Research Topics
Genomes and Genes | Ruey Meei WuSummaryAffiliation: National Taiwan University Country: Taiwan Publications
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Publications
Effect of MAO-B inhibitors on MPP+ toxicity in VivoR M Wu
Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Ann N Y Acad Sci 899:255-61. 2000..Our result suggests that l-deprenyl may possess a unique neuroprotective action on nigral neuron against MPP+ toxicity independent of the MAO-B inhibition...- The COMT L allele modifies the association between MAOB polymorphism and PD in TaiwaneseR M Wu
Department of Neurology, College of Medicine, National Taiwan University and National Taiwan University Hospital
Neurology 56:375-82. 2001..To understand the ethnicity-specific effects of genetic polymorphism, we performed a case-control study of the association between PD susceptibility and polymorphism of MAOB and COMT, both separately and in combination, in Taiwanese... - Parkin mutations and early-onset parkinsonism in a Taiwanese cohortRuey Meei Wu
Department of Neurology, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 100, Taiwan
Arch Neurol 62:82-7. 2005..Loss of function of the parkin gene (PRKN) is the predominant genetic cause of juvenile and early-onset parkinsonism in Japan, Europe, and the United States... - Lack of mutations in spinocerebellar ataxia type 2 and 3 genes in a Taiwanese (ethnic Chinese) cohort of familial and early-onset parkinsonismChin Hsien Lin
Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Am J Med Genet B Neuropsychiatr Genet 144:434-8. 2007..PD patients without autosomal dominant family history or obvious cerebellar ataxia should not be candidates for routine screening of SCA2 or SCA3 mutations for cost-effectiveness... 
LRRK2 mutation in familial Parkinson's disease in a Taiwanese population: clinical, PET, and functional studiesChin Hsien Lin
Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
J Biomed Sci 15:661-7. 2008..Thus, LRRK2 mutations are rare in Taiwanese with familial PD. Further study is needed to identify causative genes or unique biomarkers for familial PD...- Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's diseaseYu Wen Huang
Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Mov Disord 22:550-5. 2007..07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings... - Genotype-phenotype correlates in Taiwanese patients with early-onset recessive ParkinsonismMing Jen Lee
Department of Medical Genetics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
Mov Disord 24:104-8. 2009..Although the role of heterozygosity of recessive genes in EOP remains to be resolved, molecular analysis and functional imaging will play a decisive role in differential diagnosis and determined therapeutic strategy... 
Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondriaChin Hsien Lin
Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Hum Genet 130:817-27. 2011..Our results support a biologically relevant role of HTRA2 in PD susceptibility in Taiwanese. Further large-scale association studies are warranted to confirm the role of HTRA2 Pro143Ala variant in the risk of PD...- Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's diseaseChin Shih Fong
Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, No 2, Min Sheng Road, Dalin, Chia Yi, Taiwan
Acta Neurol Taiwan 14:55-60. 2005..We investigated the association between PON1 polymorphism, pesticides exposure and risk of Parkinson's disease in Taiwanese population... - PLA2G6 mutations in PARK14-linked young-onset parkinsonism and sporadic Parkinson's diseaseChin Song Lu
Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan
Am J Med Genet B Neuropsychiatr Genet 159:183-91. 2012..Additionally, mutation data should be interpreted carefully because even a synonymous mutation could cause abnormal mRNA splicing... - Advanced Theory of Mind in patients at early stage of Parkinson's diseaseRwei Ling Yu
Department of Psychology, National Taiwan University, Taipei, Taiwan
Parkinsonism Relat Disord 18:21-4. 2012..Our findings might be helpful in developing educational and medical care programs for PD patients in the future... - Lrrk2 S1647T and BDNF V66M interact with environmental factors to increase risk of Parkinson's diseaseChin Hsien Lin
Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Parkinsonism Relat Disord 17:84-8. 2011..LRRK2 S1647T may be another risk factor for PD development in our ethnicity while considering the joint interaction effects with environmental factors... - Gene therapy for aromatic L-amino acid decarboxylase deficiencyWuh Liang Hwu
Department of Pediatrics and Medical Genetics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
Sci Transl Med 4:134ra61. 2012..Cerebrospinal fluid analysis showed increased dopamine and serotonin levels after gene transfer. Thus, gene therapy targeting primary AADC deficiency is well tolerated and leads to improved motor function... - Neuropsychological profile in patients with early stage of Parkinson's disease in TaiwanRwei Ling Yu
Department of Psychology, National Taiwan University, Taipei 10617, Taiwan
Parkinsonism Relat Disord 18:1067-72. 2012..Further follow-up study to determine how many percent of PD-MCI develop PDD is important. The effect of neurocognitive rehabilitation on executive function is also valuable in the subsequence study... - Transcranial color-coded sonography helps differentiation between idiopathic Parkinson's disease and vascular parkinsonismChung Fen Tsai
Department of Neurology, Cardinal Tien Hospital, Taipei, Taiwan
J Neurol 254:501-7. 2007..Recently, transcranial color-coded sonography (TCCS) has been found to have a diagnostic value in patients with idiopathic Parkinson's disease (IPD), which displays increased hyperechogenicity at the substantia nigra (SN)... - Catechol-O-methyltransferase and Parkinson's diseaseChun Hwi Tai
Department of Neurology, National Taiwan University Hospital, Taipei
Acta Med Okayama 56:1-6. 2002..The frequency distribution of COMT genetic polymorphisms among different populations and its implications in the etiology and drug response is also discussed... - Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's diseaseChin Shih Fong
Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, and National Taiwan University Hospital, Taipei, Taiwan
Clin Chim Acta 378:136-41. 2007..In this case-control study, we determined the role of manganese-containing superoxide dismutase (MnSOD) and NAD(P)H: quinone oxidoreductase 1 (NQO1) genes in PD risk in a population with high prevalence of pesticide exposure... - Minimal detectable change of the timed "up & go" test and the dynamic gait index in people with Parkinson diseaseSheau Ling Huang
School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan
Phys Ther 91:114-21. 2011..The MDCs of the Timed "Up & Go" Test (TUG) and the Dynamic Gait Index (DGI) in people with Parkinson disease (PD) are largely unknown, limiting the interpretability of the change scores of both measures... - A novel neuropsychiatric phenotype of KCNJ2 mutation in one Taiwanese family with Andersen-Tawil syndromeHoi Fong Chan
Department of Neurology, En Chu Kong Hospital, Taipei, Taiwan
J Hum Genet 55:186-8. 2010..Patients with ATS, especially those carrying the KCNJ2 mutations, should be monitored for their potential neuropsychiatric system involvement... - Feeling-of-knowing in episodic memory in patients with Parkinson's disease with various motor symptomsRwei Ling Yu
Department of Psychology, National Taiwan University, Taipei, Taiwan
Mov Disord 25:1034-9. 2010..These findings might be useful for designing specific medical care strategies for ARD patients. Further studies are needed to determine whether impaired metamemory is an early predictor for brain alteration in PD patients... - LRRK2 Parkinson's disease: from animal models to cellular mechanismsChin Hsien Lin
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
Rev Neurosci 22:411-8. 2011..These concepts can be used to further understand disease pathophysiology and serve as a platform to develop therapeutic strategies for the treatment of Parkinson's disease... - Effects of virtual reality-augmented balance training on sensory organization and attentional demand for postural control in people with Parkinson disease: a randomized controlled trialChang Yi Yen
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan
Phys Ther 91:862-74. 2011..There is a lack of studies related to virtual reality (VR)-augmented balance training on postural control in people with Parkinson disease (PD)... - The SCA17 phenotype can include features of MSA-C, PSP and cognitive impairmentI Sheng Lin
Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
Parkinsonism Relat Disord 13:246-9. 2007..This case expands the current phenotype associated with SCA17. SCA17 should be considered in the differential diagnosis of cases resembling multiple system atrophy, especially those with atypical features... - Neurocysticercosis presenting with epilepsia partialis continua: a clinicopathologic report and literature reviewShin Joe Yeh
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
J Formos Med Assoc 107:576-81. 2008..This case calls for physicians to be aware of cysticercosis as an etiology of adult-onset epilepsy in immigrants from endemic countries... - Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutationsRuey-Meei Wu
Department of Neurology, College of Medicine, National Taiwan University, and National Taiwan University Hospital, Taipei, Taiwan, Republic of China
Mov Disord 17:670-5. 2002..Furthermore, mRNA analyses identified aberrantly spliced parkin transcripts, suggesting that unusual parkin protein isoforms may be expressed in the brain and retain some function... - Pulsed wave Doppler ultrasound is useful to assess vasomotor response in patients with multiple system atrophy and well correlated with tilt table studyKe Vin Chang
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei 10002, Taiwan
ScientificWorldJournal 2012:548529. 2012..The present study demonstrated that blunted heart rate response might explain MSA's vulnerability to postural challenge. PWD may be used to predict cardiovascular response to orthostatic stress upon head-up tilt in MSA patients... - Meige syndrome relieved by bilateral pallidal stimulation with cycling mode: case reportChun Hwei Tai
Department of Neurology, University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
Neurosurgery 69:E1333-7. 2011..The patient achieved similar good treatment effect with extended battery life in the following years... - Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicityShih Ya Hung
Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
Mol Pharmacol 74:1564-75. 2008..Our results indicate that HO-1 induction exerts neuroprotection both in vitro and in vivo. Pharmacological or genetic approaches targeting HO-1 may represent a promising and novel therapeutic strategy in treating Parkinsonism... - O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancersPei Fang Wu
Graduate Institute of Clinical Medicine, National Taiwan University, College of Medicine, Taipei, Taiwan
Lung Cancer 68:484-90. 2010..5 versus 3.5 months, P<0.001). In conclusion, MGMT expression was enhanced in brain metastases as compared with the primary lung cancers. MGMT expression in brain metastases was significantly correlated with better survival... - Lrrk2 pathogenic substitutions in Parkinson's diseaseIgnacio F Mata
Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
Neurogenetics 6:171-7. 2005..Seven of these coding changes seem to be pathogenic, as they segregate with disease and were not identified within controls. No multiplications or deletions were identified... - Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonismPaul J Lockhart
Department of Neuroscience, Birdsall Building, Mayo Clinic Jacksonville, Florida 32224, USA
Mov Disord 19:1065-9. 2004..Our results and previous studies suggest that alterations to DJ-1 are not a common cause of early-onset Parkinson's disease and other causes, genetic and/or environmental, remain to be identified... - Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in AsiaMatthew J Farrer
Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Parkinsonism Relat Disord 13:89-92. 2007..Moreover, our findings demonstrate that common genetic coding variants contribute to Parkinson's disease in a population specific manner which may have important implications for future genome-wide association studies... - Analysis of Lrrk2 R1628P as a risk factor for Parkinson's diseaseOwen A Ross
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
Ann Neurol 64:88-92. 2008..20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008... - Common variants in Parkinson's diseaseOwen A Ross
Mov Disord 22:899-900. 2007