Kou Gi Shyu

Summary

Country: Taiwan

Publications

  1. pmc Cyclic stretch enhances the expression of toll-like receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-kappaB pathway
    Kou Gi Shyu
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 17:15. 2010
  2. pmc MicroRNA-208a Increases Myocardial Fibrosis via Endoglin in Volume Overloading Heart
    Bao Wei Wang
    School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwa
    PLoS ONE 9:e84188. 2014
  3. pmc Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-alpha in macrophages
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 16:50. 2009
  4. ncbi request reprint Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction
    Kou Gi Shyu
    Division of Cardiology, Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Rd, Taipei, 111, Taiwan
    J Biomed Sci 13:47-58. 2006
  5. ncbi request reprint Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes
    Kou Gi Shyu
    Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Taipei 111, Taiwan
    Cardiovasc Res 68:405-14. 2005
  6. doi request reprint Cellular and molecular effects of mechanical stretch on vascular cells and cardiac myocytes
    Kou Gi Shyu
    Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 116:377-89. 2009
  7. ncbi request reprint Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Am Coll Cardiol 40:1383-8. 2002
  8. ncbi request reprint Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells
    Kou Gi Shyu
    Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Hypertension 46:614-21. 2005
  9. ncbi request reprint Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, and Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan, ROC
    J Biomed Sci 11:163-71. 2004
  10. ncbi request reprint Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha
    Bao Wei Wang
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 293:H2305-12. 2007

Collaborators

Detail Information

Publications81

  1. pmc Cyclic stretch enhances the expression of toll-like receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-kappaB pathway
    Kou Gi Shyu
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 17:15. 2010
    ..We sought to investigate whether mechanical stretch could regulate TLR4 expression, as well as the possible molecular mechanisms and signal pathways mediating the expression of TLR4 by cyclic mechanical stretch in cardiomyocytes...
  2. pmc MicroRNA-208a Increases Myocardial Fibrosis via Endoglin in Volume Overloading Heart
    Bao Wei Wang
    School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwa
    PLoS ONE 9:e84188. 2014
    ..Treatment with atorvastatin can attenuate the myocardial fibrosis induced by volume overload through inhibition of endoglin expression. ..
  3. pmc Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-alpha in macrophages
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 16:50. 2009
    ..In conclusion, JNK and Rac pathway mediates the inhibitory effect of atorvastatin on resistin expression induced by TNF-alpha...
  4. ncbi request reprint Mesenchymal stem cells are superior to angiogenic growth factor genes for improving myocardial performance in the mouse model of acute myocardial infarction
    Kou Gi Shyu
    Division of Cardiology, Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Rd, Taipei, 111, Taiwan
    J Biomed Sci 13:47-58. 2006
    ..Transplantation of MSCs may become the future therapy for acute myocardial infarction for myocardial regeneration...
  5. ncbi request reprint Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes
    Kou Gi Shyu
    Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Taipei 111, Taiwan
    Cardiovasc Res 68:405-14. 2005
    ..Mechanical stress is an important regulatory factor for cardiomyocyte growth. The aim of the study was to investigate the effect of cyclic stretch on the expression of myostatin gene in cardiomyocytes...
  6. doi request reprint Cellular and molecular effects of mechanical stretch on vascular cells and cardiac myocytes
    Kou Gi Shyu
    Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 116:377-89. 2009
    ....
  7. ncbi request reprint Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Am Coll Cardiol 40:1383-8. 2002
    ..We sought to evaluate the efficacy of the antioxidant acetylcysteine in limiting the nephrotoxicity after coronary procedures...
  8. ncbi request reprint Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells
    Kou Gi Shyu
    Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Hypertension 46:614-21. 2005
    ..The stretch-induced DDR2 is mediated by angiotensin II and TGF-beta1, at least in part, through p38 mitogen-activated protein kinase and Myc pathway...
  9. ncbi request reprint Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, and Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan, ROC
    J Biomed Sci 11:163-71. 2004
    ..In conclusion, Ang2 and Tie2 expressions significantly increased both spatial and temporal patterns after myocardial infarction in the rat ventricular myocardium, while Ang1 and Tie1 receptor expression did not...
  10. ncbi request reprint Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha
    Bao Wei Wang
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Am J Physiol Heart Circ Physiol 293:H2305-12. 2007
    ..The stretch-induced resistin is mediated by TNF-alpha, at least in part, through ERK MAP kinase and NF-kappaB pathways. Glucose uptake in cardiomyocytes was reduced by resistin upregulation...
  11. ncbi request reprint Peroxisome proliferator-activated receptor delta agonists attenuated the C-reactive protein-induced pro-inflammation in cardiomyocytes and H9c2 cardiomyoblasts
    Yao Jen Liang
    Department and Institute of Life Science, Fu Jen Catholic University, Taipei, Taiwan
    Eur J Pharmacol 643:84-92. 2010
    ..However, PPARdelta activation attenuated CRP-induced NF-kappaB pathway may be independent of CD32. These results may provide new evidence of PPARdelta beneficial effects for inflammatory cardiomyopathy...
  12. ncbi request reprint Mechanical stress enhances serotonin 2B receptor modulating brain natriuretic peptide through nuclear factor-kappaB in cardiomyocytes
    Yao Jen Liang
    Institute of Pharmacology, National Taiwan University, Taipei, Taiwan
    Cardiovasc Res 72:303-12. 2006
    ..Serotonin via serotonin 2B receptors (SR2BR) regulates cardiac embryonic development and adult heart functions. However, the role of SR2BR in the failing heart due to pressure overload is not well understood...
  13. doi request reprint Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 122:33-42. 2012
    ..The inhibitory effect of atorvastatin on Ang II-induced leptin expression was mediated by Rac, ROS and JNK pathways...
  14. ncbi request reprint Resveratrol inhibits angiotensin II-induced endothelin-1 gene expression and subsequent proliferation in rat aortic smooth muscle cells
    Hung hsing Chao
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan, ROC Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    Eur J Pharmacol 515:1-9. 2005
    ..Thus, this study provides important insight into the molecular pathways that may contribute to the proposed beneficial effects of resveratrol on the cardiovascular system...
  15. ncbi request reprint Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells
    Shankung Lin
    The Central Laboratory, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Shih Lin District, Taipei, Taiwan, ROC
    Biochem Biophys Res Commun 296:710-5. 2002
    ..These data indicated that HBO-induced Ang2 expression may be through transcriptional stimulation, and requires the nitric oxide signaling pathway, which may play an important role in HBO-induced angiogenesis...
  16. ncbi request reprint The plasminogen activator inhibitor-1 gene is induced by cell adhesion through the MEK/ERK pathway
    Hang Chang
    Surgical Department, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Shihlin, Taipei 111, Taiwan, ROC
    J Biomed Sci 10:738-45. 2003
    ..Based on these results, we suggest that both MEK and ERK are involved in the induction of PAI-1 gene expression during cell adhesion. Furthermore, the subsequent downstream molecules, Elk-1 and HIF-1, may also participate...
  17. ncbi request reprint Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart
    Kou Gi Shyu
    Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Rd, Taipei, Taiwan
    J Biomed Sci 12:409-20. 2005
    ..Treatment with carvedilol is associated with a reversal of abnormal regulation of HIF-1alpha, VEGF, BNP, and NGF-beta in the hypertrophic myocardium...
  18. ncbi request reprint C-reactive protein activates the nuclear factor-kappaB pathway and induces vascular cell adhesion molecule-1 expression through CD32 in human umbilical vein endothelial cells and aortic endothelial cells
    Yao Jen Liang
    Institute of Pharmacology, School of Medicine, National Taiwan University, 1, Jen Ai Road, Section, Taipei, Taiwan
    J Mol Cell Cardiol 40:412-20. 2006
    ..CRP also increased the expression of CD32, which might serve as the receptor for CRP in endothelial cells and mediated the effects of CRP...
  19. ncbi request reprint Induction of matrix metalloproteinases-14 and -2 by cyclical mechanical stretch is mediated by tumor necrosis factor-alpha in cultured human umbilical vein endothelial cells
    Bao Wei Wang
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Rd, Taipei 111, Taiwan
    Cardiovasc Res 59:460-9. 2003
    ..This study was undertaken to examine the hypothesis that tumor necrosis factor-alpha (TNF-alpha) is a potential mediator of stretch-induced effects on matrix metalloproteinase (MMP)...
  20. ncbi request reprint Intramuscular vascular endothelial growth factor gene therapy in patients with chronic critical leg ischemia
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Am J Med 114:85-92. 2003
    ..Complications were limited to transient leg edema in six limbs. Intramuscular gene therapy with VEGF(165) for patients with chronic critical leg ischemia is safe, feasible, and effective...
  21. ncbi request reprint Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Rd, Taipei 111, Taiwan
    Clin Sci (Lond) 105:287-94. 2003
    ..In conclusion, expression of both Ang2 and Tie2 increased after ischaemia/reperfusion in the rat ventricular myocardium, while the expression of Ang1 and Tie1 did not...
  22. ncbi request reprint Berberine inhibits HIF-1alpha expression via enhanced proteolysis
    Shankung Lin
    Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Shih Lin, Taipei 111, Taiwan, Republic of China
    Mol Pharmacol 66:612-9. 2004
    ..In conclusion, our data provided molecular evidence to support berberine as a potent antiangiogenic agent in cancer therapy...
  23. ncbi request reprint Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenicity
    Kou Gi Shyu
    Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Shih Lin, Taipei, Taiwan
    Life Sci 78:2234-43. 2006
    ..From these results, we suggested that evodiamine is a potent inhibitor of angiogenesis. The mechanism might involve at least the inhibition of VEGF expression, probably through repression of ERK phosphorylation...
  24. ncbi request reprint GL331 inhibits HIF-1alpha expression in a lung cancer model
    Hang Chang
    The Central Laboratory, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Shih Lin, Taipei, Taiwan, ROC
    Biochem Biophys Res Commun 302:95-100. 2003
    ..Therefore, our data showed that GL331 is a potent inhibitor of tumor-induced angiogenesis. The underlying mechanisms might involve at least the inhibition of HIF-1alpha expression, probably through transcriptional repression...
  25. ncbi request reprint Hypoxia induces discoidin domain receptor-2 expression via the p38 pathway in vascular smooth muscle cells to increase their migration
    Shih Chung Chen
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan
    Biochem Biophys Res Commun 374:662-7. 2008
    ..Our results suggested that hypoxia induces DDR2 expression in VSMCs at the transcriptional level, which is mediated by the p38 MAPK pathway and contributes to VSMC migration...
  26. ncbi request reprint Synergistic effect of angiopoietin-1 and vascular endothelial growth factor on neoangiogenesis in hypercholesterolemic rabbit model with acute hindlimb ischemia
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Taipei 111, Taiwan
    Life Sci 73:563-79. 2003
    ..Intramuscular administration of cytokines on revascularization of the ischemic hindlimb model of hyperlipidemic rabbit is feasible...
  27. ncbi request reprint Regulation of hypoxia-inducible factor-1alpha by cyclical mechanical stretch in rat vascular smooth muscle cells
    Hang Chang
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 105:447-56. 2003
    ..In conclusion, cyclical mechanical stretch activates the gene expression of HIF-1alpha in cultured VSMCs and this mechanical effect is possibly mediated by the p42/p44 MAP kinase kinase pathway...
  28. doi request reprint Long-term clinical outcomes following elective stent implantation for unprotected left main coronary artery disease
    Wei Syun Hu
    Division of Cardiology, Department of Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 110:19-26. 2011
    ..The aim of this study was to evaluate the predictors of long-term clinical outcomes in patients after elective stent implantation for unprotected LMCA disease...
  29. ncbi request reprint Cyclical mechanical stretch enhances angiopoietin-2 and Tie2 receptor expression in cultured human umbilical vein endothelial cells
    Hang Chang
    The Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 104:421-8. 2003
    ..This mechanical effect is probably mediated by the tyrosine kinase and protein kinase C pathways...
  30. ncbi request reprint Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway
    Kou Gi Shyu
    Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Cardiovasc Res 63:98-108. 2004
    ..Connexin43 (Cx43) plays an important role for arrhythmogenesis. This study was undertaken to test the hypothesis that amphetamine could induce Cx43 expression in cardiac myocytes...
  31. doi request reprint Advanced glycation end products-induced apoptosis attenuated by PPARdelta activation and epigallocatechin gallate through NF-kappaB pathway in human embryonic kidney cells and human mesangial cells
    Yao Jen Liang
    Department and Institute of Life Science, Fu Jen Catholic University, Taipei, Taiwan
    Diabetes Metab Res Rev 26:406-16. 2010
    ....
  32. ncbi request reprint Saikosaponin C induces endothelial cells growth, migration and capillary tube formation
    Kou Gi Shyu
    Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital and Graduate Institute of Medical Sciences, Taipei Medical University, 95, Wen Chang Road, Shih Lin, Taipei 111, Taiwan
    Life Sci 76:813-26. 2004
    ..From these results, we suggest that saikosaponin C may have the potential for therapeutic angiogenesis but is not suitable for cancer therapy...
  33. ncbi request reprint Carvedilol modulates the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of volume-overload heart failure
    Kou Gi Shyu
    Department of Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Card Fail 11:152-9. 2005
    ..However, the expression of HIF-1alpha in chronic heart failure resulting from volume overload and after treatment with beta-blocker is little known...
  34. doi request reprint Angiotensin II mediates urotensin II expression by hypoxia in cultured cardiac fibroblast
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Eur J Clin Invest 42:17-26. 2012
    ..We sought to investigate the regulation of urotensin II by hypoxia in cardiac fibroblasts and the effect of angiotensin II in the interaction with urotensin II...
  35. ncbi request reprint Regulation of resistin by cyclic mechanical stretch in cultured rat vascular smooth muscle cells
    Bao Wei Wang
    School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan
    Clin Sci (Lond) 118:221-30. 2010
    ..Stretch-induced resistin expression is mediated through ROS, and the p38 MAPK and STAT3 pathways. Therefore resistin induced by cyclic stretch may contribute to the pathogenesis of atherosclerosis under haemodynamic overload.Key..
  36. doi request reprint Comparison of PPARδ and PPARγ in inhibiting the pro-inflammatory effects of C-reactive protein in endothelial cells
    Yao Jen Liang
    Department and Institute of Life Science, Fu Jen Catholic University, and Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Int J Cardiol 143:361-7. 2010
    ..Recently, PPARδ has revealed benefits for dealing with inflammation. The relationship between CRP-induced inflammation and PPARδ agonist remains unclear...
  37. doi request reprint Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Eur J Heart Fail 12:219-26. 2010
    ..However, the effects of statins on TGF-beta1 and endoglin are poorly understood. We therefore sought to investigate the molecular mechanisms of atorvastatin on endoglin expression after TGF-beta1 stimulation in cardiac fibroblasts...
  38. doi request reprint Significance of left circumflex artery-related acute myocardial infarction without ST-T changes
    Su Kiat Chua
    Section of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei 111, Taiwan
    Am J Emerg Med 28:183-8. 2010
    ..Left circumflex (LC)-related acute myocardial infarction (AMI) presenting without ST-T changes has been underdiagnosed in the emergency department. There is little information on its clinical features and significance...
  39. doi request reprint RNA interference for discoidin domain receptor 2 attenuates neointimal formation in balloon injured rat carotid artery
    Kou Gi Shyu
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Rd, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 28:1447-53. 2008
    ..Little is known about the function of DDR2 in vascular system. We investigated whether inhibition of DDR2 by small interfering RNA (siRNA) can reduce neointimal formation after arterial injury...
  40. doi request reprint Resistin contributes to neointimal formation via oxidative stress after vascular injury
    Kou Gi Shyu
    Department of Neurology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 120:121-9. 2011
    ..Resistin siRNA attenuates neointimal formation after carotid injury partly through an antioxidative mechanism. Resistin may play a pivotal role in the pathogenesis of neointimal thickening after mechanical injury...
  41. doi request reprint Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro
    Chiu Mei Lin
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Agric Food Chem 60:12451-7. 2012
    ....
  42. ncbi request reprint Sesamin induces nitric oxide and decreases endothelin-1 production in HUVECs: possible implications for its antihypertensive effect
    Chun Chung Lee
    Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Hypertens 22:2329-38. 2004
    ..Alterations in the endothelial production of NO and ET-1 are known to correlate with hypertension. This study investigated the effect of sesamin on NO and ET-1 in the human umbilical vein endothelial cells (HUVECs)...
  43. ncbi request reprint Cell adhesion regulates the plasminogen activator inhibitor-1 gene expression in anchorage-dependent cells
    Chun Chung Lee
    Central Laboratory, Shin Kong Wu Ho Su Memorial Hospital, 95, Wen Chang Road, Shih Lin, Taipei, Taiwan, 111, Republic of China
    Biochem Biophys Res Commun 291:185-90. 2002
    ..PAI-1, as an inhibitor of the interaction between vitronectin and integrin alphavbeta3, may also be a regulator of its own expression...
  44. doi request reprint Acute ST-elevation myocardial infarction in young patients: 15 years of experience in a single center
    Su Kiat Chua
    Division of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, No 95 Wen Chang Road, Taipei, Taiwan
    Clin Cardiol 33:140-8. 2010
    ..The purpose of this study was to investigate the clinical characteristics and coronary angiographic features in young patients with STEMI...
  45. ncbi request reprint Hyperbaric oxygen induces placental growth factor expression in bone marrow-derived mesenchymal stem cells
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, and Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Life Sci 83:65-73. 2008
    ..In conclusion, HBO induced the expression of PlGF in human bone marrow-derived MSCs at least through the oxidative stress-related pathways, which may play an important role in HBO-induced vasculogenesis...
  46. ncbi request reprint Hyperbaric oxygen activates discoidin domain receptor 2 via tumour necrosis factor-alpha and the p38 MAPK pathway to increase vascular smooth muscle cell migration through matrix metalloproteinase 2
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei 111, Taiwan
    Clin Sci (Lond) 116:575-83. 2009
    ..In conclusion, HBO activates DDR2 expression in cultured rat VSMCs. HBO-induced DDR2 is mediated by TNF-alpha and at least in part through the p38 MAPK and Myc pathways...
  47. pmc Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes
    Chiung Zuan Chiu
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Clin Sci (Lond) 119:273-82. 2010
    ..Myocardial hypertrophy was identified as an increase in transcriptional activities, elevated hypertrophic and cardiomyocyte phenotype markers, and morphological hypertrophic changes in cardiomyocytes...
  48. doi request reprint Gastrointestinal bleeding and outcomes after percutaneous coronary intervention for ST-segment elevation myocardial infarction
    Su Kiat Chua
    Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Am J Crit Care 20:218-25. 2011
    ..Gastrointestinal bleeding is a hemorrhagic complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction (STEMI)...
  49. doi request reprint Hypoxia activates muscle-restricted coiled-coil protein (MURC) expression via transforming growth factor-β in cardiac myocytes
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Clin Sci (Lond) 126:367-75. 2014
    ..These findings suggest that MURC plays a role in hypoxia-induced hypertrophy in cardiomyocytes...
  50. ncbi request reprint Temporal and spatial expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of myocardial ischemia with or without reperfusion
    Ming Jen Lu
    Department of Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 104:707-14. 2005
    ..This study examined the role of HIF-1alpha and vascular endothelial growth factor (VEGF) in myocardial ischemia-reperfusion...
  51. ncbi request reprint Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells
    Hang Chang
    Surgical Department, Shin Kong Wu Ho Su Memorial Hospital and Surgical Department of Taipei Medical University, Taipei, Taiwan
    Cell Commun Adhes 9:239-47. 2002
    ..Hence, we conclude that the induction of PAI-1 gene expression is cell adhesion dependent and is through PI-3 kinase and Akt activation...
  52. doi request reprint Use of atorvastatin to inhibit hypoxia-induced myocardin expression
    Chiung Zuan Chiu
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Eur J Clin Invest 42:564-71. 2012
    ..We evaluated the pathways of atorvastatin in repressing ROS and myocardin after hypoxia to prevent cardiomyocyte hypertrophy...
  53. ncbi request reprint Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells
    Chun Chung Lee
    Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 13:143-56. 2006
    ..We suggest that VEGF induced by HBO is through c-Jun/AP-1 activation, and through simultaneous activation of ERK and JNK pathways...
  54. doi request reprint Angiotensin II and the JNK pathway mediate urotensin II expression in response to hypoxia in rat cardiomyocytes
    Chiung Zuan Chiu
    School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan, Republic of China Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Taipei 111, Taiwan, Republic of China College of Medicine, Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan, Republic of China
    J Endocrinol 220:233-46. 2014
    ..In summary, hypoxia in cardiomyocytes increases UII and collagen I expression through the induction of AngII, ROS, and the JNK pathway causing cardiomyocyte hypertrophy and fibrosis. ..
  55. doi request reprint Clinical utility of CHADS2 and CHA2DS2-VASc scoring systems for predicting postoperative atrial fibrillation after cardiac surgery
    Su Kiat Chua
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan Division of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan Department of General Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Thorac Cardiovasc Surg 146:919-926.e1. 2013
    ..The aim of this study was to investigate whether the CHADS2 and CHA2DS2-VASc scores are useful risk assessment tools for new-onset atrial fibrillation after cardiac surgery...
  56. doi request reprint The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia
    Huei Fong Hung
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Hypertens 26:2349-60. 2008
    ..We sought to investigate the molecular regulation of resistin expression under hypoxia in cultured vascular smooth muscle cells...
  57. ncbi request reprint Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Cardiovasc Res 54:576-83. 2002
    ..We aimed to test the hypothesis that exogenous administration of HIF-1alpha/VP16 could enhance collateral vessel formation in a rat acute myocardial infarction model...
  58. ncbi request reprint Chrysin suppresses IL-6-induced angiogenesis via down-regulation of JAK1/STAT3 and VEGF: an in vitro and in ovo approach
    Chiu Mei Lin
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei City, Taiwan
    J Agric Food Chem 58:7082-7. 2010
    ..Chrysin may provide new therapeutic potential for IL-6-induced pathological angiogenesis...
  59. doi request reprint Angiotensin II activates myostatin expression in cultured rat neonatal cardiomyocytes via p38 MAP kinase and myocyte enhance factor 2 pathway
    Bao Wei Wang
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Taipei 111, Taiwan, ROC
    J Endocrinol 197:85-93. 2008
    ..In conclusion, AngII enhances myostatin expression in cultured rat neonatal cardiomyocytes. The AngII-induced myostatin is mediated through p38 MAP kinase and MEF-2 pathway...
  60. pmc Tumor necrosis factor-α enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells
    Bao Wei Wang
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, and School of Medicine, Fu Jen Catholic University, New Taipei City, Taipei, Taiwan
    J Biomed Sci 18:27. 2011
    ..However, the molecular mechanism of beneficial effects of HBO is poorly understood. We sought to investigate the cellular and molecular mechanisms of regulation of visfatin by HBO in human coronary arterial endothelial cells (CAECs)...
  61. pmc Regulation of PUMA induced by mechanical stress in rat cardiomyocytes
    Wen pin Cheng
    Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 19:72. 2012
    ..However, the expression of PUMA in cardiomyocytes under mechanical stress is little known. We aimed to investigate the regulation mechanism of PUMA expression and apoptosis induced by mechanical stress in cardiomyocytes...
  62. ncbi request reprint Predictors of long-term outcomes in patients after elective stent implantation for unprotected left main coronary artery disease
    Ren Jen Lee
    Yuanpei Institute of Science and Technology, Fu Jen Catholic University and Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Heart Vessels 22:99-103. 2007
    ..Furthermore, a history of CVA could predict the cardiovascular mortality and lower LVEF could predict the total mortality...
  63. ncbi request reprint Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells
    Hung hsing Chao
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Eur J Pharmacol 573:49-54. 2007
    ....
  64. ncbi request reprint The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch
    Wen pin Cheng
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Cardiovasc Res 77:551-9. 2008
    ..We aimed to test the hypothesis that mechanical stretch induces GADD153 expression in VSMCs undergoing apoptosis...
  65. doi request reprint Human mesenchymal stem cells improve myocardial performance in a splenectomized rat model of chronic myocardial infarction
    Jen Fu Liu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 107:165-74. 2008
    ..The goal of this study was to investigate myocardial performance after human bone marrow-derived mesenchymal stem cell (hMSCs) transplantation in rats with chronic myocardial infarction...
  66. doi request reprint Acute hypoxia enhances proteins' S-nitrosylation in endothelial cells
    Shih Chung Chen
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Biochem Biophys Res Commun 377:1274-8. 2008
    ..Further understanding of the functional relevance of these S-nitrosylated proteins may provide a molecular basis for treating ischemia-induced vascular disorders...
  67. ncbi request reprint Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products
    Yao Jen Liang
    Institute of Pharmacology, National Taiwan University, Taipei, Taiwan
    Cardiology 110:182-90. 2008
    ..We tested the hypothesis that simvastatin inhibited CRP-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products...
  68. ncbi request reprint Hypoxia-inducible factor 1alpha regulates lung adenocarcinoma cell invasion
    Kou Gi Shyu
    Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    Exp Cell Res 313:1181-91. 2007
    ....
  69. doi request reprint Mechanical stretch via transforming growth factor-β1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts
    Kou Gi Shyu
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Eur J Heart Fail 15:36-45. 2013
    ..We sought to investigate the mechanism of regulation of miR208a and the target gene of miR208a in cardiac cells by mechanical stretch...
  70. ncbi request reprint Improvement in door-to-balloon (D2B) time in acute ST-elevation myocardial infarction through the D2B alliance--experience of 15 primary percutaneous coronary intervention centers in Taiwan
    Su Kiat Chua
    Graduate Instituate of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
    Circ J 77:383-9. 2013
    ....
  71. doi request reprint Mechanical stretch induces the apoptosis regulator PUMA in vascular smooth muscle cells
    Wen pin Cheng
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Cardiovasc Res 93:181-9. 2012
    ..The mechanisms by which cyclic stretch influences the regulation of PUMA in vascular smooth muscle cells (VSMCs) during apoptosis remain unclear. We hypothesized that cyclic stretch enhances PUMA expression in VSMCs undergoing apoptosis...
  72. ncbi request reprint Angiographic and clinical manifestations of coronary fistulas in Chinese people: 15-year experience
    Chiung Zuan Chiu
    School of Medicine, Fu Jen Catholic University, and Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Circ J 72:1242-8. 2008
    ..Coronary artery fistula (CAF) is an anomaly resulting in the steal phenomenon of coronary blood flow, which may cause morbidity or mortality. CAFs in Chinese patients after long-term follow-up of 15 years were retrospectively analyzed...
  73. doi request reprint The diagnostic accuracy of 256-row computed tomographic angiography compared with invasive coronary angiography in patients with suspected coronary artery disease
    Shu Ping Chao
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, No 95, Wenchang Road, Taipei 111, Taiwan
    Eur Heart J 31:1916-23. 2010
    ..The accuracy of 256-row CTA has not yet been studied. We sought to assess the accuracy of 256-row CTA compared with invasive coronary angiography (ICA) in the diagnosis and assessment of CAD...
  74. doi request reprint Association of blood active matrix metalloproteinase-3 with carotid plaque score from a community population in Taiwan
    Li Ming Lien
    Graduate Institute of Clinical Medicine, College of Medicine, School of Medicine, Taipei Medical University, Department of Neurology, Shin Kong WHS Memorial Hospital, Taipei, Taiwan
    Atherosclerosis 212:595-600. 2010
    ..We assessed blood levels of active MMPs in relation to the extent of carotid plaque formation and intima-media thickness (IMT) in a community population in Taiwan...
  75. doi request reprint Acute hypoxia to endothelial cells induces activating transcription factor 3 (ATF3) expression that is mediated via nitric oxide
    Shih Chung Chen
    Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan
    Atherosclerosis 201:281-8. 2008
    ..These results suggest that the ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK pathway in ECs. Our findings provide a molecular basis for the mechanism in which ECs respond to acute hypoxia...
  76. ncbi request reprint Functional role of wogonin in anti-angiogenesis
    Chiu Mei Lin
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, No 95 Wen Cheng Road, Shin Lin, Taipei, Taiwan
    Am J Chin Med 40:415-27. 2012
    ..Based on this study, we suggest that wogonin may provide a new potential therapeutic option for treatment of IL-6-related pathological angiogenesis...
  77. doi request reprint Moderate to high concentrations of high-density lipoprotein from healthy subjects paradoxically impair human endothelial progenitor cells and related angiogenesis by activating Rho-associated kinase pathways
    Chun Yao Huang
    Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 32:2405-17. 2012
    ..This study aimed to investigate the concentration-related effects of HDL on in vitro and in vivo functions of human endothelial progenitor cells (EPCs) and related angiogenesis...
  78. doi request reprint Hypertension due to co-existing paraganglioma and unilateral adrenal cortical hyperplasia
    Kuo Hsuan Chiang
    Division of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 106:1043-7. 2007
    ..Postoperatively, blood pressure, plasma renin, aldosterone and urine VMA all returned to within normal ranges. The possible relationship of these two diseases is discussed...
  79. doi request reprint 2010 guidelines of the Taiwan Society of Cardiology for the management of hypertension
    Chern En Chiang
    Division of Cardiology and General Clinical Research Center, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    J Formos Med Assoc 109:740-73. 2010
    ..Finally, these guidelines are not mandatory; the responsible physician's decision remains most important in hypertension management...
  80. ncbi request reprint Enhancement of new vessel formation by angiopoietin-2/Tie2 signaling in endothelial progenitor cells: a new hope for future therapy?
    Kou Gi Shyu
    Cardiovasc Res 72:359-60. 2006
  81. ncbi request reprint Pericardial fluid and serum levels of vascular endothelial growth factor and endostatin in patients with or without coronary artery disease
    Jer Young Liou
    Division of Cardiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 105:377-83. 2006
    ..Vascular endothelial growth factor (VEGF) and endostatin are related to ischemic heart disease. This study investigated pericardial fluid and serum levels of VEGF and endostatin in patients with or without ischemic heart disease...