  71. doi request reprint Factors related to clinical hypothyroid severity in thyroid cancer patients after thyroid hormone withdrawal
    Shu Chuan Huang
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taichung, Taiwan, Republic of China
    Thyroid 19:13-20. 2009
    ..This prospective study was performed to test the hypothesis that selected factors, including serum thyroid hormone levels and insulin resistance, are associated with the development of overt features of hypothyroidism...
  72. doi request reprint Protein nitration is associated with increased proteolysis in skeletal muscle of bile duct ligation-induced cirrhotic rats
    Ya Yu Wang
    Division of Family Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Metabolism 59:468-72. 2010
    ..In conclusion, nitrosative stress occurred in the skeletal muscle of BDL-induced cirrhotic rats and may lead to increased proteolysis of muscle-specific structural proteins...
  73. ncbi request reprint Different tumor necrosis factor-alpha-associated leptin expression in rats with dimethylnitrosamine and bile duct ligation-induced liver cirrhosis
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taiwan
    Metabolism 54:445-52. 2005
    ..The observed TNF-alpha-associated leptin up-regulation in DMN-induced, but not in BDL-induced, cirrhotic rats is consistent with distinctly different roles for TNF-alpha in rats with nonbiliary, as opposed to biliary, cirrhosis...
  74. doi request reprint Improvement in health-related quality of life, independent of fasting glucose concentration, via insulin pen device in diabetic patients
    I Te Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    J Eval Clin Pract 15:699-703. 2009
    ..However, glycemic control and its relationship to better QOL are controversial. The aim of this study was to determine the relationship between health-related QOL and glycemic control in diabetic patients using insulin pen...
  75. ncbi request reprint Diagnosis of thyroid metastasis in cancer patients with thyroid mass by fine needle aspiration cytology and ultrasonography
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taiwan, ROC
    Zhonghua Yi Xue Za Zhi (Taipei) 65:101-5. 2002
    ..Thyroid metastasis is generally thought to be infrequent. To evaluate its occurrence, fine needle aspiration cytology and ultrasound of the thyroid gland were performed in nonthyroid cancer patients with thyroid mass...
  76. doi request reprint Relation of adiponectin and high-sensitivity C-reactive protein to pulse-wave velocity and N-terminal pro-B-type natriuretic peptide in the general population
    Shih Hsien Sung
    Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Am J Cardiol 103:1411-6. 2009
    ..In contrast, hs-CRP may independently contribute to ventricular dysfunction, but not arterial stiffening...
  77. ncbi request reprint Progression of cognitive dysfunction in elderly chronic kidney disease patients in a veteran's institution in central Taiwan: a 3-year longitudinal study
    Shuo Chun Weng
    Center of Geriatrics and Gerontology, Taichung Veterans General Hospital, Taiwan
    Intern Med 51:29-35. 2012
    ..The purpose of this study was to investigate the factors affecting progression of cognitive dysfunction in the elderly with different levels of kidney function...
  78. pmc Risk factors for recurrent hypoglycemia in hospitalized diabetic patients admitted for severe hypoglycemia
    Yen Yue Lin
    Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Neihu 114, Taipei, Taiwan
    Yonsei Med J 51:367-74. 2010
    ..Our purpose is to identify risk factors for developing recurrent hypoglycemia in diabetic patients admitted for severe hypoglycemia...
  79. doi request reprint Low estimated glomerular filtration rate is a major determinant of low ankle-brachial index and toe-brachial index in type 2 diabetes
    Yi Jing Sheen
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Hospital Department of Health, Executive Yuan, Taichung, Taiwan, Republic of China
    Angiology 63:55-61. 2012
    ..001). After adjusting for confounding factors, age and eGFR were significantly associated with TBI and ABI. Low eGFR is associated with peripheral arterial disease in type 2 diabetes with mild to moderate renal insufficiency...
  80. pmc Impact of clinical characteristics of individual metabolic syndrome on the severity of insulin resistance in Chinese adults
    Chang Hsun Hsieh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri Service General Hospital, Taipei, Taiwan, R O C
    J Korean Med Sci 22:74-80. 2007
    ..The clustering of the SSPG, BMI, triglyceride and HDLcholesterol was noted. Our data suggest that adiposity, higher FPG and triglyceride levels have stronger correlation with IR and subjects with the highest BMI have the highest IR...
  81. ncbi request reprint Benign parathyroid adenoma presenting with unusual parathyroid crisis, anemia and myelofibrosis
    Shu Chuan Huang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taoyuan Veterans Hospital, Taoyuan, Taiwan
    J Formos Med Assoc 106:S13-6. 2007
    ..In addition, primary hyperparathyroidism can be associated with anemia and myelofibrosis...
  82. doi request reprint Justifying the high prevalence of microalbuminuria for type 2 diabetic patients in Taiwan with conditional probability approach--a DEMAND II study
    Shu Chiung Chiang
    Information Management Office, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 74:3-10. 2011
    ..To examine the prevalence of microalbuminuria (MAU) and chronic kidney disease as well as the correlation between MAU and renal and cardiovascular risks of Type 2 diabetes mellitus (T2DM) patients for public health policy making in Taiwan...
  83. ncbi request reprint Serial body composition by bioimpedance analysis in a diabetic subject with rapid insulin-induced weight gain--a case report
    I Tee Lee
    Division of Endocrinology and Metabolism, Department of Medicine, Veterans General Hospital, No 160, Section 3, Chung Kang Road, Taichung 407, Taiwan
    Kaohsiung J Med Sci 18:45-8. 2002
    ..Rapid weight gain shortly after insulin therapy may be due to excessive but reversible water retention, detected by repeated BIA measurements...
  84. ncbi request reprint Familial form of thyroid dysgenesis: report of thyroid hemiagenesis with accompanying Graves' disease in a woman whose daughter has thyroid agenesis
    I Te Lee
    Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Horm Res 59:47-9. 2003
    ..In reviewing her family history, her daughter was found to have thyroid agenesis, and other thyroid disorders were found in 2 female family members...
  85. ncbi request reprint An emerging link between insulin resistance and inflammation
    Shih Yi Lin
    J Chin Med Assoc 69:245-7. 2006
  86. ncbi request reprint Metabolic effects of growth hormone therapy in an Alström syndrome patient
    Tsai Sung Tai
    Division of Endocrinology and Metabolism, Chia Yi Christian Hospital, Chia Yi, Republic of China
    Horm Res 60:297-301. 2003
    ..To investigate the metabolic effects of recombinant human growth hormone (rhGH) in an Alström syndrome patient with growth hormone deficiency...
  87. ncbi request reprint The metabolic syndrome: what have we learned?
    Wayne Huey Herng Sheu
    J Chin Med Assoc 67:597-9. 2004
  88. ncbi request reprint Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia
    Tse Min Lu
    Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming University, Taiwan, People s Republic of China
    Am J Cardiol 94:157-61. 2004
    ....
  89. ncbi request reprint Clustering and heritability of insulin resistance in Chinese and Japanese hypertensive families: a Stanford-Asian Pacific Program in Hypertension and Insulin Resistance sibling study
    Kwan Dun Wu
    Department of Medicine, National Taiwan University Hospital, Taipei
    Hypertens Res 25:529-36. 2002
    ..The clustering characteristics and the significance of heritability estimation for these metabolic variables indicate that IRS is familial in nature and heritable in Chinese and Japanese hypertensive families...
  90. ncbi request reprint Exercise paradoxically modulates oxidized low density lipoprotein-induced adhesion molecules expression and trans-endothelial migration of monocyte in men
    Jong Shyan Wang
    Graduate Institute of Rehabilitation Science and Center for Gerontological Research, Chang Gung University, Tao Yuan, Taiwan
    Thromb Haemost 94:846-52. 2005
    ..These findings provide a new insight into the may aid the development of suitable exercise intensity enable people to prevent early atherogenesis...
  91. ncbi request reprint Combined use of fasting glucose and hemoglobin a levels in screening for new type 2 diabetes mellitus in elderly men: TCVGHAGE
    Wayne Huey Herng Sheu
    J Am Geriatr Soc 52:1777-8. 2004