Ruey Meei Wu

Summary

Affiliation: National Taiwan University
Country: Taiwan

Publications

  1. ncbi request reprint Effect of MAO-B inhibitors on MPP+ toxicity in Vivo
    R M Wu
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Ann N Y Acad Sci 899:255-61. 2000
  2. ncbi request reprint The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese
    R M Wu
    Department of Neurology, College of Medicine, National Taiwan University and National Taiwan University Hospital
    Neurology 56:375-82. 2001
  3. ncbi request reprint Parkin mutations and early-onset parkinsonism in a Taiwanese cohort
    Ruey Meei Wu
    Department of Neurology, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 100, Taiwan
    Arch Neurol 62:82-7. 2005
  4. doi request reprint Increase of oxidative stress by a novel PINK1 mutation, P209A
    Wei Lin Chien
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Free Radic Biol Med 58:160-9. 2013
  5. ncbi request reprint Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations
    Ruey Meei Wu
    Department of Neurology, College of Medicine, National Taiwan University, and National Taiwan University Hospital, Taipei, Taiwan, Republic of China
    Mov Disord 17:670-5. 2002
  6. doi request reprint LRRK2 mutation in familial Parkinson's disease in a Taiwanese population: clinical, PET, and functional studies
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
    J Biomed Sci 15:661-7. 2008
  7. ncbi request reprint Early-onset autosomal-recessive parkinsonian-pyramidal syndrome
    Hsing Jung Lai
    Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
    Acta Neurol Taiwan 21:99-107. 2012
  8. ncbi request reprint Lack of mutations in spinocerebellar ataxia type 2 and 3 genes in a Taiwanese (ethnic Chinese) cohort of familial and early-onset parkinsonism
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Am J Med Genet B Neuropsychiatr Genet 144:434-8. 2007
  9. doi request reprint Genotype-phenotype correlates in Taiwanese patients with early-onset recessive Parkinsonism
    Ming Jen Lee
    Department of Medical Genetics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Mov Disord 24:104-8. 2009
  10. ncbi request reprint Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease
    Yu Wen Huang
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mov Disord 22:550-5. 2007

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Effect of MAO-B inhibitors on MPP+ toxicity in Vivo
    R M Wu
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Ann N Y Acad Sci 899:255-61. 2000
    ..Our result suggests that l-deprenyl may possess a unique neuroprotective action on nigral neuron against MPP+ toxicity independent of the MAO-B inhibition...
  2. ncbi request reprint The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese
    R M Wu
    Department of Neurology, College of Medicine, National Taiwan University and National Taiwan University Hospital
    Neurology 56:375-82. 2001
    ..To understand the ethnicity-specific effects of genetic polymorphism, we performed a case-control study of the association between PD susceptibility and polymorphism of MAOB and COMT, both separately and in combination, in Taiwanese...
  3. ncbi request reprint Parkin mutations and early-onset parkinsonism in a Taiwanese cohort
    Ruey Meei Wu
    Department of Neurology, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei 100, Taiwan
    Arch Neurol 62:82-7. 2005
    ..Loss of function of the parkin gene (PRKN) is the predominant genetic cause of juvenile and early-onset parkinsonism in Japan, Europe, and the United States...
  4. doi request reprint Increase of oxidative stress by a novel PINK1 mutation, P209A
    Wei Lin Chien
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Free Radic Biol Med 58:160-9. 2013
    ..These results indicate a novel pathway by which the P209A defect in the PINK1 kinase domain inhibits oxidative stress-induced HO-1 and SOD2 induction, which may accelerate the neurodegeneration in PD with PINK1 defect...
  5. ncbi request reprint Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations
    Ruey Meei Wu
    Department of Neurology, College of Medicine, National Taiwan University, and National Taiwan University Hospital, Taipei, Taiwan, Republic of China
    Mov Disord 17:670-5. 2002
    ..Furthermore, mRNA analyses identified aberrantly spliced parkin transcripts, suggesting that unusual parkin protein isoforms may be expressed in the brain and retain some function...
  6. doi request reprint LRRK2 mutation in familial Parkinson's disease in a Taiwanese population: clinical, PET, and functional studies
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
    J Biomed Sci 15:661-7. 2008
    ..Thus, LRRK2 mutations are rare in Taiwanese with familial PD. Further study is needed to identify causative genes or unique biomarkers for familial PD...
  7. ncbi request reprint Early-onset autosomal-recessive parkinsonian-pyramidal syndrome
    Hsing Jung Lai
    Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
    Acta Neurol Taiwan 21:99-107. 2012
    ....
  8. ncbi request reprint Lack of mutations in spinocerebellar ataxia type 2 and 3 genes in a Taiwanese (ethnic Chinese) cohort of familial and early-onset parkinsonism
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Am J Med Genet B Neuropsychiatr Genet 144:434-8. 2007
    ..PD patients without autosomal dominant family history or obvious cerebellar ataxia should not be candidates for routine screening of SCA2 or SCA3 mutations for cost-effectiveness...
  9. doi request reprint Genotype-phenotype correlates in Taiwanese patients with early-onset recessive Parkinsonism
    Ming Jen Lee
    Department of Medical Genetics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Mov Disord 24:104-8. 2009
    ..Although the role of heterozygosity of recessive genes in EOP remains to be resolved, molecular analysis and functional imaging will play a decisive role in differential diagnosis and determined therapeutic strategy...
  10. ncbi request reprint Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease
    Yu Wen Huang
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mov Disord 22:550-5. 2007
    ..07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings...
  11. doi request reprint Neuropsychological profile in patients with early stage of Parkinson's disease in Taiwan
    Rwei Ling Yu
    Department of Psychology, National Taiwan University, Taipei 10617, Taiwan
    Parkinsonism Relat Disord 18:1067-72. 2012
    ..Further follow-up study to determine how many percent of PD-MCI develop PDD is important. The effect of neurocognitive rehabilitation on executive function is also valuable in the subsequence study...
  12. pmc Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Hum Genet 130:817-27. 2011
    ..Our results support a biologically relevant role of HTRA2 in PD susceptibility in Taiwanese. Further large-scale association studies are warranted to confirm the role of HTRA2 Pro143Ala variant in the risk of PD...
  13. doi request reprint RIT2 variant is not associated with Parkinson's disease in a Taiwanese population
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Neurobiol Aging 34:2236.e1-3. 2013
    ..03, 95% confidence interval = 0.73-1.46, p = 0.86). We failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for PD in our population...
  14. doi request reprint Mutational analysis of FBXO7 gene in Parkinson's disease in a Taiwanese population
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Neurobiol Aging 34:1713.e1-4. 2013
    ..We conclude that FBXO7 gene contributes little to typical PD in our population. Further studies in other ethnic cohorts will be important to address its potential pathophysiological role in PD...
  15. ncbi request reprint Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease
    Chin Shih Fong
    Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, No 2, Min Sheng Road, Dalin, Chia Yi, Taiwan
    Acta Neurol Taiwan 14:55-60. 2005
    ..We investigated the association between PON1 polymorphism, pesticides exposure and risk of Parkinson's disease in Taiwanese population...
  16. doi request reprint PLA2G6 mutations in PARK14-linked young-onset parkinsonism and sporadic Parkinson's disease
    Chin Song Lu
    Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan
    Am J Med Genet B Neuropsychiatr Genet 159:183-91. 2012
    ..Additionally, mutation data should be interpreted carefully because even a synonymous mutation could cause abnormal mRNA splicing...
  17. doi request reprint Advanced Theory of Mind in patients at early stage of Parkinson's disease
    Rwei Ling Yu
    Department of Psychology, National Taiwan University, Taipei, Taiwan
    Parkinsonism Relat Disord 18:21-4. 2012
    ..Our findings might be helpful in developing educational and medical care programs for PD patients in the future...
  18. doi request reprint Lrrk2 S1647T and BDNF V66M interact with environmental factors to increase risk of Parkinson's disease
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Parkinsonism Relat Disord 17:84-8. 2011
    ..LRRK2 S1647T may be another risk factor for PD development in our ethnicity while considering the joint interaction effects with environmental factors...
  19. doi request reprint Predictors of road crossing safety in pedestrians with Parkinson's disease
    Chin Hsien Lin
    Department of Neurology, National Taiwan University Hospital Yun Lin Branch, Yunlin, Taiwan
    Accid Anal Prev 51:202-7. 2013
    ..Future large sample studies are needed to confirm our findings. Training programs or portable stimulator devices that compensate for the visual-spatial disabilities of PD patients are required to improve road safety for PD patients...
  20. doi request reprint Gene therapy for aromatic L-amino acid decarboxylase deficiency
    Wuh Liang Hwu
    Department of Pediatrics and Medical Genetics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
    Sci Transl Med 4:134ra61. 2012
    ..Cerebrospinal fluid analysis showed increased dopamine and serotonin levels after gene transfer. Thus, gene therapy targeting primary AADC deficiency is well tolerated and leads to improved motor function...
  21. doi request reprint Discontinuation of statin therapy associates with Parkinson disease: a population-based study
    Yen Chieh Lee
    Department of Family Medicine, Cathay General Hospital, Taipei, Taiwan
    Neurology 81:410-6. 2013
    ..To evaluate the effect of discontinuing statin therapy on incidence of Parkinson disease (PD) in statin users...
  22. doi request reprint Minimal detectable change of the timed "up & go" test and the dynamic gait index in people with Parkinson disease
    Sheau Ling Huang
    School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Phys Ther 91:114-21. 2011
    ..The MDCs of the Timed "Up & Go" Test (TUG) and the Dynamic Gait Index (DGI) in people with Parkinson disease (PD) are largely unknown, limiting the interpretability of the change scores of both measures...
  23. doi request reprint A novel neuropsychiatric phenotype of KCNJ2 mutation in one Taiwanese family with Andersen-Tawil syndrome
    Hoi Fong Chan
    Department of Neurology, En Chu Kong Hospital, Taipei, Taiwan
    J Hum Genet 55:186-8. 2010
    ..Patients with ATS, especially those carrying the KCNJ2 mutations, should be monitored for their potential neuropsychiatric system involvement...
  24. doi request reprint Feeling-of-knowing in episodic memory in patients with Parkinson's disease with various motor symptoms
    Rwei Ling Yu
    Department of Psychology, National Taiwan University, Taipei, Taiwan
    Mov Disord 25:1034-9. 2010
    ..These findings might be useful for designing specific medical care strategies for ARD patients. Further studies are needed to determine whether impaired metamemory is an early predictor for brain alteration in PD patients...
  25. ncbi request reprint Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease
    Chin Shih Fong
    Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, and National Taiwan University Hospital, Taipei, Taiwan
    Clin Chim Acta 378:136-41. 2007
    ..In this case-control study, we determined the role of manganese-containing superoxide dismutase (MnSOD) and NAD(P)H: quinone oxidoreductase 1 (NQO1) genes in PD risk in a population with high prevalence of pesticide exposure...
  26. ncbi request reprint Catechol-O-methyltransferase and Parkinson's disease
    Chun Hwi Tai
    Department of Neurology, National Taiwan University Hospital, Taipei
    Acta Med Okayama 56:1-6. 2002
    ..The frequency distribution of COMT genetic polymorphisms among different populations and its implications in the etiology and drug response is also discussed...
  27. ncbi request reprint Transcranial color-coded sonography helps differentiation between idiopathic Parkinson's disease and vascular parkinsonism
    Chung Fen Tsai
    Department of Neurology, Cardinal Tien Hospital, Taipei, Taiwan
    J Neurol 254:501-7. 2007
    ..Recently, transcranial color-coded sonography (TCCS) has been found to have a diagnostic value in patients with idiopathic Parkinson's disease (IPD), which displays increased hyperechogenicity at the substantia nigra (SN)...
  28. doi request reprint LRRK2 Parkinson's disease: from animal models to cellular mechanisms
    Chin Hsien Lin
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    Rev Neurosci 22:411-8. 2011
    ..These concepts can be used to further understand disease pathophysiology and serve as a platform to develop therapeutic strategies for the treatment of Parkinson's disease...
  29. doi request reprint Hemiballism in a patient with parietal lobe infarction
    Meng Chen Wu
    Department of Neurology, National Taiwan University Hospital, Taipei
    Neurology 80:e22. 2013
    ..Brain MRI showed acute infarction of the right posterior parietal lobe (figure 1) and SPECT revealed hypoperfusion in the right frontoparietal areas (figure 2)...
  30. doi request reprint Effects of virtual reality-augmented balance training on sensory organization and attentional demand for postural control in people with Parkinson disease: a randomized controlled trial
    Chang Yi Yen
    School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Phys Ther 91:862-74. 2011
    ..There is a lack of studies related to virtual reality (VR)-augmented balance training on postural control in people with Parkinson disease (PD)...
  31. ncbi request reprint The SCA17 phenotype can include features of MSA-C, PSP and cognitive impairment
    I Sheng Lin
    Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
    Parkinsonism Relat Disord 13:246-9. 2007
    ..This case expands the current phenotype associated with SCA17. SCA17 should be considered in the differential diagnosis of cases resembling multiple system atrophy, especially those with atypical features...
  32. doi request reprint Neurocysticercosis presenting with epilepsia partialis continua: a clinicopathologic report and literature review
    Shin Joe Yeh
    Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 107:576-81. 2008
    ..This case calls for physicians to be aware of cysticercosis as an etiology of adult-onset epilepsy in immigrants from endemic countries...
  33. ncbi request reprint Small-cell lung cancer presenting with Lambert-Eaton myasthenic syndrome and respiratory failure
    Jung Rern Jiang
    Department of Internal Medicine, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan
    J Formos Med Assoc 101:871-4. 2002
    ..This case suggests that plasma exchange and chemotherapy can be effective in treating SCLC with severe LEMS that produces ventilatory failure...
  34. pmc Social brain dysfunctions in patients with Parkinson's disease: a review of theory of mind studies
    Rwei Ling Yu
    Department of Psychology, National Taiwan University, Taipei, Taiwan
    Transl Neurodegener 2:7. 2013
    ..Further studies to investigate the progression of ToM and its relationship with dementia in subjects in PD are needed...
  35. pmc Pulsed wave Doppler ultrasound is useful to assess vasomotor response in patients with multiple system atrophy and well correlated with tilt table study
    Ke Vin Chang
    Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei 10002, Taiwan
    ScientificWorldJournal 2012:548529. 2012
    ..The present study demonstrated that blunted heart rate response might explain MSA's vulnerability to postural challenge. PWD may be used to predict cardiovascular response to orthostatic stress upon head-up tilt in MSA patients...
  36. doi request reprint O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers
    Pei Fang Wu
    Graduate Institute of Clinical Medicine, National Taiwan University, College of Medicine, Taipei, Taiwan
    Lung Cancer 68:484-90. 2010
    ..5 versus 3.5 months, P<0.001). In conclusion, MGMT expression was enhanced in brain metastases as compared with the primary lung cancers. MGMT expression in brain metastases was significantly correlated with better survival...
  37. doi request reprint Meige syndrome relieved by bilateral pallidal stimulation with cycling mode: case report
    Chun Hwei Tai
    Department of Neurology, University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Neurosurgery 69:E1333-7. 2011
    ..The patient achieved similar good treatment effect with extended battery life in the following years...
  38. doi request reprint Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity
    Shih Ya Hung
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Pharmacol 74:1564-75. 2008
    ..Our results indicate that HO-1 induction exerts neuroprotection both in vitro and in vivo. Pharmacological or genetic approaches targeting HO-1 may represent a promising and novel therapeutic strategy in treating Parkinsonism...
  39. ncbi request reprint Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism
    Paul J Lockhart
    Department of Neuroscience, Birdsall Building, Mayo Clinic Jacksonville, Florida 32224, USA
    Mov Disord 19:1065-9. 2004
    ..Our results and previous studies suggest that alterations to DJ-1 are not a common cause of early-onset Parkinson's disease and other causes, genetic and/or environmental, remain to be identified...
  40. ncbi request reprint Lrrk2 pathogenic substitutions in Parkinson's disease
    Ignacio F Mata
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurogenetics 6:171-7. 2005
    ..Seven of these coding changes seem to be pathogenic, as they segregate with disease and were not identified within controls. No multiplications or deletions were identified...
  41. doi request reprint Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Ann Neurol 64:88-92. 2008
    ..20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008...
  42. ncbi request reprint Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia
    Matthew J Farrer
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 13:89-92. 2007
    ..Moreover, our findings demonstrate that common genetic coding variants contribute to Parkinson's disease in a population specific manner which may have important implications for future genome-wide association studies...
  43. ncbi request reprint Common variants in Parkinson's disease
    Owen A Ross
    Mov Disord 22:899-900. 2007