Sheng Nan Wu


Affiliation: National Cheng Kung University
Country: Taiwan


  1. Hsiao H, Liu Y, Liu P, Wu S. Concerted suppression of Ih and activation of IK(M) by ivabradine, an HCN-channel inhibitor, in pituitary cells and hippocampal neurons. Brain Res Bull. 2019;149:11-20 pubmed publisher
    ..In summary, both inhibition of Ih and activation of IK(M) caused by IVA can synergistically combine to influence electrical behaviors in different types of electrically excitable cells occurring in vivo. ..
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    Wu S, Lo Y, Shen A, Chen B. Contribution of non-inactivating Na+ current induced by oxidizing agents to the firing behavior of neuronal action potentials: experimental and theoretical studies from NG108-15 neuronal cells. Chin J Physiol. 2011;54:19-29 pubmed
    ..Taken together, it is anticipated that the effects of oxidizing agents on I(Na(NI)) could be an important mechanism underlying their neurotoxic actions in neurons or neuroendocrine cells occurring in vivo. ..
  3. So E, Foo N, Ko S, Wu S. Bisoprolol, Known to Be a Selective β₁-Receptor Antagonist, Differentially but Directly Suppresses IK(M) and IK(erg) in Pituitary Cells and Hippocampal Neurons. Int J Mol Sci. 2019;20: pubmed publisher
    ..This demonstrated that in pituitary cells and hippocampal neurons the presence of BIS is capable of directly and differentially suppressing IK(M) and IK(erg), despite its antagonism of β₁-adrenergic receptors. ..
  4. Wu S, Yeh C, Huang H, Yang W. Cholesterol depletion with (2-hydroxypropyl)- β-cyclodextrin modifies the gating of membrane electroporation-induced inward current in pituitary tumor GH3 cells: experimental and analytical studies. Cell Physiol Biochem. 2011;28:959-68 pubmed publisher
    ..The channel-suppressing properties during membrane cholesterol depletion with HPβCD might thus contribute to the underlying mechanisms by which such maneuver alters neuronal or neuroendocrine function. ..
  5. Liu Y, Hsiao H, Wang J, Liu Y, Wu S. Parecoxib, a selective blocker of cyclooxygenase-2, directly inhibits neuronal delayed-rectifier K+ current, M-type K+ current and Na+ current. Eur J Pharmacol. 2019;844:95-101 pubmed publisher
    ..The inhibition of these ion channels by parecoxib may partly contribute to the underlying mechanisms by which it affects neuronal function in vivo. ..
  6. Wu S, Huang Y, Liao Y. Effects of ibandronate sodium, a nitrogen-containing bisphosphonate, on intermediate-conductance calcium-activated potassium channels in osteoclast precursor cells (RAW 264.7). J Membr Biol. 2015;248:103-15 pubmed publisher
    ..7 cells in a concentration-dependent manner. Therefore, the inhibition by Iban of IKCa channels would be an important mechanism underlying its actions on the functional activity of osteoclasts occurring in vivo. ..
  7. Wu S, Chen B, Lin M, Liu Y. Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: experimental and theoretical studies. J Theor Biol. 2008;252:711-21 pubmed publisher
    ..The results also suggest that aconitine modulation of I(K)(dr) gating is an important molecular mechanism through which it can contribute to neuronal firing. ..
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    Wu S, Wu Y, Chen B, Lo Y, Liu Y. Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons. Toxicology. 2009;258:70-7 pubmed
    ..Taken together, the effects of Tef and its structural related pyrethroids on ion currents can contribute to the underlying mechanisms through which they affect endocrine or neuroendocrine function in vivo. ..
  9. So E, Wang Y, Yang L, So K, Lo Y, Wu S. Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons. Biochem Pharmacol. 2018;151:79-88 pubmed publisher
    ..Caution should be taken in the interpretation of in vivo experimental results when GMQ or other structurally similar compounds are used as targets to characterize the potential functions of ASIC3 channels. ..

More Information


  1. Hsu H, Tseng Y, Lo Y, Wu S. Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with α-hSlo subunit. BMC Neurosci. 2014;15:135 pubmed publisher
    ..The present results demonstrate that activation of both K(M) and BK(Ca) channels caused by NGEN might combine to influence neuronal activity if similar channels were functionally co-expressed in central neurons in vivo. ..
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    Wu S, Liu S, Huang M. Cilostazol, an inhibitor of type 3 phosphodiesterase, stimulates large-conductance, calcium-activated potassium channels in pituitary GH3 cells and pheochromocytoma PC12 cells. Endocrinology. 2004;145:1175-84 pubmed
    ..The channel-stimulating properties of cilostazol may, at least in part, contribute to the underlying mechanisms by which it affects neuroendocrine function. ..
  3. Wu S, Huang Y, Kao C, Chen B, Lo Y. Investigations on contribution of glial inwardly-rectifying K(+) current to membrane potential and ion flux: an experimental and theoretical study. Kaohsiung J Med Sci. 2015;31:9-17 pubmed publisher
    ..It is thus anticipated that glial IK(IR) may be a potential target utilized to influence the activity of neuronal and glial cells as well as their interaction. ..
  4. So E, Huang Y, Hsing C, Liao Y, Wu S. Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines. Eur J Pharmacol. 2015;758:177-87 pubmed publisher
    ..The effects of ARE on these channels may partially be responsible for the underlying cellular mechanisms by which it influences the functional activities of glioma cells or oral keratinocytes, if similar findings occur in vivo. ..
  5. Huang C, Hung T, Wu S. The inhibitory actions by lacosamide, a functionalized amino acid, on voltage-gated Na+ currents. Neuroscience. 2015;287:125-36 pubmed publisher
    ..The unique effects of LCS on NaV currents presented here may contribute to its in vivo modulation of cellular excitability. ..
  6. Wu S, Huang H, Yeh C, Yang W, Lo Y. Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells. Biochem Biophys Res Commun. 2011;405:508-13 pubmed publisher
    ..The channel-suppressing properties of MEM might contribute to the underlying mechanisms by which it and its structurally related compounds affect neuronal or neuroendocrine function. ..
  7. Wu S, Chen B, Hsu T, Peng H, Wu Y, Lo Y. Analytical studies of rapidly inactivating and noninactivating sodium currents in differentiated NG108-15 neuronal cells. J Theor Biol. 2009;259:828-36 pubmed publisher
    ..The underlying mechanism of the inhibitory actions of ranolazine or riluzole on membrane potential in neurons or neuroendocrine cells in vivo may thus be associated with their blocking of I(Na)(()(NI)()). ..
  8. Chiang N, Wu S, Chen L. The potent activation of Ca(2+)-activated K(+) current by NVP-AUY922 in the human pancreatic duct cell line (PANC-1) possibly independent of heat shock protein 90 inhibition. J Pharmacol Sci. 2015;127:404-13 pubmed publisher
    ..Collectively, AUY can interact with the BKCa channel to largely increase IK(Ca) in PDECs. ..
  9. Wang Y, Chan M, Chen L, Wu S, Chen H. Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels. J Biomed Sci. 2016;23:47 pubmed publisher
  10. Hsu H, Lo Y, Huang Y, Tseng Y, Wu S. Important modifications by sugammadex, a modified ?-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells. BMC Neurosci. 2017;18:6 pubmed publisher
    ..The treatment of SGX may influence the amplitude and gating of I K(DR) and its actions could potentially contribute to functional activities of motor neurons if similar results were found in vivo. ..
  11. So E, Wu S, Lo Y, Su K. Differential regulation of tefluthrin and telmisartan on the gating charges of INa activation and inactivation as well as on resurgent and persistent INa in a pituitary cell line (GH3). Toxicol Lett. 2018;285:104-112 pubmed publisher
    ..Taken together, the results indicated that Tef- or TEL-mediated changes in the gating kinetics of INa are linked to their actions on functional activity of neurons, neuroendocrine or endocrine cells. ..
  12. Lai M, Hung T, Lin K, Sung P, Wu S, Yang C, et al. Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity. Neurotox Res. 2018;34:1-15 pubmed publisher
    ..We conclude that SMB contributes to the sodium channel-activating mechanism through which it alters cellular excitability and excitotoxicity in wide-spectrum excitable cells. ..
  13. Kuo P, Yang C, Lee Y, Chen P, Liu Y, Wu S. The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K+ currents in insulin-secreting cells. Eur J Pharmacol. 2018;819:233-241 pubmed publisher
    ..Taken these results together, these effects may be one of the possible mechanisms contributing their insulin-releasing effect. ..
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    Wu S, Wu A, Sung R. Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes. Life Sci. 2007;80:378-87 pubmed
    ..The present results suggest that these two types of K(ATP) channels may functionally be related to the activity of heart cells. ..