Research Topics
Species | Lung YuSummaryAffiliation: National Cheng Kung University Country: Taiwan Publications
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Publications
Estrogen and progesterone distinctively modulate methamphetamine-induced dopamine and serotonin depletions in C57BL/6J miceL Yu
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
J Neural Transm 107:1139-47. 2000..In conclusion, sexual differences observed in methamphetamine-induced striatal neurotoxicity may be modulated by ovarian hormones...- Sexual differences and estrous cycle in methamphetamine-induced dopamine and serotonin depletions in the striatum of miceL Yu
Institute of Behavioral Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
J Neural Transm 107:419-27. 2000..These results suggest that sex hormones and other modulating factors may play a role in methamphetamine-induced dopamine and serotonin neurotoxicity... - Ovarian hormones do not attenuate methamphetamine-induced dopaminergic neurotoxicity in mice gonadectomized at 4 weeks postpartumLung Yu
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
Neuroendocrinology 75:282-7. 2002..4OHT did not block the protecting effects of EB on MA-induced DA depletion in female and male mice, suggesting that the estrogen receptor may not be involved in the protective effects of EB on attenuating MA-induced DA toxicity... - Opioid peptides alleviated while naloxone potentiated methamphetamine-induced striatal dopamine depletion in miceL Yu
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
J Neural Transm 108:1231-7. 2001..These results suggest that the opioid ligands may, directly or indirectly, modulate this methamphetamine-induced dopamine neurotoxicity in the nigrostriatal system via a temperature-independent mechanism... - Melatonin in concentrated ethanol and ethanol alone attenuate methamphetamine-induced dopamine depletions in C57BL/6J miceL Yu
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, 1 University Road, Tainan 70101, Taiwan
J Neural Transm 109:1477-90. 2002..Finally, the protective effects of ethanol were not blocked by bicuculline. Together, we conclude that ethanol may protect mice against methamphetamine-induced dopamine depletion probably via non-GABAA receptor activation... 
Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin IYu Fan Liu
Institute of Basic Medical Sciences, Department of Physiology, National Cheng Kung University, Tainan, Taiwan
J Physiol 587:3221-31. 2009..Therefore, our results support the notion that different forms of exercise induce neuroplasticity changes in different brain regions, and thus exert diverse effects on various forms of learning and memory...
Glucocorticoid signaling and exercise-induced downregulation of the mineralocorticoid receptor in the induction of adult mouse dentate neurogenesis by treadmill runningYa Ting Chang
Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan, Taiwan
Psychoneuroendocrinology 33:1173-82. 2008....- Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathwayShih Ying Wu
Department of Cell Biology and Anatomy, National Cheng Kung University Medical College, Tainan, Taiwan
Brain Behav Immun 25:135-46. 2011..The neuroprotective effects of Ex are not due to the modulation of inflammation status, but rather to the activation of the BDNF-TrkB signaling pathway... - Medial prefrontal cortex and nucleus accumbens core are involved in retrieval of the methamphetamine-associated memoryChih Yuan Chiang
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan 701, Taiwan
Behav Brain Res 197:24-30. 2009..These results, taken together, suggest that the medial prefrontal cortex and the core of the nucleus accumbens are anatomical substrates responsible for reactivation of the MA-CPP memory... - Lipopolysaccharide mitagates methamphetamine-induced striatal dopamine depletion via modulating local TNF-alpha and dopamine transporter expressionYu Ting Lai
Behavioral Neuropharmacology Laboratory, Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, 1 University Rd, Tainan, 70101, Taiwan, ROC
J Neural Transm 116:405-15. 2009.... - Presence of conspecifics and their odor-impregnated objects reverse stress-decreased neurogenesis in mouse dentate gyrusChianfang G Cherng
Department of Health Psychology, Chang Jung Christian University, Tainan, Taiwan
J Neurochem 112:1138-46. 2010..Conspecific companions or presence of their odors reverse stress-decreased neurogenesis in the dentate gyrus, suggesting that social support during stress exposure may improve neurogenesis-related psychological functions... - Systemic treatment with protein synthesis inhibitors attenuates the expression of cocaine memoryHsin Yi Fan
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan, ROC
Behav Brain Res 208:522-7. 2010..More importantly, reactivation of cocaine-CPP could be achieved by presentation of cocaine-conditioned cues as well as by administering additional cocaine and saline conditioning trials in a balanced fashion... - Attenuation of methamphetamine-induced nigrostriatal dopaminergic neurotoxicity in mice by lipopolysaccharide pretreatmentYin Chiu Lin
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine Tainan 701, Taiwan
Chin J Physiol 50:51-6. 2007..We concluded a critical time window for systemic lipopolysaccharide pretreatment in exerting effective protection against methamphetamine-induced nigrostriatal dopamine neurotoxicity... - Memantine abolishes the formation of cocaine-induced conditioned place preference possibly via its IL-6-modulating effect in medial prefrontal cortexKuei Ying Lin
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC
Behav Brain Res 220:126-31. 2011..Moreover, an extremely low dose of memantine may decrease the acquisition of cocaine-induced CPP by reversing cocaine conditioning-increased IL-6 levels in mPFC... - Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged miceChih Wei Wu
Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
J Appl Physiol 105:1585-94. 2008..Taken together, mandatory running exercise alters the brain chemistries of middle-aged animals toward an environment that is favorable to NSC proliferation, survival, and maturation... - Involvement of amygdaloid protein synthesis in early- and late-phase reconsolidation of emotion-related memoriesJia Ying Chuang
National Cheng Kung University College of Medicine, Tainan, Taiwan, Republic of China
Chin J Physiol 55:314-22. 2012..Protein synthesis in the CeA is required for late phase reconsolidation of retrieved emotion-related memories... - Repeated co-administrations of alcohol- and methamphetamine-produced anxiogenic effect could be associated with the neurotoxicity in the dentate gyrusJia Ying Chuang
Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan, ROC
J Neural Transm 118:1559-69. 2011..In contrast, such an anxiogenic effect is less likely related to this combination-caused glial toxicity in limbic regions or cell proliferation-inhibiting effect in the SVZ or DG... - Odors from proximal species reverse the stress-decreased neurogenesis via main olfactory processingChian Fang G Cherng
Department of Health Psychology, Chang Jung Christian University, Tainan, 71101, Taiwan, ROC
Behav Brain Res 229:106-12. 2012..Phylogenetic distances of the odor-generating species and mice might contribute to the odors' protective effects against the stress-induced decreases in cell proliferation and neurogenesis... - Mutual enhancement of central neurotoxicity induced by ketamine followed by methamphetamineJing Jer Ke
Department of Physiology, National Cheng Kung University College of Medicine, Tainan, Taiwan
Toxicol Appl Pharmacol 227:239-47. 2008.... - Long-term compulsive exercise reduces the rewarding efficacy of 3,4-methylenedioxymethamphetamineHsiun Ing Chen
Department of Physiology, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC
Behav Brain Res 187:185-9. 2008..We conclude that the long-term, compulsive exercise is effective in curbing the reward efficacy of MDMA possibly via its direct effect on reversing the MDMA-stimulated dopamine release in nucleus accumbens... - Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in miceMing Che Ho
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan, 70101, Republic of China
Psychopharmacology (Berl) 205:141-9. 2009..This study was undertaken to examine effects of a long-term dosing regimen with selective MAOIs on cocaine and food reward... - Ketamine pretreatment exacerbated 3,4-methylenedioxymethamphetamine-induced central dopamine toxicityJing Jer Ke
Department of Physiology, National Cheng Kung University College of Medicine, Tainan, Taiwan, Republic of China
Chin J Physiol 51:65-70. 2008..These results, taken together, indicate that binge use of ketamine specifically enhances the MDMA-induced central dopaminergic neurotoxicity in adult mouse brain... - 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized miceYu-Min Kuo
Department of Cell Biology and Anatomy, National Cheng Kung University College of Medicine, Tainan, Taiwan
J Neurochem 87:1436-43. 2003..The free radical-scavenging ability of 4-OHT calls for further investigations for its uses in clinical practice... - Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellumTung Yi Huang
Department of Physiology, National Cheng Kung University, Tainan, Taiwan, Republic of China
J Appl Physiol 113:889-95. 2012..Furthermore, as Purkinje cells in the exercise group were relatively toxin resistant, the exercised rats showed good motor performance, even under toxin-treated conditions... - Chronic treadmill running in normotensive rats resets the resting blood pressure to lower levels by upregulating the hypothalamic GABAergic systemYuan Chang Hsu
Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan, ROC
J Hypertens 29:2339-48. 2011..We hypothesize that GABAergic adaptations in the hypothalamus participate in the chronic exercise-induced cardiovascular resetting effects in conscious normotensive animals... - Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in miceYu Fan Liu
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
Neurobiol Learn Mem 90:81-9. 2008..Taken together, these data suggest that the upregulation of TrkB and synaptotagmin in the hippocampus contributes to the exercise-facilitated aversive memory... - Blood pressure variations real-time reflect the conditioned fear learning and memoryYuan Chang Hsu
Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
PLoS ONE 7:e32855. 2012..Altogether, real-time blood pressure variations faithfully revealed the critical steps involved in conditioned fear learning and memory, and our results supported a coupling between the cued learning and the post-shock calmness... - Disruption of memory reconsolidation impairs storage of other, non-reactivated memoryWen Yu Tzeng
Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan 701, Taiwan
Neurobiol Learn Mem 97:241-9. 2012..More importantly, retrieval of a memory does not seem to be an absolute condition for rapidly changing the memory... - Accumbal 14-3-3ζ protein downregulation is associated with cocaine-conditioned memoryGour Shenq Kao
Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan, ROC
Neurosignals 19:175-88. 2011..Further understanding of the function of accumbal 14-3-3ζ protein may shed light on the treatment of cocaine craving and relapse... - Treadmill exercise counteracts the suppressive effects of peripheral lipopolysaccharide on hippocampal neurogenesis and learning and memoryChih Wei Wu
Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
J Neurochem 103:2471-81. 2007..Such advantageous effects of running exercise are not due to the alteration of inflammatory response, but possibly by the restoring the LPS-lessened brain-derived neurotrophic factor signaling pathway... - Local proteins associated with methamphetamine-induced nigrostriatal dopaminergic neurotoxicityPao-Chi Liao
Department of Environmental and Occupational Health, National Cheng Kung University College of Medicine, Tainan, Taiwan
J Neurochem 95:160-8. 2005..Taken together, these results suggest that local up-regulation of alpha-synuclein and down-regulation of ubiquitin carboxy-terminal hydrolase/PGP 9.5 could be linked to the MA-induced dopaminergic terminal toxicity... - Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrusWen Yu Tzeng
Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan 70101, Taiwan, ROC
Psychoneuroendocrinology 38:425-37. 2013..The presence of companions reverses the stressor-decreased DG neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in DG... - Activation of amygdaloid PKC pathway is necessary for conditioned cues-provoked cocaine memory performanceYu Ting Lai
Behavioral Neuropharmacology Laboratory, Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, 1 University Road, Tainan 701, Taiwan, ROC
Neurobiol Learn Mem 90:164-70. 2008..However, temporary inhibition of this signaling pathway does not seem to affect cocaine CPP memory per se... - Cocaine-but not methamphetamine-associated memory requires de novo protein synthesisYu Min Kuo
Department of Anatomy and Cell Biology, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC
Neurobiol Learn Mem 87:93-100. 2007.... - Neonatal isolation decreases cued fear conditioning and frontal cortical histone 3 lysine 9 methylation in adult female ratsGour Shenq Kao
Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan 70101, Taiwan ROC
Eur J Pharmacol 697:65-72. 2012..We, hereby, suggest that decreased frontal cortical H3K9 mono- and tri-methylation may be involved in early life separation-decreased fear memory of adult rats... - Interactions between amyloid-β and hemoglobin: implications for amyloid plaque formation in Alzheimer's diseaseJia Ying Chuang
Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
PLoS ONE 7:e33120. 2012.... - Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in miceMei Feng Chen
Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
J Physiol 591:985-1000. 2013..Overall, moderate exercise shortly after CHI reversed the deficits in recognition memory and prevented the progression of brain injury... - Methamphetamine-induced conditioned place preference is facilitated by estradiol pretreatment in female miceH H Chen
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, Republic of China
Chin J Physiol 46:169-74. 2003..Taken together, we conclude that the facilitating effects of estradiol on methamphetamine-induced conditioned place preference could be sex-dependent with an eminent sensitivity associated with the adult female mice... - Associated alterations of striatal dopamine D2/D3 receptor and transporter binding in drug-naive patients with schizophrenia: a dual-isotope SPECT studyYen Kuang Yang
Department of Psychiatry, Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan 704, ROC
Am J Psychiatry 161:1496-8. 2004.... - Impairment of an electroconvulsive stimulus on reconsolidation of memories established by conditioningTsun Jung Lu
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan 70101, Taiwan, Republic of China
Chin J Physiol 56:xxx. 2013..Taken together, we conclude that a short-lasting electroconvulsive stimulus can deteriorate the reconsolidation of various forms of memory established by conditioning... - Hemoglobin promotes Abeta oligomer formation and localizes in neurons and amyloid depositsChih-Wei Wu
Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan
Neurobiol Dis 17:367-77. 2004..We propose that an elevation in brain Hb via circulation leakage or perturbations of Hb gene regulation may participate in AD pathogenesis... - Proteomics analysis of plasma for potential biomarkers in the diagnosis of Alzheimer's diseasePao Chi Liao
Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan
Proteomics Clin Appl 1:506-12. 2007.... - Prenatal exposure of bupropion may enhance agitation, anxiety responses, and sensitivity to cocaine effects in adult miceShu Wen Su
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC
Chin J Physiol 50:1-8. 2007.... - Cycloheximide enhances maintenance of methamphetamine-induced conditioned place preferenceW H Lien
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC
Chin J Physiol 47:23-30. 2004.... - Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factorA M Huang
Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
J Neural Transm 113:803-11. 2006..We conclude that compulsive treadmill exercise with pre-familiarization acutely upregulates rat hippocampal BDNF gene expression... - Prenatal bupropion exposure enhances the cocaine reward and stress susceptibility in adult miceS Y Hsiao
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
Chin J Physiol 48:223-9. 2005..Taken together, these results suggest that use of bupropion in the late pregnancy may run a risk of enhancing the offspring's susceptibility to stress and cocaine reward in adulthood... - Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pupsYing-Chao Chang
Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Guang University College of Medicine, Kaohsiung, Taiwan
Neurobiol Dis 24:101-13. 2006..These findings suggest that functional deficits after HI in the developing brain can be reduced by agents that enhance neural plasticity and neurogenesis through CREB activation... - Methamphetamine-disrupted sensory processing mediates conditioned place preference performanceChianfang G Cherng
Institute of Medical Research, Chang Jung Christian University, Tainan 71101, Taiwan
Behav Brain Res 182:103-8. 2007..Taken together, we conclude that methamphetamine-induced CPP performance may be, in part, caused by methamphetamine-impaired sensory processing... - Pavlovian autoshaping procedures increase plasma corticosterone and levels of norepinephrine and serotonin in prefrontal cortex in ratsArthur Tomie
Department of Psychology and Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, NJ 08854 8001, USA
Behav Brain Res 153:97-105. 2004..Autoshaping, therefore, may be useful for the study of endocrine and central processes associated with appetitive conditions...