Rong Sen Yang

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Immunohistochemical analysis of matrix proteolytic enzymes in the periprosthetic tissue in the patients with loosening prostheses
    R S Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei
    Tohoku J Exp Med 184:99-111. 1998
  2. ncbi request reprint Relation between histological intensity of transforming growth factor-beta isoforms in human osteosarcoma and the rate of lung metastasis
    R S Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei
    Tohoku J Exp Med 184:133-42. 1998
  3. ncbi request reprint Rhodostomin inhibits the transforming growth factor-beta1-enhanced adhesion activity of ROS 17/2.8 osteosarcoma cells
    R S Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei
    Tohoku J Exp Med 191:145-55. 2000
  4. ncbi request reprint Contact stress on polyethylene components of a new rotating hinge with a spherical contact surface
    R S Yang
    Department of Orthopaedics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan, ROC
    Clin Biomech (Bristol, Avon) 16:540-6. 2001
  5. ncbi request reprint Effects of exercise on lipid metabolism and musculoskeletal fitness in female athletes
    Kung tung Chen
    Department of Orthopaedics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 10043, Taiwan, China
    World J Gastroenterol 10:122-6. 2004
  6. ncbi request reprint Rhodostomin inhibits thrombin-enhanced adhesion of ROS 17/2.8 cells through the blockade of alphavbeta3 integrin
    Rong Sen Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei, Taiwan, ROC
    Toxicon 46:387-93. 2005
  7. ncbi request reprint Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts
    Chih Hsin Tang
    Departments of Pharmacology and Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biol Chem 280:22907-16. 2005
  8. doi request reprint Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Cell Physiol 222:757-68. 2010
  9. ncbi request reprint Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    Mol Pharmacol 69:2047-57. 2006
  10. doi request reprint 15-deoxy-Δ(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Physiol 226:3242-50. 2011

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Immunohistochemical analysis of matrix proteolytic enzymes in the periprosthetic tissue in the patients with loosening prostheses
    R S Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei
    Tohoku J Exp Med 184:99-111. 1998
    ..1% to 68.1% of strong to moderate positivity. Since these enzymes were related to the degradation of matrix protein, they may be related to the periprosthetic bone resorption. The further clinical significance needs further investigation...
  2. ncbi request reprint Relation between histological intensity of transforming growth factor-beta isoforms in human osteosarcoma and the rate of lung metastasis
    R S Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei
    Tohoku J Exp Med 184:133-42. 1998
    ..05, chi-square test). Further research is warranted to determine the utility of routine TGF-beta analysis in the clinical practice...
  3. ncbi request reprint Rhodostomin inhibits the transforming growth factor-beta1-enhanced adhesion activity of ROS 17/2.8 osteosarcoma cells
    R S Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei
    Tohoku J Exp Med 191:145-55. 2000
    ..This study demonstrated that the up-regulated cell adhesion activity of ROS 17/2.8 cells by the TGF-beta1 can be inhibited by the rhodostomin...
  4. ncbi request reprint Contact stress on polyethylene components of a new rotating hinge with a spherical contact surface
    R S Yang
    Department of Orthopaedics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan, ROC
    Clin Biomech (Bristol, Avon) 16:540-6. 2001
    ..To assess the nonlinear contact stress of a new rotating hinge of our knee prosthesis at various rotation angles...
  5. ncbi request reprint Effects of exercise on lipid metabolism and musculoskeletal fitness in female athletes
    Kung tung Chen
    Department of Orthopaedics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 10043, Taiwan, China
    World J Gastroenterol 10:122-6. 2004
    ..This study investigated the effects of intense training on lipid metabolism, bone metabolism and bone mineral density (BMD) in female athletes...
  6. ncbi request reprint Rhodostomin inhibits thrombin-enhanced adhesion of ROS 17/2.8 cells through the blockade of alphavbeta3 integrin
    Rong Sen Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei, Taiwan, ROC
    Toxicon 46:387-93. 2005
    ..8 cells to HUVEC or ECM through an upregulation of beta3 integrins, and rhodostomin was a strong inhibitor on thrombin-enhanced cell adhesion, either to HUVEC or fibronectin substratum...
  7. ncbi request reprint Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts
    Chih Hsin Tang
    Departments of Pharmacology and Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biol Chem 280:22907-16. 2005
    ..Taken together, our results provided evidence that PGE(2) increased Fn and promoted bone formation in rat osteoblasts via the EP(1)/phospholipase C/PKCalpha/c-Src signaling pathway...
  8. doi request reprint Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Cell Physiol 222:757-68. 2010
    ..Our results indicate that upregulation of HO-1 inhibits the maturation of osteoblasts and HO-1 may be involved in oxidative- or inflammation-induced bone loss...
  9. ncbi request reprint Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    Mol Pharmacol 69:2047-57. 2006
    ..Taken together, our results provide evidence that US stimulation increases COX-2 expression and promotes bone formation in osteoblasts via the integrin/FAK/PI3K/Akt and ERK signaling pathway...
  10. doi request reprint 15-deoxy-Δ(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Physiol 226:3242-50. 2011
    ..These compounds may have therapeutic application in inflammatory arthritis...
  11. ncbi request reprint PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Bone 41:562-74. 2007
    ..These data may reflect osteoporosis and less bone formation in the aging people and patients treated with thiazolidinediones...
  12. ncbi request reprint Ultrasound induces hypoxia-inducible factor-1 activation and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of rapamycin pathway in osteoblasts
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, China Medical University, Taichung 404, Taiwan
    J Biol Chem 282:25406-15. 2007
    ..Taken together, our results provide evidence that US stimulation up-regulates iNOS expression in osteoblasts by an HIF-1alpha-dependent mechanism involving the activation of ILK/Akt and mTOR pathways via integrin receptor...
  13. ncbi request reprint Enhancement of fibronectin fibrillogenesis and bone formation by basic fibroblast growth factor via protein kinase C-dependent pathway in rat osteoblasts
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    Mol Pharmacol 66:440-9. 2004
    ..These results suggest that bFGF increased bone formation and Fn fibrillogenesis both in vitro and in vivo via PKC-dependent pathway...
  14. ncbi request reprint The role of titanium in the altered endotoxin-induced nitric oxide synthase expression in alveolar macrophages from titanium-alloy-implanted rats
    Rong Sen Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei 10043, Taiwan
    J Biomed Mater Res A 66:802-10. 2003
    ..The inhibitory action of Ti on cellular responses of alveolar macrophages may be anti-inflammatory and thus may depress local defense mechanisms related to microbial killing...
  15. ncbi request reprint Enhancement of PLGF production by 15-(S)-HETE via PI3K-Akt, NF-κB and COX-2 pathways in rheumatoid arthritis synovial fibroblast
    Ming Yueh Wu
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Sec 1, Jen Ai Road, Taiwan 100 Taipei, Taiwan
    Eur J Pharmacol 714:388-96. 2013
    ..These results indicated that PLGF up-regulation by 15-LOX downstream product may be involved in inflammatory arthritis. ..
  16. ncbi request reprint Motorcycle exhaust particulates enhance vasoconstriction in organ culture of rat aortas and involve reactive oxygen species
    Hui Ping Tzeng
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Toxicol Sci 75:66-73. 2003
    ..These results indicate that MEPE induces a marked enhancement of vasoconstriction in aortas under organ culture conditions and imply that a ROS-Ca2+-MLCK pathway may be involved in this MEPE-induced response...
  17. ncbi request reprint Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Eur J Pharmacol 579:40-9. 2008
    ..Taken together, our results provide evidence that coumarin derivatives increase BMP-2 expression and enhance bone formation in rat via the p38 and ERK-dependent signaling pathway...
  18. ncbi request reprint Differential susceptibility of osteosarcoma cells and primary osteoblasts to cell detachment caused by snake venom metalloproteinase protein
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, No 1, Sec 1 Jen Ai Road, Taipei 100, Taiwan
    Toxicon 43:11-20. 2004
    ..8 is much more susceptible to be detached by crovidisin. The matrix degradation by crovidisin may be responsible for the preferential detachment of ROS 17/2.8 osteosarcoma cells...
  19. ncbi request reprint Growth hormone cannot enhance the recovery of dexamethasone-induced osteopenia after withdrawal in young female wistar rats
    Tien Shang Huang
    Department of Internal Medicine, National Taiwan University and Hospital, Taipei, Taiwan
    Tohoku J Exp Med 204:257-66. 2004
    ..Unfortunately, immediate administration of GH after withdrawal of DEX did not enhance the recovery process...
  20. pmc Advanced glycation end products induce peroxisome proliferator-activated receptor γ down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products
    Ying Ju Chen
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    PLoS ONE 8:e66611. 2013
    ....
  21. ncbi request reprint Basic fibroblast growth factor stimulates fibronectin expression through phospholipase C gamma, protein kinase C alpha, c-Src, NF-kappaB, and p300 pathway in osteoblasts
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Physiol 211:45-55. 2007
    ..Our results suggest that bFGF increased Fn expression in rat osteoblasts via the FGFR2/PLCgamma2/PKCalpha/c-Src/NF-kappaB signaling pathway...
  22. ncbi request reprint Functional outcomes after endoprosthetic knee reconstruction following resection of osteosarcoma near the knee
    Jau Yih Tsauo
    School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei
    Disabil Rehabil 28:61-6. 2006
    ....
  23. doi request reprint Involvement of 15-lipoxygenase in the inflammatory arthritis
    Ming Yueh Wu
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Biochem 113:2279-89. 2012
    ..15-LOX is thus a good target for developing drugs in the treatment of inflammatory arthritis...
  24. ncbi request reprint Enhancement of fibronectin synthesis and fibrillogenesis by BMP-4 in cultured rat osteoblast
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Bone Miner Res 18:502-11. 2003
    ..ERK is involved in the signaling pathway of BMP-4 in regulating Fn fibrillogenesis in osteoblasts...
  25. doi request reprint EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee
    Ying Ju Chen
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Orthop Res 31:1032-8. 2013
    ..Our results suggested that EGb761 exerts the anti-inflammatory effects on human articular chondrocytes and OA rats...
  26. doi request reprint Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway
    Yuan Peng Yen
    College of Medicine, Institute of Toxicology, National Taiwan University, Taipei, Taiwan
    Arch Toxicol 86:923-33. 2012
    ..Taken together, these results suggest that As(2)O(3) may exert its cytotoxicity on myoblasts by inducing apoptosis through a ROS-induced mitochondrial dysfunction, ER stress, and Akt inactivation signaling pathway...
  27. ncbi request reprint The effects of low-intensity ultrasound on growing bone after sciatic neurectomy
    Rong Sen Yang
    Department of Orthopaedics, National Taiwan University, Taipei, Taiwan
    Ultrasound Med Biol 31:431-7. 2005
    ..Thus, the low-intensity US generated micromechanical strains might not induce enough bone formation activity to reverse the bone loss in this model of intact bones...
  28. ncbi request reprint Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes
    Ying Ju Chen
    Institute of Toxicology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei, 10051, Taiwan
    J Orthop Res 32:573-80. 2014
    ..2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:573-580, 2014. ..
  29. ncbi request reprint Regulation of fibronectin fibrillogenesis by protein kinases in cultured rat osteoblasts
    Rong Sen Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 61:1163-73. 2002
    ..Cytosolic Fn synthesis and extracellular Fn assembly may be differentially regulated by the activation of PKA...
  30. ncbi request reprint Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, China Medical University, Taichung, Taiwan
    J Immunol 179:5483-92. 2007
    ..Our results suggest that adiponectin increased IL-6 production in synovial fibroblasts via the AdipoR1 receptor/AMPK/p38/IKKalphabeta and NF-kappaB signaling pathway...
  31. pmc Arsenic inhibits myogenic differentiation and muscle regeneration
    Yuan Peng Yen
    Institute of Toxicology, National Taiwan University, Taipei, Taiwan
    Environ Health Perspect 118:949-56. 2010
    ..We hypothesized that effects of arsenic on birth weight may be related to effects on myogenic differentiation...
  32. ncbi request reprint Regulation by ultrasound treatment on the integrin expression and differentiation of osteoblasts
    Rong Sen Yang
    Department of Orthopaedics, National Taiwan University Hospital, Taipei, Taiwan
    Bone 36:276-83. 2005
    ..These findings suggest that US has a regulatory effect on the integrin expression and the differentiation of osteoblasts and osteoclastogenesis, which may contribute to the beneficial effects of US on the fracture repair...
  33. ncbi request reprint Inhibition of tumor formation by snake venom disintegrin
    Rong Sen Yang
    Department of Orthopaedics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Toxicon 45:661-9. 2005
    ..Therefore, disintegrins may be developed as alternate therapy for bone metastasis of cancer cells...
  34. doi request reprint High false negative rate of Tc-99m MDP whole-body bone scintigraphy in detecting skeletal metastases for patients with hepatoma
    Chih Yu Chen
    Department of Orthopedic Surgery, Taipei Medical University, Shuang Ho Hospital, Taipei, Taiwan
    J Formos Med Assoc 111:140-6. 2012
    ..In addition, the anatomic distribution of the metastatic bone lesions and the prognoses of the HCC patients are also analyzed...
  35. ncbi request reprint Ultrasound induces cyclooxygenase-2 expression through integrin, integrin-linked kinase, Akt, NF-kappaB and p300 pathway in human chondrocytes
    Horng Chaung Hsu
    Department of Orthopaedics, China Medical University Hospital, Taichung, Taiwan
    Cell Signal 19:2317-28. 2007
    ..Taken together, our results provide evidence that US stimulation increases COX-2 expression in chondrocytes via the integrin/ILK/Akt/NF-kappaB and p300 signaling pathway...
  36. doi request reprint Caffeine enhances osteoclast differentiation from bone marrow hematopoietic cells and reduces bone mineral density in growing rats
    Shing Hwa Liu
    Institute of Toxicology, National Taiwan University, Taipei, Taiwan
    J Orthop Res 29:954-60. 2011
    ..Taken together, these results suggest that caffeine may reduce BMD in growing rats through the enhancement in osteoclastogenesis. Caffeine may possess the ability to enhance a COX-2/PGE(2) -regulated RANKL-mediated osteoclastogenesis...
  37. ncbi request reprint How to evaluate three dimensional angle error from plain radiographs
    Chen Kun Liaw
    Department of Orthopaedics, Shin Kong Wu Ho Su Memorial Hospital and Health System, Taipei city 11101, Taiwan Department of Orthopaedics, College of Medicine, National Taiwan University and Hospital, Taipei City 10002, Taiwan Department of Healthcare Information and Management, School of Health Technology, Ming Chuan University, TaoYuan city 33348, Taiwan College of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan
    J Arthroplasty 28:1788-90. 2013
    ..We also encode it into Micorsoft Excel (Redmond Campus, Redmond, Washington, U.S.) so that it becomes more user-friendly. We hope this tool can be used when evaluating TKR, corrective osteotomy, fracture fixation, and so on. ..
  38. ncbi request reprint Estimated risk score for spine fracture in the specific bending activity of normal Taiwanese men and women
    Rong Sen Yang
    Department of Orthopedics, National Taiwan University, Taiwan, Republic of China
    Spine (Phila Pa 1976) 30:2288-92. 2005
    ..To investigate the effects of biologic age, as well as chronologic age, on the vertebral ultimate load (strength) and risk score of vertebral fracture (Phi) between the genders...
  39. ncbi request reprint Thrombin-induced IL-6 production in human synovial fibroblasts is mediated by PAR1, phospholipase C, protein kinase C alpha, c-Src, NF-kappa B and p300 pathway
    Yung Cheng Chiu
    Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan Department of Pharmacology, College of Medicine, China Medical University, Taichung, Taiwan
    Mol Immunol 45:1587-99. 2008
    ..Our results suggest that thrombin increased IL-6 production in synovial fibroblasts via the PAR1 receptor/PI-PLC/PKC alpha/c-Src/NF-kappaB and p300 signaling pathway...
  40. pmc Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models
    Feng Lin Hsu
    Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan
    Diabetes 62:628-38. 2013
    ..These findings indicate that pterosin A may be a potential therapeutic option for diabetes...
  41. ncbi request reprint Stromal cell-derived factor-1 induces matrix metalloprotease-13 expression in human chondrocytes
    Yung Cheng Chiu
    Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan
    Mol Pharmacol 72:695-703. 2007
    ....
  42. doi request reprint Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway
    Rong Sen Yang
    Department of Orthopedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Acta Biomater 5:3258-64. 2009
    ..PKC inhibitors RO320432 and chelerythrine effectively inhibited Ti-enhanced phosphorylation of eNOS and PKC (pan). These results indicate that Ti in the circulation may alter endothelial function and reduce vasoconstriction...
  43. ncbi request reprint Computerized ellipse method for measuring acetabular version after total hip replacement--a precision study using synthetic and real radiographs
    Chen Kun Liaw
    Department of Orthopaedics, Shin Kong Wu Ho Su Memorial Hospital and Health System, Taipei, Taiwan
    Comput Aided Surg 18:195-200. 2013
    ..This method may help the early diagnosis of acetabular loosening. In the present study, we hypothesized that our computerized ellipse method could improve the precision of measuring acetabular version...
  44. ncbi request reprint Knee proprioception in patients with osteosarcoma around the knee after modular endoprosthetic reconstruction
    Wei Chun Li
    Department of Physical Therapy and Rehabilitation, Chung Hsiao Municipal Hospital, no 87, Tong Teh Road, Nan Kang, Taipei, Taiwan, Republic of China
    J Bone Joint Surg Am 87:850-6. 2005
    ..We also compared differences in proprioception between patients with tumors at different sites and between patients who had different proportions of bone length excised...
  45. doi request reprint Extract isolated from Angelica hirsutiflora with insulin secretagogue activity
    Yann Lii Leu
    Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Tao Yuan, Taiwan
    J Ethnopharmacol 123:208-12. 2009
    ..Angelica hirsutiflora Liu Chao & Chuang is an endemic species and a folk medicine in Taiwan...
  46. ncbi request reprint Effects of 24 h ultra-marathon on biochemical and hematological parameters
    Huey june Wu
    Department of Physical Education, Chinese Culture University, Taipei 111, Taiwan, China
    World J Gastroenterol 10:2711-4. 2004
    ..To analyze detailed changes in hematology and biochemistry tests parameters before and after a long-distance race in ultramarathon runners...
  47. doi request reprint Enhancement of placenta growth factor expression by oncostatin M in human rheumatoid arthritis synovial fibroblasts
    Huang Ju Tu
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Physiol 228:983-90. 2013
    ..These findings demonstrated the important role of OSM in the pathology network of RA and provided novel therapeutic drug targets for RA treatment...
  48. doi request reprint Upregulation of drug transporter expression by osteopontin in prostate cancer cells
    I Shan Hsieh
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 83:968-77. 2013
    ..The animal studies also showed that OPN knockdown enhanced the cytotoxic action of DUN. These results indicate that OPN is a potential therapeutic target for cancer therapy to reduce drug resistance in sensitive tumors...
  49. doi request reprint Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamate
    Tzu Hung Lin
    Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan
    Eur J Pharmacol 589:37-44. 2008
    ..Activation of both AMPA and NMDA receptors regulates the maturation of osteoblasts. NMDA but not AMPA affects receptor for activation of NF-kappaB ligand (RANKL)-induced osteoclastogenesis...
  50. ncbi request reprint Nitric oxide is not involved in the endotoxemia-induced alterations in Ca2+ and ryanodine responses in mouse diaphragms
    Shing Hwa Liu
    Institute of Toxicology, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Section 1, Taipei 10043, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 366:327-34. 2002
    ..These results imply that the NO-related pathway may not be involved in the dysfunction of the Ca(2+) release mechanism in the sarcoplasmic reticulum of mouse diaphragm during endotoxemia...
  51. ncbi request reprint Effects on function and quality of life of postoperative home-based physical therapy for patients with hip fracture
    Jau Yih Tsauo
    School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei
    Arch Phys Med Rehabil 86:1953-7. 2005
    ..To evaluate the effects of a 3-month home-based physical therapy (PT) program for patients with hip fracture after surgery...
  52. ncbi request reprint Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice
    Chih Hsin Tang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 100
    J Biol Chem 282:2346-54. 2007
    ..These results indicate that DcR3 may play an important role in osteoporosis or other bone diseases...
  53. ncbi request reprint The diagnostic and prognostic effectiveness of F-18 sodium fluoride PET-CT in detecting bone metastases for hepatocellular carcinoma patients
    Ruoh Fang Yen
    Department of Nuclear Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Nucl Med Commun 31:637-45. 2010
    ....
  54. ncbi request reprint A 12-year ecological study of hip fracture rates among older Taiwanese adults
    Ding Cheng Chan
    Department of Geriatrics and Gerontology, National Taiwan University Hospital, No 7 Chung Shan S Rd, Taipei, 100, Taiwan
    Calcif Tissue Int 93:397-404. 2013
    ..4 to 15.9 ‰ (both p for trend < 0.001). From 1999 to 2010, there was a decline in hip fracture rates among elderly Taiwanese adults with a concomitant increase in antiosteoporosis medication expenditure...
  55. pmc Effects of arsenic on osteoblast differentiation in vitro and on bone mineral density and microstructure in rats
    Cheng Tien Wu
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Environ Health Perspect 122:559-65. 2014
    ..2014. Effects of arsenic on osteoblast differentiation in vitro and on bone mineral density and microstructure in rats. Environ Health Perspect 122:559-565; http://dx.doi.org/10.1289/ehp.1307832. ..
  56. doi request reprint Low-dose benzo(a)pyrene and its epoxide metabolite inhibit myogenic differentiation in human skeletal muscle-derived progenitor cells
    Chen Yuan Chiu
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    Toxicol Sci 138:344-53. 2014
    ..These results suggest that both BaP and BPDE are capable of inhibiting myogenesis via an AhR- or/and ER-regulated NF-κB/Akt signaling pathway...
  57. ncbi request reprint Ultrasound stimulates MMP-13 expression through p38 and JNK pathway in osteoblasts
    Yung Cheng Chiu
    Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan
    J Cell Physiol 215:356-65. 2008
    ..Taken together, our results provide evidence that US stimulation increases MMP-13 expression through p38 and JNK signaling pathway to regulate bone remodeling...
  58. pmc Factors associated with low bone mass in the hemodialysis patients--a cross-sectional correlation study
    Guey Shiun Huang
    Department of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan
    BMC Musculoskelet Disord 10:60. 2009
    ..It can lead to serious bone health problems such as fragility fractures. The purpose of this study is to investigate the risk factors of low bone mass in the hemodialysis patients...
  59. doi request reprint Comparing hook plates and Kirschner tension band wiring for unstable lateral clavicle fractures
    Karl Wu
    Department of Orthopaedics, Division of Surgery, Far Eastern Memorial Hospital, Ban Chaio, China
    Orthopedics 34:e718-23. 2011
    ..Our findings suggest that hook plates are useful for treating unstable lateral clavicular fractures...
  60. doi request reprint Direct measurement of acetabular radiographic version using an ordinary goniometer: a precision study
    Chen Kun Liaw
    Department of Orthopaedics, Tao Yuan General Hospital, Taiwan
    Comput Aided Surg 16:196-201. 2011
    ..054). Conclusions: The method of Wan and colleagues can be used when acetabular radiographic version is less than 20°. For larger radiographic versions, however, mathematical correction is necessary to obtain precise results...
  61. doi request reprint Phantom limb pain treated by far infrared ray
    Chi Yu Huang
    Department of Electrical Engineering, Biomedical Group, National Taiwan University, Taipei, 10617 Taiwan
    Conf Proc IEEE Eng Med Biol Soc 2009:1589-91. 2009
    ..The results of this study demonstrate an easy, non-invasive and effective treatment modality for phantom limb pain...
  62. ncbi request reprint Evaluation of osteoporosis prevention by adlay using a tissue culture model
    Rong Sen Yang
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    Asia Pac J Clin Nutr 17:143-6. 2008
    ..Taken together, these findings imply that adlay is capable of reversing the osteoporotic status in rats, and may be a helpful healthy food for osteoporosis prevention...
  63. ncbi request reprint Functional recovery after hip fracture: six months' follow-up of patients in a multidisciplinary rehabilitation program
    Yu Tzu Dai
    School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Formos Med Assoc 101:846-53. 2002
    ....
  64. ncbi request reprint Quantitative evaluation of focused ultrasound with a contrast agent on blood-brain barrier disruption
    Feng Yi Yang
    Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei, Taiwan
    Ultrasound Med Biol 33:1421-7. 2007
    ..This study demonstrates that BBB disruption can be both increased and localized to the focal region by injecting an appropriate quantity of UCA before performing focused ultrasound sonications...
  65. pmc Rare clinical experiences for surgical treatment of melanoma with osseous metastases in Taiwan
    Kuo Yuan Huang
    Department of Orthopaedics and Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Medical Center, Tainan City, Taiwan
    BMC Musculoskelet Disord 8:70. 2007
    ..Malignant melanoma occurs infrequently in Taiwan. Once it has progressed into osseous metastases, the prognosis is poor. There are no reported clinical experiences of surgical management in this area...
  66. doi request reprint Effects of exercise programmes on quality of life in osteoporotic and osteopenic postmenopausal women: a systematic review and meta-analysis
    Wei Chun Li
    School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University and Department of Physical Therapy, Hungkuang University, Taipei, Taiwan
    Clin Rehabil 23:888-96. 2009
    ..To examine the effect of exercise therapy on quality of life in postmenopausal women with osteoporosis or osteopenia...
  67. doi request reprint TNF-α increases αvβ3 integrin expression and migration in human chondrosarcoma cells
    Chun Han Hou
    Department of Orthopedic Surgery, National Taiwan University Hospital, and Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Physiol 226:792-9. 2011
    ..Taken together, our results indicated that TNF-α enhances the migration of chondrosarcoma cells by increasing αvβ3 integrin expression through the MEK/ERK/NF-κB signal transduction pathway...
  68. doi request reprint Prognostic factors of treatment outcomes in patients with granulocytic sarcoma
    Tsung Yu Lan
    Department of Orthopedics, National Taiwan University and Hospital, Taipei, Taiwan, ROC
    Acta Haematol 122:238-46. 2009
    ..To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS)...
  69. ncbi request reprint Cross-sectional survey of women in Taiwan with first-degree relatives with osteoporosis: knowledge, health beliefs, and preventive behaviors
    Shu Fang Chang
    Department of Nursing, National Taipei College of Nursing, National Taiwan Normal University, and Department of Orthopaedics, National Taiwan University Hospital, Taipei, Taiwan, ROC
    J Nurs Res 15:224-32. 2007
    ..The results of this work can be applied to provide effective implementation guidelines for preventing osteoporosis, especially for women with a family history of the disease...
  70. ncbi request reprint Excellent survival of pediatric dermatofibrosarcoma protuberans in Taiwanese
    Chun Ru Chien
    National Taiwan University Hospital, Taipei, Taiwan
    Pediatr Surg Int 23:211-4. 2007
    ..The 10-year and 15-year overall survival rates were 100 and 83%, respectively, without obvious complications. The prognosis of pediatric DFSP in Taiwanese was excellent...
  71. ncbi request reprint Titanium implants enhance pulmonary nitric oxide production and lung injury in rats exposed to endotoxin
    Rong Sen Yang
    Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei, 10043, Taiwan
    J Biomed Mater Res A 69:561-6. 2004
    ..These results provide the first experimental evidence that circulating Ti released from Ti alloy implants has an ability to affect pulmonary iNOS protein expression, and enhance the pathogenesis of acute lung injury during endotoxemia...
  72. doi request reprint Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide
    Ching Chia Wang
    Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taiwan
    Toxicol Sci 131:302-10. 2013
    ..These findings may help us to find a new strategy to treat cyclophosphamide-induced hemorrhagic cystitis...
  73. ncbi request reprint Factors associated with falls among community-dwelling older people in Taiwan
    Tai Yin Wu
    Institute of Epidemiology and Preventive Medicine and Department of Public Health, College of Public Health, National Taiwan University, Taiwan
    Ann Acad Med Singapore 42:320-7. 2013
    ..Previous studies have shown that falls were multifactorial. However, data regarding community-dwelling Chinese population are minimal. We aimed to study factors associated with falls among community-dwelling older Chinese people...
  74. pmc Pelvic skeletal metastasis of hepatocellular carcinoma with sarcomatous change: a case report
    Chih Yu Chen
    Department of Orthopedic Surgery, National Taiwan University and Hospital, Taipei, Taiwan
    Diagn Pathol 5:33. 2010
    ..And the clinical course suggests sarcomatoid hepatocellular carcinoma is derived from the transition of an ordinary hepatocellular carcinoma...
  75. doi request reprint Treatment of unicameral bone cyst: surgical technique
    Hsien Yang Hou
    Department of Orthopaedics, College of Medicine, National Taiwan University Hospital, Number 7, Chung Shan South Road, Taipei, Taiwan 10002
    J Bone Joint Surg Am 93:92-9. 2011
    ..We introduce a novel, minimally invasive treatment method and compare its clinical outcomes with those of other methods of treatment of this lesion...
  76. doi request reprint The effects of sensorimotor training on knee proprioception and function for patients with knee osteoarthritis: a preliminary report
    Jau Yih Tsauo
    School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Clin Rehabil 22:448-57. 2008
    ..To investigate the effects of a sensorimotor training programme in osteoarthritic patients...
  77. pmc The metastasectomy and timing of pulmonary metastases on the outcome of osteosarcoma patients
    Yu Min Huang
    Departments of Orthopaedics, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan
    Clin Med Oncol 3:99-105. 2009
    ..The author intended to clarify the therapeutic effect and prognostic factors of metastasectomy and timing of pulmonary metastases in osteosarcoma patents...
  78. pmc Thyroid carcinoma with bone metastases: a prognostic factor study
    Karl Wu
    Department of Orthopedics, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan
    Clin Med Oncol 2:129-34. 2008
    ..We retrospectively investigated the clinical outcomes of such patients from 1993 to 2004 and analyzed the prognostic parameters...
  79. doi request reprint Slipped capital femoral epiphysis in an adult with panhypopituitarism
    Ming Hsiao Hu
    Department of Orthopedic Surgery, National Taiwan University Hospital, Taiwan
    Orthopedics 34:222. 2011
    ..A high index of suspicion of endocrinal disorder and proper management are essential for successful treatment of adult slipped capital femoral epiphysis...
  80. ncbi request reprint Muscle torque in total knee arthroplasty: comparison of subvastus and midvastus approaches
    Chih Hung Chang
    Division of Orthopedics, Surgical Department, Far Eastern Memorial Hospital, Pan Chiao, Taipei, Taiwan
    Knee Surg Sports Traumatol Arthrosc 18:934-8. 2010
    ..We thus conclude peak muscle torque and H/Q ratios were not statistically different with the SV or MV approach, therefore functional outcome is comparable...
  81. ncbi request reprint Decreased anaerobic performance and hormone adaptation after expedition to Peak Lenin
    Kung tung Chen
    College of Humanities, Social and Natural Sciences, Ming Hsin University of Science and Technology, Hsinchu 304, Taiwan, China
    Chin Med J (Engl) 121:2229-33. 2008
    ..To evaluate the effects of an extreme-altitude expedition on anaerobic performance, the 10-second supramaximal test and endocrine hormones were evaluated before and after an expedition to Peak Lenin...
  82. pmc A simplified guide ruler from numeric table method in doing rotational osteotomy
    Chen Kun Liaw
    Institute of Computer Science and Information Engineering, National Taiwan University, Taipei City, Taiwan
    BMC Musculoskelet Disord 9:87. 2008
    ..The numeric table requires four pages in length that is rather inconvenient during performing an osteotomy operation...
  83. ncbi request reprint Methylmercury induces pancreatic beta-cell apoptosis and dysfunction
    Ya Wen Chen
    Institute of Toxicology, Department of Laboratory Medicine, and Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Chem Res Toxicol 19:1080-5. 2006
    ..Antioxidant N-acetylcysteine effectively reversed the MeHg-induced cellular responses. Altogether, our data clearly indicate that MeHg-induced oxidative stress causes pancreatic beta-cell apoptosis and dysfunction...
  84. ncbi request reprint The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo
    Ya Wen Chen
    Institute of Toxicology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, 10043, Taiwan
    Diabetes 55:1614-24. 2006
    ..These results demonstrate that low-dose mercury-induced oxidative stress and PI3K activation cause Akt signaling-related pancreatic beta-cell dysfunction...
  85. ncbi request reprint High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway
    Meei Ling Sheu
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 25:539-45. 2005
    ....
  86. ncbi request reprint Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor gamma signaling
    Chia Chi Chuang
    Institute of Toxicology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10043, Taiwan
    Endocrinology 148:4267-75. 2007
    ..These results suggest that hyperglycemia enhances the adipogenic induction of lipid accumulation through an ERK1/2-activated PI3K/Akt-regulated PPAR gamma pathway...
  87. doi request reprint Endurance treadmill running training benefits the biomaterial quality of bone in growing male Wistar rats
    Tsang Hai Huang
    Institute of Physical Education, Health and Leisure Studies, National Cheng King University, Tainan, Taiwan
    J Bone Miner Metab 26:350-7. 2008
    ..Further study would be valuable to investigate the effects of endurance running on other components of bone, such as organization of bone matrix and its relationship with bone biomaterial properties...
  88. doi request reprint Onion decreases the ovariectomy-induced osteopenia in young adult rats
    Tsang Hai Huang
    Institute of Physical Education, Health and Leisure Studies, National Cheng Kung University, No 1, University Road, Tainan City 701, Taiwan
    Bone 42:1154-63. 2008
    ..05). The present study further verified that an onion-enriched diet could counteract ovariectomy-induced bone loss and deterioration of biomechanical properties...
  89. ncbi request reprint Osteoblast-derived TGF-beta1 stimulates IL-8 release through AP-1 and NF-kappaB in human cancer cells
    Yi Chin Fong
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    J Bone Miner Res 23:961-70. 2008
    ..The aim of this study was to investigate whether osteoblast-derived TGF-beta1 is associated with osteolytic bone diseases...
  90. ncbi request reprint Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia
    Chih Hsin Tang
    Department of Pharmacology, China Medical University, Taichung, Taiwan
    J Immunol 179:1292-302. 2007
    ..Our results suggest that leptin increased IL-6 production in microglia via the leptin receptor/IRS-1/PI3K/Akt/NF-kappaB and p300 signaling pathway...
  91. doi request reprint Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins
    Tzu Hsiu Lai
    Department of Pharmacology, China Medical University, Taichung, Taiwan
    Prostate 68:1341-53. 2008
    ..The aim of this study was to investigate whether osteoblast-derived BMP-2 is associated with prostate cancer metastasis...
  92. ncbi request reprint Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
    Chih Hsin Tang
    Department of Pharmacology, China Medical University, Taichung, 404 Taiwan
    Carcinogenesis 29:35-43. 2008
    ..Taken together, our results indicated that bone marrow-derived-SDF-1alpha enhances the invasiveness of lung cancer cells by increasing MMP-9 expression through the CXCR4/ERK/NF-kappaB signal transduction pathway...
  93. ncbi request reprint Unstratified chemotherapy for non-metastatic osteosarcoma of the extremities in children
    Ming Tsan Lin
    Department of Pediatrics, Changhua Christian Hospital, Changhua, Taiwan
    J Formos Med Assoc 102:387-93. 2003
    ..This multicenter study evaluated the effectiveness of an intensive unstratified chemotherapy regimen in Taiwanese children with osteosarcoma...