Kun Huei Yeh

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Down-regulation of thymidylate synthase expression and its steady-state mRNA by oxaliplatin in colon cancer cells
    Kun Huei Yeh
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taiwan
    Anticancer Drugs 15:371-6. 2004
  2. ncbi request reprint High-dose tamoxifen modulates drug resistance to doxorubicin, dacarbazine and ifosfamide in metastatic uterine leiomyosarcoma
    Kun Huei Yeh
    Division of Oncology, Department of Internal Medicine, Far Eastern Memorial Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Anticancer Res 23:5133-7. 2003
  3. ncbi request reprint P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection
    Jin Tung Liang
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cancer 97:451-7. 2002
  4. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
    Blood 106:1037-41. 2005
  5. ncbi request reprint A phase II study of weekly methotrexate, cisplatin, and 24-hour infusion of high-dose 5-fluorouracil and leucovorin (MP-HDFL) in patients with metastatic and recurrent esophageal cancer-improving toxicity profile by infusional schedule and double biochemi
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Cancer Research Center, National Taiwan University College of Medicine, Taiwan
    Anticancer Res 22:3621-7. 2002
  6. ncbi request reprint Phase II study of weekly paclitaxel and 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of recurrent or metastatic gastric cancer
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 69:88-95. 2005
  7. ncbi request reprint Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan, China
    World J Gastroenterol 11:4357-62. 2005
  8. ncbi request reprint A phase II trial of weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in patients with chemotherapy-pretreated metastatic breast cancer
    Chia Chi Lin
    Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Anticancer Res 27:641-5. 2007
  9. ncbi request reprint Phase II study of combination doxorubicin, interferon-alpha, and high-dose tamoxifen treatment for advanced hepatocellular carcinoma
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Hepatogastroenterology 51:815-9. 2004
  10. ncbi request reprint Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Biochem Pharmacol 63:1423-30. 2002

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Down-regulation of thymidylate synthase expression and its steady-state mRNA by oxaliplatin in colon cancer cells
    Kun Huei Yeh
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taiwan
    Anticancer Drugs 15:371-6. 2004
    ..Our data also suggest that TS down-regulation happens at the transcriptional level. TS modulation and down-regulation had, thus, shed light on the useful potential strategy to achieve objective responses in 5-FU-resistant CRC patients...
  2. ncbi request reprint High-dose tamoxifen modulates drug resistance to doxorubicin, dacarbazine and ifosfamide in metastatic uterine leiomyosarcoma
    Kun Huei Yeh
    Division of Oncology, Department of Internal Medicine, Far Eastern Memorial Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Anticancer Res 23:5133-7. 2003
    ..The excellent tumor response by simple addition of high-dose tamoxifen into a previously inactive ADI regimen advocates further investigation for the development of chemotherapy in metastatic uterine leiomyosarcoma...
  3. ncbi request reprint P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection
    Jin Tung Liang
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cancer 97:451-7. 2002
    ..05). We thus concluded that the poorer prognosis of stage IV colorectal cancers with p53 overexpression was associated with their poorer chemosensitivity rather than the more biologic aggressiveness...
  4. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
    Blood 106:1037-41. 2005
    ..In summary, nuclear expression of BCL10 or NF-kappaB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21)...
  5. ncbi request reprint A phase II study of weekly methotrexate, cisplatin, and 24-hour infusion of high-dose 5-fluorouracil and leucovorin (MP-HDFL) in patients with metastatic and recurrent esophageal cancer-improving toxicity profile by infusional schedule and double biochemi
    Chih Hung Hsu
    Department of Oncology, National Taiwan University Hospital, Cancer Research Center, National Taiwan University College of Medicine, Taiwan
    Anticancer Res 22:3621-7. 2002
    ....
  6. ncbi request reprint Phase II study of weekly paclitaxel and 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of recurrent or metastatic gastric cancer
    Kun Huei Yeh
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Oncology 69:88-95. 2005
    ..This paclitaxel-HDFL regimen is effective and well tolerated in the treatment of advanced gastric cancer...
  7. ncbi request reprint Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan, China
    World J Gastroenterol 11:4357-62. 2005
    ..To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma...
  8. ncbi request reprint A phase II trial of weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in patients with chemotherapy-pretreated metastatic breast cancer
    Chia Chi Lin
    Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Anticancer Res 27:641-5. 2007
    ..Weekly paclitaxel and infusional high-dose 5-fluorouracil/leucovorin (HDFL) are both effective regimens for metastatic breast cancer (MBC) patients...
  9. ncbi request reprint Phase II study of combination doxorubicin, interferon-alpha, and high-dose tamoxifen treatment for advanced hepatocellular carcinoma
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Hepatogastroenterology 51:815-9. 2004
    ..In this study, we sought to clarify if the addition of Interferon-alpha2b to HTD regimen could further improve the control of advanced hepatocellular carcinoma...
  10. ncbi request reprint Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Biochem Pharmacol 63:1423-30. 2002
    ..The mechanism responsible for the discrepant effect of PD98059 on NF kappa B activation and hence the chemosensitivity of SiHa cells towards cisplatin and doxorubicin remains to be investigated...
  11. ncbi request reprint Survival outcome of inoperable non-small cell lung cancer patients receiving conventional dose epirubicin and Paclitaxel as first-line treatment
    Chih Hsin Yang
    Department of Oncology and Cancer Research Center, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Oncology 68:350-5. 2005
    ..A phase II study was designed to test the effectiveness of combining paclitaxel with a conventional dose of epirubicin in inoperable NSCLC patients...
  12. doi request reprint Helicobacter pylori eradication therapy is effective in the treatment of early-stage H pylori-positive gastric diffuse large B-cell lymphomas
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Blood 119:4838-44; quiz 5057. 2012
    ..Similar to DLBCL(MALT), a substantial portion of early-stage HP-positive gastric pure (de novo) DLBCLs remains HP-dependent and responds to antibiotic treatment. Prospective studies to validate the findings are warranted...
  13. doi request reprint t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Cancer Chemother Pharmacol 68:1387-95. 2011
    ..Thalidomide is an anti-angiogenic agent with anti-TNF-α and anti-NF-κB activity. This retrospective study evaluated the efficacy of thalidomide in standard therapy-failure gastric MALT lymphoma...
  14. ncbi request reprint Involvement of nuclear transcription factor-kappa B in low-dose doxorubicin-induced drug resistance of cervical carcinoma cells
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Biochem Pharmacol 66:25-33. 2003
    ..These results suggest that even a transient exposure to a small dose of anticancer drugs may induce drug resistance in some cancer cells via upregulation of NF-kappa B activity...
  15. ncbi request reprint Somatic mutations in epidermal growth factor receptor underlying complete responsiveness to gefitinib in a Taiwanese female patient with metastatic adenocarcinoma of lung
    Kun Huei Yeh
    Division of Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    Anticancer Drugs 16:739-42. 2005
    ..Our patient supports the proposition that somatic mutation L858R in exon 21 of the EGFR gene accounts for complete responsiveness to gefitinib in a Taiwanese female patient with metastatic adenocarcinoma of lung...
  16. pmc Oxaliplatin-based Chemotherapy Might Provide Longer Progression-Free Survival in KRAS Mutant Metastatic Colorectal Cancer
    Yu lin Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Transl Oncol 6:363-9. 2013
    ..In conclusion, oxaliplatin-based chemotherapy in KRAS mutant mCRC might result in longer PFS than in KRAS wild-type mCRC...
  17. doi request reprint A phase II and pharmacokinetic study of first line S-1 for advanced gastric cancer in Taiwan
    Jen Shi Chen
    Division of Hematology Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, No 5, Fu Hsing Street, Kwei Shan Township, Taoyuan County 33305, Taiwan
    Cancer Chemother Pharmacol 67:1281-9. 2011
    ..To evaluate the efficacy, safety and pharmacokinetic profiles of S-1, which composed of tegafur (FT, a prodrug of 5-FU), 5-chloro-2,4-dihydroxypyridine and potassium oxonate (Oxo), in Taiwanese advanced gastric cancer (AGC) patients...
  18. ncbi request reprint Multifractionated paclitaxel and cisplatin combined with 5-fluorouracil and leucovorin in patients with metastatic or recurrent esophageal squamous cell carcinoma
    Chia Chi Lin
    Department of Oncology, National Taiwan University, Taipei, Taiwan, ROC
    Anticancer Drugs 18:703-8. 2007
    ..3 and 8.9 months (range 1-50+), respectively. Twice-weekly TP-HDFL has the activity and toxicity profile similar to the previously reported same three-drug combination for advanced esophageal cancer...
  19. ncbi request reprint High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resection
    Jin Tung Liang
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cancer 101:519-25. 2002
    ..05). Thus, the better prognosis of stage IV sporadic colorectal cancers with MSI-H may be associated with better chemosensitivity, rather than lower aggressiveness in biologic behavior...
  20. doi request reprint Phase I, pharmacokinetic, and bone marrow drug-level studies of tri-monthly 48-h infusion of high-dose 5-fluorouracil and leucovorin in patients with metastatic colorectal cancers
    Yunn Fang Ho
    Graduate Institute of Clinical Pharmacy, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
    Anticancer Drugs 22:290-8. 2011
    ..63-fold concentration gradient between plasma and BM compartments at steady state. The recommended 5-FU dose for use in future trials was 3500 mg/m²/48 h/week, with a fixed dose of LV at 300 mg/m²/48 h/week...
  21. ncbi request reprint Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medidine, Taipei, Taiwan
    J Clin Oncol 22:3491-7. 2004
    ..This study examined whether nuclear expression of BCL10 or nuclear factor kappa B (NF-kappaB) is useful in predicting H. pylori-independent status in patients with stage IE high-grade gastric MALT lymphomas...
  22. pmc KRAS mutation is a predictor of oxaliplatin sensitivity in colon cancer cells
    Yu lin Lin
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    PLoS ONE 7:e50701. 2012
    ..Overall, our findings suggest that KRAS mutation is a predictor of oxaliplatin sensitivity in colon cancer cells by the mechanism of ERCC1 downregulation...
  23. doi request reprint Telomerase-specific oncolytic adenoviral therapy for orthotopic hepatocellular carcinoma in HBx transgenic mice
    Wei Hsiang Lin
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    Int J Cancer 132:1451-62. 2013
    ..This preclinical study shows that Telomelysin can be used for treatment of human HCC at an appropriate dosage and that its tumor-killing activity persists after multiple injections...
  24. ncbi request reprint Weekly 24-hour infusional 5-fluorouracil as initial treatment for advanced gastric cancer with acute disseminated intravascular coagulation
    Ta Chen Huang
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC
    Anticancer Res 28:1293-7. 2008
    ..Conventional cytotoxic chemotherapy is usually not possible. Preliminary reports have suggested that non-myelosuppressive weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and leucovorin (HDFL) may be helpful...
  25. pmc ADAR2-Mediated Editing of miR-214 and miR-122 Precursor and Antisense RNA Transcripts in Liver Cancers
    Wan Hsin Liu
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan National Taiwan University Center for Genomic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
    PLoS ONE 8:e81922. 2013
    ..In conclusion, the current study discovered ADAR2-mediated editing of the complementary antisense transcripts as a novel mechanism for regulating the biogenesis of specific miRNAs during hepatocarcinogenesis. ..
  26. doi request reprint Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study
    Atsushi Ohtsu
    Atsushi Ohtsu, National Cancer Center Hospital East, Kashiwa Keisho Chin, Cancer Institute Hospital of Japanese Foundation For Cancer Research, Tokyo Kei Muro, Aichi Cancer Center Hospital, Nagoya, Japan Jaffer A Ajani, University of Texas MD Anderson Cancer Center, Houston, TX Tarek Sahmoud, Heind Smith, Syed Rizvi, David Lebwohl, Novartis Pharmaceuticals, Florham Park, NJ Yu Xian Bai, Tumor Hospital of Harbin Medical University, Harbin Hong Ming Pan, Sir Run Run Shaw Hospital, Zhejiang Lin Shen, Peking University Cancer Hospital, Beijing, People s Republic of China Yung Jue Bang, Seoul National University College of Medicine Hyun Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine Yeul Hong Kim, Korea University Anam Hospital, Seoul, South Korea Kun Huei Yeh, National Taiwan University Hospital, Taipei, Taiwan, Republic of China David Ferry, New Cross Hospital, Wolverhampton, United Kingdom Niall C Tebbutt, Austin Health, Heidelberg, Germany
    J Clin Oncol 31:3935-43. 2013
    ..This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer...
  27. doi request reprint EGFR intron 1 dinucleotide repeat polymorphism is associated with the occurrence of skin rash with gefitinib treatment
    Chin Lun Huang
    Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
    Lung Cancer 64:346-51. 2009
    ..Skin rash is the most common toxicity of epidermal growth factor receptor (EGFR)-targeted therapy. This study investigated the clinical and genetic factors associated with this skin rash...
  28. ncbi request reprint Recent advances in therapy for gastric cancer
    Kun Huei Yeh
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 103:171-85. 2004
    ..Further clinical research is mandatory to develop optimal therapies for gastric cancer...
  29. doi request reprint Long-term follow-up of gastrectomized patients with mucosa-associated lymphoid tissue lymphoma: need for a revisit of surgical treatment
    Sung Hsin Kuo
    Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Ann Surg 247:265-9. 2008
    ....
  30. ncbi request reprint Disseminated Mycobacterium kansasii infection in an HIV-negative patient presenting with mimicking multiple bone metastases
    Ching Wei Tsai
    Department of Internal Medicine, Far Eastern Memorial Hospital, Ban Ciao, Taipei 220, Taiwan
    Diagn Microbiol Infect Dis 54:211-6. 2006
    ..kansasii infection manifested with vertebral osteomyelitis, sacroiliitis, psoas abscess, bone marrow granuloma, liver granuloma, and possible spleen abscesses. The clinical manifestations are described and discussed in details...
  31. doi request reprint Estrogen receptor α represses transcription of HBV genes via interaction with hepatocyte nuclear factor 4α
    Sheng Han Wang
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    Gastroenterology 142:989-998.e4. 2012
    ..There are 2 androgen-responsive elements in the HBV enhancer I that contribute to higher viral titers in men. We investigated whether and how estrogen signaling affects progression of HBV infection...
  32. doi request reprint Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells
    Kuen Feng Chen
    Department of Medical Research, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
    Cancer Res 68:6698-707. 2008
    ..Targeting Akt signaling overcomes drug resistance to bortezomib in HCC cells, which provides a new approach for the combinational therapy of HCC...
  33. ncbi request reprint Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death
    Pei Yen Yeh
    Department of Oncology, National Taiwan University Hospital, Taipei 10016, Taiwan, ROC
    Oncogene 23:3580-8. 2004
    ..In summary, our results suggest that phosphorylation of p53Thr55 by ERK2 is important for doxorubicin-induced p53 activation and cell death...
  34. ncbi request reprint Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation
    Pei Yen Yeh
    Cancer Research Center, College of Medicine, National Taiwan University, Republic of China
    J Biol Chem 279:26143-8. 2004
    ..Further studies by site-directed mutagenesis suggested that Thr(435) was the major phosphorylation site...